TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, I. M. T1 - Mit Statistik gemeistert: perfekte Augentropfen und idealer Screeningtest : Möglichkeiten und Grenzen statistischer Methoden beim Glaukom JF - Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft N2 - Hintergrund Die Anwendung und das Verständnis von Statistik sind sehr wichtig für die biomedizinische Forschung und für die klinische Praxis. Dies gilt insbesondere auch zur Abschätzung der Möglichkeiten unterschiedlichster Diagnostik- und Therapieoptionen beim Glaukom. Die scheinbare Komplexität der Statistik, die zum Teil dem „gesunden Menschenverstand“ zu widersprechen scheint, zusammen mit der nur vorsichtigen Akzeptanz der Statistik bei vielen Medizinern können zu bewussten und unbewussten Manipulationen bei der Datendarstellung und -interpretation führen. Ziel der Arbeit Ziel ist die verständliche Darstellung einiger typischer Fehler in der medizinisch-statistischen Datenbehandlung. Material und Methoden Anhand hypothetischer Beispiele aus der Glaukomdiagnostik erfolgen die Darstellung der Wirkung eines hypotensiven Medikamentes sowie die Beurteilung der Ergebnisse eines diagnostischen Tests. Es werden die typischsten statistischen Einsatzbereiche und Irrtumsquellen ausführlich und verständlich analysiert Ergebnisse Mechanismen von Datenmanipulation und falscher Dateninterpretation werden aufgeklärt. Typische Irrtumsquellen bei der statistischen Auswertung und Datendarstellung werden dabei erläutert. Schlussfolgerungen Die erläuterten praktischen Beispiele zeigen die Notwendigkeit, die Grundlagen der Statistik zu verstehen und korrekt anwenden zu können. Fehlendes Grundlagenwissen und Halbwissen der medizinischen Statistik können zu folgenschweren Missverständnissen und falschen Entscheidungen in der medizinischen Forschung, aber auch in der klinischen Praxis führen. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s00347-016-0312-y SN - 0941-293X SN - 1433-0423 N1 - Englischer Titel: Mastered with statistics: perfect eye drops and ideal screening test : possibilities and limits of statistical methods for glaucoma IS - 113 SP - 838 EP - 843 PB - Springer CY - Berlin ER - TY - JOUR A1 - Knobe, M. A1 - Giesen, M. A1 - Plate, S. A1 - Gradl-Dietsch, G. A1 - Buecking, B. A1 - Eschbach, D. A1 - Laack, Walter van A1 - Pape, H.-C. T1 - The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale JF - European Journal Of Trauma And Emergency Surgery N2 - Purpose The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale. Methods For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland–Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated. Results The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = −0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points). Conclusion The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status. KW - Tinetti test KW - Mobility KW - Mobility tests KW - Ground-level falls KW - Elderly KW - Fall prevention KW - Co-managed care KW - Balance Y1 - 2016 U6 - http://dx.doi.org/10.1007/s00068-016-0693-2 SN - 1863-9941 VL - 42 IS - 5 SP - 537 EP - 545 PB - Springer CY - Berlin ER - TY - JOUR A1 - Belavy, Daniel L. A1 - Albracht, Kirsten A1 - Bruggemann, Gert-Peter A1 - Vergroesen, Pieter-Paul A. A1 - Dieen, Jaap H. van T1 - Can exercise positively influence the intervertebral disc? JF - Sports Medicine N2 - To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a ‘critical period’ for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research. KW - Intradiscal Pressure KW - Annulus Fibrosus KW - Disc Degeneration KW - Nucleus Pulposus KW - Intervertebral Disc Y1 - 2016 U6 - http://dx.doi.org/10.1007/s40279-015-0444-2 SN - 1179-2035 VL - 46 IS - 4 SP - 473 EP - 485 PB - Springer CY - Berlin ER - TY - JOUR A1 - Albracht, Kirsten A1 - Arampatzis, Adamantios T1 - Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans JF - European Journal of Applied Physiology Y1 - 2013 U6 - http://dx.doi.org/10.1007/s00421-012-2585-4 SN - 1439-6327 VL - 113 IS - 6 SP - 1605 EP - 1615 PB - Springer CY - Berlin ER - TY - JOUR A1 - Ferrein, Alexander A1 - Steinbauer, Gerald T1 - 20 Years of RoboCup - A Subjective Retrospection JF - KI - Künstliche Intelligenz N2 - This summer, RoboCup competitions were held for the 20th time in Leipzig, Germany. It was the second time that RoboCup took place in Germany, 10 years after the 2006 RoboCup in Bremen. In this article, we give an overview on the latest developments of RoboCup and what happened in the different leagues over the last decade. With its 20th edition, RoboCup clearly is a success story and a role model for robotics competitions. From our personal view point, we acknowledge this by giving a retrospection about what makes RoboCup such a success. