TY - JOUR A1 - Schusser, Sebastian A1 - Krischer, M. A1 - Molin, D. G. M. A1 - Akker, N. M. S. van den A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation JF - Procedia Engineering N2 - A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.815 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 948 EP - 951 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Pilas, Johanna A1 - Mariano, K. A1 - Keusgen, M. A1 - Selmer, Thorsten A1 - Schöning, Michael Josef T1 - Optimization of an Enzyme-based Multi-parameter Biosensor for Monitoring Biogas Processes JF - Procedia Engineering Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.702 SN - 1877-7058 N1 - Part of special issue "Eurosensors 2015" VL - 120 SP - 532 EP - 535 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Bing, Yu A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Visualization of Defects on a Cultured Cell Layer by Utilizing Chemical Imaging Sensor JF - Procedia Engineering N2 - The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) inthe sample. In this study, a novel wound-healing assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the defect of a cell layer brought into proximity of the sensing surface.A reduced impedance inside the defect, which was artificially formed ina cell layer, was successfully visualized in a photocurrent image. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.806 SN - 1877-7058 N1 - Part of special issue "Eurosensors 2015" VL - 120 SP - 936 EP - 939 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bronder, Thomas A1 - Poghossian, Arshak A1 - Scheja, S. A1 - Wu, Chunsheng A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Electrostatic Detection of Unlabelled Single- and Double-stranded DNA Using Capacitive Field-effect Devices Functionalized with a Positively Charged Polyelectrolyte Layer JF - Procedia Engineering N2 - Capacitive field-effect electrolyte-insulator-semiconductor sensors consisting of an Al-p-Si-SiO2 structure have been used for the electrical detection of unlabelled single- and double-stranded DNA (dsDNA) molecules by their intrinsic charge. A simple functionalization protocol based on the layer-by-layer (LbL) technique was used to prepare a weak polyelectrolyte/probe-DNA bilayer, followed by the hybridization with complementary target DNA molecules. Due to the flat orientation of the LbL-adsorbed DNA molecules, a high sensor signal has been achieved. In addition, direct label-free detection of in-solution hybridized dsDNA molecules has been studied. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.710 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 544 EP - 547 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Poghossian, Arshak A1 - Ingebrandt, S. A1 - Platen, J. A1 - Schöning, Michael Josef T1 - Field-effect sensors with charged macromolecules – from micro towards nano aspects T2 - Biochemical Sensing Utilisation of Micro-and Nanotechnologies, Warschau, Nov. 2005 : Lecture Notes of the ICB Seminar / ed.: M. Mascini, W. Torbicz Y1 - 2006 SP - 74 EP - 81 PB - Polish Academy Sciences Press CY - Warsaw ER - TY - JOUR A1 - Yoshinobu, Tatsuo A1 - Moritz, Werner A1 - Finger, Friedhelm A1 - Schöning, Michael Josef ED - Comini, Elisabetta T1 - Application of thin-film amorphous silicon to chemical imaging JF - Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A. Y1 - 2006 SN - 9781558998711 N1 - Materials Research Society symposia proceedings; v. 915 IS - Paper 0910-A-20-01 SP - 1 EP - 10 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Abouzar, Maryam H. A1 - Ingebrandt, Sven A1 - Platen, Johannes A1 - Offenhäusser, Andreas A1 - Poghossian, Arshak ED - Comini, Elisabetta T1 - Towards label-free detection of charged macromolecules using field-effect-based structures : Scaling down from capacitive EIS sensor over ISFET to nano-scale devices JF - Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A. Y1 - 2006 SN - 9781558998711 IS - paper 0915-R05-04 SP - 89 EP - 94 ER - TY - JOUR A1 - Takenaga, Shoko A1 - Schneider, Benno A1 - Erbay, E. A1 - Biselli, Manfred A1 - Schnitzler, Thomas A1 - Schöning, Michael Josef A1 - Wagner, Torsten T1 - Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process JF - Physica status solidi (a) N2 - A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation. Y1 - 2015 U6 - http://dx.doi.org/10.1002/pssa.201532053 SN - 1862-6319 VL - 212 IS - 6 SP - 1347 EP - 1352 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Warmer, Johannes A1 - Wagner, Patrick A1 - Schöning, Michael Josef A1 - Kaul, Peter T1 - Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors JF - Physica status solidi (a) Y1 - 2015 U6 - http://dx.doi.org/10.1002/pssa.201431882 SN - 1862-6319 VL - 212 IS - 6 SP - 1289 EP - 1298 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Delle, Lotta E. A1 - Huck, Christina A1 - Bäcker, Matthias A1 - Müller, Frank A1 - Grandthyll, Samuel A1 - Jacobs, Karin A1 - Lilischkis, Rainer A1 - Vu, Xuan T. A1 - Schöning, Michael Josef A1 - Wagner, Patrick A1 - Thoelen, Roland A1 - Weil, Maryam A1 - Ingebrandt, Sven T1 - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide JF - Physica status solidi (a) Y1 - 2015 U6 - http://dx.doi.org/10.1002/pssa.201431863 SN - 1862-6319 VL - 212 IS - 6 SP - 1327 EP - 1334 PB - Wiley CY - Weinheim ER -