TY  - JOUR
A1  - Pieper, Martin
A1  - Klein, Peter
T1  - A simple and accurate numerical network flow model for bionic micro heat exchangers
JF  - Heat mass transfer
Y1  - 2011
SN  - 0947-7411
VL  - 47
IS  - 5
SP  - 491
EP  - 503
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pieper, Martin
A1  - Klein, Peter
T1  - Application of simple, periodic homogenization techniques to non-linear heat conduction problems in non-periodic, porous media
JF  - Heat mass transfer
N2  - Often, detailed simulations of heat conduction in complicated, porous media have large runtimes. Then homogenization is a powerful tool to speed up the calculations by preserving accurate solutions at the same time. Unfortunately real structures are generally non-periodic, which requires unpractical, complicated homogenization techniques. We demonstrate in this paper, that the application of simple, periodic techniques to realistic media, that are just close to periodic, gives accurate, approximative solutions. In order to obtain effective parameters for the homogenized heat equation, we have to solve a so called “cell problem”. In contrast to periodic structures it is not trivial to determine a suitable unit cell, which represents a non-periodic media. To overcome this problem, we give a rule of thumb on how to choose a good cell. Finally we demonstrate the efficiency of our method for virtually generated foams as well as real foams and compare these results to periodic structures.
Y1  - 2012
U6  - http://dx.doi.org/10.1007/s00231-011-0879-4
SN  - 0947-7411
VL  - 48
IS  - 2
SP  - 291
EP  - 300
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pham, Phu Tinh
A1  - Staat, Manfred
T1  - An Upper Bound Algorithm for Limit and Shakedown Analysis of Bounded Linearly Kinematic Hardening Structures
JF  - Limit State of Materials and Structures : Direct Methods 2. Saxcé, Géry de (Hrsg.)
Y1  - 2013
SN  - 978-94-007-5424-9
SP  - 71
EP  - 87
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
T1  - An Edge-Based Smoothed Finite Element Method for Primal-Dual Shakedown Analysis of Structures Under Uncertainties
JF  - Limit State of Materials and Structures : Direct Methods 2. Saxcé, Géry de (Hrsg.)
Y1  - 2013
SN  - 978-94-007-5424-9
SP  - 89
EP  - 102
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Nomdedeu, Mar Monsonis
A1  - Willen, Christine
A1  - Schieffer, Andre
A1  - Arndt, Hartmut
T1  - Temperature-dependent ranges of coexistence in a model of a two-prey-one-predator microbial food web
JF  - Marine Biology
N2  - The objective of our study was to analyze the effects of temperature on the population dynamics of a three-species food web consisting of two prey bacteria (Pedobacter sp. and Acinetobacter johnsonii) and a protozoan predator (Tetrahymena pyriformis) as model organisms. We assessed the effects of temperature on the growth rates of all three species with the objective of developing a model with four differential equations based on the experimental data. The following hypotheses were tested at a theoretical level: Firstly, temperature changes can affect the dynamic behavior of a system by temperature-dependent parameters and interactions and secondly, food web response to temperature cannot be derived from the single species temperature response. The main outcome of the study is that temperature changes affect the parameter range where coexistence is possible within all three species. This has significant consequences on our ideas regarding the evaluation of effects of global warming.
Y1  - 2012
U6  - http://dx.doi.org/10.1007/s00227-012-1966-x
SN  - 1432-1793
VL  - 159
IS  - 11
SP  - 2423
EP  - 2430
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Dietzel, F.
A1  - Weber, Hans-Joachim
A1  - Porschen, W.
A1  - Feinendegen, L. E.
T1  - Zur Wärmeempfindlichkeit von oxischen und hypoxischen Zellen in einem Tumor
JF  - Naturwissenschaften
Y1  - 1976
U6  - http://dx.doi.org/10.1007/BF00622808
SN  - 0028-1042
VL  - 63
IS  - 12
SP  - 585
EP  - 586
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Reisgen, Uwe
A1  - Schleser, Markus
A1  - Mokrov, Oleg
A1  - Zabirov, Alexander
T1  - Virtual welding equipment for simulation of GMAW processes with integration of power source regulation
JF  - Frontiers of materials science
Y1  - 2011
SN  - 2095-0268 (E-Journal); 2095-025X (Print)
VL  - Vol. 5
IS  - Iss. 2
SP  - 79
EP  - 89
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Winckler, Silvia
