TY  - JOUR
A1  - Gasparyan, Ferdinand V.
A1  - Poghossian, Arshak
A1  - Vitusevich, Svetlana A.
A1  - Petrychuk, Mykhaylo V.
A1  - Sydoruk, Viktor A.
A1  - Siqueira, José R. Jr.
A1  - Oliveira, Osvaldo N. Jr.
A1  - Offenhäusser, Andreas
A1  - Schöning, Michael Josef
T1  - Low-Frequency Noise in Field-Effect Devices Functionalized With Dendrimer/Carbon-Nanotube Multilayers
JF  - IEEE Sensors Journal. 11 (2011), H. 1
Y1  - 2011
SN  - 1530-437X
SP  - 142
EP  - 149
PB  - IEEE
CY  - New York
ER  - 
TY  - CHAP
A1  - Jablonski, Melanie
A1  - Koch, Claudia
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Field-Effect Biosensors Modified with Tobacco Mosaic Virus Nanotubes as Enzyme Nanocarrier
T2  - MDPI Proceeding
Y1  - 2017
U6  - https://doi.org/10.3390/proceedings1040505
N1  - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017
VL  - 1
IS  - 4
ER  - 
TY  - JOUR
A1  - Gun, Jenny
A1  - Gutkin, Vitaly
A1  - Lev, Ovadia
A1  - Boyen, Hans-Gerd
A1  - Saitner, Marc
A1  - Wagner, Patrick
A1  - Olieslaeger, Marc D´
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Tracing gold nanoparticle charge by electrolyte-insulator-semiconductor devices
JF  - Journal of Physical Chemistry C. 115 (2011), H. 11
Y1  - 2011
SN  - 1932-7455
SP  - 4439
EP  - 4445
PB  - American Cemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Gun, Jenny
A1  - Rizkov, Dan
A1  - Lev, Ovadia
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Oxygen plasma-treated gold nanoparticle-based field-effect devices as transducer structures for bio-chemical sensing
JF  - Microchimica Acta. 164 (2008), H. 3-4
Y1  - 2008
SN  - 1436-5073
SP  - 395
EP  - 404
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - Flow-velocity microsensors based on semiconductor field-effect structures
JF  - Sensors. 3 (2003), H. 7
Y1  - 2003
SN  - 1424-8220
SP  - 202
EP  - 212
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Silicon-based chemical and biological field-effect sensors
T2  - Encyclopedia of Sensors. Vol. 9 S - Sk
Y1  - 2006
SN  - 1-58883-065-9
SP  - 463
EP  - 534
PB  - ASP, American Scientific Publ.
CY  - Stevenson Ranch, Calif.
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Christiaens, P.
A1  - Williams, O. A.
A1  - Haenen, K.
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Sensing charged macromolecules with nanocrystalline diamond-based field-effect capacitive sensors
JF  - Journal of Contemporary Physics. 43 (2008), H. 2
Y1  - 2008
SN  - 1934-9378
N1  - Armenian Academy of Sciences
SP  - 77
EP  - 81
ER  - 
TY  - JOUR
A1  - Ingebrandt, S.
A1  - Han, Y.
A1  - Nakamura, F.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Offenhäusser, A.
T1  - Label-free detection of single nucleotide polymorphisms utilizing the differential transfer function of field-effect transistors
JF  - Biosensors and Bioelectronics. 22 (2007), H. 12
Y1  - 2007
SN  - 0956-5663
SP  - 2834
EP  - 2840
ER  - 
TY  - JOUR
A1  - Katz, Evgeny
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics
JF  - Analytical and Bioanalytical Chemistry
N2  - The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a “filter” system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion.
Y1  - 2017
U6  - https://doi.org/10.1007/s00216-016-0079-7
SN  - 1618-2650
VL  - 409
SP  - 81
EP  - 94
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Capacitive field-effect eis chemical sensors and biosensors: A status report
JF  - Sensors
N2  - Electrolyte-insulator-semiconductor (EIS) field-effect sensors belong to a new generation of electronic chips for biochemical sensing, enabling a direct electronic readout. The review gives an overview on recent advances and current trends in the research and development of chemical sensors and biosensors based on the capacitive field-effect EIS structure—the simplest field-effect device, which represents a biochemically sensitive capacitor. Fundamental concepts, physicochemical phenomena underlying the transduction mechanism and application of capacitive EIS sensors for the detection of pH, ion concentrations, and enzymatic reactions, as well as the label-free detection of charged molecules (nucleic acids, proteins, and polyelectrolytes) and nanoparticles, are presented and discussed.
