TY  - JOUR
A1  - Droop, Philipp
A1  - Chen, Shaohuang
A1  - Radford, Melissa J.
A1  - Paulßen, Elisabeth
A1  - Gates, Byron D.
A1  - Reilly, Raymond M.
A1  - Radchenko, Valery
A1  - Hoehr, Cornelia
T1  - Synthesis of 197m/gHg labelled gold nanoparticles for targeted radionuclide therapy
JF  - Radiochimica Acta
N2  - Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 h and 64.1 h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 μg (gold)/mL with an activity of 151 ± 93 kBq/mL (197gHg, time corrected to the end of bombardment).
KW  - 197m/gHg
KW  - Gold nanoparticle (AuNP)
KW  - Meitner-Auger-electron (MAE)
KW  - Targeted radionuclide therapy (TRT)
Y1  - 2023
U6  - https://doi.org/10.1515/ract-2023-0144
SN  - 2193-3405
VL  - 111
IS  - 10
SP  - 773
EP  - 779
PB  - De Gruyter
CY  - Berlin [u.a.]
ER  - 
TY  - CHAP
A1  - Bung, Daniel Bernhard
A1  - Langohr, Phillip
A1  - Waldenberger, Lisa
ED  - Habersack, Helmut
ED  - Tritthart, Michael
T1  - Influence of cycle number in CFD studies of labyrinth weirs
T2  - Proceedings of the 40th IAHR World Congress (Vienna, 2023)
N2  - The major advantage of labyrinth weirs over linear weirs is hydraulic efficiency. In hydraulic modeling efforts, this strength contrasts with limited pump capacity as well as limited computational power for CFD simulations. For the latter, reducing the number of investigated cycles can significantly reduce necessary computational time. In this study, a labyrinth weir with different cycle numbers was investigated. The simulations were conducted in FLOW-3D HYDRO as a Large Eddy Simulation. With a mean deviation of 1.75 % between simulated discharge coefficients and literature design equations, a reasonable agreement was found. For downstream conditions, overall consistent results were observed as well. However, the orientation of labyrinth weirs with a single cycle should be chosen carefully under consideration of the individual research purpose.
KW  - CFD
KW  - Large Eddy Simulation
KW  - Labyfrinth weirs
Y1  - 2023
SN  - 978-90-833476-1-5
U6  - https://doi.org/10.3850/978-90-833476-1-5_iahr40wc-p0531-cd
SN  - L 2521-7119 (online)
N1  - Vienna, Austria, from August 21 to 25, 2023
PB  - International Association for Hydro-Environment Engineering and Research (IAHR)
CY  - Madrid
ER  - 
TY  - JOUR
A1  - Ulmer, Jessica
A1  - Braun, Sebastian
A1  - Cheng, Chi-Tsun
A1  - Dowey, Steve
A1  - Wollert, Jörg
T1  - A human factors-aware assistance system in manufacturing based on gamification and hardware modularisation
JF  - International Journal of Production Research
N2  - Assistance systems have been widely adopted in the manufacturing sector to facilitate various processes and tasks in production environments. However, existing systems are mostly equipped with rigid functional logic and do not provide individual user experiences or adapt to their capabilities. This work integrates human factors in assistance systems by adjusting the hardware and instruction presented to the workers’ cognitive and physical demands. A modular system architecture is designed accordingly, which allows a flexible component exchange according to the user and the work task. Gamification, the use of game elements in non-gaming contexts, has been further adopted in this work to provide level-based instructions and personalised feedback. The developed framework is validated by applying it to a manual workstation for industrial assembly routines.
KW  - Human factors
KW  - assistance system
KW  - gamification
KW  - adaptive systems
KW  - manufacturing
Y1  - 2023
U6  - https://doi.org/10.1080/00207543.2023.2166140
SN  - 0020-7543 (Print)
SN  - 1366-588X (Online)
PB  - Taylor & Francis
ER  -