A1  - Krueger, Rolf
A1  - Schnitzler, Thomas
A1  - Zang, Werner
A1  - Fischer, Rainer
A1  - Biselli, Manfred
T1  - A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach
JF  - Bioprocess and biosystems engineering
N2  - Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.
Y1  - 2014
U6  - http://dx.doi.org/10.1007/s00449-013-1062-8
SN  - 1615-7591 (Print) 1615-7605 (Online)
VL  - 37
IS  - 5
SP  - 901
EP  - 912
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Deppe, Veronika Maria
A1  - Bongaerts, Johannes
A1  - O'Connell, Timothy
A1  - Maurer, Karl-Heinz
A1  - Meinhardt, Friedhelm
T1  - Enzymatic deglycation of Amadori products in bacteria
JF  - Applied microbiology and biotechnology
Y1  - 2011
SN  - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print)
VL  - Vol. 90
IS  - Iss. 2
SP  - 399
EP  - 406
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Kirschner-Hermanns, Ruth
A1  - Klementz, T.
A1  - Haselhuhn, Angelika
A1  - Jakse, Gerhard
A1  - Heidenreich, A.
A1  - Brehmer, Bernhard
T1  - Drangsymptomatik nach onkologisch erfolgreicher Prostatakarzinomtherapie : prospektive Studie zum Einfluss von Therapiemodalität, Morbidität und epidemiologischen Faktoren auf die Lebensqualität
JF  - Der Urologe
Y1  - 2011
SN  - 1433-0563
VL  - Vol. 50
IS  - Iss. 11
SP  - 1412
EP  - 1419
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Bung, Daniel B.
T1  - Fließcharakteristik und Sauerstoffeintrag bei selbstbelüfteten Gerinneströmungen auf Kaskaden mit gemäßigter Neigung
JF  - Österreichische Wasser- und Abfallwirtschaft
Y1  - 2011
SN  - 1613-7566 (E-Journal); 0945-358X (Print)
VL  - Vol. 63
IS  - Iss. 3-4
SP  - 76
EP  - 81
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Alebouyeh Samami, Behzad
A1  - Pieper, Martin
A1  - Breitbach, Gerd
A1  - Hodapp, Josef
T1  - Heat production in the windings of the stators of electric machines under stationary condition
JF  - Heat and mass transfer
N2  - In electric machines due to high currents and resistive losses (joule heating) heat is produced. To avoid damages by overheating the design of effective cooling systems is required. Therefore the knowledge of heat sources and heat transfer processes is necessary. The purpose of this paper is to illustrate a good and effective calculation method for the temperature analysis based on homogenization techniques. These methods have been applied for the stator windings in a slot of an electric machine consisting of copper wires and resin. The key quantity here is an effective thermal conductivity, which characterizes the heterogeneous wire resin-arrangement inside the stator slot. To illustrate the applicability of the method, the analysis of a simplified, homogenized model is compared with the detailed analysis of temperature behavior inside a slot of an electric machine according to the heat generation. We considered here only the stationary situation. The achieved numerical results are accurate and show that the applied homogenization technique works in practice. Finally the results of simulations for the two cases, the original model of the slot and the homogenized model chosen for the slot (unit cell), are compared to experimental results.
Y1  - 2014
U6  - http://dx.doi.org/10.1007/s00231-014-1371-8
SN  - 0947-7411 (Print) ; 1432-1181 (E-Journal)
VL  - 50
SP  - 1707
EP  - 1716
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Khaydukova, M. M.
A1  - Zadorozhnaya, O. A.
A1  - Kirsanov, D. O.
A1  - Iken, Heiko
A1  - Rolka, David
A1  - Schöning, Michael Josef
A1  - Babain, V. A.
A1  - Vlasov, Yu. G.
A1  - Legin, A. V.
T1  - Multivariate processing of atomic-force microscopy images for detection of the response of plasticized polymeric membranes
JF  - Russian journal of applied chemistry
N2  - The possibility of using the atomic-force microscopy as a method for detection of the analytical signal from plasticized polymeric sensor membranes was analyzed. The surfaces of cadmium-selective membranes based on two polymeric matrices were examined. The digital images were processed with multivariate image analysis techniques. A correlation was found between the surface profile of an ion-selective membrane and the concentration of the ion in solution.
Y1  - 2014
U6  - http://dx.doi.org/10.1134/S1070427214030112
SN  - 1608-3296 (E-Journal); 1070-4272 (Print)
VL  - 87
IS  - 3
SP  - 307
EP  - 314
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Jakob, Felix
A1  - Martinez, Ronny
