TY  - JOUR
A1  - Tippkötter, Nils
A1  - Wollny, Steffen
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - Recycling of spent oil bleaching earth as source of glycerol for the anaerobic production of acetone, butanol, and ethanol with Clostridium diolis and lipolytic Clostridium lundense
JF  - Engineering in Life Sciences
N2  - A major part of edible oil is subjected to bleaching procedures, primarily with minerals applied as adsorbers. Their recycling is currently done either by regaining the oil via organic solvent extraction or by using the spent bleaching earth (SBE) as additive for animal feed, etc. As a new method, the reutilization of the by-product SBE for the microbiologic formation of acetone, butanol, and ethanol (ABE) is presented as proof-of-concept. The SBE was taken from a palm oil cleaning process. The recycling concept is based on the application of lipolytic clostridia strains. Due to considerably long fermentation times, co-fermentation with Candida rugosa and enzymatic hydrolyses of the bound oil with a subsequent clostridia fermentation are shown as alternative routes. Anaerobic fermentations under comparison of different clostridia strains were performed with glycerol media, enzymatically hydrolyzed palm oil and SBE. Solutes, side product compositions and productivities were quantified via HPLC. A successful production of ABE solutes from SBE has been done with a yield of 0.15 g butanol per gram of bound glycerol. Thus, the biotechnological recycling of the waste stream is possible in principle. Inhibition of the substrate suspension has been observed. A chromatographic ion-exchange of substrates increased the biomass concentration.
Y1  - 2014
U6  - https://doi.org/10.1002/elsc.201300113
SN  - 1618-2863
VL  - 14
IS  - 4
SP  - 425
EP  - 432
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Thiel, Alexander
A1  - Muffler, Kai
A1  - Tippkötter, Nils
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - Aufarbeitung von Polyphenolen aus Weizen mittels Zeolithen am Beispiel der Ferulasäure
JF  - Chemie IngenieurTechnik
N2  - Aufarbeitung von Polyphenolen aus Weizenmittels Zeolithen am Beispiel der Ferulasa¨ ureAlexander Thiel1, Kai Muffler1, Nils Tippko¨ tter1, Kirstin Suck2, Ulrich Sohling2, Friedrich Ruf3und Roland Ulber1,*DOI: 10.1002/cite.201400031Bei der Ferulasa¨ure handelt es sich um einen Wertstoff, der aus Weizen gewonnen und in der Lebensmittel- und Pharma-industrie eingesetzt werden kann. Der Einsatz von Weizen als nachwachsende Rohstoffquelle ist allerdings nur dann wirt-schaftlich durchfu¨hrbar, wenn eine Prozessintegration in die bestehenden industriellen Verfahren gewa¨hrleistet oder einedirekte Konkurrenz zur Mehl- und Sta¨rkeindustrie vermieden werden kann. In diesem Artikel wird ein Verfahren aufge-zeigt, welches hohe Ausbeuten ermo¨glicht und eine Konkurrenz zu bestehenden Verwertungspfaden vermeidet.
Y1  - 2015
U6  - https://doi.org/10.1002/cite.201400031
N1  - Englischer Titel: Downstream Processing of Polyphenols from Wheat by Zeolites using the Example of Ferulic Acid
VL  - 87
IS  - 1-2
SP  - 128
EP  - 136
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Al-Kaidy, Huschyar
A1  - Duwe, Anna
A1  - Huster, Manuel
A1  - Muffler, Kai
A1  - Schlegel, Christin
A1  - Tim, Sieker
A1  - Stadtmüller, Ralf
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - Biotechnology and bioprocess engineering – from the first ullmann's article to recent trends
JF  - ChemBioEng Reviews
N2  - For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed.
Y1  - 2015
U6  - https://doi.org/10.1002/cben.201500008
VL  - 2
IS  - 3
SP  - 175
EP  - 184
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Leinhos, Marcel
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers
JF  - Physica Status Solidi (A)
N2  - Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution.
Y1  - 2013
U6  - https://doi.org/10.1002/pssa.201200941
SN  - 1521-396X ; 0031-8965
VL  - 210
IS  - 5
SP  - 905
EP  - 910
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Drumm, Christian
A1  - Emhardt, Selina N.
A1  - Kok, Ellen M.
