TY - CHAP A1 - Müller-Veggian, Mattea A1 - Neskakis, A. A1 - Lieder, R. M. A1 - Beuscher, H. T1 - Study of rotational aligned bands in ¹⁹⁰,¹⁹²,¹⁹⁴ Au T2 - Nuclear interactions : International Conference on Nuclear Interactions held in Canberra, 28 Aug. - 1 Sept. 1978 / ed. by Brian Albert Robson. - (Lecture notes in physics ; 92) Y1 - 1978 SN - 978-3-540-09102-8 N1 - Australian Academy of Science ; International Conference on Nuclear Interactions <1978, Canberra> SP - 428 PB - Springer CY - Berlin ER - TY - CHAP A1 - Müller-Veggian, Mattea A1 - Kops, Elena Rota A1 - Quin, Peng A1 - Herzog, Hans T1 - MRI Based Attenuation Correction for Brain PET Images T2 - Advances in medical engineering / [3rd RPT - Remagener Physiktage together with the Second Scientific Workshop of Medical Robotics, Navigation and Visualization ... Remagen ... 7.-9. März 2007]. Thorsten M. Buzug (ed.) Part 1. N2 - This work describes a procedure to yield attenuation maps from MR images which are used for the absorption correction (AC) of brain PET data. Such an approach could be mandatory for future combined PET and MRI scanners, which probably do not include a transmission facility. T1-weighted MR images were segmented into brain tissue, bone, soft tissue, and sinus; attenuation coefficients corresponding to elemental composition and density as well as to 511 keV photon energy were respectively assigned. Attenuation maps containing up to four compartments were created and forward projected into sinograms with attenuation factors which then were used for AC during reconstruction of FDG-PET data. The commonly used AC based on a radioactive (68Ge) transmission scan served as reference. The reconstructed radioactivity values obtained with the MRI-based AC were about 20% lower than those obtained with PET-based AC if the skull was not taken into account. Considering the skull the difference was still about 10%. Our investigations demonstrate the feasibility of a MRI-based AC, but revealed also the necessity of a satisfying delineation of bone thickness which tends to be underestimated in our first approach of T1-weighted MR image segmentation. Y1 - 2007 SN - 978-3-540-68763-4 U6 - https://doi.org/10.1007/978-3-540-68764-1_15 N1 - Springer proceedings in physics ; 114 SP - 93 EP - 97 PB - Springer CY - Berlin ER - TY - JOUR A1 - Paczkowski, Sebastian A1 - Weißbecker, Bernhard A1 - Schöning, Michael Josef A1 - Schütz, Stefan T1 - Biosensors on the Basis of Insect Olfaction JF - Insect biotechnology / Andreas Vilcinskas, ed. Y1 - 2011 SN - 978-90-481-9640-1 N1 - Biologically-inspired system ; 2 SP - 225 EP - 240 PB - Springer CY - Dordrecht [u.a.] ER - TY - JOUR A1 - Nomdedeu, Mar Monsonis A1 - Willen, Christine A1 - Schieffer, Andre A1 - Arndt, Hartmut T1 - Temperature-dependent ranges of coexistence in a model of a two-prey-one-predator microbial food web JF - Marine Biology N2 - The objective of our study was to analyze the effects of temperature on the population dynamics of a three-species food web consisting of two prey bacteria (Pedobacter sp. and Acinetobacter johnsonii) and a protozoan predator (Tetrahymena pyriformis) as model organisms. We assessed the effects of temperature on the growth rates of all three species with the objective of developing a model with four differential equations based on the experimental data. The following hypotheses were tested at a theoretical level: Firstly, temperature changes can affect the dynamic behavior of a system by temperature-dependent parameters and interactions and secondly, food web response to temperature cannot be derived from the single species temperature response. The main outcome of the study is that temperature changes affect the parameter range where coexistence is possible within all three species. This has significant consequences on our ideas regarding the evaluation of effects of global warming. Y1 - 2012 U6 - https://doi.org/10.1007/s00227-012-1966-x SN - 1432-1793 VL - 159 IS - 11 SP - 2423 EP - 2430 PB - Springer CY - Berlin ER - TY - JOUR A1 - Pawelke, Siegfried A1 - Butzer, Paul L. T1 - Semi-groups and resolvent operators JF - Archive for Rational Mechanics and Analysis KW - Resolvent Operator KW - Electromagnetism KW - Complex System KW - Neural Network KW - Nonlinear Dynamics Y1 - 1968 U6 - https://doi.org/10.1007/BF00250941 SN - 0003-9527 VL - 30 IS - 2 SP - 127 EP - 147 PB - Springer CY - Berlin ER - TY - JOUR A1 - Berretz, Frank A1 - Skorupa, Sasche A1 - Sander, Volker A1 - Belloum, Adam A1 - Bubak, Marian T1 - Actor-Driven Workflow Execution in Distributed Environments JF - Euro-Par 2010 Parallel Processing Workshops : HeteroPAR, HPCC, HiBB, CoreGrid, UCHPC, HPCF, PROPER, CCPI, VHPC ; Ischia, Italy, August 31 - September 3, 2010 ; revised selected papers / Mario R. Guarracino ... (eds.) Y1 - 2011 SN - 978-3-642-21877-4 N1 - Lecture Notes in Computer Science ; 6586 SP - 287 EP - 294 PB - Springer CY - Berlin ER - TY - CHAP A1 - Weber, Hans-Joachim T1 - Applied physics of compressible and incompressible fluids T2 - Critical care nephrology / [Hrsg.:] Claudio Ronco and Rinaldo Bellomo Y1 - 1998 SN - 978-94-010-6306-7 SP - 63 EP - 84 PB - Springer CY - Dordrecht ER - TY - CHAP A1 - Dikta, Gerhard T1 - Fundamentals of applied probability and basic statistics T2 - Critical care nephrology / [Hrsg.:] Claudio Ronco and Rinaldo Bellomo Y1 - 1998 SN - 978-94-010-6306-7 SP - 51 EP - 61 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Behnam, S. A1 - Becker, A. A1 - Weber, Hans-Joachim T1 - Clinical benefit and cost-efficiency of minimized perfusion circuits for extracorporeal circulation during cardiac surgery JF - Zeitschrift für Herz-, Thorax- und Gefäßchirurgie Y1 - 2011 SN - 0930-9225 N1 - Abstracts der 40. Internationalen Jahrestagung der DGfK und 3. Fokustagung