TY - JOUR A1 - Ferrein, Alexander A1 - Beck, Daniel A1 - Lakemeyer, Gerhard T1 - Landmark-Based Representations for Navigating Holonomic Soccer Robots / Beck, Daniel ; Ferrein, Alexander ; Lakemeyer, Gerhard JF - RoboCup 2008 : robot soccer world cup XII / Luca Iocchi ... (eds.) Y1 - 2009 SN - 978-3-642-02921-9 N1 - Lecture Notes in Computer Science ; 5399 SP - 25 EP - 36 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Schiffer, Stefan A1 - Ferrein, Alexander A1 - Lakemeyer, Gerhard T1 - Reasoning with Qualitative Positional Information for Domestic Domains in the Situation Calculus JF - Journal of Intelligent & Robotic Systems Y1 - 2011 SN - 0921-0296 VL - 63 IS - 2 SP - 273 EP - 300 PB - Springer CY - Berlin ER - TY - JOUR A1 - Pichler, A. A1 - George, A. A1 - Seiler, F. A1 - Srulijes, J. A1 - Havermann, Marc T1 - Doppler Picture Velocimetry (DPV) applied to hypersonics JF - Shock Waves [Elektronische Ressource] : 26th International Symposium on Shock Waves, Volume 1 / edited by Klaus Hannemann, Friedrich Seiler Y1 - 2009 SN - 978-3-540-85168-4 N1 - International Symposium on Shock Waves ; (26 ; 2007.07.15-20 ; Göttingen) ; ISSW ; (26 ; 2007.07.15-20 ; Göttingen) SP - 503 EP - 508 PB - Springer CY - Berlin ER - TY - CHAP A1 - Luczak, Holger A1 - Wolf, Martin A1 - Mühlfelder, M. ED - Schwabe, Gerhard T1 - Arbeitswissenschaft T2 - CSCW-Kompendium : Lehr- und Handbuch zum computerunterstützten kooperativen Arbeiten ; mit 9 Tabellen N2 - Unter Arbeit wird das Tätigsein des Menschen verstanden, bei dem dieser mit anderen Menschen und (technischen) Hilfsmitteln in Interaktion tritt, um unter wirtschaftlichen Zielsetzungen Güter und Dienstleistungen zu erstellen (Luczak, 1998a). Arbeit dient direkt oder indirekt der Erhaltung der eigenen Existenz und der Existenz der Gesellschaft. Arbeit ist deshalb eine besondere Form des Tätigseins neben anderen wie Spiel, Sport, Lemen usw. Y1 - 2001 SN - 978-3-540-67552-5 SN - 978-3-642-56848-0 U6 - http://dx.doi.org/10.1007/978-3-642-56848-0_2 SP - 7 EP - 14 PB - Springer CY - Berlin ER - TY - CHAP A1 - Luczak, Holger A1 - Wolf, Martin A1 - Schlick, Christopher A1 - Springer, J. A1 - Foltz, Christian ED - Nagl, Walter T1 - Personenorientierte Arbeitsprozesse und Kommunikationsforrnen T2 - Integration von Entwicklungssystemen in Ingenieuranwendungen : substantielle Verbesserung der Entwicklungsprozesse Y1 - 1999 SN - 3-540-63920-9 SP - 403 EP - 422 PB - Springer CY - Berlin ER - TY - CHAP A1 - Helsper, Christoph A1 - Dressler, Jörg ED - Gail, Lothar ED - Gommel, Udo ED - Hortig, Hans-Peter T1 - Partikelmesstechnik T2 - Reinraumtechnik N2 - Der Schutz von Produkten vor der Kontamination durch Partikel gilt als eine zentrale Aufgabe der Reinraumtechnik. Da es dabei um Kontaminationseffekte weit unterhalb der visuellen Wahrnehmbarkeit geht, braucht es leistungsfähige Verfahren, um die Messgröße „Partikelkontamination“ über den gesamten Bereich, den Anwender fordern, präzise zu bestimmen. Neben der Partikelhäufigkeit ist dabei die Größe der Partikel, die sowohl das Transportverhalten wie auch die mögliche Wirkung auf das Produkt beeinflusst, von entscheidender Bedeutung. Ferner kann es für die Ermittlung von Kontaminationsquellen von Interesse sein, die Form und die chemische Natur der Partikel zu bestimmen (z. B. textile Fasern, Metallabrieb, flüssige Tröpfchen). Die Partikelhäufigkeit wird üblicherweise als Konzentration, d. h. bezogen auf das analysierte Gasvolumen angegeben. Bei den in reinen Technologien üblichen niedrigen Konzentrationen dient als Häufigkeitsmaß die Partikelanzahlkonzentration, also die Partikelanzahl pro Volumeneinheit des Trägermediums. Y1 - 2012 SN - 978-3-642-19435-1 U6 - http://dx.doi.org/10.1007/978-3-642-19435-1_3 VL - 2012 SP - 69 EP - 95 PB - Springer CY - Berlin ET - 3 ER - TY - JOUR A1 - Digel, Ilya T1 - Primary thermosensory events in cells JF - Transient receptor potential channels / Md. Shahidul Islam, ed. Y1 - 2011 SN - 978-94-007-0264-6 N1 - (Advances in experimental medicine and biology ; 704) SP - 451 EP - 468 PB - Springer CY - Dordrecht [u.a.] ER - TY - JOUR A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül T1 - The emperor's new body : seeking for a blueprint of limb regeneration in humans JF - Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds. Y1 - 2011 SN - 978-3-642-11864-7 SP - 3 EP - 37 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Dashevsky, Alexey V. A1 - Lanzl, Ines M. A1 - Kotliar, Konstantin T1 - Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal JF - Graefe's Archive for Clinical and Experimental Ophthalmology Y1 - 2011 SN - 0721-832x VL - 249 IS - 4 SP - 565 EP - 573 PB - Springer CY - Berlin ER - TY - JOUR A1 - Seidova, Seid-Fatima A1 - Kotliar, Konstantin A1 - Foerger, Frauke A1 - Klopfer, Matthias A1 - Lanzl, Ines T1 - Functional retinal changes in Gaucher disease JF - Documenta Ophthalmologica Y1 - 2009 SN - 1573-2622 VL - 118 IS - 2 SP - 151 EP - 154 PB - Springer CY - Berlin ER - TY - JOUR A1 - Pieper, Martin A1 - Klein, Peter T1 - A simple and accurate numerical network flow model for bionic micro heat exchangers JF - Heat mass transfer Y1 - 2011 SN - 0947-7411 VL - 47 IS - 5 SP - 491 EP - 503 PB - Springer CY - Berlin ER - TY - JOUR A1 - Pieper, Martin A1 - Klein, Peter T1 - Application of simple, periodic homogenization techniques to non-linear heat conduction problems in non-periodic, porous media JF - Heat mass transfer N2 - Often, detailed simulations of heat conduction in complicated, porous media have large runtimes. Then homogenization is a powerful tool to speed up the calculations by preserving accurate solutions at the same time. Unfortunately real structures are generally non-periodic, which requires unpractical, complicated homogenization techniques. We demonstrate in this paper, that the application of simple, periodic techniques to realistic media, that are just close to periodic, gives accurate, approximative solutions. In order to obtain effective parameters for the homogenized heat equation, we have to solve a so called “cell problem”. In contrast to periodic structures it is not trivial to determine a suitable unit cell, which represents a non-periodic media. To overcome this problem, we give a rule of thumb on how to choose a good cell. Finally we demonstrate the efficiency of our method for virtually generated foams as well as real foams and compare these results to periodic structures. Y1 - 2012 U6 - http://dx.doi.org/10.1007/s00231-011-0879-4 SN - 0947-7411 VL - 48 IS - 2 SP - 291 EP - 300 PB - Springer CY - Berlin ER - TY - JOUR A1 - Pham, Phu Tinh A1 - Staat, Manfred T1 - An Upper Bound Algorithm for Limit and Shakedown Analysis of Bounded Linearly Kinematic Hardening Structures JF - Limit State of Materials and Structures : Direct Methods 2. Saxcé, Géry de (Hrsg.) Y1 - 2013 SN - 978-94-007-5424-9 SP - 71 EP - 87 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Tran, Thanh Ngoc A1 - Staat, Manfred T1 - An Edge-Based Smoothed Finite Element Method for Primal-Dual Shakedown Analysis of Structures Under Uncertainties JF - Limit State of Materials and Structures : Direct Methods 2. Saxcé, Géry de (Hrsg.) Y1 - 2013 SN - 978-94-007-5424-9 SP - 89 EP - 102 PB - Springer CY - Dordrecht ER - TY - CHAP A1 - Mandelartz, Johannes T1 - VDI-Richtlinien – mit Technischen Regeln Wirtschaftlichkeit erhöhen und Standards setzen T2 - Betriebliche Instandhaltung N2 - Der Verein Deutscher Ingenieure e.V. (VDI) ist ein gemeinnütziger, wirtschaftlich und politisch unabhängiger, technisch-wissenschaftlicher Verein von Ingenieuren und Naturwissenschaftlern. Mit über 137 000 persönlich zugeordneten Mitgliedern ist er eine der größten Ingenieur-Vereinigungen Europas und gilt in Deutschland als führender Sprecher der Technik und der Ingenieure. 1856 gegründet, hat er viele für die Technik wesentliche Entwicklungen in Gang gesetzt, so im Bereich der technischen Überwachung, der technischen Regelsetzung und Normung, der Arbeitsstudien, im gewerblichen Rechtsschutz und im Patentwesen. Seit seiner Gründung sieht es der VDI als seine Aufgabe, "das Zusammenwirken aller geistiger Kräfte der Technik im Bewusstsein ethischer Verantwortung zu fördern" und die Lebensmöglichkeiten aller Menschen durch Entwicklung und sinnvoller Anwendung technischer Mittel zu verbessern. Y1 - 2009 SN - 978-3-642-00502-2 U6 - http://dx.doi.org/10.1007/978-3-642-00502-2_26 SP - 311 EP - 317 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Nomdedeu, Mar Monsonis A1 - Willen, Christine A1 - Schieffer, Andre A1 - Arndt, Hartmut T1 - Temperature-dependent ranges of coexistence in a model of a two-prey-one-predator microbial food web JF - Marine Biology N2 - The objective of our study was to analyze the effects of temperature on the population dynamics of a three-species food web consisting of two prey bacteria (Pedobacter sp. and Acinetobacter johnsonii) and a protozoan predator (Tetrahymena pyriformis) as model organisms. We assessed the effects of temperature on the growth rates of all three species with the objective of developing a model with four differential equations based on the experimental data. The following hypotheses were tested at a theoretical level: Firstly, temperature changes can affect the dynamic behavior of a system by temperature-dependent parameters and interactions and secondly, food web response to temperature cannot be derived from the single species temperature response. The main outcome of the study is that temperature changes affect the parameter range where coexistence is possible within all three species. This has significant consequences on our ideas regarding the evaluation of effects of global warming. Y1 - 2012 U6 - http://dx.doi.org/10.1007/s00227-012-1966-x SN - 1432-1793 VL - 159 IS - 11 SP - 2423 EP - 2430 PB - Springer CY - Berlin ER - TY - CHAP A1 - Röth, Thilo A1 - Kampker, Achim A1 - Reisgen, Uwe A1 - Hameyer, Kay A1 - De Doncker, R. W. T1 - Entwicklung von elektrofahrzeugspezifischen Systemen T2 - Elektromobilität : Grundlagen einer Zukunftstechnologie N2 - Die Fahrzeugkarosserie bildet als größte funktionale und organisatorische Systemeinheit ein zentrales Kompetenzfeld der OEMs. Für den Fahrzeughersteller stellt der Karosserierohbau eine hohe Kernkompetenz sowohl in der Produktentwicklung als auch in der Produktion dar. Neue, innovative Karosseriebauweisen, bspw. aufgrund eines neuen Fahrzeugkonzeptes oder neuer Anforderungen, bedeuten für den OEM auch gleichzeitig