TY  - JOUR
A1  - Hoehr, Cornelia
A1  - Paulßen, Elisabeth
A1  - Benard, Francois
A1  - Lee, Chris Jaeil
A1  - Hou, Xinchi
A1  - Badesso, Brian
A1  - Ferguson, Simon
A1  - Miao, Qing
A1  - Yang, Hua
A1  - Buckley, Ken
A1  - Hanemaayer, Victoire
A1  - Zeisler, Stefan
A1  - Ruth, Thomas J.
A1  - Celler, Anna
A1  - Schaffer, Paul
T1  - ⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron
JF  - Nuclear medicine and biology
N2  - Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.
Y1  - 2014
U6  - https://doi.org/10.1016/j.nucmedbio.2013.12.016
SN  - 1872-9614
VL  - 41
IS  - 5
SP  - 401
EP  - 406
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Fiedler, Thomas M.
A1  - Ladd, Mark E.
A1  - Bitz, Andreas
T1  - SAR Simulations & Safety
JF  - NeuroImage
Y1  - 2017
U6  - https://doi.org/10.1016/j.neuroimage.2017.03.035
SN  - 1053-8119
IS  - Epub ahead of print
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Orzada, Stephan
A1  - Fiedler, Thomas M.
A1  - Bitz, Andreas
A1  - Ladd, Mark E.
A1  - Quick, Harald H.
T1  - Local SAR compression with overestimation control to reduce maximum relative SAR overestimation and improve multi-channel RF array performance
JF  - Magnetic Resonance Materials in Physics, Biology and Medicine
N2  - Objective
In local SAR compression algorithms, the overestimation is generally not linearly dependent on actual local SAR. This can lead to large relative overestimation at low actual SAR values, unnecessarily constraining transmit array performance.

Method
Two strategies are proposed to reduce maximum relative overestimation for a given number of VOPs. The first strategy uses an overestimation matrix that roughly approximates actual local SAR; the second strategy uses a small set of pre-calculated VOPs as the overestimation term for the compression.

Result
Comparison with a previous method shows that for a given maximum relative overestimation the number of VOPs can be reduced by around 20% at the cost of a higher absolute overestimation at high actual local SAR values.

Conclusion
The proposed strategies outperform a previously published strategy and can improve the SAR compression where maximum relative overestimation constrains the performance of parallel transmission.
Y1  - 2020
SN  - 1352-8661
U6  - https://doi.org/10.1007/s10334-020-00890-0
IS  - 34 (2021)
SP  - 153
EP  - 164
PB  - Springer
CY  - Heidelberg
ER  -