Herz Kardiotechnik – Intensivmedizin – Herzchirurgie – Rhythmustherapie 11. bis 13. November 2011 in Weimar VL - 25 IS - 5 SP - 305 EP - 306 PB - Springer CY - Berlin ER - TY - JOUR A1 - Lanzl, Ines M. A1 - Seidova, Seid-Fatima A1 - Erben, A. A1 - Thürmel, K. A1 - Kotliar, Konstantin T1 - Diffuse stromale Hornhauttrübungen und Veränderungen der Hände JF - Der Ophthalmologe N2 - Bilaterale stromale Hornhauttrübungen sind für den Augenarzt eine differenzialdiagnostische Herausforderung. Im folgenden Beitrag werden 2 Patieninnen (30 und 36 Jahre) mit unterschiedlich stark ausgeprägter stromaler diffuser Hornhauttrübung vorgestellt. Patientin 1 war kleinwüchsig (114 cm) und Patientin 2 normal groß (172 cm). Beide Patientinnen wiesen veränderte Gelenkstrukturen an Hand und Fußgelenken sowie diffuse stromale Hornhauttrübungen auf. Des Weiteren lagen eine Mitral- und Aorteninsuffizienz (Patientin 1) bzw. eine Aorteninsuffizienz (Patientin 2) vor. Die stromalen diffusen Hornhauttrübungen ließen im Zusammenhang mit den Gelenkveränderungen ein Scheie-Syndrom vermuten. Therapeutisch ist bei Patienten mit Visusminderung eine (lamelläre) Keratoplastik sinnvoll. Y1 - 2010 U6 - https://doi.org/10.1007/s00347-009-2066-2 SN - 1433-0423 VL - 107 IS - 4 SP - 363 EP - 365 PB - Springer CY - Berlin ER - TY - JOUR A1 - Wiescher, A. A1 - Kotliar, Konstantin A1 - Neuhann, T. A1 - Lanzl, Ines M. T1 - Rasch progrediente Visusminderung beider Augen bei einem jungen Patienten JF - Der Ophthalmologe N2 - Ein 34-jähriger männlicher Patient stellte sich zur Abklärung einer seit dem 9. Lebensjahr bestehenden und im letzten Jahr rasch progredienten Visusminderung beider Augen bei uns vor. Er beschrieb eine subjektiv zunehmende, im Spiegel für ihn selbst sichtbare, weißliche Trübung in der Pupille beidseits und eine starke Blendempfindlichkeit. Nebenbefundlich gab er rezidivierende Konjunktivitiden und morgens verklebte Lider an. Eine Allergie auf Gräserpollen und eine Unverträglichkeit auf Alkohol sowie mehrere Lebensmittel seien ebenfalls bekannt. Zusätzlich leidet der Patient an stark ausgeprägtem atopischem Ekzem. Dieses wurde nie systemisch, sondern nur bei Bedarf mit kortisonhaltiger Salbe therapiert. Y1 - 2010 U6 - https://doi.org/10.1007/s00347-007-1586-x SN - 1433-0423 VL - 105 IS - 4 SP - 389 EP - 392 PB - Springer CY - Berlin ER - TY - JOUR A1 - Dashevsky, Alexey V. A1 - Lanzl, Ines M. A1 - Kotliar, Konstantin T1 - Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal JF - Graefe's Archive for Clinical and Experimental Ophthalmology Y1 - 2011 SN - 0721-832x VL - 249 IS - 4 SP - 565 EP - 573 PB - Springer CY - Berlin ER - TY - JOUR A1 - Seidova, Seid-Fatima A1 - Kotliar, Konstantin A1 - Foerger, Frauke A1 - Klopfer, Matthias A1 - Lanzl, Ines T1 - Functional retinal changes in Gaucher disease JF - Documenta Ophthalmologica Y1 - 2009 SN - 1573-2622 VL - 118 IS - 2 SP - 151 EP - 154 PB - Springer CY - Berlin ER - TY - JOUR A1 - Dikta, Gerhard T1 - Time series methods to forecast patent filings JF - Forecasting innovations : methods for predicting numbers of patent filings ; with 71 tables / Peter Hingley ; Marc Nicolas (ed.), Y1 - 2006 SN - 978-3-540-35991-3 U6 - https://doi.org/10.1007/3-540-35992-3_6 N1 - ISBN 3-540-35991-5 SP - 95 EP - 124 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Khaydukova, M. M. A1 - Zadorozhnaya, O. A. A1 - Kirsanov, D. O. A1 - Iken, Heiko A1 - Rolka, David A1 - Schöning, Michael Josef A1 - Babain, V. A. A1 - Vlasov, Yu. G. A1 - Legin, A. V. T1 - Multivariate processing of atomic-force microscopy images for detection of the response of plasticized polymeric membranes JF - Russian journal of applied chemistry N2 - The possibility of using the atomic-force microscopy as a method for detection of the analytical signal from plasticized polymeric sensor membranes was analyzed. The surfaces of cadmium-selective membranes based on two polymeric matrices were examined. The digital images were processed with multivariate image analysis techniques. A correlation was found between the surface profile of an ion-selective membrane and the concentration of the ion in solution. Y1 - 2014 U6 - https://doi.org/10.1134/S1070427214030112 SN - 1608-3296 (E-Journal); 1070-4272 (Print) VL - 87 IS - 3 SP - 307 EP - 314 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Fischer, Felix A1 - Selver, M. Alper A1 - Gezer, Sinem A1 - Dicle, Oguz A1 - Hillen, Walter T1 - Systematic Parameterization, Storage, and Representation of Volumetric DICOM Data JF - Journal of Medical and Biological Engineering Y1 - 2015 U6 - https://doi.org/10.1007/s40846-015-0097-5 SN - 2199-4757 VL - 35 IS - 6 SP - 709 EP - 723 PB - Springer CY - Berlin ER - TY - CHAP A1 - Tran, Thanh Ngoc A1 - Staat, Manfred T1 - Uncertainty multimode failure and shakedown analysis of shells T2 - Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ... N2 - This paper presents a numerical procedure for reliability analysis of thin plates and shells with respect to plastic collapse or to inadaptation. The procedure involves a deterministic shakedown analysis for each probabilistic iteration, which is based on the upper bound approach and the use of the exact Ilyushin yield surface. Probabilistic shakedown analysis deals with uncertainties originated from the loads, material strength and thickness of the shell. Based on a direct definition of the limit state function, the calculation of the failure probability may be efficiently solved by using the First and Second Order Reliability Methods (FORM and SORM). The problem of reliability of structural systems (series systems) is handled by the application of a special technique which permits to find all the design points corresponding to all the failure modes. Studies show, in this case, that it improves