A1  - Jarodzka, Halzka
A1  - Brand-Gruwel, Saskia
A1  - van Gog, Tamara
T1  - How Experts Adapt Their Gaze Behavior When Modeling a Task to Novices
JF  - Cognitive science
N2  - Domain experts regularly teach novice students how to perform a task. This often requires them to adjust their behavior to the less knowledgeable audience and, hence, to behave in a more didactic manner. Eye movement modeling examples (EMMEs) are a contemporary educational tool for displaying experts’ (natural or didactic) problem-solving behavior as well as their eye movements to learners. While research on expert-novice communication mainly focused on experts’ changes in explicit, verbal communication behavior, it is as yet unclear whether and how exactly experts adjust their nonverbal behavior. This study first investigated whether and how experts change their eye movements and mouse clicks (that are displayed in EMMEs) when they perform a task naturally versus teach a task didactically. Programming experts and novices initially debugged short computer codes in a natural manner. We first characterized experts’ natural problem-solving behavior by contrasting it with that of novices. Then, we explored the changes in experts’ behavior when being subsequently instructed to model their task solution didactically. Experts became more similar to novices on measures associated with experts’ automatized processes (i.e., shorter fixation durations, fewer transitions between code and output per click on the run button when behaving didactically). This adaptation might make it easier for novices to follow or imitate the expert behavior. In contrast, experts became less similar to novices for measures associated with more strategic behavior (i.e., code reading linearity, clicks on run button) when behaving didactically.
Y1  - 2020
U6  - https://doi.org/10.1111/cogs.12893
SN  - 1551-6709
VL  - 44
IS  - 9
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Schusser, Sebastian
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Multi-Parametererfassung mit siliziumbasiertem Sensorchip: Aus Drei mach Eins
JF  - GIT Labor-Fachzeitschrift
Y1  - 2014
SN  - 0016-3538
IS  - 2
SP  - 28
EP  - 30
PB  - Wiley
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Reisert, Steffen
A1  - Kramer, Friederike
A1  - Begoyan, Vardges K.
A1  - Buniatyan, Vahe V.
A1  - Schöning, Michael Josef
T1  - Multi-parameter sensing using high-k oxide of barium strontium titanate
JF  - Physica status solidi (a)
N2  - High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors. In this work, a Si-based sensor chip containing Pt interdigitated electrodes covered with a thin BST layer (485 nm) has been developed for multi-parameter chemical sensing. The chip has been applied for the contactless measurement of the electrolyte conductivity, the detection of adsorbed charged macromolecules (positively charged polyelectrolytes of polyethylenimine) and the concentration of hydrogen peroxide (H2O2) vapor. The experimental results of functional testing of individual sensors are presented. The mechanism of the BST sensitivity to charged polyelectrolytes and H2O2 vapor has been proposed and discussed.
Y1  - 2015
U6  - https://doi.org/10.1002/pssa.201431911
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1259
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Laumann, Jörg
A1  - Mainz, Stefan
T1  - Direkte Ermittlung der erforderlichen Einspanntiefe von I‑förmigen Stahlquerschnitten in Betonkonstruktionen
N2  - Für die Ermittlung der erforderlichen Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen existieren verschiedene Bemessungsmodelle. Diese basieren vorwiegend auf Grundlage nationaler Normen wie z. B. DIN 18800 [1] und DIN 1045 [2], die durch die europäische Normung ersetzt wurden. Aus diesem Grund wird in diesem Aufsatz ein Berechnungsmodell für die erforderliche Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen auf Grundlage des Eurocodes vorgestellt. Das Grundgerüst für dieses Berechnungsmodell bildet das Verfahren nach Kindmann und Laumann, welches in [3] behandelt wurde. Gleichzeitig werden neue Formeln zur direkten Ermittlung der Mindesteinspanntiefe vorgestellt. Behandelt werden gewalzte I-Profile für einachsige Biegung um die starke Achse (y-y) mit Drucknormalkraft.
Y1  - 2012
U6  - https://doi.org/10.1002/stab.201201620
SN  - 1437-1049
VL  - 81
IS  - 11
SP  - 850
EP  - 860
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Grinsven, B. van
A1  - Grieten, L.
A1  - Janssens, S. D.
A1  - Vermeeren, V.
A1  - Eersels, K.
A1  - Broeders, J.
A1  - Ameloot, Marcel
A1  - Michiels, L.
