TY  - JOUR
A1  - Droop, Philipp
A1  - Chen, Shaohuang
A1  - Radford, Melissa J.
A1  - Paulßen, Elisabeth
A1  - Gates, Byron D.
A1  - Reilly, Raymond M.
A1  - Radchenko, Valery
A1  - Hoehr, Cornelia
T1  - Synthesis of 197m/gHg labelled gold nanoparticles for targeted radionuclide therapy
JF  - Radiochimica Acta
N2  - Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 h and 64.1 h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 μg (gold)/mL with an activity of 151 ± 93 kBq/mL (197gHg, time corrected to the end of bombardment).
KW  - 197m/gHg
KW  - Gold nanoparticle (AuNP)
KW  - Meitner-Auger-electron (MAE)
KW  - Targeted radionuclide therapy (TRT)
Y1  - 2023
U6  - https://doi.org/10.1515/ract-2023-0144
SN  - 2193-3405
VL  - 111
IS  - 10
SP  - 773
EP  - 779
PB  - De Gruyter
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Bhattarai, Aroj
A1  - Staat, Manfred
T1  - Computational comparison of different textile implants to correct apical prolapse in females
JF  - Current Directions in Biomedical Engineering
N2  - Prosthetic textile implants of different shapes, sizes and polymers are used to correct the apical prolapse after hysterectomy (removal of the uterus). The selection of the implant before or during minimally invasive surgery depends on the patient’s anatomical defect, intended function after reconstruction and most importantly the surgeon’s preference. Weakness or damage of the supporting tissues during childbirth, menopause or previous pelvic surgeries may put females in higher risk of prolapse. Numerical simulations of reconstructed pelvic floor with weakened tissues and organ supported by textile product models: DynaMesh®-PRS soft, DynaMesh®-PRP soft and DynaMesh®-CESA from FEG Textiletechnik mbH, Germany are compared.
Y1  - 2018
U6  - https://doi.org/10.1515/cdbme-2018-0159
VL  - 4
IS  - 1
SP  - 661
EP  - 664
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Staat, Manfred
T1  - Optical strain measurement for the modeling of surgical meshes and their porosity
JF  - Current Directions in Biomedical Engineering
N2  - The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.
Y1  - 2018
U6  - https://doi.org/10.1515/cdbme-2018-0045
SN  - 2364-5504
VL  - Band 4
IS  - 1
SP  - 181
EP  - 184
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Berndt, Heinz
A1  - Gattner, Hans-Gregor
A1  - Zahn, Helmut
T1  - Semisynthetisches Des-A1-glycin-Schafinsulin
JF  - Biological Chemistry
Y1  - 1975
U6  - https://doi.org/10.1515/bchm2.1975.356.2.1455
SN  - 1437-4315
VL  - 356
IS  - 2
SP  - 1469
EP  - 1472
PB  - De Gruyter
CY  - Berlin
ER  -