A1  - Mandawe, John
A1  - Hellmuth, Hendrik
A1  - Siegert, Petra
A1  - Maurer, Karl-Heinz
A1  - Schwaneberg, Ulrich
T1  - Surface charge engineering of a Bacillus gibsonii subtilisin protease
JF  - Applied microbiology and biotechnology
Y1  - 2013
SN  - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print)
VL  - Vol. 97
IS  - Iss. 15
SP  - 6793
EP  - 6802
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Niehaus, F.
A1  - Gabor, E.
A1  - Wieland, S.
A1  - Siegert, Petra
A1  - Maurer, Karl-Heinz
A1  - Eck, J.
T1  - Enzymes for the laundry industries: tapping the vast metagenomic pool of alkaline proteases
JF  - Microbial biotechnology
Y1  - 2011
SN  - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print)
VL  - Vol. 4
IS  - Iss. 6
SP  - 767
EP  - 776
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Fonti, Patrick
A1  - Eilmann, Britta
A1  - García-González, Ignacio
A1  - von Arx, Georg
T1  - Expeditious building of ring-porous earlywood vessel chronologies without loosing signal information
JF  - Trees : structure and function
Y1  - 2009
U6  - http://dx.doi.org/10.1007/s00468-008-0310-z
SN  - 0931-1890 (Print)
SN  - 1432-2285 (Online)
VL  - 23
IS  - 3
SP  - 665
EP  - 671
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hafner, David
A1  - Demetz, Oliver
A1  - Weickert, Joachim
A1  - Reißel, Martin
T1  - Mathematical Foundations and Generalisations of the Census Transform for Robust Optic Flow Computation
JF  - Journal of Mathematical Imaging and Vision
Y1  - 2014
U6  - http://dx.doi.org/10.1007/s10851-014-0529-9
SN  - 1573-7683 (Online)
N1  - Springer Online First (ohne Seitenang. und Heftzuteilung)
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Borchert, Jörg
A1  - Hasenbeck, Marc
A1  - Jungbluth, Christian
A1  - Schemm, Ralf
T1  - Bewertung und Steuerung von Gasspeichern bzw. Gasspeicherscheiben
JF  - Zeitschrift für Energiewirtschaft
N2  - In diesem Artikel werden zunächst einleitend der Gasmarkt Deutschland und der sich daraus ergebende Speicherbedarf skizziert. Folgend wird auf verschiedene Speichernutzen aus betriebswirtschaftlicher Perspektive eingegangen und die in diesem Artikel vorgestellten Bewertungsverfahren einleitend beschrieben. In diesem Artikel werden stochastische Optimierungsmethoden aufgegriffen, die sowohl eine Bewertung der Speicher gegenüber einem Spotpreis, als auch gegenüber einer gesamten Forwardcurve ermöglichen. Hierzu werden zunächst Modelle zur Beschreibung der Marktpreise vorgestellt und anhand empirischer Daten kalibriert. Dann wird eine beispielhafte Speicherscheibe zunächst auf Basis der LeastSquareMonteCarloTechnik gegenüber dem stochastischen mehrfaktoriellen Spotpreismodell bewertet. Hieran schließt sich die Vorstellung der Bewertung sowie des Hedgings gegenüber der Forwardcurve an. Abschließend erfolgt eine vergleichende Gegenüberstellung beider Verfahren.
Y1  - 2009
U6  - http://dx.doi.org/10.1007/s12398-009-0033-x
SN  - 1866-2765
VL  - 33
IS  - 4
SP  - 279
EP  - 293
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Staat, Manfred
T1  - Physical response of hyperelastic models for composite materials and soft tissues
JF  - Asia pacific journal on computational engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1186/s40540-015-0015-x
SN  - 2196-1166
VL  - 2
IS  - 3 (December 2015)
SP  - 1
EP  - 18
ER  - 
TY  - JOUR
A1  - Kürten, Sylvia
A1  - Mottaghy, Darius
A1  - Ziegler, Martin
T1  - A new model for the description of the heat transfer for plane thermo-active geotechnical systems based on thermal resistances
JF  - Acta Geotechnica
Y1  - 2015
U6  - http://dx.doi.org/10.1007/s11440-014-0311-6
SN  - 1861-1133
VL  - 10
IS  - 2
SP  - 219
EP  - 229
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Fischer, Felix
A1  - Selver, M. Alper
A1  - Gezer, Sinem
A1  - Dicle, Oguz
A1  - Hillen, Walter
T1  - Systematic Parameterization, Storage, and Representation of Volumetric DICOM Data
JF  - Journal of Medical and Biological Engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1007/s40846-015-0097-5
SN  - 2199-4757
VL  - 35
IS  - 6
SP  - 709
EP  - 723
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Müller, Lars-Peter
A1  - Staat, Manfred
A1  - Kahmann, Stephanie Lucina
A1  - Wegmann, Kilian
T1  - Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 148
EP  - 149
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Kahmann, Stephanie Lucina
A1  - Wegmann, Kilian
A1  - Ries, Christian
