TY  - JOUR
A1  - Balakrishnan, Karthikeyan
A1  - Andrei-Selmer, Luminita-Cornelia
A1  - Selmer, Thorsten
A1  - Bacher, Michael
A1  - Dodel, Richard
T1  - Comparison of intravenous immunoglobulins for naturally occurring autoantibodies against amyloid-β
JF  - Journal of Alzheimer's Disease
N2  - Intravenous immunoglobulins (IVIG) are currently used for therapeutic purposes in autoimmune disorders. Recently, we demonstrated the presence of naturally occurring antibodies against amyloid- β (nAbs-Aβ) within the pool of IVIG. In this study, we compared different brands of IVIG for nAbs-Aβ and have found differences in the specificity of the nAbs-Aβ towards Aβ1–40 and Aβ1–42 . We analyzed the influence of a pH-shift over the course of antibody storage using ELISA and investigated antibody dimerization at acidic and neutral pH as well as differences in the IgG subclass distributions among the IVIG using both HPLC and a nephelometric assay. Furthermore, we investigated the epitope region of purified nAbs-Aβ. The differences found in Aβ specificity are not directly proportionate to the binding nature of these antibodies when administered in vivo. This information, however, may serve as a guide when choosing the commercial source of IVIG for therapeutic applications in Alzheimer's disease
Y1  - 2010
U6  - https://doi.org/10.3233/JAD-2010-1353
SN  - 1387-2877
VL  - 20
IS  - 1
SP  - 135
EP  - 143
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Kim, Jihoe
A1  - Darley, Daniel
A1  - Buckel, Wolfgang
T1  - Characterization of (R)-2-hydroxyisocaproate dehydrogenase and a family III coenzyme A transferase involved in reduction of L-leucine to isocaproate by Clostridium difficile / Kim, J. ; Darley, D. ; Selmer, T. ; Buckel, W.
JF  - Applied and Environmental Microbiology. 72 (2006), H. 9
Y1  - 2006
SN  - 0099-2240
N1  - PMID: 16957230
SP  - 6062
EP  - 6069
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Yu, Lihua
A1  - Blaser, Martin
A1  - Andrei, Paula I.
T1  - 4-Hydroxyphenylacetate decarboxylases: properties of a novel subclass of glycyl radical enzyme systems / Yu, L. ; Blaser, M. ; Andrei, PI. ; Pierik, AJ. Selmer, T.
JF  - Biochemistry. 31 (2006), H. 45
Y1  - 2006
N1  - PMID: 16878993
SP  - 9584
EP  - 9592
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Pierik, Antonio J.
A1  - Heider, Johann
T1  - New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria
JF  - Biological Chemistry. 386 (2005), H. 10
Y1  - 2005
SN  - 1431-6730
SP  - 981
EP  - 988
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Achebach, Stephanie
A1  - Unden, Gottfried
T1  - Properties and significance of apoFNR as a second form of air-inactivated [4Fe-4S]·FNR of Escherichia coli / Achebach, S. ; Selmer, T. ; Unden, G.
JF  - The FEBS Journal. 272 (2005), H. 16
Y1  - 2005
SN  - 1742-464X
SP  - 4260
EP  - 4269
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Hermann, Gloria
A1  - Jessen, Holly
A1  - Gokarn, Ravi R.
T1  - Two beta-alanyl-CoA:ammonia lyases in Clostridium propionicum / Herrmann , G. ;  Selmer,  T. ; Jessen,  HJ. ; Gokarn,  RR. ; Selifonova,  O. ;  Gort , SJ. ; , Buckel, W.
JF  - The FEBS Journal. 272 (2005), H. 3
Y1  - 2005
SN  - 1742-464X
SP  - 813
EP  - 821
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Andrei, Paula I.
A1  - Pierik, Antonio J.
A1  - Zauner, Stefan
T1  - Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity / Andrei, PI. ;  Pierik,  AJ. ; Zauner , S. ; Andrei-Selmer, LC.  ; Selmer, T.
JF  - European Journal of Biochemistry. 271 (2004), H. 11
Y1  - 2004
SN  - 0014-2956
SP  - 2225
EP  - 2230
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Hetzel, Marc
A1  - Brock, Matthias
A1  - Pierik, Antonio J.
T1  - Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein  / Hetzel, Marc ; Brock, Matthias ; Selmer, Thorsten, Pierik, Antonio J. ; Golding, Bernard T. ; Buckel, Wolfgang
JF  - European Journal of Biochemistry. 270 (2003), H. 5
Y1  - 2003
SN  - 0014-2956
SP  - 902
EP  - 910
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Willanzheimer, Angela
A1  - Hetzel, Marc
T1  - Propionate CoA-transferase from Clostridium propionicum. Cloning of the gene and identification of glutamate 324 at the active site
JF  - European Journal of Biochemistry. 269 (2002), H. 1
Y1  - 2002
SN  - 0014-2956
SP  - 372
EP  - 380
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Andrei, Paula I.