die intensive Auseinandersetzung mit Kompetenzfokussierung bzw. Wertschöpfungsverlagerungen. Y1 - 2013 SN - 978-3-642-31986-0 SP - 235 EP - 336 PB - Springer CY - Berlin ER - TY - CHAP A1 - Reimer, Lars A1 - Braun, Carsten A1 - Wellmer, Georg A1 - Behr, Marek A1 - Ballmann, Josef T1 - Development of a modular method for computational aero-structural analysis of aircraft T2 - Summary of flow modulation and fluid-structure interaction findings. Results of the Collaborative Research Center SFB 401 at the RWTH Aachen University, Aachen, Germany, 1997-2008 / ed.: Wolfgang Schröder. Notes on numerical fluid mechanics and multidisciplinary design. Vol. 109 Y1 - 2010 SN - 978-3-642-04087-0 SP - 205 EP - 238 PB - Springer CY - Berlin ER - TY - CHAP A1 - Reimer, Lars A1 - Wellmer, Georg A1 - Braun, Carsten A1 - Ballmann, Josef T1 - Computational methods for aero-structural analysis and optimisation of aircrafts based on reduced-order structural models T2 - MEGADESIGN and MegaOpt - German initiatives for aerodynamic simulation and optimization in aircraft design. Results of the closing symposium of the MEGADESIGN and MegaOpt projects, Braunschweig, Germany, 23 - 24 May, 2007 / Norbert Kroll ... (Eds.) Notes on numerical fluid mechanics and multidisciplinary design. Vol. 107 N2 - In this part of the MEGADESIGN project, aeroelastic effects are introduced into the aerodynamic analysis of aircrafts by coupling DLR’s flow solvers TAU and FLOWer to a Timoshenko-beam solver. The emerging aeroelastic solvers and a method for the automatic identification of Timoshenko-beam models for wing-box structures were integrated into a simulation environment enabling the combined optimisation of aerodynamic wing shape and structure. Y1 - 2009 SN - 978-3-642-04092-4 SP - 135 EP - 150 PB - Springer CY - Berlin ER - TY - CHAP A1 - Reimer, Lars A1 - Braun, Carsten A1 - Ballmann, Josef T1 - Computational study of the aeroelastic equilibrium configuration of a swept wind tunnel wing model in subsonic flow T2 - High performance computing in science and engineering '06. Transactions of the High Performance Computing Center Stuttgart (HLRS) 2006 / Wolfgang E. Nagel ... Eds. N2 - In the Collaborative Research Center SFB 401 at RWTH Aachen University, the numerical aeroelastic method SOFIA for direct numerical aeroelastic simulation is being progressively developed. Numerical results obtained by applying SOFIA were compared with measured data of static and dynamic aeroelastic wind tunnel tests for an elastic swept wing in subsonic flow. Y1 - 2007 SN - 978-3-540-36165-7 SP - 421 EP - 434 PB - Springer CY - Berlin [u.a.] ER - TY - CHAP A1 - Braun, Carsten A1 - Boucke, Alexander A1 - Ballmann, Josef T1 - Numerical study of the influence of dynamic pressure and deflected ailerons on the deformation of a high speed wing model T2 - High performance computing in science and engineering '04. Transactions of the High Performance Computing Center Stuttgart (HLRS) 2004 / Eds.: Egon Krause ... Y1 - 2005 SN - 3-540-22943-4 SP - 225 EP - 236 PB - Springer CY - Berlin ER - TY - CHAP A1 - Braun, Carsten A1 - Boucke, Alexander A1 - Hanke, M. A1 - Karavas, Alexandros A1 - Ballmann, Josef T1 - Prediction of the model deformation of a high speed transport aircraft type wing by direct aeroelastic simulation T2 - High performance computing in science and engineering '03. Transactions of the High Performance Computing Center Stuttgart (HLRS) 2003 / Eds.: Egon Krause ... Y1 - 2003 SN - 978-3-540-40850-5 SP - 331 EP - 342 PB - Springer CY - Berlin ER - TY - CHAP A1 - Britten, G. A1 - Braun, Carsten A1 - Hesse, M. A1 - Ballmann, Josef T1 - Computational aeroelasticity with reduced structural models T2 - Flow modulation and fluid-structure interaction at airplane wings : research results of the Collaborative Research Center SFB 401 at RWTH Aachen, University of Technology, Aachen, Germany / Josef Ballmann (Ed.) Notes on numerical fluid mechanics and multidisciplinary design. Vol. 84 Y1 - 2003 SN - 3-540-40209-8 SP - 275 EP - 299 PB - Springer CY - Berlin ER - TY - CHAP A1 - Cresser, J. D. A1 - Häger, J. A1 - Leuchs, G. A1 - Rateike, Franz-Matthias A1 - Walther, H. T1 - Resonance fluorescence of atoms in strong monochromatic laser fields T2 - Dissipative systems in quantum optics. Ed. by Rodolfo Bonifacio. Topics in current physics. Vol. 27 N2 - The investigation of atomic resonance fluorescence has always been of special interest as a means for the determination of atomic parameters. In addition, information on the interaction mechanism between atoms and radiation can be obtained. In the standard fluorescence experiment the frequency distribution of the incident photons is larger than the natural width of the respective transition; as a consequence the correlation time in the photon-atom interaction is determined by the lifetime of the atoms in the excited state. With the development of lasers and especially of tunable dye lasers in recent years it became possible to study the case where the incident radiation has a spectral distribution which is narrower than the natural width. This corresponds to a correlation time of the incoming light wave which is much longer than the excited-state lifetime. In this chapter a survey of experiments on the resonance fluorescence of atoms in monochromatic laser fields will be given. Y1 - 1982 SN - 978-3-642-81719-9 U6 - http://dx.doi.org/10.1007/978-3-642-81717-5_3 SP - 21 EP - 59 PB - Springer CY - Berlin ER - TY - CHAP A1 - Weber, Hans-Joachim T1 - Applied physics of compressible and incompressible fluids T2 - Critical care nephrology / [Hrsg.:] Claudio Ronco and Rinaldo Bellomo Y1 - 1998 SN - 978-94-010-6306-7 SP - 63 EP - 84 PB - Springer CY - Dordrecht ER - TY - CHAP A1 - Dikta, Gerhard T1 - Fundamentals of applied probability and basic statistics T2 - Critical care nephrology / [Hrsg.:] Claudio Ronco and Rinaldo Bellomo Y1 - 1998 SN - 978-94-010-6306-7 SP - 51 EP - 61 PB - Springer CY - Dordrecht ER - TY - CHAP A1 - Dachwald, Bernd A1 - Ulamec, Stephan A1 - Biele, Jens T1 - Clean in situ subsurface exploration of icy environments in the solar system T2 - Habitability of other planets and satellites. - (Cellular origin, life in extreme habitats and astrobiology ; 28) N2 - "To assess the habitability of the icy environments in the solar system, for example, on Mars, Europa, and Enceladus, the scientific analysis of material embedded in or underneath their ice layers is very important. We consider self-steering robotic ice melting probes to be the best method to cleanly access these environments, that is, in compliance with planetary protection standards. The required technologies are currently developed and tested." Y1 - 2013 SN - 978-94-007-6545-0 (Druckausgabe) SN - 978-94-007-6546-7 (E-Book) SP - 367 EP - 397 PB - Springer CY - Dordrecht ER - TY - CHAP A1 - Meliß, Michael A1 - Späte, Frank T1 - Berechnung von Sonnenstand und -strahlung T2 - Regenerative Energiequellen : Praktikum / ed. Michael Meliß Y1 - 1997 SN - 3-540-63218-2 U6 - http://dx.doi.org/10.1007/978-3-642-60864-3_2 SP - 5 EP - 22 PB - Springer CY - Berlin ER - TY - CHAP A1 - Meliß, Michael A1 - Späte, Frank T1 - Auslegung von solarthermischen Anlagen T2 - Regenerative Energiequellen : Praktikum / ed. Michael Meliß Y1 - 1997 SN - 3-540-63218-2 U6 - http://dx.doi.org/10.1007/978-3-642-60864-3_3 SP - 23 EP - 47 PB - Springer CY - Berlin ER - TY - JOUR A1 - Dietzel, F. A1 - Weber, Hans-Joachim A1 - Porschen, W. A1 - Feinendegen, L. E. T1 - Zur Wärmeempfindlichkeit von oxischen und hypoxischen Zellen in einem Tumor JF - Naturwissenschaften Y1 - 1976 U6 - http://dx.doi.org/10.1007/BF00622808 SN - 0028-1042 VL - 63 IS - 12 SP - 585 EP - 586 PB - Springer CY - Heidelberg ER - TY - CHAP A1 - Dilthey, Ulrich A1 - Brandenburg, Annette A1 - Schleser, Markus T1 - Mikrokleben T2 - Montage hybrider Mikrosysteme : Handhabungs- und Fügetechniken für die Klein- und Mittelserienfertigung Y1 - 2005 SN - 978-3-540-23706-8 SP - 161 EP - 172 PB - Springer CY - Berlin [u.a.] ER - TY - CHAP A1 - Hirt, Gerhard A1 - Bleck, Wolfgang A1 - Bobzin, Kirsten A1 - Schleser, Markus A1 - [u.a.], T1 - Hybride Produktionssysteme T2 - Integrative Produktionstechnik für Hochlohnländer / hrsg. von Christian Brecher N2 - Während die virtuelle Produktentstehungskette große Gestaltungsfreiräume bietet, ist die reale Produktentstehungskette durch wesentlich mehr Randbedingungen gekennzeichnet, die nicht oder nur ansatzweise beeinflussbar sind. Die Realisierung des aus logistischer Sicht optimalen One-Piece-Flow bei gleichzeitiger Steigerung von Flexibilität und Produktivität sowie des Verschiebens der Grenze des technologisch Machbaren müssen in zukünftigen Forschungsansätzen gleichermaßen betrachtet werden. Die Grenzverschiebung auf Basis der Integration von Technologien ist dabei ein viel versprechender Ansatz, der es in vielen Fällen ermöglicht, in allen genannten Zielrichtungen gleichermaßen Potentiale zu erschließen. Y1 - 2011 SN - 978-3-642-20692-4 (Print) ; 978-3-642-20693-1 (E-Book) U6 - http://dx.doi.org/10.1007/978-3-642-20693-1_5 SP - 465 EP - 745 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Mokrov, Oleg A1 - Zabirov, Alexander T1 - Virtual welding equipment for simulation of GMAW processes with integration of power source regulation JF - Frontiers of materials science Y1 - 2011 SN - 2095-0268 (E-Journal); 2095-025X (Print) VL - Vol. 5 IS - Iss. 2 SP - 79 EP - 89 PB - Springer CY - Berlin ER - TY - CHAP A1 - Tran, Thanh Ngoc A1 - Staat, Manfred T1 - Shakedown analysis of Reissner-Mindlin plates using the edge-based smoothed finite element method T2 - Direct methods for limit states in structures and materials / Dieter Weichert ; Alan Ponter, ed. N2 - This paper concerns the development of a primal-dual algorithm for limit and shakedown analysis of Reissner-Mindlin plates made of von Mises material. At each optimization iteration, the lower bound of the shakedown load multiplier is calculated simultaneously with the upper bound using the duality theory. An edge-based smoothed finite element method (ES-FEM) combined with the discrete shear gap (DSG) technique is used to improve the accuracy of the solutions and to avoid the transverse shear locking behaviour. The method not only possesses all inherent features of convergence and accuracy from ES-FEM, but also ensures that the total number of variables in the optimization problem is kept to a minimum compared with the standard