A1  - Staat, Manfred
A1  - Müller, Lars-Peter
T1  - Shortening osteotomy of the proximal radius — a treatment option for isolated osteoarthritis of the lateral column of the elbow joint?
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Treatment of posttraumatic osteoarthritis of the radial column of the elbow joint remains a challenging yet common issue.
While partial joint replacement leads to high revision rates, radial head excision has shown to severely increase joint instability. Shortening osteotomy of the radius could be an option to decrease the contact pressure of the radiohumeral joint and thereby pain levels without causing valgus instability. Hence, the aim of this biomechanical study was to evaluate the effects of radial shortening on axial load distribution and valgus stability of the elbow joint.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 128
EP  - 129
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Leschinger, T.
A1  - Staat, Manfred
A1  - Müller, Lars-Peter
A1  - Wegmann, Kilian
T1  - Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 130
EP  - 131
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wegmann, Kilian
A1  - Hackl, Michael
A1  - Staat, Manfred
A1  - Mayer, Katharina
A1  - Müller, Lars-Peter
T1  - Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4079-0
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 58
EP  - 59
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Scheidweiler, Robert
A1  - Triesch, Eberhard
T1  - A note on the duality between matchings and vertex covers in balanced hypergraphs
JF  - Journal of Combinatorial Optimization
N2  - We present a new Min-Max theorem for an optimization problem closely connected to matchings and vertex covers in balanced hypergraphs. The result generalizes Kőnig’s Theorem (Berge and Las Vergnas in Ann N Y Acad Sci 175:32–40, 1970; Fulkerson et al. in Math Progr Study 1:120–132, 1974) and Hall’s Theorem (Conforti et al. in Combinatorica 16:325–329, 1996) for balanced hypergraphs.
KW  - Hall’s Theorem
KW  - Koenig’s Theorem
KW  - Duality
KW  - Balanced hypergraph
KW  - Hypergraph
KW  - Vertex cover
KW  - Matching
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s10878-015-9887-5
SN  - 1573-2886
N1  - Lehrstuhl II für Mathematik RWTH Aachen
VL  - 32
IS  - 2
SP  - 639
EP  - 644
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Lopes, Pedro
A1  - Leandro, Jorge
A1  - Carvalho, Rita F.
A1  - Bung, Daniel B.
T1  - Alternating skimming flow over a stepped spillway
JF  - Environmental Fluid Mechanics
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s10652-016-9484-x
SN  - 1573-1510
VL  - 17
IS  - 2
SP  - 303
EP  - 322
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pinkenburg, Olaf
A1  - Schiffels, Johannes
A1  - Selmer, Thorsten
T1  - Das CoLibry-Konzept – ein Werkzeugkasten für die Synthetische Biologie: Bioproduktion
JF  - BIOspektrum
N2  - Regardless of size or destination, synthetic biology starts with com-parably small information units, which need to be combined and properly arranged in order to achieve a certain goal. This may be the de novo synthesis of individual genes from oligonucleotides, a shuffling of protein domains in order to create novel biocatalysts, the assembly of multiple enzyme encoding genes in metabolic pathway design, or strain development at the production stage. The CoLibry concept has been designed in order to close the gap between recombinant production of individual genes and genome editing.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s12268-016-0734-8
VL  - 22
IS  - 6
SP  - 593
EP  - 595
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Lanzl, I. M.
T1  - Mit Statistik gemeistert: perfekte Augentropfen und idealer Screeningtest : Möglichkeiten und Grenzen statistischer Methoden beim Glaukom
JF  - Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
N2  - Hintergrund
Die Anwendung und das Verständnis von Statistik sind sehr wichtig für die biomedizinische Forschung und für die klinische Praxis. Dies gilt insbesondere auch zur Abschätzung der Möglichkeiten unterschiedlichster Diagnostik- und Therapieoptionen beim Glaukom. Die scheinbare Komplexität der Statistik, die zum Teil dem „gesunden Menschenverstand“ zu widersprechen scheint, zusammen mit der nur vorsichtigen Akzeptanz der Statistik bei vielen Medizinern können zu bewussten und unbewussten Manipulationen bei der Datendarstellung und -interpretation führen.