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s13218-016-0449-5 SN - 1610-1987 VL - 30 IS - 3 SP - 225 EP - 232 PB - Springer CY - Berlin ER - TY - JOUR A1 - Noureddine, Yacine A1 - Bitz, Andreas A1 - Ladd, Mark E. A1 - Thürling, Markus A1 - Ladd, Susanne C. A1 - Schaefers, Gregor A1 - Kraff, Oliver T1 - Experience with magnetic resonance imaging of human subjects with passive implants and tattoos at 7 T: a retrospective study JF - Magnetic Resonance Materials in Physics, Biology and Medicine Y1 - 2015 U6 - http://dx.doi.org/10.1007/s10334-015-0499-y SN - 1352-8661 VL - 28 IS - 6 SP - 577 EP - 590 PB - Springer CY - Berlin ER - TY - JOUR A1 - Vos, E. K. A1 - Lagemaat, M. W. A1 - Barentsz, J. O. A1 - Fütterer, J. J. A1 - Zamecnik, P. A1 - Roozen, H. A1 - Orzada, S. A1 - Bitz, Andreas A1 - Maas, M. C. A1 - Scheenen, T. W. J. T1 - Image quality and cancer visibility of T2-weighted Magnetic Resonance Imaging of the prostate at 7 Tesla JF - European Radiology N2 - Objectives To assess the image quality of T2-weighted (T2w) magnetic resonance imaging of the prostate and the visibility of prostate cancer at 7 Tesla (T). Materials & methods Seventeen prostate cancer patients underwent T2w imaging at 7T with only an external transmit/receive array coil. Three radiologists independently scored images for image quality, visibility of anatomical structures, and presence of artefacts. Krippendorff’s alpha and weighted kappa statistics were used to assess inter-observer agreement. Visibility of prostate cancer lesions was assessed by directly linking the T2w images to the confirmed location of prostate cancer on histopathology. Results T2w imaging at 7T was achievable with ‘satisfactory’ (3/5) to ‘good’ (4/5) quality. Visibility of anatomical structures was predominantly scored as ‘satisfactory’ (3/5) and ‘good’ (4/5). If artefacts were present, they were mostly motion artefacts and, to a lesser extent, aliasing artefacts and noise. Krippendorff’s analysis revealed an α = 0.44 between three readers for the overall image quality scores. Clinically significant cancer lesions in both peripheral zone and transition zone were visible at 7T. Conclusion T2w imaging with satisfactory to good quality can be routinely acquired, and cancer lesions were visible in patients with prostate cancer at 7T using only an external transmit/receive body array coil. Y1 - 2014 U6 - http://dx.doi.org/10.1007/s00330-014-3234-6 SN - 1432-1084 VL - 24 IS - 8 SP - 1950 EP - 1958 PB - Springer CY - Cham ER - TY - JOUR A1 - Chen, Bixia A1 - Schoemberg, Tobias A1 - Kraff, Oliver A1 - Dammann, Philipp A1 - Bitz, Andreas A1 - Schlamann, Marc A1 - Quick, Harald H. A1 - Ladd, Mark E. A1 - Sure, Ulrich A1 - Wrede, Karsten H. T1 - Cranial fixation plates in cerebral magnetic resonance imaging: a 3 and 7 Tesla in vivo image quality study JF - Magnetic Resonance Materials in Physics, Biology and Medicine N2 - Objective This study assesses and quantifies impairment of postoperative magnetic resonance imaging (MRI) at 7 Tesla (T) after implantation of titanium cranial fixation plates (CFPs) for neurosurgical bone flap fixation. Materials and methods The study group comprised five patients who were intra-individually examined with 3 and 7 T MRI preoperatively and postoperatively (within 72 h/3 months) after implantation of CFPs. Acquired sequences included T₁-weighted magnetization-prepared rapid-acquisition gradient-echo (MPRAGE), T₂-weighted turbo-spin-echo (TSE) imaging, and susceptibility-weighted imaging (SWI). Two experienced neurosurgeons and a neuroradiologist rated image quality and the presence of artifacts in consensus reading. Results Minor artifacts occurred around the CFPs in MPRAGE and T2 TSE at both field strengths, with no significant differences between 3 and 7 T. In SWI, artifacts were accentuated in the early postoperative scans at both field strengths due to intracranial air and hemorrhagic remnants. After resorption, the brain tissue directly adjacent to skull bone could still be assessed. Image quality after 3 months was equal to the preoperative examinations at 3 and 7 T. Conclusion Image quality after CFP implantation was not significantly impaired in 7 T MRI, and artifacts were comparable to those in 3 T MRI. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s10334-016-0548-1 SN - 1352-8661 VL - 29 IS - 3 SP - 389 EP - 398 PB - Springer CY - Berlin ER - TY - JOUR A1 - Katz, Evgeny A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics JF - Analytical and Bioanalytical Chemistry N2 - The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a “filter” system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion. Y1 - 2017 U6 - http://dx.doi.org/10.1007/s00216-016-0079-7 SN - 1618-2650 VL - 409 SP - 81 EP - 94 PB - Springer CY - Berlin ER - TY - JOUR A1 - Umutlu, Lale A1 - Kraff, Oliver A1 - Fischer, Anja A1 - Kinner, Sonja A1 - Maderwald, Stefan A1 - Nassenstein, Kai A1 - Nensa, Felix A1 - Grüneisen, Johannes A1 - Orzada, Stephan A1 - Bitz, Andreas A1 - Forsting, Michael A1 - Ladd, Mark E. A1 - Lauenstein, Thomas C. T1 - Seven-Tesla MRI of the female pelvis JF - European Radiology Y1 - 2013 U6 - http://dx.doi.org/10.1007/s00330-013-2868-0 SN - 1432-1084 VL - 23 IS - 9 SP - 2364 EP - 2373 PB - Springer CY - Berlin ER - TY - JOUR A1 - Umutlu, L. A1 - Maderwald, S. A1 - Kinner, S. A1 - Kraff, O. A1 - Bitz, Andreas A1 - Orzada, S. A1 - Johst, S. A1 - Wrede, K. A1 - Forsting, M. A1 - Ladd, M. E. A1 - Lauenstein, T. C. A1 - Quick, H. H. T1 - First-pass contrast-enhanced renal MRA at 7 Tesla: initial results JF - European Radiology Y1 - 2013 U6 - http://dx.doi.org/10.1007/s00330-012-2666-0 SN - 1432-1084 VL - 23 IS - 4 SP - 1059 EP - 1066 PB - Springer CY - Berlin ER - TY - JOUR A1 - Umutlu, Lale A1 - Orzada, Stephan A1 - Kinner, Sonja A1 - Maderwald, Stefan A1 - Bronte, Irina