TY - JOUR A1 - Langen, Karl J. A1 - Ziemons, Karl A1 - Kiwit, Jürgen C. W. A1 - Herzog, Hans A1 - Kuwert, Torsten A1 - Bock, Wolfgang A1 - Stöcklin, Gerhard A1 - Feinendegen, Ludwig E. A1 - Müller-Gärtner, Hans-W. T1 - 3-[123I]iodo-α-methyltyrosine and [methyl-11C]-L-methionine uptake in cerebral gliomas: a compara-tive study using SPECT and PET JF - Journal of Nuclear Medicine Y1 - 1997 SN - 0161-5505 VL - 38 IS - 4 SP - 517 EP - 522 ER - TY - JOUR A1 - Weckesser, Matthias A1 - Hufnagel, Andreas A1 - Ziemons, Karl A1 - Grießmeier, Martin A1 - Sonnenberg, Frank A1 - Hackländer, Thomas A1 - Langen, Karl-J. A1 - Holschbach, Markus A1 - Elger, Christian E. A1 - Müller-Gärtner, Hans-W. T1 - Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy JF - European Journal of Nuclear Medicine N2 - Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration. Y1 - 1997 SN - 1619-7089 VL - 24 IS - 9 SP - 1156 EP - 1161 ER - TY - JOUR A1 - Schmidt, Daniela A1 - Langen, Karl-J. A1 - Herzog, Hans A1 - Wirths, Jochen A1 - Holschbach, Markus A1 - Kiwit, Jürgen C. W. A1 - Ziemons, Karl A1 - Coenen, Heinz-H. A1 - Müller-Gärtner, Hans-W. T1 - Whole-body kinetics and dosimetry of L-3[123I]-iodo-α-methyltyrosine JF - European Journal of Nuclear Medicine Y1 - 1997 SN - 1619-7089 VL - 24 IS - 9 SP - 1162 EP - 1166 ER - TY - JOUR A1 - Balewski, J. A1 - Brauksiepe, S. A1 - Hardt, Arno T1 - Threshold measurements at the internal experimental facility COSY-11 / J. Balewski [u.a.] JF - Nuclear physics A. Vol. 626, iss. 1-2 Y1 - 1997 SN - 1873-1554 (E-Journal) ; 0375-9474 (Print) SP - 85 EP - 92 ER - TY - JOUR A1 - Makovicka, C. A1 - Gärtner, G. A1 - Hardt, Arno A1 - Hermann, W. A1 - Wiechert, D. U. T1 - Impregnated cathode surface investigations by SFM/STM and SEM/EDX JF - Applied surface science. Vol. 111 Y1 - 1997 SN - 1873-5584 (E-Journal); 0169-4332 (Print) SP - 70 EP - 75 ER - TY - CHAP A1 - Klein, Stefan A1 - Lindemann, Markus ED - Vogel, Douglas R. T1 - New architectures for web-enabled EDI-applications and their impact on VANS T2 - Global business in practice : proceedings of the Tenth International Bled Electronic Commerce Conference BLED '97, Bled, Slovenia, June 9-11 1997 Y1 - 1997 SP - 556 EP - 573 PB - Moderna organizacija CY - Kranj ER - TY - JOUR A1 - Lindemann, Markus A1 - Runge, Alexander T1 - Permanent IT-support in electronic commerce transactions JF - Electronic markets : the international journal of networked business. Vol. 7 (1997), iss. 1 Y1 - 1997 SN - 1422-8890 SP - 18 EP - 20 ER - TY - CHAP A1 - Mertens, Josef ED - Sobieczky, H. T1 - Required aerodynamic technologies T2 - New design concepts for high speed air transport. - (Courses and lectures / International Centre for Mechanical Sciences ; 366) N2 - In the preceeding chapters on “Son of Concorde, a Technology Challenge” and “Aerodynamic Multipoint Design Challenge” it was explained, that a well balanced contribution of new technologies in all major disciplines is required for realisation of a new Supersonic Commercial Transport (SCT). One of these technologies - usually one of the most important for aircraft-is aerodynamics. Here, the required “pure” aerodynamic technologies are specified in more detail, according to our present knowledge. Increasing insight into the problems may change the balance of importance of the individual technologies and may require some more contributions. We must never confine our knowledge to the knowledge base of an expert at a given time, but must stay open for new insights. KW - Mach Number KW - Wind Tunnel KW - Supersonic Flow KW - Pitching Moment