Y1  - 2020
U6  - https://doi.org/10.3390/s20195639
SN  - 1424-8220
VL  - 20
IS  - 19
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Hardt, Gabriel
A1  - Siegert, Petra
A1  - Willenberg, Holger S.
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Detection of Adrenaline in Blood Plasma as Biomarker for Adrenal Venous Sampling
JF  - Electroanalysis
N2  - An amperometric bi-enzyme biosensor based on substrate recycling principle for the amplification of the sensor signal has been developed for the detection of adrenaline in blood. Adrenaline can be used as biomarker verifying successful adrenal venous sampling procedure. The adrenaline biosensor has been realized via modification of a galvanic oxygen sensor with a bi-enzyme membrane combining a genetically modified laccase and a pyrroloquinoline quinone-dependent glucose dehydrogenase. The measurement conditions such as pH value and temperature were optimized to enhance the sensor performance. A high sensitivity and a low detection limit of about 0.5–1 nM adrenaline have been achieved in phosphate buffer at pH 7.4, relevant for measurements in blood samples. The sensitivity of the biosensor to other catecholamines such as noradrenaline, dopamine and dobutamine has been studied. Finally, the sensor has been successfully applied for the detection of adrenaline in human blood plasma.
Y1  - 2018
U6  - https://doi.org/10.1002/elan.201800026
SN  - 1521-4109
VL  - 30
IS  - 5
SP  - 937
EP  - 942
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Christiaens, P.
A1  - Williams, O. A.
A1  - Haenen, K.
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Nanocrystalline diamond-based field-effect (bio-)chemical sensor
JF  - 8. Dresdner Sensor-Symposium : Sensoren für Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme für die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung für die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)
Y1  - 2007
SN  - 978-3-940046-45-1
N1  - Dresdner Sensor-Symposium <8, 2007, Dresden> ; Dresdner Beiträge zur Sensorik ; 29
SP  - 191
EP  - 194
PB  - TUDpress, Verl. der Wissenschaften
CY  - Dresden
ER  - 
TY  - CHAP
A1  - Beging, Stefan
A1  - Poghossian, Arshak
A1  - Mlynek, D.
A1  - Hataihimakul, S.
A1  - Pedraza, A.
A1  - Dhawan, S.
A1  - Laube, N.
A1  - Kleinen, L.
A1  - Baldsiefen, G.
A1  - Busch, H.
A1  - Schöning, Michael Josef
T1  - Ion-selective sensors for the determination of the risk of urinary stone formation
T2  - Micro- and Nanosystems in biochemical diagnosis : Principles and applications
Y1  - 2010
SP  - 74
EP  - 80
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Krischer, Maximillian
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors
JF  - Analytical Chemistry
N2  - Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(d,l-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers.
Y1  - 2015
U6  - https://doi.org/10.1021/acs.analchem.5b00617
SN  - 1520-6882
VL  - 87
IS  - 13
SP  - 6607
EP  - 6613
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Kramer, Friederike
A1  - Halamkova, Lenka
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
A1  - Halamek, Jan
T1  - Biocatalytic analysis of biomarkers for forensic identification of ethnicity between Caucasian and African American
JF  - The analyst. August 2013
Y1  - 2013
SN  - 1364-5528 (E-Journal); 0003-2654 (Print)
VL  - Vol. 138
SP  - 6251
EP  - 6257
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - CHAP
A1  - Bäcker, Matthias
A1  - Schusser, Sebastian
A1  - Leinhos, Marcel
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Sensor system for the monitoring of degradation processes of biodegradable biopolymers
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 4
PB  - VDE-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Rakowski, D.
