TY - CHAP A1 - Samuelsson, K. A1 - Scheer, Nico A1 - Wilson, I. A1 - Wolf, C.R. A1 - Henderson, C.J. ED - Chackalamannil, Samuel T1 - Genetically Humanized Animal Models T2 - Comprehensive Medicinal Chemistry III. 3rd Edition N2 - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development. KW - Chimeric liver-humanized mice KW - Drug distribution KW - Drug metabolism KW - Toxicology KW - Knockout mice Y1 - 2017 SN - 978-0-12-803201-5 U6 - https://doi.org/10.1016/B978-0-12-409547-2.12376-5 SP - 130 EP - 149 PB - Elsevier CY - Saint Louis ER - TY - CHAP A1 - Butenweg, Christoph T1 - Passt, wackelt und hat Luft: Mauerwerksbauten aus Leichtbeton in Erdbebengebieten T2 - Beton-Bauteile, 65. Ausgabe (2017): Entwerfen - Planen - Ausführen Y1 - 2017 SN - 978-3-7625-3676-5 N1 - gedruckt in der Bereichsbibliothek Bayernallee unter der Signatur 11 XCF 81-2017 vorhanden SP - 136 EP - 140 PB - Bauverl. CY - Gütersloh ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Nguyen, Nhu Huynh A1 - Staat, Manfred T1 - Physical response of hyperelastic models for composite materials and soft tissues T2 - Advances in Composite Material Y1 - 2017 SN - 978-1-61896-300-0 (Hardcover), 978-1-61896-299-7 (Paperback) N1 - Chapter 5 PB - Scientific Research Publishing CY - Wuhan ER - TY - CHAP A1 - Barnat, Miriam A1 - Bosse, Elke A1 - Tight, Malcolm T1 - The Guiding Role of Theory in Mixed-Methods Research: Combining Individual and Institutional Perspectives on the Transition to Higher Education T2 - Theory and Method in Higher Education Research. Vol 3 N2 - The methodological discourse of mixed-methods research offers general procedures to combine quantitative and qualitative methods for investigating complex fields of research such as higher education. However, integrating different methods still poses considerable challenges. To move beyond general recommendations for mixed-methods research, this chapter proposes to discuss methodological issues with respect to a particular research domain. Taking current studies on the transition to higher education as an example, the authors first provide an overview of the potentials and limitations of quantitative and qualitative methods in the research domain. Second, they show the need for a conceptual framework grounded in the theory of the research object to guide the integration of different methods and findings. Finally, an example study that investigates transition with regard to the interplay of the individual student and the institutional context serves to illustrate the guiding role of theory. The framework integrates different theoretical perspectives on transition, informs the selection of the research methods, and defines the nexus of the two strands that constitute the mixed-methods design. As the interplay of individual and context is of concern for teaching and learning in general, the example presented may be fruitful for the wider field of higher education research. KW - Quantitative research KW - Mixed-Methods Research KW - Transition KW - Students KW - Higher education Y1 - 2017 SN - 978-1-78743-222-2 U6 - https://doi.org/10.1108/S2056-375220170000003001 SP - 1 EP - 19 PB - Emerald Publishing Limited ER - TY - CHAP A1 - Wilke, Thomas T1 - Peyre, Marie-Josephe T2 - Allgemeines Künstler-Lexikon. Bd. 95 Y1 - 2017 SN - 978-3-11-023261-5 N1 - namentlich gekennzeichneter Lexikon-Eintrag SP - 301 EP - 302 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Wilke, Thomas T1 - Peyre, Antoine-Francois T2 - Allgemeines Künstler-Lexikon. Bd. 95 Y1 - 2017 SN - 978-3-11-023261-5 N1 - namentlich gekennzeichneter Lexikon-Eintrag SP - 300 EP - 301 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Wilke, Thomas T1 - Patte, Pierre T2 - Allgemeines Künstler-Lexikon. Bd. 94 Y1 - 2017 SN - 978-3-11-023260-8 N1 - namentlich gekennzeichneter Lexikon-Eintrag SP - 429 EP - 430 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Wilke, Thomas T1 - Ranson, Pierre T2 - Allgemeines Künstler-Lexikon. Online Y1 - 2017 N1 - namentlich gekennzeichneter Lexikon-Eintrag PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Herrmann, Ulf A1 - Kearney, D. A1 - Röger, M. A1 - Prahl, C. T1 - System performance measurements T2 - The Performance of Concentrated Solar Power (CSP) Systems : Modelling, Measurement and Assessment N2 - This chapter introduces performance and acceptance testing and describes state-of-the-art tools, methods, and instruments to assess the plant performance or realize plant acceptance testing. The status of the development of standards for performance assessment is given. KW - Performance measurement KW - Acceptance tests KW - Plant efficiency Y1 - 2017 SN - 978-0-08-100448-7 U6 - https://doi.org/https://doi.org/10.1016/B978-0-08-100447-0.00005-5 SP - 115 EP - 165 PB - Woodhead Publishing CY - Duxford ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin ED - Weller, Marc-Philippe ED - Kindler, Peter T1 - Art. 48 EGBGB: Wahl eines in einem anderen Mitgliedstaat der Europäischen Union erworbenen Namens, Rn. 5-8, Rn. 11-14, Rn. 45-47, Rn. 48-51 T2 - Beck‘scher Online-Großkommentar zum Bürgerlichen Recht (BeckOGK), Band: Internationales Privatrecht Y1 - 2017 PB - C.H.Beck CY - München ER -