TY  - JOUR
A1  - Pookhalil, Ali
A1  - Amoabediny, Ghassem
A1  - Tabesh, Hadi
A1  - Behbahani, Mehdi
A1  - Mottaghy, Khosrow
T1  - A new approach for semiempirical modeling of mechanical blood trauma
JF  - The international journal of artificial organs
N2  - Purpose
Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena.
Methods
Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model.
Results
A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained.
Conclusions
The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.
Y1  - 2016
U6  - https://doi.org/10.5301/ijao.5000474
SN  - 1724-6040
VL  - 39
IS  - 4
SP  - 171
EP  - 177
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Hoffschmidt, Bernhard
A1  - Pitz-Paal, Robert
A1  - Böhmer, M.
T1  - A new closed/open volumetric receiver concept for parabolictrough collectors (test results)
JF  - Journal de physique. 9 (1999), H. 3
Y1  - 1999
SN  - 1155-4339
SP  - 3
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Schmidt, S.
A1  - Büchs, J.
A1  - Born, C.
T1  - A new correlation for the wall-to-fluid mass transfer in liquid-sol fluidized beds / Schmidt, S. ; Büchs, J. ; Born, C. ; Biselli, M.
JF  - Chemical Engineering Science. 54 (1999), H. 6
Y1  - 1999
SN  - 0009-2509
SP  - 829
EP  - 839
ER  - 
TY  - JOUR
A1  - Linder, Peter
A1  - Beckler, Matthias
A1  - Doerr, Leo
A1  - Stoelzle-Feix, Sonja
A1  - Fertig, Niels
A1  - Jung, Alexander
A1  - Staat, Manfred
A1  - Gossmann, Matthias
T1  - A new in vitro tool to investigate cardiac contractility under physiological mechanical conditions
JF  - Journal of Pharmacological and Toxicological Methods
Y1  - 2019
U6  - https://doi.org/10.1016/j.vascn.2019.05.162
SN  - 1056-8719
VL  - 99
IS  - Article number 106595
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jeromin, Günter Erich
A1  - Zoor, Annegreth
T1  - A new irreversible enzyme-aided esterification method in organic solvents
JF  - Biotechnology letters. 30 (2008), H. 5
Y1  - 2008
SN  - 1573-6776
SP  - 925
EP  - 928
ER  - 
TY  - JOUR
A1  - Grottke, O.
A1  - Braunschweig, T.
A1  - Philippen, B.
A1  - Gatzweiler, Karl-Heinz
A1  - Gronloh, N.
A1  - Staat, Manfred
A1  - Rossaint, R.
A1  - Tolba, R.
T1  - A New Model for Blunt Liver Injuries in the Swine
JF  - European Surgical Research. 44 (2010), H. 2
Y1  - 2010
SN  - 1421-9921
SP  - 65
EP  - 73
ER  - 
TY  - JOUR
A1  - Kürten, Sylvia
A1  - Mottaghy, Darius
A1  - Ziegler, Martin
T1  - A new model for the description of the heat transfer for plane thermo-active geotechnical systems based on thermal resistances
JF  - Acta Geotechnica
Y1  - 2015
U6  - https://doi.org/10.1007/s11440-014-0311-6
SN  - 1861-1133
VL  - 10
IS  - 2
SP  - 219
EP  - 229
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Schwarzer, Klemens
A1  - da Silva, Vieira E.
A1  - Hoffschmidt, Bernhard
A1  - Schwarzer, T.
T1  - A new solar desalination system with heat recovery for decentralised drinking water production
JF  - Desalination. 248 (2009), H. 1-3
Y1  - 2009
SN  - 0011-9164
N1  - Water and Sanitation in International Development and Disaster Relief (WSIDDR) International Workshop Edinburgh, Scotland, UK, 28–30 May 2008
SP  - 204
EP  - 211
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Mourzina, Y.G.
A1  - Schöning, Michael Josef
A1  - Schubert, J.
A1  - Zander, W.
A1  - Legin, A. V.
A1  - Vlasov, Y. G.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - A new thin film Pb microsensor based on chalcogenide glasses
JF  - Sensors and Actuators B. 71 (2000), H. 1-2
Y1  - 2000
SN  - 0925-4005
SP  - 13
EP  - 18
ER  - 
TY  - JOUR
A1  - Göttsche, Joachim
A1  - Goetzberger, Adolf
A1  - Dengler, J.
A1  - Rommel, M. (u.a.)
T1  - A new transparently insulated, bifacially irradiated solar flat-plate collector / A. Goetzberger ; J. Dengler ; M. Rommel ; J. Göttsche ; V. Wittwer
JF  - Solar energy. 49 (1992), H. 5
Y1  - 1992
SN  - 0038-092X
SP  - 403
EP  - 411
ER  -