considerably the FORM and SORM results. KW - Limit analysis KW - Shakedown analysis KW - Reliability analysis KW - Multimode failure KW - Non-linear optimization Y1 - 2015 SN - 978-3-319-12927-3 (print) ; 978-3-319-12928-0 (online) U6 - https://doi.org/10.1007/978-3-319-12928-0_14 SP - 279 EP - 298 PB - Springer CY - Cham ER - TY - CHAP A1 - Burgeth, Bernhard A1 - Kleefeld, Andreas A1 - Zhang, Eugene A1 - Zhang, Yue ED - Baudrier, Étienne ED - Naegel, Benoît ED - Krähenbühl, Adrien ED - Tajine, Mohamed T1 - Towards Topological Analysis of Non-symmetric Tensor Fields via Complexification T2 - Discrete Geometry and Mathematical Morphology N2 - Fields of asymmetric tensors play an important role in many applications such as medical imaging (diffusion tensor magnetic resonance imaging), physics, and civil engineering (for example Cauchy-Green-deformation tensor, strain tensor with local rotations, etc.). However, such asymmetric tensors are usually symmetrized and then further processed. Using this procedure results in a loss of information. A new method for the processing of asymmetric tensor fields is proposed restricting our attention to tensors of second-order given by a 2x2 array or matrix with real entries. This is achieved by a transformation resulting in Hermitian matrices that have an eigendecomposition similar to symmetric matrices. With this new idea numerical results for real-world data arising from a deformation of an object by external forces are given. It is shown that the asymmetric part indeed contains valuable information. Y1 - 2022 SN - 978-3-031-19897-7 U6 - https://doi.org/10.1007/978-3-031-19897-7_5 N1 - Second International Joint Conference, DGMM 2022, Strasbourg, France, October 24–27, 2022 N1 - Corresponding author: Andreas Kleefeld SP - 48 EP - 59 PB - Springer CY - Cham ER - TY - CHAP A1 - Tran, Thanh Ngoc A1 - Staat, Manfred T1 - Shakedown analysis of Reissner-Mindlin plates using the edge-based smoothed finite element method T2 - Direct methods for limit states in structures and materials / Dieter Weichert ; Alan Ponter, ed. N2 - This paper concerns the development of a primal-dual algorithm for limit and shakedown analysis of Reissner-Mindlin plates made of von Mises material. At each optimization iteration, the lower bound of the shakedown load multiplier is calculated simultaneously with the upper bound using the duality theory. An edge-based smoothed finite element method (ES-FEM) combined with the discrete shear gap (DSG) technique is used to improve the accuracy of the solutions and to avoid the transverse shear locking behaviour. The method not only possesses all inherent features of convergence and accuracy from ES-FEM, but also ensures that the total number of variables in the optimization problem is kept to a minimum compared with the standard finite element formulation. Numerical examples are presented to demonstrate the effectiveness of the present method. Y1 - 2014 SN - 978-94-007-6826-0 (Print) 978-94-007-6827-7 (Online) U6 - https://doi.org/10.1007/978-94-007-6827-7_5 SP - 101 EP - 117 PB - Springer CY - Dordrecht [u.a.] ER - TY - CHAP A1 - Tran, N. T. A1 - Tran, Thanh Ngoc A1 - Matthies, M. G. A1 - Stavroulakis, G. E. A1 - Staat, Manfred T1 - Shakedown Analysis Under Stochastic Uncertainty by Chance Constrained Programming T2 - Advances in Direct Methods for Materials and Structures N2 - In this paper we propose a stochastic programming method to analyse limit and shakedown of structures under uncertainty condition of strength. Based on the duality theory, the shakedown load multiplier formulated by the kinematic theorem is proved actually to be the dual form of the shakedown load multiplier formulated by static theorem. In this investigation a dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) with three-node linear triangular elements is used for structural analysis. Y1 - 2017 SN - 978-3-319-59810-9 U6 - https://doi.org/10.1007/978-3-319-59810-9_6 SP - 85 EP - 103 PB - Springer CY - Cham ER - TY - CHAP A1 - Knott, Thomas C. A1 - Sofronia, Raluca E. A1 - Gerressen, Marcus A1 - Law, Yuen A1 - Davidescu, Arjana A1 - Savii, George G. A1 - Gatzweiler, Karl-Heinz A1 - Staat, Manfred A1 - Kuhlen, Torsten W. T1 - Preliminary bone sawing model for a virtual reality-based training simulator of bilateral sagittal split osteotomy T2 - Biomedical simulation : 6th International Symposium, ISBMS 2014, Strasbourg, France, October 16-17, 2014 : proceedings (Lecture notes in computer science : vol. 8789) N2 - Successful bone sawing requires a high level of skill and experience, which could be gained by the use of Virtual Reality-based simulators. A key aspect of these medical simulators is realistic force feedback. The aim of this paper is to model the bone sawing process in order to develop a valid training simulator for the bilateral sagittal split osteotomy, the most often applied corrective surgery in case of a malposition of the mandible. Bone samples from a human cadaveric mandible were tested using a designed experimental system. Image processing and statistical analysis were used for the selection of four models for the bone sawing process. The results revealed a polynomial dependency between the material removal rate and the applied force. Differences between the three segments of the osteotomy line and between the cortical and cancellous bone were highlighted. KW - Bone sawing KW - virtual reality KW - training simulator Y1 - 2014 SN - 978-3-319-12057-7 (Online) SN - 978-3-319-12056-0 (Print) U6 - https://doi.org/10.1007/978-3-319-12057-7_1 SP - 1 EP - 10 PB - Springer CY - Cham ER - TY - JOUR A1 - Doorschodt, B. M. A1 - Schreinemachers, M. C. J. M. A1 - Behbahani, Mehdi A1 - Florquin, S. A1 - Weis, J. A1 - Staat, Manfred A1 - Tolba, R. H. T1 - Hypothermic machine perfusion of kidney grafts: which pressure is preferred JF - Annals of Biomedical Engineering. 