A1 - Bitz, Andreas A1 - Kraff, Oliver A1 - Ladd, Susanne C. A1 - Antoch, Gerald A1 - Ladd, Mark E. A1 - Quick, Harald H. A1 - Lauenstein, Thomas C. T1 - Renal imaging at 7 Tesla: preliminary results JF - European Radiology N2 - Objective To investigate the feasibility of 7T MR imaging of the kidneys utilising a custom-built 8-channel transmit/receive radiofrequency body coil. Methods In vivo unenhanced MR was performed in 8 healthy volunteers on a 7T whole-body MR system. After B0 shimming the following sequences were obtained: 1) 2D and 3D spoiled gradient-echo sequences (FLASH, VIBE), 2) T1-weighted 2D in and opposed phase 3) True-FISP imaging and 4) a T2-weighted turbo spin echo (TSE) sequence. Visual evaluation of the overall image quality was performed by two radiologists. Results Renal MRI at 7T was feasible in all eight subjects. Best image quality was found using T1-weighted gradient echo MRI, providing high anatomical details and excellent conspicuity of the non-enhanced vasculature. With successful shimming, B1 signal voids could be effectively reduced and/or shifted out of the region of interest in most sequence types. However, T2-weighted TSE imaging remained challenging and strongly impaired because of signal heterogeneities in three volunteers. Conclusion The results demonstrate the feasibility and diagnostic potential of dedicated 7T renal imaging. Further optimisation of imaging sequences and dedicated RF coil concepts are expected to improve the acquisition quality and ultimately provide high clinical diagnostic value. Y1 - 2011 SN - 1432-1084 VL - 21 IS - 4 SP - 841 EP - 849 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Kahmann, Stephanie Lucina A1 - Heinze, Nicolai A1 - Staat, Manfred A1 - Neiss, Wolfram F. A1 - Scaal, Martin A1 - Müller, Lars P. T1 - Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow JF - Knee Surgery, Sports Traumatology, Arthroscopy Y1 - 2017 U6 - http://dx.doi.org/10.1007/s00167-017-4468-z SN - 1433-7347 VL - 25 IS - 7 SP - 2280 EP - 2288 PB - Springer CY - Berlin ER - TY - JOUR A1 - Balzer, Hermann A1 - Streit, Daniel T1 - Das Translationsrisiko multinationaler Konzerne in Deutschland: Eine explorative Analyse von Verständnis, Bedeutung und Management-Praxis mit Hilfe der Critical Incident Technique JF - Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung Y1 - 2017 U6 - http://dx.doi.org/10.1007/s41471-017-0029-x SN - 2366-6153 N1 - Arbeitskreis Finanzierung der Schmalenbach-Gesellschaft e.V. IS - Online first SP - 1 EP - 40 PB - Springer CY - Berlin ER - TY - JOUR A1 - Wiesen, Sebastian A1 - Tippkötter, Nils A1 - Muffler, Kai A1 - Suck, Kirstin A1 - Sohling, Ulrich A1 - Ruf, Friedrich A1 - Ulber, Roland T1 - Adsorption of fatty acids to layered double hydroxides in aqueous systems JF - Adsorption N2 - Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L−1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32−. Y1 - 2015 VL - 21 IS - 6-7 SP - 459 EP - 466 PB - Springer CY - Berlin ER - TY - JOUR A1 - Morais, Paulo V. A1 - Gomes, Vanderley F., Jr. A1 - Silva, Anielle C. A. A1 - Dantas, Noelio O. A1 - Schöning, Michael Josef A1 - Siqueira, José R., Jr. T1 - Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices JF - Journal of Materials Science N2 - The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance–voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film’s surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications. Y1 - 2017 U6 - http://dx.doi.org/10.1007/s10853-017-1369-y SN - 1573-4803 VL - 52 IS - 20 SP - 12314 EP - 12325 PB - Springer CY - Berlin ER - TY - CHAP A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Nanomaterial-Modified Capacitive Field-Effect Biosensors T2 - Springer Series on Chemical Sensors and Biosensors (Methods and Applications) N2 - The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte–insulator–semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing. KW - Biomolecular logic gate KW - DNA KW - Enzyme biosensor KW - Field-effect sensor KW - Gold nanoparticle Y1 - 2017 U6 - http://dx.doi.org/10.1007/5346_2017_2 SP - 1 EP - 25 PB - Springer CY - Berlin, Heidelberg ER - TY - CHAP A1 - Tran, N. T. A1 - Tran, Thanh Ngoc A1 - Matthies, M. G. A1 - Stavroulakis, G. E. A1 - Staat, Manfred T1 - Shakedown Analysis Under Stochastic Uncertainty by Chance Constrained Programming T2 - Advances in Direct Methods for Materials and Structures N2 - In this paper we propose a stochastic programming method to analyse limit and shakedown of structures under uncertainty condition of strength. Based on the duality theory, the shakedown load multiplier formulated by the kinematic theorem is proved actually to be the dual form of the shakedown load multiplier formulated by static theorem. In this investigation a dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) with three-node linear triangular elements is used for structural analysis. Y1 - 2017 SN - 978-3-319-59810-9 U6 - http://dx.doi.org/10.1007/978-3-319-59810-9_6 SP - 85 EP - 103 PB - Springer CY - Cham ER - TY - CHAP A1 - Engemann, Heiko A1 - Wiesen, Patrick A1 - Kallweit, Stephan A1 - Deshpande, Harshavardhan A1 - Schleupen, Josef T1 - Autonomous mobile manipulation using ROS T2 - Advances in Service and Industrial Robotics Y1 - 2018 SN - 978-3-319-61276-8 U6 - http://dx.doi.org/10.1007/978-3-319-61276-8_43 N1 - International Conference on Robotics in Alpe-Adria Danube Region RAAD 2017; Mechanisms and Machince Science book series, Vol 49. SP - 389 EP - 401 PB - Springer CY - Cham ER - TY - JOUR A1 - Röhlen, Desiree A1 - Pilas, Johanna A1 - Schöning, Michael Josef A1 - Selmer, Thorsten T1 - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid JF - Applied Biochemistry and Biotechnology N2 - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates. Y1 - 2017 U6 - http://dx.doi.org/10.1007/s12010-017-2578-1 SN - 1559-0291 VL - 183 SP - 566 EP - 581 PB - Springer CY - Berlin ER - TY - JOUR A1 - Srivastava, A. A1 - Chahar, V. A1 - Sharma, V. A1 - Sun, Y. A1 - Bol, R. A1 - Knolle, F. A1 - Schnug, E. A1 - Hoyler, Friedrich A1 - Naskar, N. A1 - Lahiri, S. A1 - Patnaik, R. T1 - Study of uranium toxicity using low-background gamma-ray spectrometry JF - Journal of Radioanalytical and Nuclear Chemistry Y1 - 2017 U6 - http://dx.doi.org/10.1007/s10967-017-5466-9 SN - 1588-2780 IS - Online first SP - 1 EP - 7 PB - Springer CY - Berlin ER - TY - CHAP A1 - Muffler, Kai A1 - Tippkötter, Nils A1 - Ulber, Roland ED - Timmis, Kenneth N. T1 - Chemical feedstocks and fine chemicals from other substrates T2 - Handbook of hydrocarbon and lipid microbiology. Volume 4: Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference) Y1 - 2010 SN - 978-3-540-77588-1 U6 - http://dx.doi.org/10.1007%2F978-3-540-77587-4_214 SP - 2891 EP - 2902 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Tippkötter, Nils A1 - Stückmann, Henning A1 - Kroll, Stephen A1 - Winkelmann, Gunda A1 - Noack, Udo A1 - Scheper, Thomas A1 - Ulber, Roland T1 - A semi-quantitative dipstick assay for microcystin JF - Analytical and Bioanalytical Chemistry N2 - An immunochromatographic lateral flow dipstick assay for the fast detection of microcystin-LR was developed. Colloid gold particles with diameters of 40 nm were used as red-colored antibody labels for the visual detection of the antigen. The new dipstick sensor is capable of detecting down to 5 µg·l−1 (ppb; total inversion of the color signal) or 1 ppb (observation of color grading) of microcystin-LR. The course of the labeling reaction was observed via spectrometric wave shifts caused by the change of particle size during the binding of antibodies. Different stabilizing reagents showed that especially bovine serum albumin (BSA) and casein increase the assays sensitivity and the conjugate stability. Performance of the dipsticks was quantified by pattern processing of capture zone CCD images. Storage stability of dipsticks and conjugate suspensions over 115 days under different conditions were monitored. The ready-to-use dipsticks were successfully tested with microcystin-LR-spiked samples of outdoor drinking- and salt water and applied to the tissue of microcystin-fed mussels. Y1 - 2009 U6 - http://dx.doi.org/10.1007/s00216-009-2750-8 SN - 1618-2650 VL - 394 IS - 3 SP - 863 EP - 869 PB - springer CY - Berlin ER - TY - JOUR A1 - Garibaldi, F. A1 - Beging, Stefan A1 - Canese, R. A1 - Carpinelli, G. A1 - Clinthorne, N. A1 - Colilli, S. A1 - Cosentino, L. A1 - Finocchiaro, P. A1 - Giuliani, F. A1 - Gricia, M. A1 - Lucentini, M. A1 - Majewski, S. A1 - Monno, E. A1 - Musico, P. A1 - Santavenere, F. A1 - Tödter, J. A1 - Wegener, Hans-Peter A1 - Ziemons, Karl T1 - A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer JF - European Physical Journal Plus Y1 - 2017 U6 - http://dx.doi.org/10.1140/epjp/i2017-11662-x SN - 2190-5444 VL - 132 IS - 9 PB - Springer CY - Berlin ER - TY - JOUR A1 - Balzer, Hermann A1 - Streit, Daniel A1 - Heinze, Marcel ED - Krause, Stefan T1 - Implikationen der Digitalisierung für den Finanzbereich der Unternehmung und das Rollenbild des CFO JF - Betriebswirtschaftliche Implikationen der digitalen Transformation. ZfbF - Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung, Sonderheft 72 Y1 - 2017 U6 - http://dx.doi.org/10.1007/978-3-658-18751-4_14 N1 - ZfbF - Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung. Sonderheft 72. Arbeitskreis Finanzierung der Schmalenbach-Gesellschaft e.V. IS - 72 SP - 267 EP - 283 PB - Springer CY - Berlin ER - TY - JOUR A1 - Ferrein, Alexander A1 - Steinbauer, Gerald T1 - The Interplay of Aldebaran and RoboCup JF - KI - Künstliche Intelligenz Y1 - 2016 U6 - http://dx.doi.org/10.1007/s13218-016-0440-1 SN - 1610-1987 VL - 30 IS - 3-4 SP - 325 EP - 326 PB - Springer CY - Berlin ER - TY - JOUR A1 - Steinbauer, Gerald A1 - Ferrein, Alexander T1 - 20 Years of RoboCup JF - KI - Künstliche Intelligenz Y1 - 2016 U6 - http://dx.doi.org/10.1007/s13218-016-0442-z SN - 1610-1987 VL - 30 IS - 3-4 SP - 221 EP - 224 PB - Springer CY - Berlin ER - TY - JOUR A1 - Ferrein, Alexander A1 - Steinbauer, Gerald T1 - Looking back on 20 Years of RoboCup JF - KI - Künstliche Intelligenz Y1 - 2016 U6 - http://dx.doi.org/10.1007/s13218-016-0443-y SN - 1610-1987 VL - 30 IS - 3-4 SP - 321 EP - 323 PB - Springer CY - Berlin ER - TY - CHAP A1 - Niemueller, Tim A1 - Zwilling, Frederik A1 - Lakemeyer, Gerhard A1 - Löbach, Matthias A1 - Reuter, Sebastian A1 - Jeschke, Sabina A1 - Ferrein, Alexander T1 - Cyber-Physical System Intelligence T2 - Industrial Internet of Things N2 - Cyber-physical systems are ever more common in manufacturing industries. Increasing