A1  - Poghossian, Arshak
A1  - Biselli, Manfred
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis
JF  - Journal of Biotechnology
N2  - A microfluidic chip integrating amperometric enzyme sensors for the detection of glucose, glutamate and glutamine in cell-culture fermentation processes has been developed. The enzymes glucose oxidase, glutamate oxidase and glutaminase were immobilized by means of cross-linking with glutaraldehyde on platinum thin-film electrodes integrated within a microfluidic channel. The biosensor chip was coupled to a flow-injection analysis system for electrochemical characterization of the sensors. The sensors have been characterized in terms of sensitivity, linear working range and detection limit. The sensitivity evaluated from the respective peak areas was 1.47, 3.68 and 0.28 μAs/mM for the glucose, glutamate and glutamine sensor, respectively. The calibration curves were linear up to a concentration of 20 mM glucose and glutamine and up to 10 mM for glutamate. The lower detection limit amounted to be 0.05 mM for the glucose and glutamate sensor, respectively, and 0.1 mM for the glutamine sensor. Experiments in cell-culture medium have demonstrated a good correlation between the glutamate, glutamine and glucose concentrations measured with the chip-based biosensors in a differential-mode and the commercially available instrumentation. The obtained results demonstrate the feasibility of the realized microfluidic biosensor chip for monitoring of bioprocesses.
Y1  - 2013
U6  - https://doi.org/10.1016/j.jbiotec.2012.03.014
SN  - 0168-1656
VL  - 163
IS  - 4
SP  - 371
EP  - 376
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Combined amperometric/field-effect sensor for the detection of dissolved hydrogen
JF  - Sensors and  actuators B: Chemical
N2  - Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3% (v/v) with a slope of 198.4 ± 13.7 nA/% (v/v) and 14.9 ± 0.5 mV/% (v/v), respectively.
Y1  - 2012
U6  - https://doi.org/10.1016/j.snb.2012.10.050
SN  - 0925-4005
N1  - Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors"
VL  - 187
SP  - 168
EP  - 173
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Mai, D.-T.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
T1  - Impedance effect of an ion-sensitive membrane: characterisation of an EMIS sensor by impedance spectroscopy, capacitance-voltage and constant-capacitance method
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 423
EP  - 428
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Silicon-based field-effect devices with nanostructured surfaces for bio-/chemical sensing
JF  - Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009
Y1  - 2009
SP  - 51
EP  - 53
ER  - 
TY  - JOUR
A1  - Spelthahn, Heiko
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Self-aligned nanogaps and nanochannels via conventional photolithography and pattern-size reduction technique
JF  - Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI
Y1  - 2009
SN  - 0013-4686
SP  - 6010
EP  - 6014
ER  - 
TY  - JOUR
A1  - Beging, Stefan
A1  - Leinhos, Marcel
A1  - Jablonski, Melanie
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Studying the spatially resolved immobilisation of enzymes on a capacitive field-effect structure by means of nano-spotting
JF  - Physica status solidi (a)
Y1  - 2015
U6  - https://doi.org/10.1002/pssa.201431891
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1353
EP  - 1358
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Ingebrandt, S.
A1  - Platen, J.
A1  - Schöning, Michael Josef
T1  - Field-effect sensors with charged macromolecules – from micro towards nano aspects
T2  - Biochemical Sensing Utilisation of Micro-and                       Nanotechnologies, Warschau, Nov. 2005 : Lecture Notes of the                       ICB Seminar / ed.: M. Mascini, W. Torbicz
Y1  - 2006
SP  - 74
EP  - 81
PB  - Polish Academy Sciences Press
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Leinhos, Marcel
A1  - Schusser, Sebastian
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Micromachined multi-parameter sensor chip for the control of polymer-degradation medium
JF  - Physica Status Solidi (A) : special issue on engineering and functional interfaces
N2  - It is well known that the degradation environment can strongly influence the biodegradability and kinetics of biodegradation processes of polymers. Therefore, besides the monitoring of the degradation process, it is also necessary to control the medium in which the degradation takes place. In this work, a micromachined multi-parameter sensor chip for the control of the polymer-degradation medium has been developed. The chip combines a capacitive field-effect pH sensor, a four-electrode electrolyte-conductivity sensor and a thin-film Pt-temperature sensor. The results of characterization of individual sensors are presented. In addition, the multi-parameter sensor chip together with an impedimetric polymer-degradation sensor was simultaneously characterized in degradation solutions with different pH and electrolyte conductivity. The obtained results demonstrate the feasibility of the multi-parameter sensor chip for the control of the polymer-degradation medium.
Y1  - 2014
U6  - https://doi.org/10.1002/pssa.201330364
SN  - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1346
EP  - 1351
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Chaudhuri, S.