A1  - Ceuninck, W. De
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
T1  - Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates
JF  - Physica Status Solidi (A). Vol. 210 (2013), iss. 5
Y1  - 2013
SN  - 0031-8965
SP  - 911
EP  - 917
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Butenweg, Christoph
A1  - Fehling, Ekkehard
T1  - Hintergrund für die vereinfachten Regeln bei Mauerwerksgebäuden im Erdbebenfall
JF  - Mauerwerk : European journal of masonry
N2  - Bei der Ausarbeitung des nationalen Anwendungsdokumentes zur DIN EN 1998-1 waren die in der ENV-Fassung enthaltenen vereinfachten Regeln im Lichte aktueller Forschungsergebnisse zu überprüfen und zu überarbeiten. Die gleiche Aufgabe stellte sich auch für die Neufassung der DIN 4149. In beiden Fällen sind neben konstruktiven Regeln für die Art und Anordnung der zur Gebäudeaussteifung heranzuziehenden Wände im Grundriss Tabellen enthalten, die unter bestimmten Bedingungen den Entfall eines rechnerischen Nachweises der Tragwände im Erdbebenfall ermöglichen. Dies ist für Schwachbebengebiete, wie sie in Deutschland und anderen Ländern Mitteleuropas anzutreffen sind, sinnvoll, um unnötigen Rechenaufwand sowie Probleme mit der Führbarkeit von Nachweisen so weit wie möglich auszuschalten. Im vorliegenden Beitrag werden die Hintergründe der vereinfachten Regeln diskutiert und die Ergebnisse der Anwendung mit verschiedenen Rechenverfahren verglichen und bewertet.
Y1  - 2012
U6  - https://doi.org/10.1002/dama.201200537
SN  - 1437-1022 (E-Journal); 1432-3427 (Print)
VL  - 16
IS  - 3
SP  - 127
EP  - 137
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Butenweg, Christoph
A1  - Gellert, Christoph
T1  - Integrale Gebäudeplanung am Beispiel eines Geschossbaus in Ziegelmauerwerk
JF  - Mauerwerk : European journal of masonry
N2  - Moderne Mauerwerksbauten müssen nach heutigen Anforderungen architektonisch, statisch, energetisch sowie schall- und brandschutztechnisch optimal ausgelegt sein. Aufgrund der Komplexität und engen Verzahnung der einzelnen Anforderungen ist eine integrale Gebäudeplanung zur Erzielung einer qualitativ hochwertigen Bauwerkslösung unbedingt notwendig. Diese erfordert von den Fachplanern vertieftes Spezialwissen in den verschiedenen Bereichen, um insbesondere die Schnittstellen und Bauwerksdetails korrekt zu planen und auszuführen. Der Beitrag stellt die integrale Gebäudeplanung am Beispiel eines Geschossbaus in Ziegelbauweise mit Lösungen für wesentliche Detailpunkte vor
Y1  - 2012
U6  - https://doi.org/10.1002/dama.201200550
SN  - 1437-1022 (E-Journal); 1432-3427 (Print)
VL  - 16
IS  - 5
SP  - 247
EP  - 254
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Brockhaus, Moritz K.
A1  - Behbahani, Mehdi
A1  - Muris, Farina
A1  - Jansen, Sebastian V.
A1  - Schmitz-Rode, Thomas
A1  - Steinseifer, Ulrich
A1  - Clauser, Johanna C.
T1  - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept
JF  - Artificial Organs
N2  - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.
Y1  - 2021
U6  - https://doi.org/10.1111/aor.14046
SN  - 1525-1594
VL  - 45
IS  - 12
SP  - 1513
EP  - 1521
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Ribitsch, D.
A1  - Heumann, S.
A1  - Trotscha, E.
A1  - Herrero Acero, E.
A1  - Greimel, K.
A1  - Leber, R.
A1  - Birner-Gruenberger, R.
A1  - Deller, S.
A1  - Eiteljoerg, I.
A1  - Remler, P.
A1  - Weber, Th.
A1  - Siegert, Petra
A1  - Maurer, Karl-Heinz
A1  - Donelli, I.
A1  - Freddi, G.
A1  - Schwab, H.
A1  - Guebitz, G. M.
T1  - Hydrolysis of polyethyleneterephthalate by p-nitrobenzylesterase from Bacillus subtilis
JF  - Biotechnology progress
Y1  - 2011
SN  - 1520-6033 (E-Journal); 8756-7938 (Print)
VL  - Vol. 27
IS  - Iss. 4
SP  - 951
EP  - 960
PB  - Wiley
CY  - Hoboken
ER  -