TY - JOUR A1 - Immel, Timo A. A1 - Groth, Ulrich A1 - Huhn, Thomas A1 - Öhlschläger, Peter T1 - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice JF - PLoS ONE N2 - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future. Y1 - 2011 U6 - http://dx.doi.org/10.1371/journal.pone.0017869 VL - 6 IS - 3 PB - Plos CY - San Francisco, California, US ER - TY - JOUR A1 - Hüning, Felix T1 - PowerMOSFETs in ANL2-Technologie : Ansteuerungen bis in den kW-Bereich mit wenig Verlustleistung und Platzbedarf JF - Elektronik-Industrie Y1 - 2011 SN - 0174-5522 VL - 42 IS - 10 SP - 36 EP - 39 PB - Hüthig CY - Heidelberg ER - TY - JOUR A1 - Huck, Christina A1 - Jolly, Christina A1 - Wagner, Patrick A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen JF - Procedia Engineering. 25 (2011) Y1 - 2011 SN - 1877-7058 N1 - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece SP - 1161 EP - 1164 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Herzwurm, Georg A1 - Fehlmann, Thomas A1 - Pietsch, Wolfram A1 - Schockert, Sixten T1 - Der Qualität ein Haus. Best-Practice-Analyse des Quality Function Deployments JF - Qualität und Zuverlässigkeit : QZ Y1 - 2011 SN - 0720-1214 VL - 56 IS - 8 SP - 23 EP - 27 PB - Hanser CY - München ER - TY - JOUR A1 - Heiden, W. A1 - Turek, M. A1 - Schöning, Michael Josef T1 - TasteIT : Analyzing chemical sensor data using fuzzy logic Y1 - 2011 SN - 978-1-4244-9910-6 N1 - 2011 IEEE Workshop on Merging Fields of Computational Intelligence and Sensor Technology ; 11.-15. April 2011 Paris, France SP - 1 EP - 6 PB - IEEE CY - New York ER - TY - JOUR A1 - Heiden, W. A1 - Turek, M. A1 - Schöning, Michael Josef T1 - Analysis of chemical sensor data JF - Proceedings of the 4th Russian-German Workshop "Innovation Information Technologies: Theory and practice" : Ufa, Russia, April 8-13, 2011 / eds. Yupsova, Nafisa ... Y1 - 2011 SN - 978-5-4221-0159-7 SP - 76 EP - 81 PB - State Aviation Technical Univ. CY - Ufa ER - TY - JOUR A1 - Hegger, Josef A1 - Claßen, Martin A1 - Feldmann, Markus A1 - Döring, Bernd A1 - Schaumann, Peter A1 - Sothmann, Jörg A1 - Bohne, Dirk A1 - Hargus, Steen A1 - Barben, Daniel A1 - Aarden, Erik A1 - Schielke, Sabine T1 - Integrierte und nachhaltigkeitsorientierte Deckensysteme im Stahl- und Verbundbau JF - Stahlbau Y1 - 2011 SN - 1437-1049 (E-Journal); 0038-9145 (Print) VL - Vol. 80 IS - Iss. 10 SP - 728 EP - 733 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Hebel, Christoph A1 - Billion, Bernd A1 - Johänning, Katja T1 - Evaluation von Planungswerkstätten in der StädteRegion JF - Stadt Region Land. 2011 (2011), H. 88 Y1 - 2011 SN - 978-3-88354-162-4 SP - 15 EP - 20 PB - RWTH CY - Aachen ER - TY - JOUR A1 - Hebel, Christoph T1 - Anwendungen von makroskopischen Personenverkehrsnachfragemodellen JF - Stadt Region Land. 2011 (2011), H. 88 Y1 - 2011 SN - 978-3-88354-162-4 SP - 7 EP - 14 PB - ISB CY - Aachen ER - TY - JOUR A1 - Hebel, Christoph T1 - Makroskopische Personenverkehrsnachfragemodelle: Anwendungspraxis in deutschen Großstädten JF - Ansprüche einer mobilen Gesellschaft an ein verlässliches Verkehrssystem / hrsg. Deutsche Verkehrswissenschaftliche Gesellschaft e. V Y1 - 2011 SN - 978-3-942488-05-1 N1 - DVWG-Jahresband ; 2009/10 SP - 226 EP - 231 PB - Dt. Verkehrswiss. Ges. CY - Berlin ER -