A1  - Zander, W.
A1  - Schubert, J.
A1  - Begoyan, V. K.
A1  - Buniatyan, V. V.
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Capacitively coupled electrolyte-conductivity sensor based on high-k material of barium strontium titanate
JF  - Sensors and actuators. B: Chemical
Y1  - 2014
U6  - https://doi.org/10.1016/j.snb.2014.02.103
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
IS  - 198
SP  - 102
EP  - 109
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Amberger, F.
A1  - Mayer, D.
A1  - Han, Y.
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Field-effect sensors with charged macromolecules: Characterisation by capacitance–voltage, constant-capacitance, impedance spectroscopy and atomic-force microscopy methods
JF  - Biosensors and Bioelectronics. 22 (2007), H. 9-10
Y1  - 2007
SN  - 0956-5663
N1  - Selected Papers from the Ninth World Congress On Biosensors. Toronto, Canada 10 - 12 May 2006, Alice X. J . Tang
SP  - 2100
EP  - 2107
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Menzel, S.
A1  - Bäcker, Matthias
A1  - Leinhos, Marcel
A1  - Poghossian, Arshak
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Degradation of thin poly(lactic acid) films: characterization by capacitance-voltage, atomic force microscopy, scanning electron microscopy and contact-angle measurements
JF  - Electrochimica Acta
Y1  - 2013
SN  - 1873-3859 (E-Journal); 0013-4686 (Print)
VL  - Vol. 113
SP  - 779
EP  - 784
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Koch, Claudia
A1  - Eiben, Sabine
A1  - Geiger, Fania
A1  - Eber, Fabian
A1  - Gliemann, Hartmut
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors
JF  - Sensors and Actuators B: Chemical
N2  - The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips.
Y1  - 2017
U6  - https://doi.org/10.1016/j.snb.2016.07.096
SN  - 0925-4005
VL  - 238
SP  - 716
EP  - 722
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Kramer, F.
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bratov, A.
A1  - Abramova, N.
A1  - Schöning, Michael Josef
T1  - Planar and 3D interdigitated electrodes for biosensing applications: The impact of a dielectric barrier on the sensor properties
JF  - Physica Status Solidi (A) - Applications and Materials Science
N2  - Planar and three-dimensional (3D) interdigitated electrodes (IDE) with electrode digits separated by an insulating barrier of different heights were electrochemically characterized and compared in terms of their sensing properties. Due to the impact of the surface resistance, both types of IDE structures display a non-linear behavior in low-ionic strength solutions. The experimental data were fitted to an electrical equivalent circuit and interpreted taking into account the surface-charge-governed properties. The effect of a charged polyelectrolyte layer electrostatically assembled onto the sensor surface on the surface resistance in solutions with different KCl concentration is studied. In case of the same electrode footprint, 3D-IDEs show a larger cell constant and a higher sensitivity to molecular adsorption than that of planar IDEs. The obtained results demonstrate the potential of 3D-IDEs as a new transducer structure for a direct label-free sensing of charged molecules.
Y1  - 2014
U6  - https://doi.org/10.1002/pssa.201330416
SN  - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1357
EP  - 1363
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Weil, M. H.
A1  - Bäcker, Matthias
A1  - Mayer, D.
A1  - Schöning, Michael Josef
T1  - Field-effect Devices Functionalised with Gold-Nanoparticle/Macromolecule Hybrids: New Opportunities for a Label-Free Biosensing
JF  - Procedia Engineering
N2  - Field-effect capacitive electrolyte-insulator-semiconductor (EIS) sensors functionalised with citrate-capped gold nanoparticles (AuNP) have been used for the electrostatic detection of macromolecules by their intrinsic molecular charge. The EIS sensor detects the charge changes in the AuNP/macromolecule hybrids induced by the adsorption or binding events. A feasibility of the proposed detection scheme has been exemplary demonstrated by realising EIS sensors for the detection of poly-D-lysine molecules.
