TY - CHAP A1 - Marinova, V. A1 - Kerroumi, I. A1 - Lintermann, A. A1 - Göbbert, J.H. A1 - Moulinec, C. A1 - Rible, S. A1 - Fournier, Y. A1 - Behbahani, Mehdi T1 - Numerical Analysis of the FDA Centrifugal Blood Pump T2 - NIC Symposium 2016 Y1 - 2016 SN - 978-3-95806-109-5 SP - 355 EP - 364 ER - TY - CHAP A1 - Hunker, Jan A1 - Jung, Alexander A1 - Goßmann, Matthias A1 - Linder, Peter A1 - Staat, Manfred ED - Staat, Manfred ED - Erni, Daniel T1 - Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool. Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 7 EP - 8 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Raman, Aravind Hariharan A1 - Jung, Alexander A1 - Horváth, András A1 - Becker, Nadine A1 - Staat, Manfred ED - Staat, Manfred ED - Erni, Daniel T1 - Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich). Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 10 EP - 11 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Azar, Fouad A1 - Digel, Ilya ED - Staat, Manfred ED - Erni, Daniel T1 - Utilization of fluorescence spectroscopy and neural networks in clinical analysis T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Fluorescence topography of human urine in combination with learning algorithms can provide a variant pattern recognition method in analytical clinical chemistry and, eventually, diagnosis. Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 40 EP - 41 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Zingsheim, Jonas A1 - Grimmer, Timo A1 - Ortner, Marion A1 - Schmaderer, Christoph A1 - Hauser, Christine A1 - Kotliar, Konstantin ED - Staat, Manfred ED - Erni, Daniel T1 - Recognition of subjects with mild cognitive impairment (MCI) by the use of retinal arterial vessels. T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 36 EP - 37 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Blum, Yannik A1 - Albanna, Walid A1 - Benninghaus, Anne A1 - Kotliar, Konstantin ED - Staat, Manfred ED - Erni, Daniel T1 - Vasomotion in retinal vessels of patients presenting post hemorrhagic hydrocephalus following subarachnoid hemorrhage T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Clearance of blood components and fluid drainage play a crucial role in subarachnoid hemorrhage (SAH) and post hemorrhagic hydrocephalus (PHH). With the involvement of interstitial fluid (ISF) and cerebrospinal fluid (CSF), two pathways for the clearance of fluid and solutes in the brain are proposed. Starting at the level of capillaries, flow of ISF follows along the basement membranes in the walls of cerebral arteries out of the parenchyma to drain into the lymphatics and CSF [1]–[3]. Conversely, it is shown that CSF enters the parenchyma between glial and pial basement membranes of penetrating arteries [4]–[6]. Nevertheless, the involved structures and the contribution of either flow pathway to fluid balance between the subarachnoid space and interstitial space remains controversial. Low frequency oscillations in vascular tone are referred to as vasomotion and corresponding vasomotion waves are modeled as the driving force for flow of ISF out of the parenchyma [7]. Retinal vessel analysis (RVA) allows non-invasive measurement of retinal vessel vasomotion with respect to diameter changes [8]. Thus, the aim of the study is to investigate vasomotion in RVA signals of SAH and PHH patients. Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 38 EP - 39 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Bauer, Waldemar A1 - Borchers, Kai A1 - Dumont, Etienne A1 - Grimm, Christian D. A1 - Ho, Tra-Mi A1 - Jahnke, Rico A1 - Lange, Caroline A1 - Maiwald, Volker A1 - Mikulz, Eugen A1 - Quantius, Dominik A1 - Reershemius, Siebo A1 - Renger, Thomas A1 - Riemann, Johannes A1 - Sasaki, Kaname A1 - Seefeldt, Patric A1 - Spietz, Peter A1 - Spröwitz, Tom A1 - Toth, Norbert A1 - Wejmo, Elisabet A1 - Biele, Jens A1 - Krause, Christian A1 - Cerotti, Matteo A1 - Peloni, Alessandro A1 - Dachwald, Bernd T1 - Small Spacecraft Solar Sailing for Small Solar System Body Multiple Rendezvous and Landing T2 - 2018 IEEE Aerospace Conference : 3-10 March 2018 Y1 - 2018 SN - 978-1-5386-2014-4 ER - TY - CHAP A1 - Waldmann, Christoph A1 - Vera, Jean-Pierre de A1 - Dachwald, Bernd A1 - Strasdeit, Henry A1 - Sohl, Frank A1 - Hanff, Hendrik A1 - Kowalski, Julia A1 - Heinen, Dirk A1 - Macht, Sabine A1 - Bestmann, Ulf A1 - Meckel, Sebastian A1 - Hildebrandt, Marc A1 - Funke, Oliver A1 - Gehrt, Jan-Jöran T1 - Search for life in ice-covered oceans and lakes beyond Earth T2 - 2018 IEEE/OES Autonomous Underwater Vehicle Workshop, Proceedings November 2018, Article number 8729761 N2 - The quest for life on other planets is closely connected with the search for water in liquid state. Recent discoveries of deep oceans on icy moons like Europa and Enceladus have spurred an intensive discussion about how these waters can be accessed. The challenge of this endeavor lies in the unforeseeable requirements on instrumental characteristics both with respect to the scientific and technical methods. The TRIPLE/nanoAUV initiative is aiming at developing a mission concept for exploring exo-oceans and demonstrating the achievements in an earth-analogue context, exploring the ocean under the ice shield of Antarctica and lakes like Dome-C on the Antarctic continent. KW - Planetary exploration KW - Jupiter KW - ice moons KW - underwater vehicle KW - Antarctica Y1 - 2018 U6 - http://dx.doi.org/10.1109/AUV.2018.8729761 ER - TY - CHAP A1 - Savitskaya, Irina S. A1 - Kistaubayeva, Aida S. A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Zhubanova, Azhar A. T1 - Performance of Bio-Composite Carbonized Materials in Probiotic Applications T2 - World Academy of Science, Engineering and Technology International Journal of Biotechnology and Bioengineering Y1 - 2013 VL - 7 IS - 7 SP - 685 EP - 689 ER - TY - CHAP A1 - Baader, Fabian A1 - Keller, Denis A1 - Lehmann, Raphael A1 - Gerber, Lukas A1 - Reiswich, Martin A1 - Dachwald, Bernd A1 - Förstner, Roger T1 - Operating melting probes for ice penetration under sublimation conditions and in reduced gravity on a sounding rocket T2 - Proceedings of the 24th ESA Symposium on European Rocket and Balloon Programmes and related Research Y1 - 2019 SN - 0379-6566 N1 - 24th PAC Symposium 2019 ER -