Ziel der Arbeit
Ziel ist die verständliche Darstellung einiger typischer Fehler in der medizinisch-statistischen Datenbehandlung.

Material und Methoden
Anhand hypothetischer Beispiele aus der Glaukomdiagnostik erfolgen die Darstellung der Wirkung eines hypotensiven Medikamentes sowie die Beurteilung der Ergebnisse eines diagnostischen Tests. Es werden die typischsten statistischen Einsatzbereiche und Irrtumsquellen ausführlich und verständlich analysiert

Ergebnisse
Mechanismen von Datenmanipulation und falscher Dateninterpretation werden aufgeklärt. Typische Irrtumsquellen bei der statistischen Auswertung und Datendarstellung werden dabei erläutert.

Schlussfolgerungen
Die erläuterten praktischen Beispiele zeigen die Notwendigkeit, die Grundlagen der Statistik zu verstehen und korrekt anwenden zu können. Fehlendes Grundlagenwissen und Halbwissen der medizinischen Statistik können zu folgenschweren Missverständnissen und falschen Entscheidungen in der medizinischen Forschung, aber auch in der klinischen Praxis führen.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00347-016-0312-y
SN  - 0941-293X
SN  - 1433-0423
N1  - Englischer Titel: Mastered with statistics: perfect eye drops and ideal screening test : possibilities and limits of statistical methods for glaucoma
IS  - 113
SP  - 838
EP  - 843
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Knobe, M.
A1  - Giesen, M.
A1  - Plate, S.
A1  - Gradl-Dietsch, G.
A1  - Buecking, B.
A1  - Eschbach, D.
A1  - Laack, Walter van
A1  - Pape, H.-C.
T1  - The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale
JF  - European Journal Of Trauma And Emergency Surgery
N2  - Purpose
The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale.

Methods
For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland–Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated.

Results
The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = −0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points).

Conclusion
The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status.
KW  - Tinetti test
KW  - Mobility
KW  - Mobility tests
KW  - Ground-level falls
KW  - Elderly
KW  - Fall prevention
KW  - Co-managed care
KW  - Balance
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00068-016-0693-2
SN  - 1863-9941
VL  - 42
IS  - 5
SP  - 537
EP  - 545
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Belavy, Daniel L.
A1  - Albracht, Kirsten
A1  - Bruggemann, Gert-Peter
A1  - Vergroesen, Pieter-Paul A.
A1  - Dieen, Jaap H. van
T1  - Can exercise positively influence the intervertebral disc?
JF  - Sports Medicine
N2  - To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a ‘critical period’ for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research.
KW  - Intradiscal Pressure
KW  - Annulus Fibrosus
KW  - Disc Degeneration
KW  - Nucleus Pulposus
KW  - Intervertebral Disc
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s40279-015-0444-2
SN  - 1179-2035
VL  - 46
IS  - 4
SP  - 473
EP  - 485
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Albracht, Kirsten
A1  - Arampatzis, Adamantios
T1  - Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans
JF  - European Journal of Applied Physiology
Y1  - 2013
U6  - http://dx.doi.org/10.1007/s00421-012-2585-4
SN  - 1439-6327
VL  - 113
IS  - 6
SP  - 1605
EP  - 1615
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Steinbauer, Gerald
T1  - 20 Years of RoboCup -  A Subjective Retrospection
JF  - KI - Künstliche Intelligenz
N2  - This summer, RoboCup competitions were held for the 20th time in Leipzig, Germany. It was the second time that RoboCup took place in Germany, 10 years after the 2006 RoboCup in Bremen. In this article, we give an overview on the latest developments of RoboCup and what happened in the different leagues over the last decade. With its 20th edition, RoboCup clearly is a success story and a role model for robotics competitions. From our personal view point, we acknowledge this by giving a retrospection about what makes RoboCup such a success.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s13218-016-0449-5
SN  - 1610-1987
VL  - 30
IS  - 3
SP  - 225
EP  - 232
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Noureddine, Yacine
A1  - Bitz, Andreas
A1  - Ladd, Mark E.
A1  - Thürling, Markus
A1  - Ladd, Susanne C.
A1  - Schaefers, Gregor
A1  - Kraff, Oliver
T1  - Experience with magnetic resonance imaging of human subjects with passive implants and tattoos at 7 T: a retrospective study
JF  - Magnetic Resonance Materials in Physics, Biology and Medicine
Y1  - 2015
U6  - http://dx.doi.org/10.1007/s10334-015-0499-y
SN  - 1352-8661
VL  - 28
IS  - 6
SP  - 577
EP  - 590
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Vos, E. K.
A1  - Lagemaat, M. W.
A1  - Barentsz, J. O.
A1  - Fütterer, J. J.
A1  - Zamecnik, P.
A1  - Roozen, H.
A1  - Orzada, S.
A1  - Bitz, Andreas
A1  - Maas, M. C.
A1  - Scheenen, T. W. J.
T1  - Image quality and cancer visibility of T2-weighted Magnetic Resonance Imaging of the prostate at 7 Tesla
JF  - European Radiology
N2  - Objectives
To assess the image quality of T2-weighted (T2w) magnetic resonance imaging of the prostate and the visibility of prostate cancer at 7 Tesla (T).

