TY  - JOUR
A1  - Tippkötter, Nils
A1  - Al-Kaidy, Huschyar
A1  - Wollny, Steffen
A1  - Ulber, Roland
T1  - Functionalized magnetizable particles for downstream processing in single-use systems
JF  - Chemie Ingenieur Technik
N2  - Biotechnological downstream processing is usually an elaborate procedure, requiring a multitude of unit operations to isolate the target component. Besides the disadvantageous space-time yield, the risks of cross-contaminations and product loss grow fast with the complexity of the isolation procedure. A significant reduction of unit operations can be achieved by application of magnetic particles, especially if these are functionalized with affinity ligands. As magnetic susceptible materials are highly uncommon in biotechnological processes, target binding and selective separation of such particles from fermentation or reactions broths can be done in a single step. Since the magnetizable particles can be produced from iron salts and low priced polymers, a single-use implementation of these systems is highly conceivable. In this article, the principles of magnetizable particles, their synthesis and functionalization are explained. Furthermore, applications in the area of reaction engineering, microfluidics and downstream processing are discussed focusing on established single-use technologies and development potential.
Y1  - 2013
U6  - http://dx.doi.org/10.1002/cite.201200130
VL  - 85
IS  - 1-2: Special Issue: Single-Use Technology
SP  - 76
EP  - 86
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Al-Kaidy, Huschyar
A1  - Duwe, Anna
A1  - Huster, Manuel
A1  - Muffler, Kai
A1  - Schlegel, Christin
A1  - Tim, Sieker
A1  - Stadtmüller, Ralf
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - Biotechnology and bioprocess engineering – from the first ullmann's article to recent trends
JF  - ChemBioEng Reviews
N2  - For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/cben.201500008
VL  - 2
IS  - 3
SP  - 175
EP  - 184
PB  - Wiley
CY  - Weinheim
ER  -