finite element formulation. Numerical examples are presented to demonstrate the effectiveness of the present method. Y1 - 2014 SN - 978-94-007-6826-0 (Print) 978-94-007-6827-7 (Online) U6 - http://dx.doi.org/10.1007/978-94-007-6827-7_5 SP - 101 EP - 117 PB - Springer CY - Dordrecht [u.a.] ER - TY - JOUR A1 - Winckler, Silvia A1 - Krueger, Rolf A1 - Schnitzler, Thomas A1 - Zang, Werner A1 - Fischer, Rainer A1 - Biselli, Manfred T1 - A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach JF - Bioprocess and biosystems engineering N2 - Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen. Y1 - 2014 U6 - http://dx.doi.org/10.1007/s00449-013-1062-8 SN - 1615-7591 (Print) 1615-7605 (Online) VL - 37 IS - 5 SP - 901 EP - 912 PB - Springer CY - Berlin, Heidelberg ER - TY - JOUR A1 - Deppe, Veronika Maria A1 - Bongaerts, Johannes A1 - O'Connell, Timothy A1 - Maurer, Karl-Heinz A1 - Meinhardt, Friedhelm T1 - Enzymatic deglycation of Amadori products in bacteria JF - Applied microbiology and biotechnology Y1 - 2011 SN - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print) VL - Vol. 90 IS - Iss. 2 SP - 399 EP - 406 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kirschner-Hermanns, Ruth A1 - Klementz, T. A1 - Haselhuhn, Angelika A1 - Jakse, Gerhard A1 - Heidenreich, A. A1 - Brehmer, Bernhard T1 - Drangsymptomatik nach onkologisch erfolgreicher Prostatakarzinomtherapie : prospektive Studie zum Einfluss von Therapiemodalität, Morbidität und epidemiologischen Faktoren auf die Lebensqualität JF - Der Urologe Y1 - 2011 SN - 1433-0563 VL - Vol. 50 IS - Iss. 11 SP - 1412 EP - 1419 PB - Springer CY - Berlin ER - TY - JOUR A1 - Bung, Daniel B. T1 - Fließcharakteristik und Sauerstoffeintrag bei selbstbelüfteten Gerinneströmungen auf Kaskaden mit gemäßigter Neigung JF - Österreichische Wasser- und Abfallwirtschaft Y1 - 2011 SN - 1613-7566 (E-Journal); 0945-358X (Print) VL - Vol. 63 IS - Iss. 3-4 SP - 76 EP - 81 PB - Springer CY - Berlin ER - TY - CHAP A1 - Wolff, Nino A1 - Seefeldt, Patric A1 - Bauer, Wolfgang A1 - Fiebig, Christopher A1 - Gerding, Patrick A1 - Parow-Souchon, Kai A1 - Pongs, Anna A1 - Reiffenrath, Matti A1 - Ziemann, Thomas T1 - Alternative application of solar sail technology T2 - Advances in solar sailing N2 - The development of Gossamer sail structures for solar sails contributes to a large field of future space applications like thin film solar generators, membrane antennas and drag sails. The focus of this paper is the development of a drag sail based on solar sail technology that could contribute to a reduction of space debris in low Earth orbits. The drag sail design and its connections to solar sail development, a first test on a sounding rocket, as well as the ongoing integration of the drag sail into a triple CubeSat is presented. Y1 - 2014 SN - 978-3-642-34906-5 (Print) ; 978-3-642-34907-2 (E-Book) U6 - http://dx.doi.org/10.1007/978-3-642-34907-2_23 SP - 351 EP - 365 PB - Springer CY - Berlin ER - TY - CHAP A1 - Dachwald, Bernd A1 - Boehnhardt, Herrmann A1 - Broj, Ulrich A1 - Geppert, Ulrich R. M. E. A1 - Grundmann, Jan-Thimo A1 - Seboldt, Wolfgang A1 - Seefeldt, Patric A1 - Spietz, Peter A1 - Johnson, Les A1 - Kührt, Ekkehard A1 - Mottola, Stefano A1 - Macdonald, Malcolm A1 - McInnes, Colin R. A1 - Vasile, Massimiliano A1 - Reinhard, Ruedeger T1 - Gossamer roadmap technology reference study for a multiple NEO Rendezvous Mission T2 - Advances in solar sailing N2 - A technology reference study for a multiple near-Earth object (NEO) rendezvous mission with solar sailcraft is currently carried out by the authors of this paper. The investigated mission builds on previous concepts, but adopts a strong micro-spacecraft philosophy based on the DLR/ESA Gossamer technology. The main scientific objective of the mission is to explore the diversity of NEOs. After direct interplanetary insertion, the solar sailcraft should—within less than 10 years—rendezvous three NEOs that are not only scientifically interesting, but also from the point of human spaceight and planetary defense. In this paper, the objectives of the study are outlined and a preliminary potential mission profile is presented. Y1 - 2014 SN - 978-3-642-34906-5 (Print) ; 978-3-642-34907-2 (E-Book) SP - 211 EP - 226 PB - Springer CY - Berlin [u.a.] ER - TY - CHAP A1 - McInnes, Colin R. A1 - Bothmer, Volker A1 - Dachwald, Bernd A1 - Geppert, Ulrich R. M. E. A1 - Heiligers, Jeannette A1 - Hilgers, Alan A1 - Johnson, Les A1 - Macdonald, Malcolm A1 - Reinhard, Ruedeger A1 - Seboldt, Wolfgang A1 - Spietz, Peter T1 - Gossamer roadmap technology reference study for a Sub-L1 Space Weather Mission T2 - Advances in solar sailing N2 - A technology reference study for a displaced Lagrange point space weather mission is presented. The mission builds on previous concepts, but adopts a strong micro-spacecraft philosophy to deliver a low mass platform and payload which can be accommodated on the DLR/ESA Gossamer-3 technology demonstration mission. A direct escape from Geostationary Transfer Orbit is assumed with the sail deployed after the escape burn. The use of a miniaturized, low mass platform and payload then allows the Gossamer-3 solar sail to potentially double the warning time of space weather events. The mission profile and mass budgets will be presented to achieve these ambitious goals. Y1 - 2014 SN - 978-3-642-34906-5 (Print) ; 978-3-642-34907-2 (E-Book) SP - 227 EP - 242 PB - Springer CY - Berlin [u.a.] ER - TY - CHAP A1 - Macdonald, Malcolm A1 - McGrath, C. A1 - Appourchaux, T. A1 - Dachwald, Bernd A1 - Finsterle, W. A1 - Gizon, L. A1 - Liewer, P. C. A1 - McInnes, Colin R. A1 - Mengali, G. A1 - Seboldt, W. A1 - Sekii, T. A1 - Solanki, S. K. A1 - Velli, M. A1 - Wimmer-Schweingruber, R. F. A1 - Spietz, Peter A1 - Reinhard, Ruedeger ED - Macdonald, Malcolm T1 - Gossamer roadmap technology reference study for a solar polar mission T2 - Advances in solar sailing N2 - A technology reference study for a solar polar mission is presented. The study uses novel analytical methods to quantify the mission design space including the required sail performance to achieve a given solar polar observation angle within a given timeframe and thus to derive mass allocations for the remaining spacecraft sub-systems, that is excluding the solar sail sub-system. A parametric, bottom-up, system mass budget analysis is then used to establish the required sail technology to deliver a range of science payloads, and to establish where such payloads can be delivered to within a given timeframe. It is found that a solar polar mission requires a solar sail of side-length 100–125 m to deliver a ‘sufficient value’ minimum science payload, and that a 2.5 μm sail film substrate is typically required, however the design is much less sensitive to the boom specific mass. Y1 - 2014 SN - 978-3-642-34906-5 U6 - http://dx.doi.org/10.1007/978-3-642-34907-2_17 SP - 243 EP - 257 PB - Springer CY - Berlin, Heidelberg ER - TY - CHAP A1 - Pulini, Paola A1 - Gligorevic, Snjezana T1 - WIMAX performance in the airport environment T2 - Multi-carrier systems & solutions 2009. (Lecture notes in electrical engineering ; 41) N2 - In this paper, the multicarrier physical layers of WiMAX are evaluated in the context of airport data links. The orthogonal frequency-division multiplexing (OFDM) and orthogonal frequency-division multiple-access (OFDMA) cases are applied to the forward link (FL) and reverse link (RL), respectively. The performance of the so called parking and taxi scenarios is presented for airport communications in C-band. Numerical results show that the proposed scheme brings good performance for both the FL and the RL. For the OFDMA case a structure changing called double-tile is also proposed to improve the system performance. Y1 - 2009 SN - 978-90-481-2529-6 (Print) ; 978-90-481-2530-2 (Online) SP - 301 EP - 310 PB - Springer CY - Berlin [u.a.] ER - TY - CHAP A1 - Priede, Gareth A1 - Ferrein, Alexander T1 - Towards passive walking for the fully-actuated biped robot Nao T2 - Emerging trends in computing, informatics, systems sciences, and engineering. (Lecture notes in electrical engineering : vol. 151) N2 - Many biped robots deploy a form of gait that follows the zero moment point (ZMP) approach, that is, the robot is in a stable position at any point in time. This requires the robot to be fully actuated. While very stable, the draw-backs of this approach are a fairly slow gait and high energy consumption. An alternative approach is the so-called passive-dynamic walking, where the gait makes use of the inertia and dynamic stability of the robot. In this paper we describe our ongoing work of combining the principles of passive-dynamic walking on the fully-actuated biped robot Nao, which is also deployed for robotic soccer applications. We present a simple controller that allows the robot to stably rock sidewards, showing a closed limit-cycle. We discuss first results of superimposing a forward motion on the sidewards motion. Based on this we expect to endow the Nao with a fast, robust, and stable passive-dynamic walk on the fully-actuated Nao in the future. Y1 - 2013 SN - 978-1-4614-3557-0 ; 978-1-4614-3558-7 U6 - http://dx.doi.org/10.1007/978-1-4614-3558-7_18 SP - 225 EP - 236 PB - Springer CY - New York, NY ER - TY - JOUR A1 - Alebouyeh Samami, Behzad A1 - Pieper, Martin A1 - Breitbach, Gerd A1 - Hodapp, Josef T1 - Heat production in the windings of the stators of electric machines under stationary condition JF - Heat and mass transfer N2 - In electric machines due to high currents and resistive losses (joule heating) heat is produced. To avoid damages by overheating the design of effective cooling systems is required. Therefore the knowledge of heat sources and heat transfer processes is necessary. The purpose of this paper is to illustrate a good and effective calculation method for the temperature analysis based on homogenization techniques. These methods have been applied for the stator windings in a slot of an electric machine consisting of copper wires and resin. The key quantity here is an effective thermal conductivity, which characterizes the heterogeneous wire resin-arrangement inside the stator slot. To illustrate the applicability of the method, the analysis of a simplified, homogenized model is compared with the detailed analysis of temperature behavior inside a slot of an electric machine according to the heat generation. We considered here only the