Y1  - 2012
U6  - https://doi.org/10.1016/j.proeng.2012.09.136
SN  - 1877-7058
N1  - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012"
IS  - 47
SP  - 273
EP  - 276
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Moseley, Fiona
A1  - Halamek, Jan
A1  - Kramer, Friederike
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - An enzyme-based reversible CNOT logic gate realized in a flow system
JF  - Analyst
N2  - An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD⁺ and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
Y1  - 2014
U6  - https://doi.org/10.1039/C4AN00133H
SN  - 1364-5528 (E-Journal) ; 0003-2654 (Print)
VL  - 139
IS  - 8
SP  - 1839
EP  - 1842
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Werner, Moritz
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Capacitance–voltage and impedance-spectroscopy characteristics of nanoplate EISOI capacitors
JF  - Physica status solidi (a) : applications and material science. 208 (2011), H. 6
Y1  - 2011
SN  - 1862-6319
SP  - 1327
EP  - 1332
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Yoshinobu, Tatsuo
A1  - Krause, Steffi
A1  - Miyamoto, Ko-ichiro
A1  - Werner, Frederik
A1  - Poghossian, Arshak
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - (Bio-)chemical Sensing and Imaging by LAPS and SPIM
T2  - Label-free biosensing: advanced materials, devices and applications
N2  - The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications.
KW  - Chemical imaging
KW  - Field-effect device
KW  - Light-addressable potentiometric sensor
KW  - Potentiometry
Y1  - 2018
SN  - 978-3-319-75219-8
SP  - 103
EP  - 132
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Silicon-based field-effect devices for (bio-)chemical sensing
JF  - International Conference on Advanced Semiconductor Devices and Microsystems, 2008. ASDAM 2008
Y1  - 2008
SN  - 978-1-4244-2325-5
SP  - 31
EP  - 38
CY  - Smolenice, Slovakia
ER  - 
TY  - CHAP
A1  - Molinnus, Denise
A1  - Hardt, Gabriel
A1  - Käver, Larissa
A1  - Willenberg, Holger S.
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology
T2  - MDPI Proceedings
Y1  - 2017
U6  - https://doi.org/10.3390/proceedings1040506
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Mayer, Dirk
A1  - Schöning, Michael Josef
T1  - Gating capacitive field-effect sensors by the charge of nanoparticle/molecule hybrids
JF  - Nanoscale
Y1  - 2015
U6  - https://doi.org/10.1039/C4NR05987E
SN  - 2040-3372 (E-Journal); 2040-3364 (Print)
SP  - 1023
EP  - 1031
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Baade, A.
A1  - Emons, H.
A1  - Schöning, Michael Josef
T1  - Application of ISFET for pH measurements in rain droplets
JF  - Sensors and Actuators B. 76 (2001), H. 1-3
Y1  - 2001
SN  - 0925-4005
SP  - 634
EP  - 638
ER  - 
TY  - JOUR
A1  - Kassab, T.
A1  - Han, Y.
A1  - Poghossian, Arshak
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Detection of layerby-layer adsorbed polyelectrolytes by means of field-effect based capacitive EIS structures
JF  - Biomedizinische Technik. 49 (2004), H. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1034
EP  - 1035
ER  - 
TY  - JOUR
A1  - Buniatyan, V. V.
A1  - Matirosyan, N. W.
A1  - Abouzar, Maryam H.
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Schubert, J.
A1  - Khachatryan, V. R.
A1  - Soukiassyan, G. R.
T1  - (Ba,Sr)TiO3 based electrolyte-insulator-semiconductor pHsensors: comparitive study
JF  - Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009
Y1  - 2009
SP  - 71
EP  - 74
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schultze, J. W.
A1  - Schöning, Michael Josef
T1  - Multi-parameter detection of (bio-)chemical and physical quantities using an identical transducer principle
JF  - Sensors and Actuators B. 91 (2003), H. 1-3
Y1  - 2003
SN  - 0925-4005
SP  - 83
EP  - 91
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Jessing, Max P.
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Surface regeneration and reusability of label-free DNA biosensors based on weak polyelectrolyte-modified capacitive field-effect structures
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2018.11.019
SN  - 0956-5663
VL  - 126
SP  - 510
EP  - 517
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Malzahn, K.
A1  - Abouzar, Maryam H.
A1  - Mehndiratta, P.
A1  - Katz, E.
A1  - Schöning, Michael Josef
T1  - Integration of biomolecular logic gates with field-effect transducers
JF  - Electrochimica Acta. 56 (2011), H. 26
Y1  - 2011
SN  - 0013-4686
SP  - 9661
EP  - 9665
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Abouzar, Maryam H.
