TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Martens, D.
A1  - Liu, X.
A1  - Bienstman, P.
A1  - Fahlman, M.
A1  - Schöning, Michael Josef
A1  - Michiels, L.
A1  - Haenen, K.
A1  - Serpengüzel, A.
A1  - Wagner, Patrick
T1  - Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands
JF  - Sensors and actuators A: Physical
N2  - In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.sna.2014.11.024
SN  - 1873-3069 (E-Journal); 0924-4247 (Print)
VL  - 222
SP  - 212
EP  - 219
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schütz, S.
A1  - Weißbecker, B.
A1  - Hummel, Hans E.
A1  - Schöning, Michael Josef
A1  - Riemer, A.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Field effect transistor-insect antenna junction
JF  - Naturwissenschaften
Y1  - 1997
SN  - 1432-1904
VL  - 84
SP  - 86
EP  - 88
ER  - 
TY  - JOUR
A1  - Thust, Marion
A1  - Schöning, Michael Josef
A1  - Frohnhoff, S.
A1  - Arens-Fischer, R.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Porous silicon as a substrate material for potentiometric biosensors
JF  - Measurement Science and Technology
Y1  - 1996
U6  - http://dx.doi.org/10.1088/0957-0233/7/1/003
VL  - 7
IS  - 1
SP  - 26
EP  - 29
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Bäcker, Matthias
T1  - Chip-basierte Sensoren für die Biotechnik
Y1  - 2012
SN  - 1611-0854
N1  - 4 Seiten
VL  - 13
IS  - 2
PB  - BIOCOM
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Miyamoto, K.
A1  - Werner, Frederik
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
T1  - Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS)
Y1  - 2011
U6  - http://dx.doi.org/10.1166/sl.2011.1620
VL  - 9
IS  - 2
SP  - 812
EP  - 815
PB  - American Scientific Publishers
CY  - Stevenson Ranch, Calif.
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - BioFEDs (field-effect devices) : State-of-the-art and new directions
JF  - Electroanalysis
Y1  - 2006
U6  - http://dx.doi.org/10.1002/elan.200603609
SN  - 1521-4109
VL  - 18
IS  - 19-20
SP  - 1893
EP  - 1900
ER  - 
TY  - JOUR
A1  - Spelthahn, Heiko
A1  - Schubert, Jürgen
A1  - Schöning, Michael Josef
T1  - Dünnschichtsensoren für die Schwermetallanalytik : Mikroelektroden auf Chalkogenidglasbasis
JF  - GIT Labor-Fachzeitschrift
N2  - Die Detektion von Schadstoffen repräsentiert in der Umweltanalytik eine wichtige Aufgabenstellung. Gerade die Abwasser- bzw. Brauchwasseranalytik sowie die Prozesskontrolle haben einen hohen Stellenwert. Siliziumbasierte Dünnschichtsensoren bieten eine kostengünstige Möglichkeit, „online“-Messungen bzw. Vor-Ort-Messungen zeitnah durchzuführen. In dieser Arbeit wird ein potentiometrisches Sensorarray auf der Basis von Chalkogenidgläsern zur Detektion von Schwermetallen in wässrigen Medien vorgestellt.
Y1  - 2012
IS  - 4
SP  - 285
EP  - 287
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wu, Chunsheng
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Werner, Frederik
A1  - Schöning, Michael Josef
T1  - Label-free detection of DNA using light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer
JF  - Nanoscale
N2  - A multi-spot (16 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al–p-Si–SiO2 structure modified with a weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. To achieve a preferentially flat orientation of DNA strands and thus, to reduce the distance between the DNA charge and MLAPS surface, the negatively charged probe single-stranded DNAs (ssDNA) were electrostatically adsorbed onto the positively charged PAH layer using a simple layer-by-layer (LbL) technique. In this way, more DNA charge can be positioned within the Debye length, yielding a higher sensor signal. The surface potential changes in each spot induced due to the surface modification steps (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), non-specific adsorption of mismatched ssDNA) were determined from the shifts of photocurrent–voltage curves along the voltage axis. A high sensor signal of 83 mV was registered after immobilization of probe ssDNA onto the PAH layer. The hybridization signal increases from 5 mV to 32 mV with increasing the concentration of cDNA from 0.1 nM to 5 μM. In contrast, a small signal of 5 mV was recorded in the case of non-specific adsorption of fully mismatched ssDNA (5 μM). The obtained results demonstrate the potential of the MLAPS in combination with the simple and rapid LbL immobilization technique as a promising platform for the future development of multi-spot light-addressable label-free DNA chips with direct electrical readout.
Y1  - 2015
U6  - http://dx.doi.org/10.1039/C4NR07225A
VL  - 14
IS  - 7
SP  - 6143
EP  - 6150
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Beging, Stefan
A1  - Leinhos, Marcel
A1  - Jablonski, Melanie
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Studying the spatially resolved immobilisation of enzymes on a capacitive field-effect structure by means of nano-spotting
JF  - Physica status solidi (a)
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431891
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1353
EP  - 1358
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Katz, Evgeny
A1  - Schöning, Michael Josef
T1  - Enzyme logic AND-Reset and OR-Reset gates based on a field-effect electronic transducer modified with multi-enzyme membrane
JF  - Chemical Communications
N2  - Capacitive field-effect sensors modified with a multi-enzyme membrane have been applied for an electronic transduction of biochemical signals processed by enzyme-based AND-Reset and OR-Reset logic gates. The local pH change at the sensor surface induced by the enzymatic reaction was used for the activation of the Reset function for the first time.
Y1  - 2015
U6  - http://dx.doi.org/10.1039/C5CC01362C
VL  - 51
SP  - 6564
EP  - 6567
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  -