TY  - JOUR
A1  - Digel, Ilya
T1  - Primary thermosensory events in cells
JF  - Transient receptor potential channels / Md. Shahidul Islam, ed.
Y1  - 2011
SN  - 978-94-007-0264-6
N1  - (Advances in experimental medicine and biology ; 704)
SP  - 451
EP  - 468
PB  - Springer
CY  - Dordrecht [u.a.]
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
T1  - The emperor's new body : seeking for a blueprint of limb regeneration in humans
JF  - Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.
Y1  - 2011
SN  - 978-3-642-11864-7
SP  - 3
EP  - 37
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Akimbekov, Nuraly Sh.
A1  - Kistaubayeva, Aida
A1  - Zhubanova, Azhar A.
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Microbial Sampling from Dry Surfaces: Current Challenges and Solutions
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - Sampling of dry surfaces for microorganisms is a main component of microbiological safety and is of critical importance in many fields including epidemiology, astrobiology as well as numerous branches of medical and food manufacturing. Aspects of biofilm formation, analysis and removal in aqueous solutions have been thoroughly discussed in literature. In contrast, microbial communities on air-exposed (dry) surfaces have received significantly less attention. Diverse surface sampling methods have been developed in order to address various surfaces and microbial groups, but they notoriously show poor repeatability, low recovery rates and suffer from lack of mutual consistency. Quantitative sampling for viable microorganisms represents a particular challenge, especially on porous and irregular surfaces. Therefore, it is essential to examine in depth the factors involved in microorganisms’ recovery efficiency and accuracy depending on the sampling technique used. Microbial colonization, retention and community composition on different dry surfaces are very complex and rely on numerous physicochemical and biological factors. This study is devoted to analyze and review the (a) physical phenomena and intermolecular forces relevant for microbiological surface sampling; (b) challenges and problems faced by existing sampling methods for viable microorganisms and (c) current directions of engineering and research aimed at improvement of quality and efficiency of microbiological surface sampling.
KW  - Sampling methods
KW  - Surface microorganisms
KW  - Dry surfaces
KW  - Microbial adhesion
KW  - Swabbing
Y1  - 2018
SN  - 978-981-10-7904-7
U6  - http://dx.doi.org/10.1007/978-981-10-7904-7_19
SP  - 421
EP  - 456
PB  - Springer
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Sherelkhan, Dinara K.
A1  - Razzaque, Mohammed S.
T1  - Vitamin D and Phosphate Interactions in Health and Disease
T2  - Phosphate Metabolism
N2  - Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30–40% and phosphate to nearly 80%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease.
KW  - Vitamin D
KW  - PTH
KW  - Phosphate
KW  - FGF23
KW  - Klotho
Y1  - 2022
SN  - 978-3-030-91621-3
U6  - http://dx.doi.org/10.1007/978-3-030-91623-7_5
SP  - 37
EP  - 46
PB  - Springer
CY  - Cham
ER  -