TY  - JOUR
A1  - Esch, Thomas
A1  - Salber, W.
A1  - Kemper, Hans
A1  - Staay, F. van der
T1  - Der elektromechanische Ventiltrieb - Systembaustein für zukünftige Antriebskonzepte, Teil 2.
JF  - Motortechnische Zeitschrift (MTZ).
Y1  - 2001
U6  - https://doi.org/10.1007/bf03227081
SN  - 0024-8525
VL  - 62
IS  - 1
SP  - 44
EP  - 55
PB  - Springer Nature
CY  - Basel
ER  - 
TY  - JOUR
A1  - Esch, Thomas
A1  - Salber, W.
A1  - Kemper, Hans
A1  - Staay, F. van der
T1  - Der elektromechanische Ventiltrieb - Systembaustein für zukünftige Antriebskonzepte, Teil 1.
JF  - Motortechnische Zeitschrift (MTZ).
Y1  - 2000
U6  - https://doi.org/10.1007/bf03227081
SN  - 0024-8525
VL  - 61
IS  - 12
SP  - 826
EP  - 836
PB  - Springer Nature
CY  - Basel
ER  - 
TY  - JOUR
A1  - Esch, Thomas
A1  - Funke, Harald
A1  - Roosen, Peter
A1  - Jarolimek, Ulrich
T1  - Biogene Automobilkraftstoffe in der allgemeinen Luftfahrt
JF  - Motortechnische Zeitschrift (MTZ).
Y1  - 2011
SN  - 0024-8525
U6  - https://doi.org/10.1365/s35146-011-0013-7
VL  - 72
IS  - 1
SP  - 54
EP  - 59
PB  - Springer Nature
CY  - Basel
ER  - 
TY  - JOUR
A1  - Esch, Thomas
T1  - Trends in der Nutzfahrzeugantriebstechnik
JF  - Motortechnische Zeitschrift (MTZ)
Y1  - 2010
SN  - 0024-8525
U6  - https://doi.org/10.1007/bf03225608
VL  - 71
IS  - 10
SP  - 652
EP  - 658
PB  - Springer Nature
CY  - Basel
ER  - 
TY  - JOUR
A1  - Atlas, Glen
A1  - Brealey, David
A1  - Dhar, Sunil
A1  - Dikta, Gerhard
A1  - Singer, Meryvn
T1  - Additional hemodynamic measurements with an esophageal Doppler monitor: a preliminary report of compliance, force, kinetic energy, and afterload in the clinical setting
JF  - Journal of clinical monitoring and computing
N2  - The esophageal Doppler monitor (EDM) is a minimally-invasive hemodynamic device which evaluates both cardiac output (CO), and fluid status, by estimating stroke volume (SV) and calculating heart rate (HR). The measurement of these parameters is based upon a continuous and accurate approximation of distal thoracic aortic blood flow. Furthermore, the peak velocity (PV) and mean acceleration (MA), of aortic blood flow at this anatomic location, are also determined by the EDM. The purpose of this preliminary report is to examine additional clinical hemodynamic calculations of: compliance (C), kinetic energy (KE), force (F), and afterload (TSVRi). These data were derived using both velocity-based measurements, provided by the EDM, as well as other contemporaneous physiologic parameters. Data were obtained from anesthetized patients undergoing surgery or who were in a critical care unit. A graphical inspection of these measurements is presented and discussed with respect to each patient’s clinical situation. When normalized to each of their initial values, F and KE both consistently demonstrated more discriminative power than either PV or MA. The EDM offers additional applications for hemodynamic monitoring. Further research regarding the accuracy, utility, and limitations of these parameters is therefore indicated.
KW  - Acceleration
KW  - Velocity
KW  - Kinetic energy
KW  - Force
KW  - Compliance
KW  - Afterload
KW  - Contractility
KW  - Volume status
KW  - Esophageal Doppler monitor
Y1  - 2012
SN  - 1573-2614
U6  - https://doi.org/10.1007/s10877-012-9386-5
IS  - 26
SP  - 473
EP  - 482
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Srivastava, A.
A1  - Lahiri, S.
A1  - Maiti, M.
A1  - Knolle, F.
