TY  - JOUR
A1  - Vogt, Christian
A1  - Iwanowski-Strahser, Katha
A1  - Marquart, Gabriele
A1  - Arnold, Juliane
A1  - Mottaghy, Darius
A1  - Pechnig, Renate
A1  - Gnjezda, Daniel
A1  - Clauser, Christoph
T1  - Modeling contribution to risk assessment of thermal production power for geothermal reservoirs
JF  - Renewable Energy
Y1  - 2013
U6  - https://doi.org/10.1016/j.renene.2012.11.026
SN  - 0960-1481
VL  - 53
SP  - 230
EP  - 241
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - McEwan, Jillian
A1  - Beuger, Vincent
A1  - Stanley, Lesley A.
A1  - Rode, Anja
A1  - Wolf, C. Roland
T1  - Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines
JF  - Molecular Pharmacology
N2  - The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.
Y1  - 2012
U6  - https://doi.org/10.1124/mol.111.075192
SN  - 1521-0111
VL  - 81
IS  - 1
SP  - 63
EP  - 72
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Pietsch, Wolfram
A1  - Kurbel, Karl
A1  - Jung, R.
T1  - Modeling Knowledge about Long-term IS-Integration and Integration-oriented Reengineering with KADS / Kurbel, K., Jung, R., Pietsch, W.
JF  - Distributed information systems in business / W. König ... (eds.)
Y1  - 1996
SN  - 3-540-61094-4
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Ritz, Thomas
A1  - Stender, Michael
T1  - Modeling of B2B mobile commerce processes
JF  - International Journal of Production Economics
Y1  - 2006
U6  - https://doi.org/10.1016/j.ijpe.2005.05.017
SN  - 0925-5273
VL  - 101
IS  - 1
SP  - 128
EP  - 139
ER  - 
TY  - JOUR
A1  - Slabu, Ioana
A1  - Roeth, Anjali A.
A1  - Engelmann, Ulrich M.
A1  - Wiekhorst, Frank
A1  - Buhl, Eva M.
A1  - Neumann, Ulf P.
A1  - Schmitz-Rode, Thomas
T1  - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro
JF  - Nanotechnology
Y1  - 2019
U6  - https://doi.org/10.1088/1361-6528/ab033e
SN  - 1361-6528
VL  - 30
IS  - 18
SP  - 184004
ER  - 
TY  - JOUR
A1  - Damm, Alexander
A1  - Erler, André
A1  - Hillen, Walter
A1  - Meroni, Michele
A1  - Schaepman, Michael E.
A1  - Verhoef, Wout
A1  - Rascher, Uwe
T1  - Modeling the impact of spectral sensor configurations on the FLD retrieval accuracy of sun-induced chlorophyll fluorescence
JF  - Remote Sensing of Environment
Y1  - 2011
SN  - 0034-4257
VL  - 115
IS  - 8
SP  - 1882
EP  - 1892
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Waluga, C.
A1  - Stock, S.
A1  - Mai, A.
A1  - Bergmann, B.
A1  - Behr, M.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Scheidt, H.
A1  - Oedekoven, B.
A1  - Mottaghy, K.
T1  - Modelling and Numerical Analysis of Platelet Reactions and Surface Thrombus Growth
Y1  - 2009
N1  - Posterpresentation ; European Society of Biomaterials (ESB), Lausanne, Switzerland, September 7-10, 2009
ER  - 
TY  - JOUR
A1  - Prume, Klaus
A1  - Franken, Klaus
A1  - Böttger, Ulrich
A1  - Waser, Rainer
T1  - Modelling and numerical simulation of the electrical, mechanical, and thermal coupled behaviour of Multilayer capacitors (MLCs) / Prume, Klaus ; Franken, Klaus ; Böttger, Ulrich ; Waser, Rainer ; Maier, Horst R.
JF  - Journal of the European Ceramic Society. 22 (2002), H. 8
Y1  - 2002
SN  - 0955-2219
SP  - 1285
EP  - 1296
ER  - 
TY  - JOUR
A1  - Reisgen, Uwe
A1  - Schleser, Markus
A1  - Mokrov, Oleg
A1  - Zabirov, Alexander
A1  - Füssel, Uwe
A1  - Schnick, Michael
A1  - Hertel, Martin
A1  - Jaeckel, Sebastian
T1  - Modelling and visualisation of the GMA process
JF  - Welding and Cutting
Y1  - 2012
SN  - 1612-3433
VL  - 11
IS  - 4
SP  - 242
EP  - 249
PB  - DVS Verlag
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Faßbender, Heinz
A1  - Bühler, Gerhard
T1  - Modelling command and control information systems by UML
JF  - Proceedings of the Information Systems Technology Panel Symposium / Information Management Challenges in Achieving Coalition Interoperability, Mai 2001, Quebec City, Kanada
Y1  - 2001
SP  - 7-1
EP  - 7-9
ER  -