their autonomy has been declared an explicit goal, for example, as part of the Industry 4.0 vision. To achieve this system intelligence, principled and software-driven methods are required to analyze sensing data, make goal-directed decisions, and eventually execute and monitor chosen tasks. In this chapter, we present a number of knowledge-based approaches to these problems and case studies with in-depth evaluation results of several different implementations for groups of autonomous mobile robots performing in-house logistics in a smart factory. We focus on knowledge-based systems because besides providing expressive languages and capable reasoning techniques, they also allow for explaining how a particular sequence of actions came about, for example, in the case of a failure. KW - Smart factory KW - Industry 4.0 KW - Multi-robot systems KW - Autonomous mobile robots KW - RoboCup Y1 - 2017 SN - 978-3-319-42559-7 U6 - http://dx.doi.org/10.1007/978-3-319-42559-7_17 N1 - Springer Series in Wireless Technology SP - 447 EP - 472 PB - Springer CY - Cham ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Computational Analysis of Pelvic Floor Dysfunction T2 - Women's Health and Biomechanics N2 - Pelvic floor dysfunction (PFD) is characterized by the failure of the levator ani (LA) muscle to maintain the pelvic hiatus, resulting in the descent of the pelvic organs below the pubococcygeal line. This chapter adopts the modified Humphrey material model to consider the effect of the muscle fiber on passive stretching of the LA muscle. The deformation of the LA muscle subjected to intra-abdominal pressure during Valsalva maneuver is compared with the magnetic resonance imaging (MRI) examination of a nulliparous female. Numerical result shows that the fiber-based Humphrey model simulates the muscle behavior better than isotropic constitutive models. Greater posterior movement of the LA muscle widens the levator hiatus due to lack of support from the anococcygeal ligament and the perineal structure as a consequence of birth-related injury and aging. Old and multiparous females with uncontrolled urogenital and rectal hiatus tend to develop PFDs such as prolapse and incontinence. KW - Pelvic muscle KW - Muscle fibers KW - Passive stretching KW - Pelvic floor dysfunction Y1 - 2018 SN - 978-3-319-71574-2 U6 - http://dx.doi.org/10.1007/978-3-319-71574-2_17 N1 - Lecture Notes in Computational Vision and Biomechanics, vol 29 SP - 217 EP - 230 PB - Springer CY - Cham ER - TY - JOUR A1 - Kerpen, Nils B. A1 - Bung, Daniel B. A1 - Valero, Daniel A1 - Schlurmann, Torsten T1 - Energy dissipation within the wave run-up at stepped revetments JF - Journal of Ocean University of China Y1 - 2017 U6 - http://dx.doi.org/10.1007/s11802-017-3355-z SN - 1993-5021 VL - 16 IS - 4 SP - 649 EP - 654 PB - Springer CY - Berlin ER - TY - JOUR A1 - Weihe, Stefan A1 - Ernst, Ansgar A1 - Röth, Thilo A1 - Proksch, Johannes T1 - Aluminium-Stahl-Verbundguss im Nutzfahrzeugbau JF - ATZ - Automobiltechnische Zeitschrift N2 - In modernen Fahrzeugkarosserien der Großserie kommen zunehmend Materialmischbauweisen zur Anwendung. In Zusammenarbeit der Daimler AG, der Tower Automotive Holding GmbH, der Imperia GmbH sowie der Partnerunternehmen KSM Castings GmbH und Schaufler Tooling GmbH & Co. KG wird das Leichtbaupotenzial von Aluminiumverbundguss-Stahlblech-Hybriden am Beispiel des vorderen Dachquerträgers des Mercedes-Benz Viano/Vito ausführlich untersucht. Y1 - 2013 SN - 2192-8800 (Online) SN - 0001-2785 (Print) VL - 115 IS - 4 SP - 312 EP - 316 PB - Springer Fachmedien Wiesbaden ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Mechanics of soft tissue reactions to textile mesh implants T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - For pelvic floor disorders that cannot be treated with non-surgical procedures, minimally invasive surgery has become a more frequent and safer repair procedure. More than 20 million prosthetic meshes are implanted each year worldwide. The simple selection of a single synthetic mesh construction for any level and type of pelvic floor dysfunctions without adopting the design to specific requirements increase the risks for mesh related complications. Adverse events are closely related to chronic foreign body reaction, with enhanced formation of scar tissue around the surgical meshes, manifested as pain, mesh erosion in adjacent structures (with organ tissue cut), mesh shrinkage, mesh rejection and eventually recurrence. Such events, especially scar formation depend on effective porosity of the mesh, which decreases discontinuously at a critical stretch when pore areas decrease making the surgical reconstruction ineffective that further augments the re-operation costs. The extent of fibrotic reaction is increased with higher amount of foreign body material, larger surface, small pore size or with inadequate textile elasticity. Standardized studies of different meshes are essential to evaluate influencing factors for the failure and success of the reconstruction. Measurements of elasticity and tensile strength have to consider the mesh anisotropy as result of the textile structure. An appropriate mesh then should show some integration with limited scar reaction and preserved pores that are filled with local fat tissue. This chapter reviews various tissue reactions to different monofilament mesh implants that are used for incontinence and hernia repairs and study their mechanical behavior. This helps to predict the functional and biological outcomes after tissue reinforcement with meshes and permits further optimization of the meshes for the specific indications to improve the success of the surgical treatment. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_11 SP - 251 EP - 275 PB - Springer CY - Singapore ER - TY - CHAP A1 - Artmann, Gerhard A1 - Meruvu, Haritha A1 - Kizildag, Sefa A1 - Temiz Artmann, Aysegül ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative “CellDrum technology” was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_7 SP - 157 EP - 192 PB - Springer CY - Singapore ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Seifarth, Volker A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries. KW - Mechanical simulation KW - Growth modelling KW - Ureter KW - Bladder KW - Reconstruction Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_9 SP - 209 EP - 232 PB - Springer CY - Singapore ER - TY - CHAP A1 - Frotscher, Ralf A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_10 SP - 233 EP - 250 PB - Springer CY - Singapore ER - TY - CHAP A1 - Digel, Ilya A1 - Akimbekov, Nuraly Sh. A1 - Kistaubayeva, Aida A1 - Zhubanova, Azhar A. ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Microbial Sampling from Dry Surfaces: Current Challenges and Solutions T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Sampling of dry surfaces for microorganisms is a main component of microbiological safety and is of critical importance in many fields including epidemiology, astrobiology as well as numerous branches of medical and food manufacturing. Aspects of biofilm formation, analysis and removal in aqueous solutions have been thoroughly discussed in literature. In contrast, microbial communities on air-exposed (dry) surfaces have received significantly less attention. Diverse surface sampling methods have been developed in order to address various surfaces and microbial groups, but they notoriously show poor repeatability, low recovery rates and suffer from lack of mutual consistency. Quantitative sampling for viable microorganisms represents a particular challenge, especially on porous and irregular surfaces. Therefore, it is essential to examine in depth the factors involved in microorganisms’ recovery efficiency and accuracy depending on the sampling technique used. Microbial colonization, retention and community composition on different dry surfaces are very complex and rely on numerous physicochemical and biological factors. This study is devoted to analyze and review the (a) physical phenomena and intermolecular forces relevant for microbiological surface sampling; (b) challenges and problems faced by existing sampling methods for viable microorganisms and (c) current directions of engineering and research aimed at improvement of quality and efficiency of microbiological surface sampling. KW - Sampling methods KW - Surface microorganisms KW - Dry surfaces KW - Microbial adhesion KW - Swabbing Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_19 SP - 421 EP - 456 PB - Springer CY - Singapore ER - TY - CHAP A1 - Wagemann, Kurt A1 - Tippkötter, Nils T1 - Biorefineries: a short introduction T2 - Biorefineries N2 - The terms bioeconomy and biorefineries are used for a variety of processes and developments. This short introduction is intended to provide a delimitation and clarification of the terminology as well as a classification of current biorefinery concepts. The basic process diagrams of the most important biorefinery types are shown. KW - Bioeconomy KW - Biorefinery definitions KW - Introduction KW - Process schemes KW - Renewable resources Y1 - 2019 SN - 978-3-319-97117-9 SN - 978-3-319-97119-3 U6 - http://dx.doi.org/10.1007/10_2017_4 N1 - (Advances in Biochemical Engineering/Biotechnology book series ; Vol. 166) SP - 1 EP - 11 PB - Springer CY - Cham ER - TY - JOUR A1 - Dikta, Gerhard T1 - Semi-parametric random censorship models JF - From Statistics to Mathematical Finance : Festschrift in Honour of Winfried Stute Y1 - 2017 SN - 978-3-319-50986-0 U6 - http://dx.doi.org/10.1007/978-3-319-50986-0_3 SP - 43 EP - 56 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kunkel, Maximilian Hugo A1 - Gebhardt, Andreas A1 - Mpofu, Khumbaulani A1 - Kallweit, Stephan T1 - Statistical assessment of mechanical properties of selective laser melted specimens of stainless steel JF - The International Journal of Advanced Manufacturing Technology N2 - The rail business is challenged by long product life cycles and a broad spectrum of assembly groups and single parts. When spare part obsolescence occurs, quick solutions are needed. A reproduction of obsolete parts is often connected to long waiting times and minimum lot quantities that need to be purchased and stored. Spare part storage is therefore challenged by growing stocks, bound capital and issues of part ageing. A possible solution could be a virtual storage of spare parts which will be 3D printed through additive manufacturing technologies in case of sudden demand. As mechanical properties of additive manufactured parts are neither guaranteed by machine