Materials & methods
Seventeen prostate cancer patients underwent T2w imaging at 7T with only an external transmit/receive array coil. Three radiologists independently scored images for image quality, visibility of anatomical structures, and presence of artefacts. Krippendorff’s alpha and weighted kappa statistics were used to assess inter-observer agreement. Visibility of prostate cancer lesions was assessed by directly linking the T2w images to the confirmed location of prostate cancer on histopathology.

Results
T2w imaging at 7T was achievable with ‘satisfactory’ (3/5) to ‘good’ (4/5) quality. Visibility of anatomical structures was predominantly scored as ‘satisfactory’ (3/5) and ‘good’ (4/5). If artefacts were present, they were mostly motion artefacts and, to a lesser extent, aliasing artefacts and noise. Krippendorff’s analysis revealed an α = 0.44 between three readers for the overall image quality scores. Clinically significant cancer lesions in both peripheral zone and transition zone were visible at 7T.

Conclusion
T2w imaging with satisfactory to good quality can be routinely acquired, and cancer lesions were visible in patients with prostate cancer at 7T using only an external transmit/receive body array coil.
Y1  - 2014
U6  - http://dx.doi.org/10.1007/s00330-014-3234-6
SN  - 1432-1084
VL  - 24
IS  - 8
SP  - 1950
EP  - 1958
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Chen, Bixia
A1  - Schoemberg, Tobias
A1  - Kraff, Oliver
A1  - Dammann, Philipp
A1  - Bitz, Andreas
A1  - Schlamann, Marc
A1  - Quick, Harald H.
A1  - Ladd, Mark E.
A1  - Sure, Ulrich
A1  - Wrede, Karsten H.
T1  - Cranial fixation plates in cerebral magnetic resonance imaging: a 3 and 7 Tesla in vivo image quality study
JF  - Magnetic Resonance Materials in Physics, Biology and Medicine
N2  - Objective
This study assesses and quantifies impairment of postoperative magnetic resonance imaging (MRI) at 7 Tesla (T) after implantation of titanium cranial fixation plates (CFPs) for neurosurgical bone flap fixation.

Materials and methods
The study group comprised five patients who were intra-individually examined with 3 and 7 T MRI preoperatively and postoperatively (within 72 h/3 months) after implantation of CFPs. Acquired sequences included T₁-weighted magnetization-prepared rapid-acquisition gradient-echo (MPRAGE), T₂-weighted turbo-spin-echo (TSE) imaging, and susceptibility-weighted imaging (SWI). Two experienced neurosurgeons and a neuroradiologist rated image quality and the presence of artifacts in consensus reading.

Results
Minor artifacts occurred around the CFPs in MPRAGE and T2 TSE at both field strengths, with no significant differences between 3 and 7 T. In SWI, artifacts were accentuated in the early postoperative scans at both field strengths due to intracranial air and hemorrhagic remnants. After resorption, the brain tissue directly adjacent to skull bone could still be assessed. Image quality after 3 months was equal to the preoperative examinations at 3 and 7 T.