39 (2011), H. 3 Y1 - 2011 SN - 1573-9686 SP - 1051 EP - 1059 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Kahmann, Stephanie Lucina A1 - Heinze, Nicolai A1 - Staat, Manfred A1 - Neiss, Wolfram F. A1 - Scaal, Martin A1 - Müller, Lars P. T1 - Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow JF - Knee Surgery, Sports Traumatology, Arthroscopy Y1 - 2017 U6 - https://doi.org/10.1007/s00167-017-4468-z SN - 1433-7347 VL - 25 IS - 7 SP - 2280 EP - 2288 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hackl, Michael A1 - Kahmann, Stephanie Lucina A1 - Wegmann, Kilian A1 - Ries, Christian A1 - Staat, Manfred A1 - Müller, Lars-Peter T1 - Shortening osteotomy of the proximal radius — a treatment option for isolated osteoarthritis of the lateral column of the elbow joint? JF - Knee surgery, sports traumatology, arthroscopy N2 - Treatment of posttraumatic osteoarthritis of the radial column of the elbow joint remains a challenging yet common issue. While partial joint replacement leads to high revision rates, radial head excision has shown to severely increase joint instability. Shortening osteotomy of the radius could be an option to decrease the contact pressure of the radiohumeral joint and thereby pain levels without causing valgus instability. Hence, the aim of this biomechanical study was to evaluate the effects of radial shortening on axial load distribution and valgus stability of the elbow joint. Y1 - 2016 U6 - https://doi.org/10.1007/s00167-016-4080-7 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 128 EP - 129 PB - Springer CY - Berlin ER - TY - CHAP A1 - Digel, Ilya A1 - Akimbekov, Nuraly S. A1 - Kistaubayeva, Aida A1 - Zhubanova, Azhar A. ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Microbial Sampling from Dry Surfaces: Current Challenges and Solutions T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Sampling of dry surfaces for microorganisms is a main component of microbiological safety and is of critical importance in many fields including epidemiology, astrobiology as well as numerous branches of medical and food manufacturing. Aspects of biofilm formation, analysis and removal in aqueous solutions have been thoroughly discussed in literature. In contrast, microbial communities on air-exposed (dry) surfaces have received significantly less attention. Diverse surface sampling methods have been developed in order to address various surfaces and microbial groups, but they notoriously show poor repeatability, low recovery rates and suffer from lack of mutual consistency. Quantitative sampling for viable microorganisms represents a particular challenge, especially on porous and irregular surfaces. Therefore, it is essential to examine in depth the factors involved in microorganisms’ recovery efficiency and accuracy depending on the sampling technique used. Microbial colonization, retention and community composition on different dry surfaces are very complex and rely on numerous physicochemical and biological factors. This study is devoted to analyze and review the (a) physical phenomena and intermolecular forces relevant for microbiological surface sampling; (b) challenges and problems faced by existing sampling methods for viable microorganisms and (c) current directions of engineering and research aimed at improvement of quality and efficiency of microbiological surface sampling. KW - Sampling methods KW - Surface microorganisms KW - Dry surfaces KW - Microbial adhesion KW - Swabbing Y1 - 2018 SN - 978-981-10-7904-7 U6 - https://doi.org/10.1007/978-981-10-7904-7_19 SP - 421 EP - 456 PB - Springer CY - Singapore ER - TY - JOUR A1 - Knobe, M. A1 - Giesen, M. A1 - Plate, S. A1 - Gradl-Dietsch, G. A1 - Buecking, B. A1 - Eschbach, D. A1 - Laack, Walter van A1 - Pape, H.-C. T1 - The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale JF - European Journal Of Trauma And Emergency Surgery N2 - Purpose The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale. Methods For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland–Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated. Results The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = −0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points). Conclusion The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status. KW - Tinetti test KW - Mobility KW - Mobility tests KW - Ground-level falls KW - Elderly KW - Fall prevention KW - Co-managed care KW - Balance Y1 - 2016 U6 - https://doi.org/10.1007/s00068-016-0693-2 SN - 1863-9941 VL - 42 IS - 5 SP - 537 EP - 545 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, I. M. T1 - Mit Statistik gemeistert: perfekte Augentropfen und idealer Screeningtest : Möglichkeiten und Grenzen statistischer Methoden beim Glaukom JF - Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft N2 - Hintergrund Die Anwendung und das Verständnis von Statistik sind sehr wichtig für die biomedizinische Forschung und für die klinische Praxis. Dies gilt insbesondere auch zur Abschätzung der Möglichkeiten unterschiedlichster Diagnostik- und Therapieoptionen beim Glaukom. Die scheinbare Komplexität der Statistik, die zum Teil dem „gesunden Menschenverstand“ zu widersprechen scheint, zusammen mit der nur vorsichtigen Akzeptanz der Statistik bei vielen Medizinern können zu bewussten und unbewussten Manipulationen bei der Datendarstellung und -interpretation führen. Ziel der Arbeit Ziel ist die verständliche Darstellung einiger typischer Fehler in der medizinisch-statistischen Datenbehandlung. Material und Methoden Anhand hypothetischer Beispiele aus der Glaukomdiagnostik erfolgen die Darstellung der Wirkung eines hypotensiven Medikamentes sowie die Beurteilung der