manufacturers nor by service providers, the utilization of this relatively young technology is impeded and research is required to address these issues. This paper presents an examination of mechanical properties of specimens manufactured from stainless steel through the selective laser melting (SLM) process. The specimens were produced in multiple batches. This paper interrogates the question if the test results follow a normal distribution pattern and if mechanical property predictions can be made. The results will be put opposite existing threshold values provided as the industrial standard. Furthermore, probability predictions will be made in order to examine the potential of the SLM process to maintain state-of-the-art mechanical property requirements. Y1 - 2018 U6 - http://dx.doi.org/10.1007/s00170-018-2040-8 SN - 0268-3768 VL - 98 IS - 5-8 SP - 1409 EP - 1431 PB - Springer CY - London ER - TY - JOUR A1 - Weihe, Stefan A1 - Ansgar, Ernst A1 - Röth, Thilo A1 - Proksch, Johannes T1 - Leichtmetall-Stahl-Verbundguss im Nutzfahrzeugbau JF - Lightweight Design N2 - In modernen Fahrzeugkarosserien der Großserie kommen zunehmend Materialmischbauweisen zur Anwendung. In Zusammenarbeit der Daimler AG, der Tower Automotive Holding GmbH, der Imperia GmbH sowie der Partnerunternehmen KSM Castings GmbH und Schaufler Tooling GmbH & Co. KG wird das Leichtbaupotenzial von Stahlblech-AluminiumverbundgussHybriden am Beispiel des vorderen Dachquerträgers des Mercedes-Benz Viano/Vito ausführlich untersucht. Y1 - 2013 SN - 2192-8738 (Online) SN - 1865-4819 (Print) VL - 6 IS - 2 SP - 38 EP - 43 PB - Springer CY - Berlin ER - TY - CHAP A1 - Schuh, Günther A1 - Gottschalk, Sebastian A1 - Höhne, Tim A1 - Attig, Philipp ED - Mitsuishi, M. T1 - Further Potentials of Smart Logistics T2 - Manufacturing Systems and Technologies for the New Frontier Y1 - 2008 SN - 978-1-84800-267-8 SN - 978-1-84800-266-1 (Printausgabe) U6 - http://dx.doi.org/10.1007/978-1-84800-267-8_18 N1 - The 41St Cirp Conference On Manufacturing Systems, May 26-28, 2008, Tokyo, Japan SP - 93 EP - 96 PB - Springer CY - London ER - TY - CHAP A1 - Tippkötter, Nils A1 - Möhring, Sophie A1 - Roth, Jasmine A1 - Wulfhorst, Helene T1 - Logistics of lignocellulosic feedstocks: preprocessing as a preferable option T2 - Biorefineries N2 - In comparison to crude oil, biorefinery raw materials are challenging in concerns of transport and storage. The plant raw materials are more voluminous, so that shredding and compacting usually are necessary before transport. These mechanical processes can have a negative influence on the subsequent biotechnological processing and shelf life of the raw materials. Various approaches and their effects on renewable raw materials are shown. In addition, aspects of decentralized pretreatment steps are discussed. Another important aspect of pretreatment is the varying composition of the raw materials depending on the growth conditions. This problem can be solved with advanced on-site spectrometric analysis of the material. KW - Analytics KW - Decentral KW - Mechanical KW - On-site KW - Pre-treatment Y1 - 2019 SN - 978-3-319-97117-9 SN - 978-3-319-97119-3 U6 - http://dx.doi.org/10.1007/10_2017_58 N1 - Advances in biochemical engineering/biotechnology ; Vol. 166 SP - 43 EP - 68 PB - Springer CY - Cham ER - TY - CHAP A1 - Duwe, A. A1 - Tippkötter, Nils A1 - Ulber, R. T1 - Lignocellulose-Biorefinery: Ethanol-Focused T2 - Biorefineries N2 - The development prospects of the world markets for petroleum and other liquid fuels are diverse and partly contradictory. However, comprehensive changes for the energy supply of the future are essential. Notwithstanding the fact that there are still very large deposits of energy resources from a geological point of view, the finite nature of conventional oil reserves is indisputable. To reduce our dependence on oil, the EU, the USA, and other major economic zones rely on energy diversification. For this purpose, alternative materials and technologies are being sought, and is most obvious in the transport sector. The objective is to progressively replace fossil fuels with renewable and more sustainable fuels. In this respect, biofuels have a pre-eminent position in terms of their capability of blending with fossil fuels and being usable in existing cars without substantial modification. Ethanol can be considered as the primary renewable liquid fuel. In this chapter enzymes, micro-organisms, and processes for ethanol production based on renewable resources are described. KW - Bioethanol KW - Biorefinery KW - Lignocellulose feedstook Y1 - 2018 U6 - http://dx.doi.org/10.1007/10_2016_72 N1 - Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE,volume 166) SP - 177 EP - 215 PB - Springer CY - Cham ER - TY - JOUR A1 - Becker, Jörg A1 - Delfmann, Patrick A1 - Dietrich, Hanns-Alexander A1 - Steinhorst, Matthias A1 - Eggert, Mathias T1 - Business Process Compliance Checking — Applying and Evaluating a Generic Pattern Matching Approach for Conceptual Models in the Financial Sector JF - Information Systems Frontiers N2 - Given the strong increase in regulatory requirements for business processes the management of business process compliance becomes a more and more regarded field in IS research. Several methods have been developed to