A1  - Bäcker, Matthias
A1  - Zucolotto, Valtencir
A1  - Poghossian, Arshak
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors
JF  - physica status solidi (a) . 206 (2009), H. 3
Y1  - 2009
SN  - 1862-6319
N1  - Special Issue: Engineering of Functional Interfaces (EnFI 08)
SP  - 462
EP  - 467
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Maris, Rob J.
A1  - Ackermann, Hans-Josef
A1  - Otto, Ralph
A1  - Beging, Stefan
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Handheld measurement device for field-effect sensor structures: Practical evaluation and limitations
JF  - Sensors and Actuators B: Chemical  . 127 (2007), H. 1
Y1  - 2007
SN  - 0925-4005
SP  - 217
EP  - 223
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Ingebrandt, S.
A1  - Poghossian, Arshak
A1  - Zhang, Y.
A1  - Vu, X. T.
A1  - Moritz, W.
A1  - Schöning, Michael Josef
T1  - Nanoplate field-effect capacitive (bio-)chemical sensor array based on SOI structure
JF  - Procedia Chemistry. 1 (2009), H. 1
Y1  - 2009
SN  - 1876-6196
N1  - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23
SP  - 670
EP  - 673
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Krischer, M.
A1  - Leinhos, Marcel
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - An application of field-effect sensors for in-situ monitoring of degradation of biopolymers
JF  - Sensors and actuators B: Chemical
N2  - The characterization of the degradation kinetics of biodegradable polymers is mandatory with regard to their proper application. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) field-effect sensors have been applied for in-situ monitoring of the pH-dependent degradation kinetics of the commercially available biopolymer poly(d,l-lactic acid) (PDLLA) in buffer solutions from pH 3 to pH 13. PDLLA films of 500 nm thickness were deposited on the surface of an Al–p-Si–SiO2–Ta2O5 structure from a polymer solution by means of spin-coating method. The PMEIS sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. A faster degradation has been observed for PDLLA films exposed to alkaline solutions (pH 9, pH 11 and pH 13).
Y1  - 2015
U6  - https://doi.org/10.1016/j.snb.2014.10.058
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
VL  - 207, Part B
SP  - 954
EP  - 959
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Christiaens, P.
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Wagner, Torsten
A1  - Bijnens, N.
A1  - Williams, O. A.
A1  - Daenen, M.
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Wagner, P.
T1  - Nanocrystalline diamond-based field-effect capacitive pH sensor
JF  - Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)
Y1  - 2007
SN  - 1-4244-0841-5
N1  - Eurosensors 21, 2007, Lyon ; International Conference on Solid-State Sensors, Actuators and Microsystems 14, 2007, Lyon
SP  - 1891
EP  - 1894
PB  - IEEE
CY  - Piscataway
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Ingebrandt, Sven
A1  - Platen, Johannes
A1  - Offenhäusser, Andreas
A1  - Poghossian, Arshak
ED  - Comini, Elisabetta
T1  - Towards label-free detection of charged macromolecules using field-effect-based structures : Scaling down from capacitive EIS sensor over ISFET to nano-scale devices
JF  - Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.
Y1  - 2006
SN  - 9781558998711
IS  - paper 0915-R05-04
SP  - 89
EP  - 94
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Pedraza, A. M.
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Label-free DNA hybridization and denaturation detection by means of field-effect nanoplate SOI capacitors functionalized with gold nanoparticles
JF  - Procedia Engineering. 5 (2010)
Y1  - 2010
SN  - 1877-7058
N1  - Proc. Eurosensors XXIV, September 5–8, 2010, Linz, Austria
SP  - 918
EP  - 921
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Leinhos, Marcel
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Characterization of biodegradable polymers with capacitive field-effect sensors
JF  - Sensors and actuators B: Chemical
N2  - In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance–voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor.
KW  - Impedance spectroscopy
KW  - C–V method
KW  - Real-time monitoring
KW  - Poly(d,l-lacticacid)
KW  - (Bio)degradation
KW  - Field-effect sensor
Y1  - 2012
U6  - https://doi.org/10.1016/j.snb.2012.07.099
SN  - 0925-4005
N1  - Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors"
VL  - 187
SP  - 2
EP  - 7
PB  - Elsevier
CY  - Amsterdam
ER  -