stationary situation. The achieved numerical results are accurate and show that the applied homogenization technique works in practice. Finally the results of simulations for the two cases, the original model of the slot and the homogenized model chosen for the slot (unit cell), are compared to experimental results. Y1 - 2014 U6 - http://dx.doi.org/10.1007/s00231-014-1371-8 SN - 0947-7411 (Print) ; 1432-1181 (E-Journal) VL - 50 SP - 1707 EP - 1716 PB - Springer CY - Heidelberg ER - TY - CHAP A1 - Niemüller, Tim A1 - Ewert, Daniel A1 - Reuter, Sebastian A1 - Ferrein, Alexander A1 - Jeschke, Sabina A1 - Lakemeyer, Gerhard T1 - RoboCup logistics league sponsored by festo: A competitive factory automation testbed T2 - RoboCup 2013: Robot World Cup XVII : Eindhoven; Netherlands; 1 July 2013 through 1 July 2013. (Lecture notes in computer science ; 8371) N2 - A new trend in automation is to deploy so-called cyber-physical systems (CPS) which combine computation with physical processes. The novel RoboCup Logistics League Sponsored by Festo (LLSF) aims at such CPS logistic scenarios in an automation setting. A team of robots has to produce products from a number of semi-finished products which they have to machine during the game. Different production plans are possible and the robots need to recycle scrap byproducts. This way, the LLSF is a very interesting league offering a number of challenging research questions for planning, coordination, or communication in an application-driven scenario. In this paper, we outline the objectives of the LLSF and present steps for developing the league further towards a benchmark for logistics scenarios for CPS. As a major milestone we present the new automated referee system which helps in governing the game play as well as keeping track of the scored points in a very complex factory scenario. Y1 - 2014 SN - 978-3-662-44467-2 (Print) 978-3-662-44468-9 (Online) SP - 336 EP - 347 PB - Springer CY - Berlin ER - TY - JOUR A1 - Khaydukova, M. M. A1 - Zadorozhnaya, O. A. A1 - Kirsanov, D. O. A1 - Iken, Heiko A1 - Rolka, David A1 - Schöning, Michael Josef A1 - Babain, V. A. A1 - Vlasov, Yu. G. A1 - Legin, A. V. T1 - Multivariate processing of atomic-force microscopy images for detection of the response of plasticized polymeric membranes JF - Russian journal of applied chemistry N2 - The possibility of using the atomic-force microscopy as a method for detection of the analytical signal from plasticized polymeric sensor membranes was analyzed. The surfaces of cadmium-selective membranes based on two polymeric matrices were examined. The digital images were processed with multivariate image analysis techniques. A correlation was found between the surface profile of an ion-selective membrane and the concentration of the ion in solution. Y1 - 2014 U6 - http://dx.doi.org/10.1134/S1070427214030112 SN - 1608-3296 (E-Journal); 1070-4272 (Print) VL - 87 IS - 3 SP - 307 EP - 314 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Jakob, Felix A1 - Martinez, Ronny A1 - Mandawe, John A1 - Hellmuth, Hendrik A1 - Siegert, Petra A1 - Maurer, Karl-Heinz A1 - Schwaneberg, Ulrich T1 - Surface charge engineering of a Bacillus gibsonii subtilisin protease JF - Applied microbiology and biotechnology Y1 - 2013 SN - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print) VL - Vol. 97 IS - Iss. 15 SP - 6793 EP - 6802 PB - Springer CY - Berlin ER - TY - JOUR A1 - Niehaus, F. A1 - Gabor, E. A1 - Wieland, S. A1 - Siegert, Petra A1 - Maurer, Karl-Heinz A1 - Eck, J. T1 - Enzymes for the laundry industries: tapping the vast metagenomic pool of alkaline proteases JF - Microbial biotechnology Y1 - 2011 SN - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print) VL - Vol. 4 IS - Iss. 6 SP - 767 EP - 776 PB - Springer CY - Berlin ER - TY - CHAP A1 - Pietsch, Wolfram T1 - A framework for strategic positioning of IT-products T2 - Software business : from physical products to software services and solutions : 4th International Conference on Software Business, ICSOB 2013; Potsdam; Germany; 11 June 2013 through 14 June 2013. (Lecture notes in business information processing ; 150) N2 - IT Products are viewed and managed differently depending on the perspectives and the stage within the life cycle. A model is presented that integrates different perspectives and stages serving as an aid for the analysis of business models and focused positioning of IT-products. Four generic business models are analysed with regard to the product management function in general and the positioning field for IT-products specifically: off-the-shelf (license), license plus service, project, and system service (incl. cloud computing). KW - Strategic Business Planning KW - IT Products KW - Business Models KW - Product Management Y1 - 2013 U6 - http://dx.doi.org/10.1007/978-3-642-39336-5_11 SP - 102 EP - 116 PB - Springer CY - Berlin ER - TY - CHAP A1 - Kirchner, Patrick A1 - Reisert, Steffen A1 - Schöning, Michael Josef T1 - Calorimetric gas sensors for hydrogen peroxide monitoring in aseptic food processes T2 - Gas sensing fundamentals. (Springer Series on Chemical Sensors and Biosensors ; 15) N2 - For the sterilisation of aseptic food packages it is taken advantage of the microbicidal properties of hydrogen peroxide (H2O2). Especially, when applied in vapour phase, it has shown high potential of microbial inactivation. In addition, it offers a high environmental compatibility compared to other chemical sterilisation agents, as it decomposes into oxygen and water, respectively. Due to a lack in sensory detection possibilities, a continuous monitoring of the H2O2 concentration was recently not available. Instead, the sterilisation efficacy is validated using microbiological tests. However, progresses in the development of calorimetric gas sensors during the last 7 years have made it possible to monitor the H2O2 concentration during operation. This chapter deals with the fundamentals of calorimetric gas sensing with special focus on the detection of gaseous hydrogen peroxide. A sensor principle based on a calorimetric differential set-up is described. Special emphasis is given to the sensor design with respect to the operational requirements under field conditions. The state-of-the-art regarding a sensor set-up for the on-line monitoring and secondly, a miniaturised sensor for in-line monitoring are summarised. Furthermore, alternative detection methods and a novel multi-sensor system for the characterisation of aseptic sterilisation processes are described. KW - Calorimetric gas sensor KW - Hydrogen peroxide KW - Multi-sensor system Y1 - 2014 SN - 978-3-642-54518-4 (Print) ; 978-3-642-54519-1 (Online) U6 - http://dx.doi.org/10.1007/5346_2013_51 SP - 279 EP - 309 PB - Springer CY - Heidelberg ER - TY - CHAP A1 - Knott, Thomas C. A1 - Sofronia, Raluca E. A1 - Gerressen, Marcus A1 - Law, Yuen A1 - Davidescu, Arjana A1 - Savii, George G. A1 - Gatzweiler, Karl-Heinz A1 - Staat, Manfred A1 - Kuhlen, Torsten W. T1 - Preliminary bone sawing model for a virtual reality-based training simulator of bilateral sagittal split osteotomy T2 - Biomedical simulation : 6th International Symposium, ISBMS 2014, Strasbourg, France, October 16-17, 2014 : proceedings (Lecture notes in computer science : vol. 8789) N2 - Successful bone sawing requires a high level of skill and experience, which could be gained by the use of Virtual Reality-based simulators. A key aspect of these medical simulators is realistic force feedback. The aim of this paper is to model the bone sawing process in order to develop a valid training simulator for the bilateral sagittal split osteotomy, the most often applied corrective surgery in case of a malposition of the mandible. Bone samples from a human cadaveric mandible were tested using a designed experimental system. Image processing and statistical analysis were used for the selection of four models for the bone sawing process. The results revealed a polynomial dependency between the material removal rate and the applied force. Differences between the three segments of the osteotomy line and between the cortical and cancellous bone were highlighted. KW - Bone sawing KW - virtual reality KW - training simulator Y1 - 2014 SN - 978-3-319-12057-7 (Online) SN - 978-3-319-12056-0 (Print) U6 - http://dx.doi.org/10.1007/978-3-319-12057-7_1 SP - 1 EP - 10 PB - Springer CY - Cham ER - TY - CHAP A1 - Frotscher, Ralf A1 - Goßmann, Matthias A1 - Raatschen, Hans-Jürgen A1 - Temiz Artmann, Aysegül A1 - Staat, Manfred T1 - Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM T2 - Shell and membrane theories in mechanics and biology. (Advanced structured materials ; 45) N2 - We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEM for plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments. Y1 - 2015 SN - 978-3-319-02534-6 ; 978-3-319-02535-3 SP - 187 EP - 212 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Fonti, Patrick A1 - Eilmann, Britta A1 - García-González, Ignacio A1 - von Arx, Georg T1 - Expeditious building of ring-porous earlywood vessel chronologies without loosing signal information JF - Trees : structure and function Y1 - 2009 U6 - http://dx.doi.org/10.1007/s00468-008-0310-z SN - 0931-1890 (Print) SN - 1432-2285 (Online) VL - 23 IS - 3 SP - 665 EP - 671 PB - Springer CY - Berlin ER - TY - CHAP A1 - Alhwarin, Faraj A1 - Ferrein, Alexander A1 - Scholl, Ingrid T1 - IR stereo kinect: improving depth images by combining structured light with IR stereo T2 - PRICAI 2014: Trends in artificial intelligence : 13th Pacific Rim International Conference on Artificial Intelligence : Gold Coast, QLD, Australia, December 1-5, 2014 : proceedings. (Lecture notes in computer science ; vol. 8862) N2 - RGB-D sensors such as the Microsoft Kinect or the Asus Xtion are inexpensive 3D sensors. A depth image is computed by calculating the distortion of a known infrared light (IR) pattern which is projected into the scene. While these sensors are great devices they have some limitations. The distance they can measure is limited and they suffer from reflection problems on transparent, shiny, or very matte and absorbing objects. If more than one RGB-D camera is used the IR patterns interfere with each other. This results in a massive loss of depth information. In this paper, we present a simple and powerful method to overcome these problems. We propose a stereo RGB-D camera system which uses the pros of RGB-D cameras and combine them with the