TY - JOUR A1 - Öhlschläger, Peter A1 - Spies, Elmar A1 - Alvarez, Gerardo A1 - Quetting, Michael A1 - Groettrup, Marcus T1 - The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA JF - International Journal of Cancer. 128 (2011), H. 2 Y1 - 2011 SN - 1097-0215 SP - 473 EP - 481 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Immel, Timo A. A1 - Groth, Ulrich A1 - Huhn, Thomas A1 - Öhlschläger, Peter T1 - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice JF - PLoS ONE N2 - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future. Y1 - 2011 U6 - https://doi.org/10.1371/journal.pone.0017869 VL - 6 IS - 3 PB - Plos CY - San Francisco, California, US ER - TY - JOUR A1 - Manea, Marilena A1 - Leurs, Ulrike A1 - Orban, Erika A1 - Baranyai, Zsuzsa A1 - Öhlschläger, Peter A1 - Marquardt, Andreas A1 - Schulcz, Akos A1 - Tejeda, Miguel T1 - Enhanced Enzymatic Stability and Antitumor Activity of Daunorubicin-GnRH-III Bioconjugates Modified in Position 4 JF - Bioconjugate Chemistry Y1 - 2011 SN - 1520-4812 VL - 22 IS - 7 SP - 1320 EP - 1329 PB - ACS CY - Washington, DC ER - TY - JOUR A1 - Spiess, Elmar A1 - Wilfried, Reichardt A1 - Alvarez, Gerardo A1 - Gottrup, Marcus A1 - Öhlschläger, Peter T1 - An Artificial PAP Gene Breaks Self-tolerance and Promotes Tumor Regression in the TRAMP Model for Prostate Carcinoma JF - Molecular Therapy Y1 - 2011 SN - 1525-0016 VL - 20 IS - 3 SP - 555 EP - 564 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Arida, Hassan A. A1 - Al-haddad, Ameera A1 - Schöning, Michael Josef T1 - New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode JF - International Journal of Electrochemical Science. 6 (2011), H. 9 Y1 - 2011 SN - 1452-3981 SP - 3858 EP - 3867 ER - TY - JOUR A1 - Kern, Alexander A1 - Scheibe, Klaus T1 - Die neuen internationalen Blitzschutz-Standards der Reihe IEC 62305:2010 : Überblick und Stand der Umsetzung in die nationale Normenreihe DIN EN 62305 JF - 9. VDE/ABB-Blitzschutztagung : Vorträge der 9. VDE/ABB-Fachtagung vom 27. bis 28. Oktober 2011 in Neu-Ulm / Veranst.: Ausschuss für Blitzschutz und Blitzforschung (ABB) im VDE Verband der Elektrotechnik Elektronik Informationstechnik e.V. Wiss. Tagungsleitung: K. Stimper Y1 - 2011 SN - 978-3-8007-3380-4 N1 - VDE/ABB-Blitzschutztagung ; (9 ; 2011.10.27-28 ; Neu-Ulm) SP - 7 EP - 12 PB - VDE-Verl. CY - Berlin ER - TY - JOUR A1 - Bühler, Yves A1 - Christen, Marc A1 - Kowalski, Julia A1 - Bartelt, Perry T1 - Sensitivity of snow avalanche simulations to digital elevation model quality and resolution JF - Annals of Glaciology N2 - Digital elevation models (DEMs), represent the three-dimensional terrain and are the basic input for numerical snow avalanche dynamics simulations. DEMs can be acquired using topographic maps or remote-sensing technologies, such as photogrammetry or lidar. Depending on the acquisition technique, different spatial resolutions and qualities are achieved. However, there is a lack of studies that investigate the sensitivity of snow avalanche simulation algorithms to the quality and resolution of DEMs. Here, we perform calculations using the numerical avalance dynamics model RAMMS, varying the quality and spatial resolution of the underlying DEMs, while holding the simulation parameters constant. We study both channelized and open-terrain avalanche tracks with variable roughness. To quantify the variance of these simulations, we use well-documented large-scale avalanche events from Davos, Switzerland (winter 2007/08), and from our large-scale avalanche test site, Valĺee de la Sionne (winter 2005/06). We find that the DEM resolution and quality is critical for modeled flow paths, run-out distances, deposits, velocities and impact pressures. Although a spatial resolution of ~25 m is sufficient for large-scale avalanche modeling, the DEM datasets must be checked carefully for anomalies and artifacts before using them for dynamics calculations. KW - snow KW - avalanche Y1 - 2011 SN - 1727-5644 VL - 52 IS - 58 SP - 72 EP - 80 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Pieper, Martin A1 - Klein, Peter T1 - A simple and accurate numerical network flow model for bionic micro heat exchangers JF - Heat mass transfer Y1 - 2011 SN - 0947-7411 VL - 47 IS - 5 SP - 491 EP - 503 PB - Springer CY - Berlin ER - TY - JOUR A1 - Pieper, Martin T1 - Multiobjective optimization with expensive objectives applied to a thermodynamic material design problem JF - Proceedings in applied mathematics and mechanics : PAMM. 11 (2011), H. 1 Y1 - 2011 SN - 1617-7061 SP - 733 EP - 734 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Fabo, Sabine ED - Mohr, Klaus T1 - Im Reich der Sinne JF - Die Dreiundzwanzigste (Boxhorn ; 23) N2 - Nach einer halben Stunde Vorführzeit im Hörsaal hört man das Zuschlagen der Tür, die ersten genervten Zuschauer fliehen. In den nächsten 30 Minuten werden ihnen noch viele folgen, bis letztlich wenige Interessierte bis zum Abspann des Films bleiben. KW - Pornographie KW - Zuschauer Y1 - 2011 SN - 1864-2535 SP - 42 EP - 44 PB - Fachhochschule CY - Aachen ER -