TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Lanzl, Ines M.
A1  - Hanssen, Henner
A1  - Eberhardt, Karla
A1  - Vilser, Walthard
A1  - Halle, Martin
A1  - Heemann, Uwe
A1  - Schmidt-Trucksäss, Arno
A1  - Baumann, Marcus
T1  - Does increased blood pressure rather than aging influence retinal pulse wave velocity?
JF  - Investigative Ophthalmology & Visual Science, IOVS
N2  - Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself.

Methods: A total of 12 young 25.5-year-old (24.0–28.8) [median(1st quartile–3rd quartile)] and 12 senior 68.5-year-old (63.8–71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8–65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5–35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated.

Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280–500] RU/s) and in validated healthy seniors (400 [320–510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains.

Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV.
Y1  - 2012
U6  - https://doi.org/10.1167/iovs.11-8815
SN  - 0146-0404
VL  - 53
IS  - 4
SP  - 2119
EP  - 2126
PB  - ARVO
CY  - Rockville, Md.
ER  - 
TY  - THES
A1  - Kotliar, Konstantin
T1  - Pathophysiologische Beurteilung und hämodynamische Analyse von mikrostrukturellen Veränderungen des retinalen Gefäßlängsschnittsprofils
Y1  - 2012
N1  - Moskau, Habil.-Schr. ,Russ. Univ., Med. Fakultät, 2012. Originaltitel in Russisch.
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Limit and shakedown analysis under uncertainty
JF  - Tap chi Khoa hoc & ung dung - Dai hoc Ton Duc Thang
Y1  - 2012
N1  - = Journal of Applied Sciences - Ton Duc Thang University
VL  - 19
SP  - 45
EP  - 47
ER  - 
TY  - JOUR
A1  - Mansurov, Z.
A1  - Digel, Ilya
A1  - Biisenbaev, M.
A1  - Savistkaya, I.
A1  - Kistaubaeva, A.
A1  - Akimbekov, Nuraly S.
A1  - Zhubanova, A.
T1  - Bio-composite material on the basis of carbonized rice husk in biomedicine and environmental applications
JF  - Eurasian Chemico-Technological Journal
Y1  - 2012
U6  - https://doi.org/10.18321/ectj105
SN  - 2522-4867
VL  - 14
IS  - 2
SP  - 115
EP  - 131
PB  - Institute of Combustion Problems
CY  - Almaty
ER  - 
TY  - THES
A1  - Oflaz, Hakan
T1  - Entwicklung eines Prototypen zur Prognose von Frühgeburten : ein biomedizintechnischer Ansatz
Y1  - 2012
U6  - https://doi.org/10.4126/38m-004639208
N1  - Köln, Univ., Diss., 2012
PB  - Deutsche Zentralbibliothek für Medizin
CY  - Köln
ER  - 
TY  - THES
A1  - Kurulgan Demirci, Eylem
T1  - The effect of rhAPC on contractile tension : an in-vitro sepsis model of cardiomyocytes and endothelial cells
T1  - Der Effekt von rhAPC auf die zelluläre Kontraktionskraft : ein In-vitro-Sepsismodell für Kardiomyozyten und Endothelzellen
Y1  - 2012
N1  - Aachen, Techn. Hochsch., Diss., 2012
ER  -