pros of stereo camera systems. The idea is to utilize the IR images of each two sensors as a stereo pair to generate a depth map. The IR patterns emitted by IR projectors are exploited here to enhance the dense stereo matching even if the observed objects or surfaces are texture-less or transparent. The resulting disparity map is then fused with the depth map offered by the RGB-D sensor to fill the regions and the holes that appear because of interference, or due to transparent or reflective objects. Our results show that the density of depth information is increased especially for transparent, shiny or matte objects. Y1 - 2014 SN - 978-3-319-13559-5 (Print) ; 978-3-319-13560-1 (E-Book) U6 - http://dx.doi.org/10.1007/978-3-319-13560-1_33 SP - 409 EP - 421 PB - Springer CY - München ER - TY - CHAP A1 - Tran, Thanh Ngoc A1 - Staat, Manfred T1 - Uncertainty multimode failure and shakedown analysis of shells T2 - Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ... N2 - This paper presents a numerical procedure for reliability analysis of thin plates and shells with respect to plastic collapse or to inadaptation. The procedure involves a deterministic shakedown analysis for each probabilistic iteration, which is based on the upper bound approach and the use of the exact Ilyushin yield surface. Probabilistic shakedown analysis deals with uncertainties originated from the loads, material strength and thickness of the shell. Based on a direct definition of the limit state function, the calculation of the failure probability may be efficiently solved by using the First and Second Order Reliability Methods (FORM and SORM). The problem of reliability of structural systems (series systems) is handled by the application of a special technique which permits to find all the design points corresponding to all the failure modes. Studies show, in this case, that it improves considerably the FORM and SORM results. KW - Limit analysis KW - Shakedown analysis KW - Reliability analysis KW - Multimode failure KW - Non-linear optimization Y1 - 2015 SN - 978-3-319-12927-3 (print) ; 978-3-319-12928-0 (online) U6 - http://dx.doi.org/10.1007/978-3-319-12928-0_14 SP - 279 EP - 298 PB - Springer CY - Cham ER - TY - CHAP A1 - Wollert, Jörg T1 - Bussysteme T2 - Handbuch der Mess- und Automatisierungstechnik in der Produktion / Hans-Jürgen Gevatter ... (Hrsg.). - 2. Aufl. Y1 - 2006 SN - 3-540-21207-8 ; 978-3-540-21207-2 SP - 475 EP - 653 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Hafner, David A1 - Demetz, Oliver A1 - Weickert, Joachim A1 - Reißel, Martin T1 - Mathematical Foundations and Generalisations of the Census Transform for Robust Optic Flow Computation JF - Journal of Mathematical Imaging and Vision Y1 - 2014 U6 - http://dx.doi.org/10.1007/s10851-014-0529-9 SN - 1573-7683 (Online) N1 - Springer Online First (ohne Seitenang. und Heftzuteilung) PB - Springer CY - New York ER - TY - CHAP A1 - Pietsch, Wolfram A1 - Siedentopf, Jukka A1 - Teubner, Alexander ED - Gaul, Wolfgang ED - Bachem, Achim ED - Habenicht, Walter ED - Runge, Walter ED - Stahl, Wolfgang W. T1 - Vergleich konnektionistischer Modelle und konventioneller Optimierungsverfahren am Beispiel der Maschinenbelegungsplanung T2 - Operations Research Proceedings 1991 / Papers of the 20th Annual Meeting = Vorträge der 20. Jahrestagung N2 - Für die Erstellung von Maschinenbelegungsplanen wurden im Operations Research aufwendige Optimierungsverfahren konzipiert und entsprechende Programme entwickelt. Maschinenbelegungsprobleme sind klassische Vertreter der Klasse der np-vollständigen Probleme, also sichere Kandidaten für kombinatorische Explosion der Lösungsalternativen. Deshalb ist der Einsatz konventioneller Planungssysteme wegen der hohen Rechneranforderungen der gängigen Verfahren an die Hardware oft nicht praktikabel. Y1 - 1992 SN - 978-3-642-46773-8 (Online) SN - 978-3-540-55410-3 (Print) U6 - http://dx.doi.org/https://doi.org/10.1007/978-3-642-46773-8_58 N1 - Part of the book series: Operations Research Proceedings (ORP, volume 1991) SP - 223 PB - Springer CY - Berlin ; Heidelberg ER - TY - JOUR A1 - Borchert, Jörg A1 - Hasenbeck, Marc A1 - Jungbluth, Christian A1 - Schemm, Ralf T1 - Bewertung und Steuerung von Gasspeichern bzw. Gasspeicherscheiben JF - Zeitschrift für Energiewirtschaft N2 - In diesem Artikel werden zunächst einleitend der Gasmarkt Deutschland und der sich daraus ergebende Speicherbedarf skizziert. Folgend wird auf verschiedene Speichernutzen aus betriebswirtschaftlicher Perspektive eingegangen und die in diesem Artikel vorgestellten Bewertungsverfahren einleitend beschrieben. In diesem Artikel werden stochastische Optimierungsmethoden aufgegriffen, die sowohl eine Bewertung der Speicher gegenüber einem Spotpreis, als auch gegenüber einer gesamten Forwardcurve ermöglichen. Hierzu werden zunächst Modelle zur Beschreibung der Marktpreise vorgestellt und anhand empirischer Daten kalibriert. Dann wird eine beispielhafte Speicherscheibe zunächst auf Basis der LeastSquareMonteCarloTechnik gegenüber dem stochastischen mehrfaktoriellen Spotpreismodell bewertet. Hieran schließt sich die Vorstellung der Bewertung sowie des Hedgings gegenüber der Forwardcurve an. Abschließend erfolgt eine vergleichende Gegenüberstellung beider Verfahren. Y1 - 2009 U6 - http://dx.doi.org/10.1007/s12398-009-0033-x SN - 1866-2765 VL - 33 IS - 4 SP - 279 EP - 293 PB - Springer CY - Berlin ER - TY - CHAP A1 - Rebel, Sören A1 - Hüning, Felix A1 - Scholl, Ingrid A1 - Ferrein, Alexander T1 - MQOne: Low-cost design for a rugged-terrain robot platform T2 - Intelligent robotics and applications : 8th International Conference, ICIRA 2015, Portsmouth, UK, August 24-27, 2015, Proceedings, Part II (Lecture notes in computer science : vol. 9245) N2 - Rugged terrain robot designs are important for field robotics missions. A number of commercial platforms are available, however, at an impressive price. In this paper, we describe the hardware and software component of a low-cost wheeled rugged-terrain robot. The robot is based on an electric children quad bike and is modified to be driven by wire. In terms of climbing properties, operation time and payload it can compete with some of the commercially available platforms, but at a far lower price. Y1 - 2015 SN - 978-3-319-22875-4 (print) ; 978-3-319-22876-1 (E-Book) U6 - http://dx.doi.org/10.1007/978-3-319-22876-1_19 SP - 209 EP - 221 PB - Springer CY - Cham ER - TY - CHAP A1 - Rahier, Michael A1 - Ritz, Thomas A1 - Wallenborn, Ramona T1 - Information and communication technology for integrated mobility concepts such as E-carsharing T2 - E-Mobility in Europe : trends and good practice N2 - During the past decade attitude towards sharing things has changed extremely. Not just personal data is shared (e.g. in social networks) but also mobility. Together with the increased ecological awareness of the recent years, new mobility concepts have evolved. E-carsharing has become a symbol for these changes of attitude. The management of a shared car fleet, the energy management of electric mobility and the management of various carsharing users with individual likes and dislikes are just some of the major challenges of e-carsharing. Weaving it into integrated mobility concepts, this raises complexity even further. These challenges can only be overcome by an appropriate amount of well-shaped information available at the right place and time. In order to gather, process and share the required information, fleet cars have to be equipped with modern information and communication technology (ICT) and become so-called fully connected cars. Ensuring the usability of these ICT systems is another challenge that is often neglected, even though it is usability that makes carsharing comfortable, attractive and supports users’ new attitudes. By means of an integrated and consistent concept for human-machine interaction (HMI), the usability of such systems can be raised tremendously. KW - Information and communication technology KW - Fully connected car KW - E-carsharing KW - Mobility management KW - Integrated mobility Y1 - 2015 SN - 978-3-319-13193-1 U6 - http://dx.doi.org/10.1007/978-3-319-13194-8_17 SP - 311 EP - 326 PB - Springer CY - Cham [u.a.] ER - TY - CHAP A1 - Busse, Daniel A1 - Esch, Thomas A1 - Muntaniol, Roman T1 - Thermal management in E-carsharing vehicles - preconditioning concepts of passenger compartments T2 - E-Mobility in Europe : trends and good practice N2 - The issue of thermal management in electric vehicles includes the topics of drivetrain cooling and heating, interior temperature, vehicle body conditioning and safety. In addition to the need to ensure optimal thermal operating conditions of the drivetrain components (drive motor, battery and electrical components), thermal comfort must be provided for the passengers. Thermal comfort is defined as the feeling which expresses the satisfaction of the passengers with the ambient conditions in the compartment. The influencing factors on thermal comfort are the temperature and humidity as well as the speed of the indoor air and the clothing and the activity of the passengers, in addition to the thermal radiation and the temperatures of the interior surfaces. The generation and the maintenance of free visibility (ice- and moisture-free windows) count just as important as on-demand heating and cooling of the entire vehicle. A Carsharing climate concept of the innovative ec2go vehicle stipulates and allows for only seating areas used by passengers to be thermally conditioned in a close-to-body manner. To enable this, a particular feature has been added to the preconditioning of the Carsharing electric vehicle during the electric charging phase at the parking station. KW - Carsharing KW - Thermal management KW - Thermal comfort KW - Electrical vehicle KW - Passenger compartment Y1 - 2015 SN - 978-3-319-13193-1 U6 - http://dx.doi.org/10.1007/978-3-319-13194-8_18 SP - 327 EP - 343 PB - Springer CY - Cham [u.a.] ER - TY - CHAP A1 - Kümmell, Steffen A1 - Hillgärtner, Michael T1 - Inductive charging comfortable and nonvisible charging stations for urbanised areas T2 - E-Mobility in Europe : trends and good practice N2 - For a wide acceptance of E-Mobility, a well-developed charging infrastructure is needed. Conductive charging stations, which are today’s state of the art, are of limited suitability for urbanised areas, since they cause a significant diversification in townscape. Furthermore, they