KW - Wave Drag Y1 - 1997 SN - 3-2118-2815-X U6 - https://doi.org/10.1007/978-3-7091-2658-5_5 SP - 69 EP - 96 PB - Springer CY - Wien [u.a.] ER - TY - CHAP A1 - Mertens, Josef ED - Sobieczky, H. T1 - Certification of supersonic civil transports T2 - New design concepts for high speed air transport. - (Courses and lectures / International Centre for Mechanical Sciences ; 366) N2 - Since certification of Concorde new certification standards were introduced including many new regulations to improve flight safety. Most of these standards are to prevent severe accidents in the future which happened in the past (here: after Concorde’s certification). A new SCT has to fulfill these standards, although Concorde had none of these accidents. But accidents - although they sometimes occurred only for a specific aircraft type - have to be avoided for any (new) aircraft. Because of existing aircraft without typical accident types having demonstrated their reliability, they are allowed to go on based on their old certification; although sometimes new rules prevent accident types which are not connected to specific aircraft types - like e.g. evacuation rules. Anyway, Concorde is allowed to fly based on its old certification, and hopefully in the future will fly as safely as in the past. But a new SCT has to fulfill updated rules like any other aircraft, and it has to be “just another aircraft” [75]. KW - Noise Exposure KW - Evacuation Rule KW - Severe Accident KW - Certification Rule KW - Thermal Fatigue Testing Y1 - 1997 SN - 3-2118-2815-X U6 - https://doi.org/10.1007/978-3-7091-2658-5_6 SP - 97 EP - 103 PB - Springer CY - Wien [u.a.] ER - TY - CHAP A1 - Mertens, Josef ED - Sobieczky, H. T1 - Supersonic laminar flow T2 - New design concepts for high speed air transport. - (Courses and lectures / International Centre for Mechanical Sciences ; 366) N2 - Supersonic transports are very drag sensitive. Technology to reduce drag by application of laminar flow, therefore, will be important; it is a prerequisite to achieve very long range capability. In earlier studies it was assumed that SCTs would only become possible by application of laminar flow [376]. But today, we request an SCT to be viable without application of laminar flow in order to maintain its competitiveness when laminar flow becomes available for subsonic and supersonic transports. By reducing fuel burned, laminar flow drag reduction reduces size and weight of the aircraft, or increases range capability -whereas otherwise size and weight would grow towards infinity. Transition mechanisms from laminar to turbulent state of the boundary layer flow (ALT, CFI, TSI) function as for transonic transports, but at more severe conditions: higher sweep angles, cooled surfaces; higher mode instabilities (HMI) must at least be taken into account, although they may not become important below Mach 3. Hitherto there is a worldwide lack of ground test facilities to investigate TSI at the expected cruise Mach numbers between 1.6 and 2.4; in Stuttgart, Germany one such facility -a Ludwieg tube- is still in the validation phase. A quiet Ludwieg tunnel could be a favourable choice for Europe. But it will require a new approach in designing aircraft which includes improved theoretical predictions, usage of classical wind tunnels for turbulent flow and flight tests for validation. KW - Wind Tunnel KW - Flight Test KW - Supersonic Wind Tunnel KW - Parabolized Stability Equation Y1 - 1997 SN - 3-2118-2815-X U6 - https://doi.org/10.1007/978-3-7091-2658-5_18 SP - 275 EP - 290 PB - Springer CY - Wien [u.a.] ER -