TY - CHAP A1 - Raman, Aravind Hariharan A1 - Jung, Alexander A1 - Horváth, András A1 - Becker, Nadine A1 - Staat, Manfred ED - Staat, Manfred ED - Erni, Daniel T1 - Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich). Y1 - 2019 SN - 978-3-940402-22-6 U6 - https://doi.org/10.17185/duepublico/48750 SP - 10 EP - 11 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Schopen, Oliver A1 - Kemper, Hans A1 - Esch, Thomas T1 - Development of a comparison methodology and evaluation matrix for electrically driven compressors in ICE and FC T2 - Proceedings of the 1st UNITED – Southeast Asia Automotive Interest Group (SAIG) International Conference N2 - In addition to electromobility and alternative drive systems, a focus is set on electrically driven compressors (EDC), with a high potential for increasing the efficiency of internal combustion engines (ICE) and fuel cells [01]. The primary objective is to increase the ICE torque, provided independently of the ICE speed by compressing the intake air and consequently the ICE filling level supported by the compressor. For operation independent from the ICE speed, the EDC compressor is decoupled from the turbine by using an electric compressor motor (CM) instead of the turbine. ICE performances can be increased by the use of EDC where individual compressor parameters are adapted to the respective application area [02] [03]. This task contains great challenges, increased by demands with regard to pollutant reduction while maintaining constant performance and reduced fuel consumption. The FH-Aachen is equipped with an EDC test bench which enables EDC-investigations in various configurations and operating modes. Characteristic properties of different compressors can be determined, which build the basis for a comparison methodology. Subject of this project is the development of a comparison methodology for EDC with an associated evaluation method and a defined overall evaluation method. For the application of this comparison methodology, corresponding series of measurements are carried out on the EDC test bench using an appropriate test device. KW - electro mobility KW - fuel cell KW - internal combustion engine KW - electrically driven compressors Y1 - 2021 SN - 978-3-902103-94-9 N1 - 1st UNITED-SAIG International Conference, 21-22 APR 2021, Chulalongkorn University, Thailand SP - 45 EP - 46 PB - FH Joanneum CY - Graz ER - TY - CHAP A1 - Funke, Harald A1 - Haj Ayed, A. A1 - Kusterer, K. A1 - Keinz, Jan A1 - Kazari, M. A1 - Kitajima, J. A1 - Horikawa, A. A1 - Okada, K. T1 - Numerical Study on Increased Energy Density for the DLN Micromix Hydrogen Combustion Principle T2 - Combustion, Fuels and Emissions (ASME Turbo Expo 2014: Turbine Technical Conference and Exposition : Düsseldorf, Germany, June 16–20, 2014 ; Vol. 4A) Y1 - 2014 SN - 978-0-7918-4568-4 N1 - Paper No. GT2014-25848 SP - V04AT04A057 PB - ASME CY - New York, N.Y. ER - TY - CHAP A1 - Hagebeuker, Bianca A1 - Ringbeck, Thorsten A1 - Frydlewicz, Paul A1 - Jesorsky, Oliver A1 - Sünkel, Thomas ED - Grote, Caspar T1 - PMD-Sensoren als Schlüsselkomponenten für die mehrdimensionale Umfelderfassung des Fahrzeuginnenraums T2 - Begleittexte zum Entwicklerforum KFZ-Elektronik & FlexRay Solution Day : 15.Mai 2007, Ludwigsburg Y1 - 2007 N1 - Entwicklerforum Kfz-Elektronik <2007, Ludwigsburg> ; FlexRay Solution Day <2007, Ludwigsburg> SP - 287 EP - 296 PB - WEKA-Fachzeitschr.-Verl. CY - Poing ER - TY - CHAP A1 - Grothof, M. A1 - Schwarte, Rudolf A1 - Buxbaum, Bernd A1 - Ringbeck, Thorsten ED - Wagner, Elmar T1 - Product monitoring with MSM-PMD-Array T2 - Proceedings / OPTO 2002 : an event of the Association for Sensor Technology AMA ; 14 - 16 May 2002, Exhibition Centre Erfurt, Germany / International Conference Optoelectronics, Optical Sensors & Measuring Techniques Y1 - 2002 N1 - OPTO <5, 2002, Erfurt> ; International Conference Optoelectronics, Optical Sensors & Measuring Techniques SP - 41 EP - 47 PB - AMA Service GmbH CY - Wunsdorf ER - TY - CHAP A1 - Buxbaum, Bernd A1 - Schwarte, Rudolf A1 - Ringbeck, Thorsten A1 - Grothof, Markus A1 - Sluiter, A. A1 - Frey, Jochen A1 - Hildebrand, M. A1 - David, Klaus ED - Korevaar, Eric John T1 - Wireless LAN based on optical CDMA using a new high-speed correlation receiver (MSM-PMD) T2 - Optical wireless communications IV : 21-22 August, 2001, Denver, USA. - (SPIE proceedings series ; 4530) Y1 - 2001 SN - 0-8194-4254-2 U6 - https://doi.org/10.1117/12.449808 N1 - Optical Wireless Communications Conference <4, 2001, Denver, Colo.> SP - 168 EP - 178 PB - SPIE CY - Bellingham, Wash. ER - TY - CHAP A1 - Kötter, Jens A1 - Decker, Stefan A1 - Detzler, Raphael A1 - Schäfer, Jochen A1 - Schmitz, Mark A1 - Herrmann, Ulf T1 - Cost Reduction of Solar Fields with HelioTrough Collector Y1 - 2012 N1 - Concentration Solar Power and Chemical Energy Systemes : SolarPaces 2012, September 11 14 2002, Marrakesh, Morroco PB - FLAGSOL CY - Köln ER - TY - CHAP A1 - Nötzold, K. A1 - Uphues, A. A1 - Wegener, R. A1 - Fink, K. A1 - Bragard, Michael A1 - Griessel, R. A1 - Soter, S. T1 - Inverter based test setup for LVRT verification of a full-scale 2 MW wind power converter T2 - 15th European Conference on Power Electronics and Applications (EPE), 2013 : 2 - 6 Sept. 2013, Lille, France / [EPE Association; PELS, IEEE Power Electronics Society] Y1 - 2013 SN - 978-1-4799-0115-9 (Online-Ausg.) U6 - https://doi.org/10.1109/EPE.2013.6634752 SP - 1037 EP - 1042 PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Ajona, J. I. A1 - Herrmann, Ulf A1 - Sperduto, F. A1 - Farinha-Mendes, J. ED - Becker, Manfred T1 - Main Achievements within ARDISS (Advanced Receiver for Direct Solar Steam Production in Parabolic Trough Solar Power Plants) Project T2 - Components, tools, facilities and measurement techniques. - (Solar thermal concentrating technologies : proceedings of the 8th international symposium, October, 6 - 11, 1996, Köln, Germany ; Vol. 2) Y1 - 1996 SN - 3-7880-7616-X SP - 733 EP - 754 PB - Müller CY - Heidelberg ER - TY - CHAP A1 - Bayer, Robin A1 - Hescheler, Jürgen A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül ED - Staat, Manfred ED - Erni, Daniel T1 - Treating arterial hypertension in a cell culture well T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW N2 - Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the “Deutsche Bluthochdruck Liga” this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching. Y1 - 2019 SN - 978-3-940402-22-6 U6 - https://doi.org/10.17185/duepublico/48750 SP - 5 EP - 6 PB - Universität Duisburg-Essen CY - Duisburg ER -