support compliance checking of conceptual models. However, their focus on distinct modeling languages and mostly linear (i.e., predecessor-successor related) compliance rules may hinder widespread adoption and application in practice. Furthermore, hardly any of them has been evaluated in a real-world setting. We address this issue by applying a generic pattern matching approach for conceptual models to business process compliance checking in the financial sector. It consists of a model query language, a search algorithm and a corresponding modelling tool prototype. It is (1) applicable for all graph-based conceptual modeling languages and (2) for different kinds of compliance rules. Furthermore, based on an applicability check, we (3) evaluate the approach in a financial industry project setting against its relevance for decision support of audit and compliance management tasks. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s10796-014-9529-y SN - 1572-9419 VL - 18 IS - 2 SP - 359 EP - 405 PB - Springer CY - Berlin ER - TY - JOUR A1 - Becker, Jörg A1 - Delfmann, Patrick A1 - Eggert, Mathias A1 - Schwittay, Sebastian T1 - Generalizability and Applicability of Model-Based Business Process Compliance-Checking Approaches — A State-of-the-Art Analysis and Research Roadmap JF - Business Research : BuR N2 - With a steady increase of regulatory requirements for business processes, automation support of compliance management is a field garnering increasing attention in Information Systems research. Several approaches have been developed to support compliance checking of process models. One major challenge for such approaches is their ability to handle different modeling techniques and compliance rules in order to enable widespread adoption and application. Applying a structured literature search strategy, we reflect and discuss compliance-checking approaches in order to provide an insight into their generalizability and evaluation. The results imply that current approaches mainly focus on special modeling techniques and/or a restricted set of types of compliance rules. Most approaches abstain from real-world evaluation which raises the question of their practical applicability. Referring to the search results, we propose a roadmap for further research in model-based business process compliance checking. Y1 - 2012 U6 - http://dx.doi.org/10.1007/BF03342739 SN - 1866-8658 VL - 5 IS - 2 SP - 221 EP - 247 PB - Springer CY - Heidelberg ER - TY - CHAP A1 - Yoshinobu, Tatsuo A1 - Krause, Steffi A1 - Miyamoto, Ko-ichiro A1 - Werner, Frederik A1 - Poghossian, Arshak A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - (Bio-)chemical Sensing and Imaging by LAPS and SPIM T2 - Label-free biosensing: advanced materials, devices and applications N2 - The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications. KW - Chemical imaging KW - Field-effect device KW - Light-addressable potentiometric sensor KW - Potentiometry Y1 - 2018 SN - 978-3-319-75219-8 SP - 103 EP - 132 PB - Springer CY - Cham ER - TY - JOUR A1 - Schneider, Felix A1 - Tran, Duc Hung T1 - On the relation between the fair value option and bid-ask spreads: descriptive evidence on the recognition of credit risk changes under IFRS JF - Journal of Business Economics Y1 - 2018 U6 - http://dx.doi.org/10.1007/s11573-015-0776-2 SN - 1861-8928 VL - 85 IS - 9 SP - 1049 EP - 1081 PB - Springer CY - Berlin ER - TY - JOUR A1 - Tran, Duc Hung T1 - Corporate Governance und Eigenkapitalkosten - Bestandsaufnahme des Schrifttums unter besonderer Berücksichtigung des Informationsaspektes und Forschungsperspektiven JF - Zeitschrift für Betriebswirtschaft Y1 - 2018 U6 - http://dx.doi.org/10.1007/s11573-011-0461-z SN - 1861-8928 VL - 81 SP - 551 EP - 585 PB - Springer CY - Berlin ER - TY - JOUR A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - Impact of electric propulsion technology and mission requirements on the performance of VTOL UAVs JF - CEAS Aeronautical Journal N2 - One of the engineering challenges in aviation is the design of transitioning vertical take-off and landing (VTOL) aircraft. Thrust-borne flight implies a higher mass fraction of the propulsion system, as well as much increased energy consumption in the take-off and landing phases. This mass increase is typically higher for aircraft with a separate lift propulsion system than for aircraft that use the cruise propulsion system to support a dedicated lift system. However, for a cost–benefit trade study, it is necessary to quantify the impact the VTOL requirement and propulsion configuration has on aircraft mass and size. For this reason, sizing studies are conducted. This paper explores the impact of considering a supplemental electric propulsion system for achieving hovering flight. Key variables in this study, apart from the lift system configuration, are the rotor disk loading and hover flight time, as well as the electrical systems technology level for both batteries and motors. Payload and endurance are typically used as the measures of merit for unmanned aircraft that carry electro-optical sensors, and therefore the analysis focuses on these particular parameters. Y1 - 2018 U6 - http://dx.doi.org/10.1007/s13272-018-0352-x SN - 1869-5582 print SN - 1869-5590 online VL - 10 IS - 3 SP - 843 PB - Springer ER -