T1  - p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol
JF  - European Journal of Biochemistry. 268 (2001), H. 5
Y1  - 2001
SN  - 0014-2956
SP  - 1363
EP  - 1372
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Jennemann, Richard
A1  - Bauer, Bernhard L.
A1  - Bertalanffy, Helmut
T1  - Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus / Jennemann, Richard ; Bauer, Bernhard, L. ; Bertalanffy, Helmut ; Geyer, Rudolf ; Gschwind, Ruth, M. ; Selmer, Thorsten ; Wiegandt, Herbert
JF  - European Journal of Biochemistry. 259 (1999), H. 1-2
Y1  - 1999
SN  - 0014-2956
SP  - 331
EP  - 338
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Kahnt, Jörg
A1  - Goubeaud, Marcel
A1  - Shima, Seigo
T1  - The biosynthesis of methylated amino acids in the active site region of methyl-coenzyme M reductase / Selmer, Thorsten ; Kahnt, Jörg ; Goubeaud, Marcel ; Shima, Seigo ; Grabarse, Wolfgang ; Ermler, Ulrich ; Thauer, Rudolf K.
JF  - Journal of Biological Chemistry. 275 (2000), H. 6
Y1  - 2000
SN  - 1083-351X
SP  - 3775
EP  - 3760
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Brüser, Thomas
A1  - Dahl, Christiane
T1  - ADP Sulfurylase" from Thiobacillus denitrificans Is an Adenylylsulfate:Phosphate Adenylyltransferase and Belongs to a New Family of Nucleotidyltransferases / Brüser, Thomas ; Selmer, Thorsten ; Dahl, Christiane
JF  - Journal of Biological Chemistry. 275 (2000), H. 3
Y1  - 2000
SN  - 1083-351X
SP  - 1691
EP  - 1690
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Buckel, Wolfgang
T1  - Oxygen Exchange between Acetate and the Catalytic Glutamate Residue in Glutaconate CoA-transferase from Acidaminococcus fermentans. IMPLICATIONS FOR THE MECHANISM OF CoA-ESTER HYDROLYSIS
JF  - Journal of Biological Chemistry. 274 (1999), H. 30
Y1  - 1999
SN  - 1083-351X
SP  - 20772
EP  - 20778
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Recksiek, Michael
A1  - Dierks, Thomas
A1  - Schmidt, Bernhard
T1  - Sulfatases, Trapping of the Sulfated Enzyme Intermediate by Substituting the Active Site Formylglycine / Recksiek, Michael ; Selmer, Thorsten ; Dierks, Thomas ; Schmidt, Bernhard ; Figura, Kurt von
JF  - Journal of Biological Chemistry. 273 (1998), H. 11
Y1  - 1998
SN  - 1083-351X
SP  - 6096
EP  - 6103
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Miech, Claudia
A1  - Dierks, Thomas
A1  - Figura, Kurt von
T1  - Arylsulfatase from Klebsiella pneumoniae Carries a Formylglycine Generated from a Serine / Miech, Claudia ; Dierks, Thomas ; Selmer, Thorsten ; Figura, Kurt von ; Schmidt, Bernd
JF  - Journal of Biological Chemistry. 273 (1998), H. 9
Y1  - 1998
SN  - 1083-351X
SP  - 4835
EP  - 4837
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Sommerlade, Hans-Jörg
A1  - Ingendoh, Arnd
A1  - Gieselmann, Volkmar
T1  - Glycosylation and phosphorylation of arylsulfatase A / Sommerlade, Hans-Jörg. ; Selmer, Thomas. ; Ingendoh, Arnd ; Gieselmann, Volkmar ; Figura, Kurt von ; Neifer, Klaus ; Schmidt, Bernhard
JF  - Journal of Biological Chemistry. 269 (1994), H. 33
Y1  - 1994
SN  - 1083-351X
SP  - 20977
EP  - 20981
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Jennemann, Richard
A1  - Bauer, Bernhard L.
A1  - Bertalanffy, Helmut
T1  - Basidiolipids from Agaricus are novel immune adjuvants / Jennemann, R. ; Bauer, BL. ; Bertalanffy, H. ; Selmer, T. ; Wiegandt, H.
JF  - Immunobiology. 200 (1999), H. 2
Y1  - 1999
SN  - 0171-2985
N1  - PMID: 10416134
SP  - 277
EP  - 289
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Figura, Kurt von
A1  - Schmidt, Bernhard
A1  - Dierks, T.
T1  - A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease / Figura, Kurt von ; Schmidt, Bernhard ; Selmer, Thorsten ; Dierks, Thomas
JF  - Bioessays. 20 (1998), H. 6
Y1  - 1998
SN  - 1521-1878
SP  - 505
EP  - 510
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Lukatela, G.
A1  - Krauss, N.
A1  - Theis, K.
T1  - Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis / Lukatela, G. ; Krauss, N. ; Theis, K. ; Selmer, T. ; Gieselmann, V. ; Figura, K. von ; Saenger,
JF  - Biochemistry. 37 (1998), H. 11
Y1  - 1998
SP  - 3654
EP  - 3664
ER  -