Conclusion
Image quality after CFP implantation was not significantly impaired in 7 T MRI, and artifacts were comparable to those in 3 T MRI.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s10334-016-0548-1
SN  - 1352-8661
VL  - 29
IS  - 3
SP  - 389
EP  - 398
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Katz, Evgeny
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics
JF  - Analytical and Bioanalytical Chemistry
N2  - The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a “filter” system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion.
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s00216-016-0079-7
SN  - 1618-2650
VL  - 409
SP  - 81
EP  - 94
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Umutlu, Lale
A1  - Kraff, Oliver
A1  - Fischer, Anja
A1  - Kinner, Sonja
A1  - Maderwald, Stefan
A1  - Nassenstein, Kai
A1  - Nensa, Felix
A1  - Grüneisen, Johannes
A1  - Orzada, Stephan
A1  - Bitz, Andreas
A1  - Forsting, Michael
A1  - Ladd, Mark E.
A1  - Lauenstein, Thomas C.
T1  - Seven-Tesla MRI of the female pelvis
JF  - European Radiology
Y1  - 2013
U6  - http://dx.doi.org/10.1007/s00330-013-2868-0
SN  - 1432-1084
VL  - 23
IS  - 9
SP  - 2364
EP  - 2373
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Umutlu, L.
A1  - Maderwald, S.
A1  - Kinner, S.
A1  - Kraff, O.
A1  - Bitz, Andreas
A1  - Orzada, S.
A1  - Johst, S.
A1  - Wrede, K.
A1  - Forsting, M.
A1  - Ladd, M. E.
A1  - Lauenstein, T. C.
A1  - Quick, H. H.
T1  - First-pass contrast-enhanced renal MRA at 7 Tesla: initial results
JF  - European Radiology
Y1  - 2013
U6  - http://dx.doi.org/10.1007/s00330-012-2666-0
SN  - 1432-1084
VL  - 23
IS  - 4
SP  - 1059
EP  - 1066
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Umutlu, Lale
A1  - Orzada, Stephan
A1  - Kinner, Sonja
A1  - Maderwald, Stefan
A1  - Bronte, Irina
A1  - Bitz, Andreas
A1  - Kraff, Oliver
A1  - Ladd, Susanne C.
A1  - Antoch, Gerald
A1  - Ladd, Mark E.
A1  - Quick, Harald H.
A1  - Lauenstein, Thomas C.
T1  - Renal imaging at 7 Tesla: preliminary results
JF  - European Radiology
N2  - Objective
To investigate the feasibility of 7T MR imaging of the kidneys utilising a custom-built 8-channel transmit/receive radiofrequency body coil.

Methods
In vivo unenhanced MR was performed in 8 healthy volunteers on a 7T whole-body MR system. After B0 shimming the following sequences were obtained: 1) 2D and 3D spoiled gradient-echo sequences (FLASH, VIBE), 2) T1-weighted 2D in and opposed phase 3) True-FISP imaging and 4) a T2-weighted turbo spin echo (TSE) sequence. Visual evaluation of the overall image quality was performed by two radiologists.

Results
Renal MRI at 7T was feasible in all eight subjects. Best image quality was found using T1-weighted gradient echo MRI, providing high anatomical details and excellent conspicuity of the non-enhanced vasculature. With successful shimming, B1 signal voids could be effectively reduced and/or shifted out of the region of interest in most sequence types. However, T2-weighted TSE imaging remained challenging and strongly impaired because of signal heterogeneities in three volunteers.