A1  - Hoyler, Friedrich
A1  - Scherer, Ulrich W.
A1  - Schnug, E. W.
T1  - Study of naturally occurring radioactive material (NORM) in top soil of Punjab State from the North Western part of India
JF  - Journal of Radioanalytical and Nuclear Chemistry
Y1  - 2014
U6  - https://doi.org/0.1007/s10967-014-3450-1
SN  - 1588-2780 (E-Journal); 0022-4081 (Print); 0134-0719 (Print); 0236-5731 (Print); 1417-2097 (Print)
VL  - 2014
IS  - 302
SP  - 1049
EP  - 1052
PB  - Springer Nature
CY  - Basel
ER  - 
TY  - JOUR
A1  - Ratke, Lorenz
A1  - Milow, Barbara
A1  - Lisinski, Susanne
A1  - Hoepfner, Sandra
T1  - On an effect of fine ceramic particles on the structure of aerogels
JF  - Microgravity science and technology
Y1  - 2014
U6  - https://doi.org/10.1007/s12217-014-9380-2
SN  - 0938-0108 ; 1875-0494
VL  - 26
SP  - 103
EP  - 110
PB  - Springer Nature
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - https://doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - JOUR
A1  - Kornfeld, Jan-Wilhelm
A1  - Baitzel, Catherina
A1  - Könner, A. Christine
A1  - Nicholls, Hayley T.
A1  - Vogt, Merly C.
A1  - Herrmanns, Karolin
A1  - Scheja, Ludger
A1  - Haumaitre, Cécile
A1  - Wolf, Anna M.
A1  - Knippschild, Uwe
A1  - Seibler, Jost
A1  - Cereghini, Silvia
A1  - Heeren, Joerg
A1  - Stoffel, Markus
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
JF  - Nature
Y1  - 2013
SN  - 0028-0836
U6  - https://doi.org/10.1038/nature11793
VL  - 494
IS  - 7435
SP  - 111
EP  - 115
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Schoenrock, Britt
A1  - Muckelt, Paul E.
A1  - Hastermann, Maria
A1  - Albracht, Kirsten
A1  - MacGregor, Robert
A1  - Martin, David
A1  - Gunga, Hans-Christian
A1  - Salanova, Michele
A1  - Stokes, Maria J.
A1  - Warner, Martin B.
A1  - Blottner, Dieter
T1  - Muscle stiffness indicating mission crew health in space
JF  - Scientific Reports
N2  - Muscle function is compromised by gravitational unloading in space affecting overall musculoskeletal health. Astronauts perform daily exercise programmes to mitigate these effects but knowing which muscles to target would optimise effectiveness. Accurate inflight assessment to inform exercise programmes is critical due to lack of technologies suitable for spaceflight. Changes in mechanical properties indicate muscle health status and can be measured rapidly and non-invasively using novel technology. A hand-held MyotonPRO device enabled monitoring of muscle health for the first time in spaceflight (> 180 days). Greater/maintained stiffness indicated countermeasures were effective. Tissue stiffness was preserved in the majority of muscles (neck, shoulder, back, thigh) but Tibialis Anterior (foot lever muscle) stiffness decreased inflight vs. preflight (p < 0.0001; mean difference 149 N/m) in all 12 crewmembers. The calf muscles showed opposing effects, Gastrocnemius increasing in stiffness Soleus decreasing. Selective stiffness decrements indicate lack of preservation despite daily inflight countermeasures. This calls for more targeted exercises for lower leg muscles with vital roles as ankle joint stabilizers and in gait. Muscle stiffness is a digital biomarker for risk monitoring during future planetary explorations (Moon, Mars), for healthcare management in challenging environments or clinical disorders in people on Earth, to enable effective tailored exercise programmes.
KW  - Ageing
KW  - Anatomy
KW  - Muscle
KW  - Musculoskeletal system
KW  - Physiology
Y1  - 2024
U6  - https://doi.org/10.1038/s41598-024-54759-6
SN  - 2045-2322
N1  - Corresponding author: Dieter Blottner
VL  - 14
IS  - Article number: 4196
PB  - Springer Nature
CY  - London
ER  -