Ergebnisse eines diagnostischen Tests. Es werden die typischsten statistischen Einsatzbereiche und Irrtumsquellen ausführlich und verständlich analysiert Ergebnisse Mechanismen von Datenmanipulation und falscher Dateninterpretation werden aufgeklärt. Typische Irrtumsquellen bei der statistischen Auswertung und Datendarstellung werden dabei erläutert. Schlussfolgerungen Die erläuterten praktischen Beispiele zeigen die Notwendigkeit, die Grundlagen der Statistik zu verstehen und korrekt anwenden zu können. Fehlendes Grundlagenwissen und Halbwissen der medizinischen Statistik können zu folgenschweren Missverständnissen und falschen Entscheidungen in der medizinischen Forschung, aber auch in der klinischen Praxis führen. Y1 - 2016 U6 - https://doi.org/10.1007/s00347-016-0312-y SN - 0941-293X SN - 1433-0423 N1 - Englischer Titel: Mastered with statistics: perfect eye drops and ideal screening test : possibilities and limits of statistical methods for glaucoma IS - 113 SP - 838 EP - 843 PB - Springer CY - Berlin ER - TY - JOUR A1 - Belavy, Daniel L. A1 - Albracht, Kirsten A1 - Bruggemann, Gert-Peter A1 - Vergroesen, Pieter-Paul A. A1 - Dieen, Jaap H. van T1 - Can exercise positively influence the intervertebral disc? JF - Sports Medicine N2 - To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a ‘critical period’ for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research. KW - Intradiscal Pressure KW - Annulus Fibrosus KW - Disc Degeneration KW - Nucleus Pulposus KW - Intervertebral Disc Y1 - 2016 U6 - https://doi.org/10.1007/s40279-015-0444-2 SN - 1179-2035 VL - 46 IS - 4 SP - 473 EP - 485 PB - Springer CY - Berlin ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans JF - European Journal of Applied Physiology Y1 - 2013 U6 - https://doi.org/10.1007/s00421-012-2585-4 SN - 1439-6327 VL - 113 IS - 6 SP - 1605 EP - 1615 PB - Springer CY - Berlin ER - TY - JOUR A1 - Dikta, Gerhard T1 - Semi-parametric random censorship models JF - From Statistics to Mathematical Finance : Festschrift in Honour of Winfried Stute Y1 - 2017 SN - 978-3-319-50986-0 U6 - https://doi.org/10.1007/978-3-319-50986-0_3 SP - 43 EP - 56 PB - Springer CY - Berlin ER - TY - CHAP A1 - Bozakov, Zdravko A1 - Sander, Volker T1 - OpenFlow: A Perspective for Building Versatile Networks T2 - Network-Embedded Management and Applications Y1 - 2013 SN - 978-1-4419-6769-5 U6 - https://doi.org/10.1007/978-1-4419-6769-5_11 SP - 217 EP - 245 PB - Springer CY - New York, NY ER - TY - JOUR A1 - Hugenroth, Kristin A1 - Borchardt, Ralf A1 - Ritter, Philine A1 - Groß‑Hardt, Sascha A1 - Meyns, Bart A1 - Verbelen, Tom A1 - Steinseifer, Ulrich A1 - Kaufmann, Tim A. S. A1 - Engelmann, Ulrich M. T1 - Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input JF - Scientific Reports N2 - Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-96397-2 SN - 2045-2322 VL - 11 IS - Art. No. 16800 SP - 1 EP - 12 PB - Springer CY - Berlin ER - TY - JOUR A1 - Krome, Cornelia A1 - Höft, Jan A1 - Sander, Volker T1 - Clustering time series applied to energy markets JF - Energy Informatics Y1 - 2019 U6 - https://doi.org/10.1186/s42162-019-0076-0 SN - 2520-8942 VL - 2 IS - Article numer 17 SP - 1 EP - 20 PB - Springer CY - Berlin ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Abel, Thomas A1 - Albracht, Kirsten A1 - Meskemper, Joshua A1 - Foitschik, Tina A1 - Strüder, Heiko K. T1 - Biomechanics of handcycling propulsion in a 30-min continuous load test at lactate threshold: Kinetics, kinematics, and muscular activity in able-bodied participants JF - European Journal of Applied Physiology N2 - Purpose This study aims to investigate the biomechanics of handcycling during a continuous load trial (CLT) to assess the mechanisms underlying fatigue in upper body exercise. Methods Twelve able-bodied triathletes performed a 30-min CLT at a power output corresponding to lactate threshold in a racing recumbent handcycle mounted on a stationary ergometer. During the CLT, ratings of perceived exertion (RPE), tangential crank kinetics, 3D joint kinematics, and muscular activity of ten muscles of the upper extremity and trunk were examined using motion capturing and surface electromyography. Results During the CLT, spontaneously chosen cadence and RPE increased, whereas crank torque decreased. Rotational work was higher during the pull phase. Peripheral RPE was higher compared to central RPE. Joint range of motion decreased for elbow-flexion and radial-duction. Integrated EMG (iEMG) increased in the forearm flexors, forearm extensors, and M. deltoideus (Pars spinalis). An earlier onset of activation was found for M. deltoideus (Pars clavicularis), M. pectoralis major, M. rectus abdominis, M. biceps brachii, and the forearm flexors. Conclusion Fatigue-related alterations seem to apply analogously in handcycling and cycling. The most distal muscles are responsible for force transmission on the cranks and might thus suffer most from neuromuscular fatigue. The findings indicate that peripheral fatigue (at similar lactate values) is higher in handcycling compared to leg cycling, at least for inexperienced participants. An increase in cadence might delay peripheral fatigue by a reduced vascular occlusion. We assume that the gap between peripheral and central fatigue can be reduced by sport-specific endurance training. Y1 - 2020 U6 - https://doi.org/10.1007/s00421-020-04373-x SN - 1439-6327 IS - 120 SP - 1403 EP - 1415 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Morais, Paulo V. A1 - Gomes, Vanderley F., Jr. A1 - Silva, Anielle C. A. A1 - Dantas, Noelio O. A1 - Schöning, Michael Josef A1 - Siqueira, José R., Jr. T1 - Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices JF - Journal of Materials Science N2 - The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance–voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film’s surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications. Y1 - 2017 U6 - https://doi.org/10.1007/s10853-017-1369-y SN - 1573-4803 VL - 52 IS - 20 SP - 12314 EP - 12325 PB - Springer CY - Berlin ER - TY - JOUR A1 - Röhlen, Desiree A1 - Pilas, Johanna A1 - Schöning, Michael Josef A1 - Selmer, Thorsten T1 - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid JF - Applied Biochemistry and Biotechnology N2 - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates. Y1 - 2017 U6 - https://doi.org/10.1007/s12010-017-2578-1 SN - 1559-0291 VL - 183 SP - 566 EP - 581 PB - Springer CY - Berlin ER - TY - JOUR A1 - Garibaldi, F. A1 - Beging, Stefan A1 - Canese, R. A1 - Carpinelli, G. A1 - Clinthorne, N. A1 - Colilli, S. A1 - Cosentino, L. A1 - Finocchiaro, P. A1 - Giuliani, F. A1 - Gricia, M. A1 - Lucentini, M. A1 - Majewski, S. A1 - Monno, E. A1 - Musico, P. A1 - Santavenere, F. A1 - Tödter, J. A1 - Wegener, Hans-Peter A1 - Ziemons, Karl T1 - A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer JF - European Physical Journal Plus Y1 - 2017 U6 - https://doi.org/10.1140/epjp/i2017-11662-x SN - 2190-5444 VL - 132 IS - 9 PB - Springer CY - Berlin ER - TY - JOUR A1 - Lenz, Maximilian A1 - Kahmann, Stephanie Lucina A1 - Behbahani, Mehdi A1 - Pennig, Lenhard A1 - Hackl, Michael A1 - Leschinger, Tim A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - Influence of rotator cuff preload on fracture configuration in proximal humerus fractures: a proof of concept for fracture simulation JF - Archives of Orthopaedic and Trauma Surgery N2 - Introduction In regard of surgical training, the reproducible simulation of life-like proximal humerus fractures in human cadaveric specimens is desirable. The aim of the present study was to develop a technique that allows simulation of realistic proximal humerus fractures and to analyse the influence of rotator cuff preload on the generated lesions in regards of fracture configuration. Materials and methods Ten cadaveric specimens (6 left, 4 right) were fractured using a custom-made drop-test bench, in two groups. Five specimens were fractured without rotator cuff preload, while the other five were fractured with the tendons of the rotator cuff preloaded with 2 kg each. The humeral shaft and the shortened scapula were potted. The humerus was positioned at 90° of abduction and 10° of internal rotation to simulate a fall on the elevated arm. In two specimens of each group, the emergence of the fractures was documented with high-speed video imaging. Pre-fracture radiographs were taken to evaluate the deltoid-tuberosity index as a measure of bone density. Post-fracture X-rays and CT scans were performed to define the exact fracture configurations. Neer’s classification was used to analyse the fractures. Results In all ten cadaveric specimens life-like proximal humerus fractures were achieved. Two III-part and three IV-part fractures resulted in each group. The preloading of the rotator cuff muscles had no further influence on the fracture configuration. High-speed videos of the fracture simulation revealed identical fracture mechanisms for both groups. We observed a two-step fracture mechanism, with initial impaction of the head segment against the glenoid followed by fracturing of the head and the tuberosities and then with further impaction of the shaft against the acromion, which lead to separation of the tuberosities. Conclusion A high energetic axial impulse can reliably induce realistic proximal humerus fractures in cadaveric specimens. The preload of the rotator cuff muscles had no influence on initial fracture configuration. Therefore, fracture simulation in the proximal humerus is less elaborate. Using the presented technique, pre-fractured specimens are available for real-life surgical education. KW - Proximal humerus fracture KW - Biomechanical simulation KW - Fracture configuration KW - Fracture simulation KW - Rotator cuff Y1 - 2022 U6 - https://doi.org/10.1007/s00402-022-04471-9 SN - 1434-3916 PB - Springer CY - Berlin, Heidelberg ER - TY - CHAP A1 - Büsgen, André A1 - Klöser, Lars A1 - Kohl, Philipp A1 - Schmidts, Oliver A1 - Kraft, Bodo A1 - Zündorf, Albert ED - Cuzzocrea, Alfredo ED - Gusikhin, Oleg ED - Hammoudi, Slimane ED - Quix, Christoph T1 - From cracked accounts to fake IDs: user profiling on German telegram black market channels T2 - Data Management Technologies and Applications N2 - Messenger apps like WhatsApp and Telegram are frequently used for everyday communication, but they can also be utilized as a platform for illegal activity. Telegram allows public groups with up to 200.000 participants. Criminals use these public groups for trading illegal commodities and services, which becomes a concern for law enforcement agencies, who manually monitor suspicious activity in these chat rooms. This research demonstrates how natural language processing (NLP) can assist in analyzing these chat rooms, providing an explorative overview of the domain and facilitating purposeful analyses of user behavior. We provide a publicly available corpus of annotated text messages with entities and relations from four self-proclaimed black market chat rooms. Our pipeline approach aggregates the extracted product attributes from user messages to profiles and uses these with their sold products as features for clustering. The extracted structured information is the foundation for further data exploration, such as identifying the top vendors or fine-granular price analyses. Our evaluation shows that pretrained word vectors perform better for unsupervised clustering than state-of-the-art transformer models, while the latter is still superior for sequence labeling. KW - Clustering KW - Natural language