might be destroyed by vandalism. Besides for those urbanistic reasons, inductive charging stations are a much more comfortable alternative, especially in urbanised areas. The usage of conductive charging stations requires more or less bulky charging cables. The handling of those standardised charging cables, especially during poor weather conditions, might cause inconvenience, such as dirty clothing etc. Wireless charging does not require visible and vandalism vulnerable charge sticks. No wired connection between charging station and vehicle is needed, which enable the placement below the surface of parking spaces or other points of interest. Inductive charging seems to be the optimal alternative for E-Mobility, as a high power transfer can be realised with a manageable technical and financial effort. For a well-accepted and working public charging infrastructure in urbanised areas it is essential that the infrastructure fits the vehicles’ needs. Hence, a well-adjusted standardisation of the charging infrastructure is essential. This is carried out by several IEC (International Electrotechnical Commission) and national standardisation committees. To ensure an optimised technical solution for future’s inductive charging infrastructures, several field tests had been carried out and are planned in near future. KW - E-mobility KW - Inductive charging KW - Charging stations KW - Urban areas Y1 - 2015 SN - 978-3-319-13193-1 U6 - http://dx.doi.org/10.1007/978-3-319-13194-8_16 SP - 297 EP - 309 PB - Springer CY - Cham [u.a.] ER - TY - CHAP A1 - Kallweit, Stephan A1 - Gottschalk, Michael A1 - Walenta, Robert T1 - ROS based safety concept for collaborative robots in industrial applications T2 - Advances in robot design and intelligent control : proceedings of the 24th International Conference on Robotics in Alpe-Adria-Danube Region (RAAD). (Advances in intelligent systems and computing ; 371) N2 - The production and assembly of customized products increases the demand for flexible automation systems. One approach is to remove the safety fences that separate human and industrial robot to combine their skills. This collaboration possesses a certain risk for the human co-worker, leading to numerous safety concepts to protect him. The human needs to be monitored and tracked by a safety system using different sensors. The proposed system consists of a RGBD camera for surveillance of the common working area, an array of optical distance sensors to compensate shadowing effects of the RGBD camera and a laser range finder to detect the co-worker when approaching the work cell. The software for collision detection, path planning, robot control and predicting the behaviour of the co-worker is based on the Robot Operating System (ROS). A first prototype of the work cell shows that with advanced algorithms from the field of mobile robotics a very flexible safety concept can be realized: the robot not simply stops its movement when detecting a collision, but plans and executes an alternative path around the obstacle. KW - Collaborative robot KW - Human-Robot interaction KW - Safety concept KW - Workspace monitoring KW - Path planning Y1 - 2016 SN - 978-3-319-21289-0 (Print) ; 978-3-319-21290-6 (E-Book) U6 - http://dx.doi.org/10.1007/978-3-319-21290-6_3 SP - 27 EP - 35 PB - Springer CY - Cham ER - TY - CHAP A1 - Bung, Daniel B. ED - Rowinski, Pawel T1 - Laboratory models of free-surface flows T2 - Rivers - physical, fluvial and environmental processes N2 - Hydraulic modeling is the classical approach to investigate and describe complex fluid motion. Many empirical formulas in the literature used for the hydraulic design of river training measures and structures have been developed using experimental data from the laboratory. Although computer capacities have increased to a high level which allows to run complex numerical simulations on standard workstation nowadays, non-standard design of structures may still raise the need to perform physical model investigations. These investigations deliver insight into details of flow patterns and the effect of varying boundary conditions. Data from hydraulic model tests may be used for calibration of numerical models as well. As the field of hydraulic modeling is very complex, this chapter intends to give a short overview on capacities and limits of hydraulic modeling in regard to river flows and hydraulic structures only. The reader shall get a first idea of modeling principles and basic considerations. More detailed information can be found in the references. KW - Physical modeling KW - Similitude KW - Open channels KW - Hydraulic structures Y1 - 2015 SN - 978-3-319-17718-2 ; 978-3-319-17719-9 U6 - http://dx.doi.org/10.1007/978-3-319-17719-9_9 SP - 213 EP - 228 PB - Springer CY - Cham ER - TY - CHAP A1 - Srivastava, Alok A1 - Knolle, Friedhart A1 - Hoyler, Friedrich A1 - Scherer, Ulrich W. A1 - Schnug, Ewald T1 - Uranium Toxicity in the State of Punjab in North-Western India T2 - Management of Natural Resources in a Changing Environment N2 - Lately there has been an increasing concern about uranium toxicity in some districts of Punjab State located in the North Western part of India after the publication of a report (Blaurock-Busch et al. 2010) which showed that the concentration of uranium in hair and urine of children suffering from physical deformities, neurological and mental disorder from Malwa region (Fig. 1) of Punjab State was manifold higher than the reference ranges. A train which connects the affected region with the nearby city of Bikaner which has a Cancer Hospital has been nicknamed as Cancer Express due to the frenzy generated on account of uranium related toxicity. Y1 - 2015 SN - 978-3-319-12559-6 U6 - http://dx.doi.org/10.1007/978-3-319-12559-6_21 SP - 271 EP - 275 PB - Springer CY - Cham ER - TY - JOUR A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Staat, Manfred T1 - Physical response of hyperelastic models for composite materials and soft tissues JF - Asia pacific journal on computational engineering Y1 - 2015 U6 - http://dx.doi.org/10.1186/s40540-015-0015-x SN - 2196-1166 VL - 2 IS - 3 (December 2015) SP - 1 EP - 18 ER - TY - JOUR A1 - Kürten, Sylvia A1 - Mottaghy, Darius A1 - Ziegler, Martin T1 - A new model for the description of the heat transfer for plane thermo-active geotechnical systems based on thermal resistances JF - Acta Geotechnica Y1 - 2015 U6 - http://dx.doi.org/10.1007/s11440-014-0311-6 SN - 1861-1133 VL - 10 IS - 2 SP - 219 EP - 229 PB - Springer CY - Berlin ER - TY - CHAP A1 - Niemueller, Tim A1 - Reuter, Sebastian A1 - Ewert, Daniel A1 - Ferrein, Alexander A1 - Jeschke, Sabina A1 - Lakemeyer, Gerhard T1 - Decisive Factors for the Success of the Carologistics RoboCup Team in the RoboCup Logistics League 2014 T2 - RoboCup 2014: Robot World Cup XVIII Y1 - 2015 SN - 978-3-319-18615-3 N1 - Lecture Notes in Computer Science ; 8992 SP - 155 EP - 167 PB - Springer ER - TY - CHAP A1 - Goeckel, Tom A1 - Schiffer, Stefan A1 - Wagner, Hermann A1 - Lakemeyer, Gerhard T1 - The Video Conference Tool Robot ViCToR T2 - Intelligent Robotics and Applications : 8th International Conference, ICIRA 2015, Portsmouth, UK, August 24-27, 2015, Proceedings, Part II N2 - We present a robotic tool that autonomously follows a conversation to enable remote presence in video conferencing. When humans participate in a meeting with the help of video conferencing tools, it is crucial that they are able to follow the conversation both with acoustic and visual input. To this end, we design and implement a video conferencing tool robot that uses binaural sound source localization as its main source to autonomously orient towards the currently talking speaker. To increase robustness of the acoustic cue against noise we supplement the sound localization with a source detection stage. Also, we include a simple onset detector to retain fast response times. Since we only use two microphones, we are confronted with ambiguities on whether a source is in front or behind the device. We resolve these ambiguities with the help of face detection and additional moves. We tailor the system to our target scenarios in experiments with a four minute scripted conversation. In these experiments we evaluate the influence of different system settings on the responsiveness and accuracy of the device. Y1 - 2015 SN - 978-3-319-22876-1 U6 - http://dx.doi.org/10.1007/978-3-319-22876-1_6 N1 - Lecture Notes in Computer Science ; 9245 SP - 61 EP - 73 PB - Springer ER - TY - CHAP A1 - Altay, Okyay A1 - Taddei, Francesca A1 - Butenweg, Christoph A1 - Klinkel, Sven T1 - Vibration mitigation of wind turbine towers with tuned mass dampers T2 - Wind turbine control and monitoring. (Advances in industrial control) N2 - Because of its minor environmental impact, electricity generation using wind power is getting remarkable. The further growth of the wind industry depends on technological solutions to the challenges in production and construction of the turbines. Wind turbine tower vibrations, which limit power generation efficiency and cause fatigue problems with high maintenance costs, count as one of the main structural difficulties in the wind energy sector. To mitigate tower vibrations auxiliary measures are necessary. The effectiveness of tuned mass damper is verified by means of a numeric study on a 5 MW onshore reference wind turbine. Hereby, also seismic-induced vibrations and soil–structure interaction are considered. Acquired results show that tuned mass damper can effectively reduce resonant tower vibrations and improve the fatigue life of wind turbines. This chapter is also concerned with tuned liquid column damper and a semiactive application of it. Due to its geometric versatility and low prime costs, tuned liquid column dampers are a good alternative to other damping measures, in particular for slender structures like wind turbines. Y1 - 2014 SN - 978-3-319-08412-1 (Print) ; 978-3-319-08413-8 (E-Book) U6 - http://dx.doi.org/10.1007/978-3-319-08413-8_12 SP - 337 EP - 373 PB - Springer CY - Cham ; Heidelberg ; New York ; Dordrecht ; London ER - TY - JOUR A1 - Fischer, Felix A1 - Selver, M. Alper A1 - Gezer, Sinem A1 - Dicle, Oguz A1 - Hillen, Walter T1 - Systematic Parameterization, Storage, and Representation of Volumetric DICOM Data JF - Journal of Medical and Biological Engineering Y1 - 2015 U6 - http://dx.doi.org/10.1007/s40846-015-0097-5 SN - 2199-4757 VL - 35 IS - 6 SP - 709 EP - 723 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hackl, Michael A1 - Müller, Lars-Peter A1 - Staat, Manfred A1 - Kahmann, Stephanie Lucina A1 - Wegmann, Kilian T1 - Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques JF - Knee surgery, sports traumatology, arthroscopy N2 - Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s00167-016-4080-7 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 148 EP - 149 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hackl, Michael A1 - Kahmann, Stephanie Lucina A1 - Wegmann, Kilian A1 - Ries, Christian A1 - Staat, Manfred A1 - Müller, Lars-Peter T1 - Shortening osteotomy of the proximal radius — a treatment option for isolated osteoarthritis of the lateral column of the elbow joint? JF - Knee surgery, sports traumatology, arthroscopy N2 - Treatment of posttraumatic osteoarthritis of the radial column of the elbow joint remains a challenging yet common issue. While partial joint replacement leads to high revision rates, radial head excision has shown to severely increase joint instability. Shortening osteotomy of the radius could be an option to decrease the contact pressure of the radiohumeral joint and thereby pain levels without causing valgus instability. Hence, the aim of this biomechanical study was to evaluate the effects of radial shortening on axial load distribution and valgus stability of the elbow joint. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s00167-016-4080-7 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 128 EP - 129 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hackl, Michael A1 - Leschinger, T. A1 - Staat, Manfred A1 - Müller, Lars-Peter A1 - Wegmann, Kilian T1 - Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation JF - Knee surgery, sports traumatology, arthroscopy N2 - Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s00167-016-4080-7 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 130 EP - 131 PB - Springer CY - Berlin ER - TY - JOUR A1 - Wegmann, Kilian A1 - Hackl, Michael A1 - Staat, Manfred A1 - Mayer, Katharina A1 - Müller, Lars-Peter T1 - Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results JF - Knee surgery, sports traumatology, arthroscopy N2 - While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s00167-016-4079-0 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 58 EP - 59 PB - Springer CY - Berlin ER - TY - JOUR A1 - Scheidweiler, Robert A1 - Triesch, Eberhard T1 - A note on the duality between matchings and vertex covers in balanced hypergraphs JF - Journal of Combinatorial Optimization N2 - We present a new Min-Max theorem for an optimization problem closely connected to matchings and vertex covers in balanced hypergraphs. The result generalizes Kőnig’s Theorem (Berge and Las Vergnas in Ann N Y Acad Sci 175:32–40, 1970; Fulkerson et al. in Math Progr Study 1:120–132, 1974) and Hall’s Theorem (Conforti et al. in Combinatorica 16:325–329, 1996) for balanced hypergraphs. KW - Hall’s Theorem KW - Koenig’s Theorem KW - Duality KW - Balanced hypergraph KW - Hypergraph KW - Vertex cover KW - Matching Y1 - 2016 U6 - http://dx.doi.org/10.1007/s10878-015-9887-5 SN - 1573-2886 N1 - Lehrstuhl II für Mathematik RWTH Aachen VL - 32 IS - 2 SP - 639 EP - 644 PB - Springer CY - Berlin ER - TY - JOUR A1 - Lopes, Pedro A1 - Leandro, Jorge A1 - Carvalho, Rita F. A1 - Bung, Daniel B. T1 - Alternating skimming flow over a stepped spillway JF - Environmental Fluid Mechanics Y1 - 2017 U6 - http://dx.doi.org/10.1007/s10652-016-9484-x SN - 1573-1510 VL - 17 IS - 2 SP - 303 EP - 322 PB - Springer CY - Berlin ER - TY - JOUR A1 - Pinkenburg, Olaf A1 - Schiffels, Johannes A1 - Selmer, Thorsten T1 - Das CoLibry-Konzept – ein Werkzeugkasten für die Synthetische Biologie: Bioproduktion JF - BIOspektrum N2 - Regardless of size or destination, synthetic biology starts with com-parably small information units, which need to be combined and properly arranged in order to achieve a certain goal. This may be the de novo synthesis of individual genes from oligonucleotides, a shuffling of protein domains in order to create novel biocatalysts, the assembly of multiple enzyme encoding genes in metabolic pathway design, or strain development at the production stage. The CoLibry concept has been designed in order to close the gap between recombinant production of individual genes and genome editing. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s12268-016-0734-8 VL - 22 IS - 6 SP - 593 EP - 595 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, I. M. T1 - Mit Statistik gemeistert: perfekte Augentropfen und idealer Screeningtest : Möglichkeiten und Grenzen statistischer Methoden beim Glaukom JF - Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft N2 - Hintergrund Die Anwendung und das Verständnis von Statistik sind sehr wichtig für die biomedizinische Forschung und für die klinische Praxis. Dies gilt insbesondere auch zur Abschätzung der Möglichkeiten unterschiedlichster Diagnostik- und Therapieoptionen beim Glaukom. Die scheinbare Komplexität der Statistik, die zum Teil dem „gesunden Menschenverstand“ zu widersprechen scheint, zusammen mit der nur vorsichtigen Akzeptanz der Statistik bei vielen Medizinern können zu bewussten und unbewussten Manipulationen bei der Datendarstellung und -interpretation führen. Ziel der Arbeit Ziel ist die verständliche Darstellung einiger typischer Fehler in der medizinisch-statistischen Datenbehandlung. Material und Methoden Anhand hypothetischer Beispiele aus der Glaukomdiagnostik erfolgen die Darstellung der Wirkung eines hypotensiven Medikamentes sowie die Beurteilung der Ergebnisse eines diagnostischen Tests. Es werden die typischsten statistischen Einsatzbereiche und Irrtumsquellen ausführlich und verständlich analysiert Ergebnisse Mechanismen von Datenmanipulation und falscher Dateninterpretation werden aufgeklärt. Typische Irrtumsquellen bei der statistischen Auswertung und Datendarstellung werden dabei erläutert. Schlussfolgerungen Die erläuterten praktischen Beispiele zeigen die Notwendigkeit, die Grundlagen der Statistik zu verstehen und korrekt anwenden zu können. Fehlendes Grundlagenwissen und Halbwissen der medizinischen Statistik können zu folgenschweren Missverständnissen und falschen Entscheidungen in der medizinischen Forschung, aber auch in der klinischen Praxis führen. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s00347-016-0312-y SN - 0941-293X SN - 1433-0423 N1 - Englischer Titel: Mastered with statistics: perfect eye drops and ideal screening test : possibilities and limits of statistical methods for glaucoma IS - 113 SP - 838 EP - 843 PB - Springer CY - Berlin ER - TY - JOUR A1 - Knobe, M. A1 - Giesen, M. A1 - Plate, S. A1 - Gradl-Dietsch, G. A1 - Buecking, B. A1 - Eschbach, D. A1 - Laack, Walter van A1 - Pape, H.-C. T1 - The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale JF - European Journal Of Trauma And Emergency Surgery N2 - Purpose The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale. Methods For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland–Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated. Results The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = −0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points). Conclusion The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status. KW - Tinetti test KW - Mobility KW - Mobility tests KW - Ground-level falls KW - Elderly KW - Fall prevention KW - Co-managed care KW - Balance Y1 - 2016 U6 - http://dx.doi.org/10.1007/s00068-016-0693-2 SN - 1863-9941 VL - 42 IS - 5 SP - 537 EP - 545 PB - Springer CY - Berlin ER - TY - JOUR A1 - Belavy, Daniel L. A1 - Albracht, Kirsten A1 - Bruggemann, Gert-Peter A1 - Vergroesen, Pieter-Paul A. A1 - Dieen, Jaap H. van T1 - Can exercise positively influence the intervertebral disc? JF - Sports Medicine N2 - To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a ‘critical period’ for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research. KW - Intradiscal Pressure KW - Annulus Fibrosus KW - Disc Degeneration KW - Nucleus Pulposus KW - Intervertebral Disc Y1 - 2016 U6 - http://dx.doi.org/10.1007/s40279-015-0444-2 SN - 1179-2035 VL - 46 IS - 4 SP - 473 EP - 485 PB - Springer CY - Berlin ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans JF - European Journal of Applied Physiology Y1 - 2013 U6 - http://dx.doi.org/10.1007/s00421-012-2585-4 SN - 1439-6327 VL - 113 IS - 6 SP - 1605 EP - 1615 PB - Springer CY - Berlin ER - TY - JOUR A1 - Ferrein, Alexander A1 - Steinbauer, Gerald T1 - 20 Years of RoboCup - A Subjective Retrospection JF - KI - Künstliche Intelligenz N2 - This summer, RoboCup competitions were held for the 20th time in Leipzig, Germany. It was the second time that RoboCup took place in Germany, 10 years after the 2006 RoboCup in Bremen. In this article, we give an overview on the latest developments of RoboCup and what happened in the different leagues over the last decade. With its 20th edition, RoboCup clearly is a success story and a role model for robotics competitions. From our personal view point, we acknowledge this by giving a retrospection about what makes RoboCup such a success. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s13218-016-0449-5 SN - 1610-1987 VL - 30 IS - 3 SP - 225 EP - 232 PB - Springer CY - Berlin ER - TY - JOUR A1 - Noureddine, Yacine A1 - Bitz, Andreas A1 - Ladd, Mark E. A1 - Thürling, Markus A1 - Ladd, Susanne C. A1 - Schaefers, Gregor A1 - Kraff, Oliver T1 - Experience with magnetic resonance imaging of human subjects with passive implants and tattoos at 7 T: a retrospective study JF - Magnetic Resonance Materials in Physics, Biology and Medicine Y1 - 2015 U6 - http://dx.doi.org/10.1007/s10334-015-0499-y SN - 1352-8661 VL - 28 IS - 6 SP - 577 EP - 590 PB - Springer CY - Berlin ER - TY - JOUR A1 - Vos, E. K. A1 - Lagemaat, M. W. A1 - Barentsz, J. O. A1 - Fütterer, J. J. A1 - Zamecnik, P. A1 - Roozen, H. A1 - Orzada, S. A1 - Bitz, Andreas A1 - Maas, M. C. A1 - Scheenen, T. W. J. T1 - Image quality and cancer visibility of T2-weighted Magnetic Resonance Imaging of the prostate at 7 Tesla JF - European Radiology N2 - Objectives To assess the image quality of T2-weighted (T2w) magnetic resonance imaging of the prostate and the visibility of prostate cancer at 7 Tesla (T). Materials & methods Seventeen prostate cancer patients underwent T2w imaging at 7T with only an external transmit/receive array coil. Three radiologists independently scored images for image quality, visibility of anatomical structures, and presence of artefacts. Krippendorff’s alpha and weighted kappa statistics were used to assess inter-observer agreement. Visibility of prostate cancer lesions was assessed by directly linking the T2w images to the confirmed location of prostate cancer on histopathology. Results T2w imaging at 7T was achievable with ‘satisfactory’ (3/5) to ‘good’ (4/5) quality. Visibility of anatomical structures was predominantly scored as ‘satisfactory’ (3/5) and ‘good’ (4/5). If artefacts were present, they were mostly motion artefacts and, to a lesser extent, aliasing artefacts and noise. Krippendorff’s analysis revealed an α = 0.44 between three readers for the overall image quality scores. Clinically significant cancer lesions in both peripheral zone and transition zone were visible at 7T. Conclusion T2w imaging with satisfactory to good quality can be routinely acquired, and cancer lesions were visible in patients with prostate cancer at 7T using only an external transmit/receive body array coil. Y1 - 2014 U6 - http://dx.doi.org/10.1007/s00330-014-3234-6 SN - 1432-1084 VL - 24 IS - 8 SP - 1950 EP - 1958 PB - Springer CY - Cham ER - TY - JOUR A1 - Chen, Bixia A1 - Schoemberg, Tobias A1 - Kraff, Oliver A1 - Dammann, Philipp A1 - Bitz, Andreas A1 - Schlamann, Marc A1 - Quick, Harald H. A1 - Ladd, Mark E. A1 - Sure, Ulrich A1 - Wrede, Karsten H. T1 - Cranial fixation plates in cerebral magnetic resonance imaging: a 3 and 7 Tesla in vivo image quality study JF - Magnetic Resonance Materials in Physics, Biology and Medicine N2 - Objective This study assesses and quantifies impairment of postoperative magnetic resonance imaging (MRI) at 7 Tesla (T) after implantation of titanium cranial fixation plates (CFPs) for neurosurgical bone flap fixation. Materials and methods The study group comprised five patients who were intra-individually examined with 3 and 7 T MRI preoperatively and postoperatively (within 72 h/3 months) after implantation of CFPs. Acquired sequences included T₁-weighted magnetization-prepared rapid-acquisition gradient-echo (MPRAGE), T₂-weighted turbo-spin-echo (TSE) imaging, and susceptibility-weighted imaging (SWI). Two experienced neurosurgeons and a neuroradiologist rated image quality and the presence of artifacts in consensus reading. Results Minor artifacts occurred around the CFPs in MPRAGE and T2 TSE at both field strengths, with no significant differences between 3 and 7 T. In SWI, artifacts were accentuated in the early postoperative scans at both field strengths due to intracranial air and hemorrhagic remnants. After resorption, the brain tissue directly adjacent to skull bone could still be assessed. Image quality after 3 months was equal to the preoperative examinations at 3 and 7 T. Conclusion Image quality after CFP implantation was not significantly impaired in 7 T MRI, and artifacts were comparable to those in 3 T MRI. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s10334-016-0548-1 SN - 1352-8661 VL - 29 IS - 3 SP - 389 EP - 398 PB - Springer CY - Berlin ER - TY - JOUR A1 - Katz, Evgeny A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics JF - Analytical and Bioanalytical Chemistry N2 - The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a “filter” system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion. Y1 - 2017 U6 - http://dx.doi.org/10.1007/s00216-016-0079-7 SN - 1618-2650 VL - 409 SP - 81 EP - 94 PB - Springer CY - Berlin ER - TY - JOUR A1 - Umutlu, Lale A1 - Kraff, Oliver A1 - Fischer, Anja A1 - Kinner, Sonja A1 - Maderwald, Stefan A1 - Nassenstein, Kai A1 - Nensa, Felix A1 - Grüneisen, Johannes A1 - Orzada, Stephan A1 - Bitz, Andreas A1 - Forsting, Michael A1 - Ladd, Mark E. A1 - Lauenstein, Thomas C. T1 - Seven-Tesla MRI of the female pelvis JF - European Radiology Y1 - 2013 U6 - http://dx.doi.org/10.1007/s00330-013-2868-0 SN - 1432-1084 VL - 23 IS - 9 SP - 2364 EP - 2373 PB - Springer CY - Berlin ER - TY - JOUR A1 - Umutlu, L. A1 - Maderwald, S. A1 - Kinner, S. A1 - Kraff, O. A1 - Bitz, Andreas A1 - Orzada, S. A1 - Johst, S. A1 - Wrede, K. A1 - Forsting, M. A1 - Ladd, M. E. A1 - Lauenstein, T. C. A1 - Quick, H. H. T1 - First-pass contrast-enhanced renal MRA at 7 Tesla: initial results JF - European Radiology Y1 - 2013 U6 - http://dx.doi.org/10.1007/s00330-012-2666-0 SN - 1432-1084 VL - 23 IS - 4 SP - 1059 EP - 1066 PB - Springer CY - Berlin ER - TY - JOUR A1 - Umutlu, Lale A1 - Orzada, Stephan A1 - Kinner, Sonja A1 - Maderwald, Stefan A1 - Bronte, Irina A1 - Bitz, Andreas A1 - Kraff, Oliver A1 - Ladd, Susanne C. A1 - Antoch, Gerald A1 - Ladd, Mark E. A1 - Quick, Harald H. A1 - Lauenstein, Thomas C. T1 - Renal imaging at 7 Tesla: preliminary results JF - European Radiology N2 - Objective To investigate the feasibility of 7T MR imaging of the kidneys utilising a custom-built 8-channel transmit/receive radiofrequency body coil. Methods In vivo unenhanced MR was performed in 8 healthy volunteers on a 7T whole-body MR system. After B0 shimming the following sequences were obtained: 1) 2D and 3D spoiled gradient-echo sequences (FLASH, VIBE), 2) T1-weighted 2D in and opposed phase 3) True-FISP imaging and 4) a T2-weighted turbo spin echo (TSE) sequence. Visual evaluation of the overall image quality was performed by two radiologists. Results Renal MRI at 7T was feasible in all eight subjects. Best image quality was found using T1-weighted gradient echo MRI, providing high anatomical details and excellent conspicuity of the non-enhanced vasculature. With successful shimming, B1 signal voids could be effectively reduced and/or shifted out of the region of interest in most sequence types. However, T2-weighted TSE imaging remained challenging and strongly impaired because of signal heterogeneities in three volunteers. Conclusion The results demonstrate the feasibility and diagnostic potential of dedicated 7T renal imaging. Further optimisation of imaging sequences and dedicated RF coil concepts are expected to improve the acquisition quality and ultimately provide high clinical diagnostic value. Y1 - 2011 SN - 1432-1084 VL - 21 IS - 4 SP - 841 EP - 849 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Kahmann, Stephanie Lucina A1 - Heinze, Nicolai A1 - Staat, Manfred A1 - Neiss, Wolfram F. A1 - Scaal, Martin A1 - Müller, Lars P. T1 - Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow JF - Knee Surgery, Sports Traumatology, Arthroscopy Y1 - 2017 U6 - http://dx.doi.org/10.1007/s00167-017-4468-z SN - 1433-7347 VL - 25 IS - 7 SP - 2280 EP - 2288 PB - Springer CY - Berlin ER - TY - JOUR A1 - Balzer, Hermann A1 - Streit, Daniel T1 - Das Translationsrisiko multinationaler Konzerne in Deutschland: Eine explorative Analyse von Verständnis, Bedeutung und Management-Praxis mit Hilfe der Critical Incident Technique JF - Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung Y1 - 2017 U6 - http://dx.doi.org/10.1007/s41471-017-0029-x SN - 2366-6153 N1 - Arbeitskreis Finanzierung der Schmalenbach-Gesellschaft e.V. IS - Online first SP - 1 EP - 40 PB - Springer CY - Berlin ER - TY - JOUR A1 - Wiesen, Sebastian A1 - Tippkötter, Nils A1 - Muffler, Kai A1 - Suck, Kirstin A1 - Sohling, Ulrich A1 - Ruf, Friedrich A1 - Ulber, Roland T1 - Adsorption of fatty acids to layered double hydroxides in aqueous systems JF - Adsorption N2 - Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L−1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32−. Y1 - 2015 VL - 21 IS - 6-7 SP - 459 EP - 466 PB - Springer CY - Berlin ER - TY - JOUR A1 - Morais, Paulo V. A1 - Gomes, Vanderley F., Jr. A1 - Silva, Anielle C. A. A1 - Dantas, Noelio O. A1 - Schöning, Michael Josef A1 - Siqueira, José R., Jr. T1 - Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices JF - Journal of Materials Science N2 - The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance–voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film’s surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications. Y1 - 2017 U6 - http://dx.doi.org/10.1007/s10853-017-1369-y SN - 1573-4803 VL - 52 IS - 20 SP - 12314 EP - 12325 PB - Springer CY - Berlin ER - TY - CHAP A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Nanomaterial-Modified Capacitive Field-Effect Biosensors T2 - Springer Series on Chemical Sensors and Biosensors (Methods and Applications) N2 - The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte–insulator–semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing. KW - Biomolecular logic gate KW - DNA KW - Enzyme biosensor KW - Field-effect sensor KW - Gold nanoparticle Y1 - 2017 U6 - http://dx.doi.org/10.1007/5346_2017_2 SP - 1 EP - 25 PB - Springer CY - Berlin, Heidelberg ER - TY - CHAP A1 - Tran, N. T. A1 - Tran, Thanh Ngoc A1 - Matthies, M. G. A1 - Stavroulakis, G. E. A1 - Staat, Manfred T1 - Shakedown Analysis Under Stochastic Uncertainty by Chance Constrained Programming T2 - Advances in Direct Methods for Materials and Structures N2 - In this paper we propose a stochastic programming method to analyse limit and shakedown of structures under uncertainty condition of strength. Based on the duality theory, the shakedown load multiplier formulated by the kinematic theorem is proved actually to be the dual form of the shakedown load multiplier formulated by static theorem. In this investigation a dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) with three-node linear triangular elements is used for structural analysis. Y1 - 2017 SN - 978-3-319-59810-9 U6 - http://dx.doi.org/10.1007/978-3-319-59810-9_6 SP - 85 EP - 103 PB - Springer CY - Cham ER - TY - CHAP A1 - Engemann, Heiko A1 - Wiesen, Patrick A1 - Kallweit, Stephan A1 - Deshpande, Harshavardhan A1 - Schleupen, Josef T1 - Autonomous mobile manipulation using ROS T2 - Advances in Service and Industrial Robotics Y1 - 2018 SN - 978-3-319-61276-8 U6 - http://dx.doi.org/10.1007/978-3-319-61276-8_43 N1 - International Conference on Robotics in Alpe-Adria Danube Region RAAD 2017; Mechanisms and Machince Science book series, Vol 49. SP - 389 EP - 401 PB - Springer CY - Cham ER - TY - JOUR A1 - Röhlen, Desiree A1 - Pilas, Johanna A1 - Schöning, Michael Josef A1 - Selmer, Thorsten T1 - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid JF - Applied Biochemistry and Biotechnology N2 - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates. Y1 - 2017 U6 - http://dx.doi.org/10.1007/s12010-017-2578-1 SN - 1559-0291 VL - 183 SP - 566 EP - 581 PB - Springer CY - Berlin ER -