TY  - GEN
A1  - Waiczies, Helmar
A1  - Kühne, André
A1  - Winter, Lukas
A1  - Frauenrath, Tobias
A1  - Hoffmann, Werner
A1  - Ittermann, Bernd
A1  - Waiczies, Sonia
A1  - Niendorf, Thoralf
T1  - Towards theranostics of rheumatoid arthritis: 1H/19F imaging of non-steroidal anti-inflammatory drugs in hand and wrist at 7 Tesla
T2  - 2013 ISMRM Annual Meeting Proceedings
N2  - We have developed a double-tuned ¹H/¹⁹F birdcage resonator dedicated for hand and wrist imaging at 7 T to locally image non-steroidal anti-inflammatory drugs (NSAID) such as 2-{[3-(Trifluoromethyl) phenyl]amino}benzoic acid. The preliminary in vivo images acquired by the double-tuned ¹H/¹⁹F birdcage resonator demonstrate the feasibility for ¹H/¹⁹F hand- and wrist-imaging at 7 T. While the diagnostic quality of the coil needs to be assessed in patients with inflammatory rheumatoid disease, first ¹⁹F images of the NSAID are encouraging, and point towards the prospect of applying ¹⁹F-MRI to visualize and quantify the concentration of therapeutically-active compound at the sites of inflammation.
Y1  - 2013
SN  - 1545-4428
N1  - ISMRM 21st Annual Meeting & Exhibition, 20-26 April 2013, Salt Lake City, Utah, USA
ER  -