processing KW - Information extraction KW - Profile extraction KW - Text mining Y1 - 2023 SN - 978-3-031-37889-8 (Print) SN - 978-3-031-37890-4 (Online) U6 - https://doi.org/10.1007/978-3-031-37890-4_9 N1 - 10th International Conference, DATA 2021, Virtual Event, July 6–8, 2021, and 11th International Conference, DATA 2022, Lisbon, Portugal, July 11-13, 2022 SP - 176 EP - 202 PB - Springer CY - Cham ER - TY - CHAP A1 - Kohl, Philipp A1 - Freyer, Nils A1 - Krämer, Yoka A1 - Werth, Henri A1 - Wolf, Steffen A1 - Kraft, Bodo A1 - Meinecke, Matthias A1 - Zündorf, Albert ED - Conte, Donatello ED - Fred, Ana ED - Gusikhin, Oleg ED - Sansone, Carlo T1 - ALE: a simulation-based active learning evaluation framework for the parameter-driven comparison of query strategies for NLP T2 - Deep Learning Theory and Applications N2 - Supervised machine learning and deep learning require a large amount of labeled data, which data scientists obtain in a manual, and time-consuming annotation process. To mitigate this challenge, Active Learning (AL) proposes promising data points to annotators they annotate next instead of a subsequent or random sample. This method is supposed to save annotation effort while maintaining model performance. However, practitioners face many AL strategies for different tasks and need an empirical basis to choose between them. Surveys categorize AL strategies into taxonomies without performance indications. Presentations of novel AL strategies compare the performance to a small subset of strategies. Our contribution addresses the empirical basis by introducing a reproducible active learning evaluation (ALE) framework for the comparative evaluation of AL strategies in NLP. The framework allows the implementation of AL strategies with low effort and a fair data-driven comparison through defining and tracking experiment parameters (e.g., initial dataset size, number of data points per query step, and the budget). ALE helps practitioners to make more informed decisions, and researchers can focus on developing new, effective AL strategies and deriving best practices for specific use cases. With best practices, practitioners can lower their annotation costs. We present a case study to illustrate how to use the framework. KW - Active learning KW - Query learning KW - Natural language processing KW - Deep learning KW - Reproducible research Y1 - 2023 SN - 978-3-031-39058-6 (Print) SN - 978-3-031-39059-3 (Online) U6 - https://doi.org/10.1007/978-3-031-39059-3_16 N1 - 4th International Conference, DeLTA 2023, Rome, Italy, July 13–14, 2023. SP - 235 EP - 253 PB - Springer CY - Cham ER - TY - CHAP A1 - Klöser, Lars A1 - Büsgen, André A1 - Kohl, Philipp A1 - Kraft, Bodo A1 - Zündorf, Albert ED - Conte, Donatello ED - Fred, Ana ED - Gusikhin, Oleg ED - Sansone, Carlo T1 - Explaining relation classification models with semantic extents T2 - Deep Learning Theory and Applications N2 - In recent years, the development of large pretrained language models, such as BERT and GPT, significantly improved information extraction systems on various tasks, including relation classification. State-of-the-art systems are highly accurate on scientific benchmarks. A lack of explainability is currently a complicating factor in many real-world applications. Comprehensible systems are necessary to prevent biased, counterintuitive, or harmful decisions. We introduce semantic extents, a concept to analyze decision patterns for the relation classification task. Semantic extents are the most influential parts of texts concerning classification decisions. Our definition allows similar procedures to determine semantic extents for humans and models. We provide an annotation tool and a software framework to determine semantic extents for humans and models conveniently and reproducibly. Comparing both reveals that models tend to learn shortcut patterns from data. These patterns are hard to detect with current interpretability methods, such as input reductions. Our approach can help detect and eliminate spurious decision patterns during model development. Semantic extents can increase the reliability and security of natural language processing systems. Semantic extents are an essential step in enabling applications in critical areas like healthcare or finance. Moreover, our work opens new research directions for developing methods to explain deep learning models. KW - Relation classification KW - Natural language processing KW - Natural language understanding KW - Information extraction KW - Trustworthy artificial intelligence Y1 - 2023 SN - 978-3-031-39058-6 (Print) SN - 978-3-031-39059-3 (Online) U6 - https://doi.org/10.1007/978-3-031-39059-3_13 N1 - 4th International Conference, DeLTA 2023, Rome, Italy, July 13–14, 2023. SP - 189 EP - 208 PB - Springer CY - Cham ER - TY - CHAP A1 - Maurer, Florian A1 - Miskiw, Kim K. A1 - Acosta, Rebeca Ramirez A1 - Harder, Nick A1 - Sander, Volker A1 - Lehnhoff, Sebastian ED - Jorgensen, Bo Norregaard ED - Pereira da Silva, Luiz Carlos ED - Ma, Zheng T1 - Market abstraction of energy markets and policies - application in an agent-based modeling toolbox T2 - EI.A 2023: Energy Informatics N2 - In light of emerging challenges in energy systems, markets are prone to changing dynamics and market design. Simulation models are commonly used to understand the changing dynamics of future electricity markets. However, existing market models were often created with specific use cases in mind, which limits their flexibility and usability. This can impose challenges for using a single model to compare different market designs. This paper introduces a new method of defining market designs for energy market simulations. The proposed concept makes it easy to incorporate different market designs into electricity