Conclusion
The results demonstrate the feasibility and diagnostic potential of dedicated 7T renal imaging. Further optimisation of imaging sequences and dedicated RF coil concepts are expected to improve the acquisition quality and ultimately provide high clinical diagnostic value.
Y1  - 2011
SN  - 1432-1084
VL  - 21
IS  - 4
SP  - 841
EP  - 849
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Wegmann, Kilian
A1  - Kahmann, Stephanie Lucina
A1  - Heinze, Nicolai
A1  - Staat, Manfred
A1  - Neiss, Wolfram F.
A1  - Scaal, Martin
A1  - Müller, Lars P.
T1  - Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow
JF  - Knee Surgery, Sports Traumatology, Arthroscopy
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s00167-017-4468-z
SN  - 1433-7347
VL  - 25
IS  - 7
SP  - 2280
EP  - 2288
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Balzer, Hermann
A1  - Streit, Daniel
T1  - Das Translationsrisiko multinationaler Konzerne in Deutschland: Eine explorative Analyse von Verständnis, Bedeutung und Management-Praxis mit Hilfe der Critical Incident Technique
JF  - Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s41471-017-0029-x
SN  - 2366-6153
N1  - Arbeitskreis Finanzierung der Schmalenbach-Gesellschaft e.V.
IS  - Online first
SP  - 1
EP  - 40
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wiesen, Sebastian
A1  - Tippkötter, Nils
A1  - Muffler, Kai
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - Adsorption of fatty acids to layered double hydroxides in aqueous systems
JF  - Adsorption
N2  - Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L−1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32−.
Y1  - 2015
VL  - 21
IS  - 6-7
SP  - 459
EP  - 466
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Morais, Paulo V.
A1  - Gomes, Vanderley F., Jr.
A1  - Silva, Anielle C. A.
A1  - Dantas, Noelio O.
A1  - Schöning, Michael Josef
A1  - Siqueira, José R., Jr.
T1  - Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices
JF  - Journal of Materials Science
N2  - The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance–voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film’s surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications.
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s10853-017-1369-y
SN  - 1573-4803
VL  - 52
IS  - 20
SP  - 12314
EP  - 12325
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Röhlen, Desiree
A1  - Pilas, Johanna
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
T1  - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid
JF  - Applied Biochemistry and Biotechnology
N2  - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates.
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s12010-017-2578-1
SN  - 1559-0291
VL  - 183
SP  - 566
EP  - 581
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Srivastava, A.
A1  - Chahar, V.
A1  - Sharma, V.
A1  - Sun, Y.
A1  - Bol, R.
A1  - Knolle, F.
A1  - Schnug, E.
A1  - Hoyler, Friedrich
A1  - Naskar, N.
A1  - Lahiri, S.
A1  - Patnaik, R.
T1  - Study of uranium toxicity using low-background gamma-ray spectrometry
JF  - Journal of Radioanalytical and Nuclear Chemistry
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s10967-017-5466-9
SN  - 1588-2780
IS  - Online first
SP  - 1
EP  - 7
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Stückmann, Henning
A1  - Kroll, Stephen
A1  - Winkelmann, Gunda
A1  - Noack, Udo
A1  - Scheper, Thomas
A1  - Ulber, Roland
T1  - A semi-quantitative dipstick assay for microcystin
JF  - Analytical and Bioanalytical Chemistry
N2  - An immunochromatographic lateral flow dipstick assay for the fast detection of microcystin-LR was developed. Colloid gold particles with diameters of 40 nm were used as red-colored antibody labels for the visual detection of the antigen. The new dipstick sensor is capable of detecting down to 5 µg·l−1 (ppb; total inversion of the color signal) or 1 ppb (observation of color grading) of microcystin-LR. The course of the labeling reaction was observed via spectrometric wave shifts caused by the change of particle size during the binding of antibodies. Different stabilizing reagents showed that especially bovine serum albumin (BSA) and casein increase the assays sensitivity and the conjugate stability. Performance of the dipsticks was quantified by pattern processing of capture zone CCD images. Storage stability of dipsticks and conjugate suspensions over 115 days under different conditions were monitored. The ready-to-use dipsticks were successfully tested with microcystin-LR-spiked samples of outdoor drinking- and salt water and applied to the tissue of microcystin-fed mussels.
Y1  - 2009
U6  - http://dx.doi.org/10.1007/s00216-009-2750-8
SN  - 1618-2650
VL  - 394
IS  - 3
SP  - 863
EP  - 869
PB  - springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Garibaldi, F.
A1  - Beging, Stefan
A1  - Canese, R.
A1  - Carpinelli, G.
A1  - Clinthorne, N.
A1  - Colilli, S.
A1  - Cosentino, L.
A1  - Finocchiaro, P.
A1  - Giuliani, F.
A1  - Gricia, M.
A1  - Lucentini, M.
A1  - Majewski, S.
A1  - Monno, E.
A1  - Musico, P.
A1  - Santavenere, F.
A1  - Tödter, J.
A1  - Wegener, Hans-Peter
A1  - Ziemons, Karl
T1  - A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer
JF  - European Physical Journal Plus
Y1  - 2017
U6  - http://dx.doi.org/10.1140/epjp/i2017-11662-x
SN  - 2190-5444
VL  - 132
IS  - 9
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Balzer, Hermann
A1  - Streit, Daniel
A1  - Heinze, Marcel
ED  - Krause, Stefan
T1  - Implikationen der Digitalisierung für den Finanzbereich der Unternehmung und das Rollenbild des CFO
JF  - Betriebswirtschaftliche Implikationen der digitalen Transformation. ZfbF - Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung, Sonderheft 72
Y1  - 2017
U6  - http://dx.doi.org/10.1007/978-3-658-18751-4_14
N1  - ZfbF - Schmalenbachs Zeitschrift für betriebswirtschaftliche Forschung. Sonderheft 72.
Arbeitskreis Finanzierung der Schmalenbach-Gesellschaft e.V.
IS  - 72
SP  - 267
EP  - 283
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Steinbauer, Gerald
T1  - The Interplay of Aldebaran and RoboCup
JF  - KI - Künstliche Intelligenz
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s13218-016-0440-1
SN  - 1610-1987
VL  - 30
IS  - 3-4
SP  - 325
EP  - 326
PB  - Springer
CY  - Berlin
ER  -