market models by using relevant parameters derived from analyzing existing simulation tools, morphological categorization and ontologies. These parameters are then used to derive a market abstraction and integrate it into an agent-based simulation framework, allowing for a unified analysis of diverse market designs. Furthermore, we showcase the usability of integrating new types of long-term contracts and over-the-counter trading. To validate this approach, two case studies are demonstrated: a pay-as-clear market and a pay-as-bid long-term market. These examples demonstrate the capabilities of the proposed framework. KW - Energy market design KW - Agent-based simulation KW - Market modeling Y1 - 2023 SN - 978-3-031-48651-7 (Print) SN - 978-3-031-48652-4 (eBook) U6 - https://doi.org/10.1007/978-3-031-48652-4_10 N1 - Energy Informatics Academy Conference, 6-8 December 23, Campinas, Brazil. N1 - Part of the Lecture Notes in Computer Science book series (LNCS,volume 14468). SP - 139 EP - 157 PB - Springer CY - Cham ER - TY - JOUR A1 - Kuerten, David A1 - Kotliar, Konstantin A1 - Fuest, Matthias A1 - Walter, Peter A1 - Hollstein, Muriel A1 - Plange, Niklas ED - Neri, Piergiorgio T1 - Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study JF - International Ophthalmology N2 - Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect. KW - Glaucoma KW - Visual field asymmetry KW - Ocular blood flow KW - RVA KW - Vascular response Y1 - 2021 SN - 1573-2630 U6 - https://doi.org/10.1007/s10792-021-01876-0 VL - 41 IS - 41 SP - 3109 EP - 3119 PB - Springer CY - Berlin ER - TY - CHAP A1 - Kotliar, Konstantin ED - Pallikaris, I. ED - Tsilimbaris, M. K. ED - Dastiridou, A. I. T1 - Ocular rigidity: clinical approach T2 - Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye N2 - The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications. KW - Coefficient of ocular rigidity KW - Eyeball KW - Corneo-scleral shell KW - Pressure-volume relationship KW - Differential tonometry Y1 - 2021 SN - 978-3-030-64422-2 U6 - https://doi.org/10.1007/978-3-030-64422-2_2 SP - 15 EP - 43 PB - Springer CY - Cham ER - TY - CHAP A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Sherelkhan, Dinara K. A1 - Razzaque, Mohammed S. T1 - Vitamin D and Phosphate Interactions in Health and Disease T2 - Phosphate Metabolism N2 - Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30–40% and phosphate to nearly 80%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease. KW - Vitamin D KW - PTH KW - Phosphate KW - FGF23 KW - Klotho Y1 - 2022 SN - 978-3-030-91621-3 U6 - https://doi.org/10.1007/978-3-030-91623-7_5 SP - 37 EP - 46 PB - Springer CY - Cham ER - TY - JOUR A1 - Hackl, Michael A1 - Leschinger, T. A1 - Staat, Manfred A1 - Müller, Lars-Peter A1 - Wegmann, Kilian T1 - Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation JF - Knee surgery, sports traumatology, arthroscopy N2 - Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique. Y1 - 2016 U6 - https://doi.org/10.1007/s00167-016-4080-7 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 130 EP - 131 PB - Springer CY - Berlin ER - TY - CHAP A1 - Frotscher, Ralf A1 - Goßmann, Matthias A1 - Raatschen, Hans-Jürgen A1 - Temiz Artmann, Aysegül A1 - Staat, Manfred T1 - Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM T2 - Shell and membrane theories in mechanics and biology. (Advanced structured materials ; 45) N2 - We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEM for plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments. Y1 - 2015 SN - 978-3-319-02534-6 ; 978-3-319-02535-3 SP - 187 EP - 212 PB - Springer CY - Heidelberg ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Computational Analysis of Pelvic Floor Dysfunction T2 - Women's Health and Biomechanics N2 - Pelvic floor dysfunction (PFD) is characterized by the failure of the levator ani (LA) muscle to maintain the pelvic hiatus, resulting in the descent of the pelvic organs below the pubococcygeal line. This chapter adopts the modified Humphrey material model to consider the effect of the muscle fiber on passive stretching of the LA muscle. The deformation of the LA muscle subjected to intra-abdominal pressure during Valsalva maneuver is compared with the magnetic resonance imaging (MRI) examination of a nulliparous female. Numerical result shows that the fiber-based Humphrey model simulates the muscle behavior better than isotropic constitutive models. Greater posterior movement of the LA muscle widens the levator hiatus due to lack of support from the anococcygeal ligament and the perineal structure as a consequence of birth-related injury and aging. Old and multiparous females with uncontrolled urogenital and rectal hiatus tend to develop PFDs such as prolapse and incontinence. KW - Pelvic muscle KW - Muscle fibers KW - Passive stretching KW - Pelvic floor dysfunction Y1 - 2018 SN - 978-3-319-71574-2 U6 - https://doi.org/10.1007/978-3-319-71574-2_17 N1 - Lecture Notes in Computational Vision and Biomechanics, vol 29 SP - 217 EP - 230 PB - Springer CY - Cham ER - TY - JOUR A1 - Wegmann, Kilian A1 - Hackl, Michael A1 - Staat, Manfred A1 - Mayer, Katharina A1 - Müller, Lars-Peter T1 - Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results JF - Knee surgery, sports traumatology, arthroscopy N2 - While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates. Y1 - 2016 U6 - https://doi.org/10.1007/s00167-016-4079-0 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 58 EP - 59 PB - Springer CY - Berlin ER - TY - JOUR A1 - Digel, Ilya T1 - Primary thermosensory events in cells JF - Transient receptor potential channels / Md. Shahidul Islam, ed. Y1 - 2011 SN - 978-94-007-0264-6 N1 - (Advances in experimental medicine and biology ; 704) SP - 451 EP - 468 PB - Springer CY - Dordrecht [u.a.] ER -