TY  - JOUR
A1  - Biselli, Manfred
A1  - Noll, Thomas
A1  - Mühlsiepen, Heinz
A1  - Engels, Ralf
T1  - A cell-culture reactor for the on-line evaluation of radiopharmaceuticals : evaluation of the lumped constant of FDG in human glioma cells / Noll, Thomas ; Mühlensiepen, Heinz ; Engels, Ralf ; Hamacher, Kurt ; Papaspyrou, Manfred ; Langen, Karl-Josef ; Bi
JF  - Journal of Nuclear Medicine. 41 (2000), H. 3
Y1  - 2000
SN  - 0022-3123
SP  - 556
EP  - 564
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Molina, R.
A1  - Biselli, Manfred
A1  - Canzoneri, Michele
A1  - Schnitzler, Thomas
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - A light-addressable potentiometric sensor system for fast, simultaneous and spatial detection of the metabolic activity of biological cells
JF  - Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)
Y1  - 2007
SN  - 1-4244-0841-5
N1  - Eurosensors 21, 2007, Lyon ; International Conference on Solid-State Sensors, Actuators and Microsystems 14, 2007, Lyon
SP  - 1107
EP  - 1110
PB  - IEEE
CY  - Piscataway
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Schmidt, S.
A1  - Büchs, J.
A1  - Born, C.
T1  - A new correlation for the wall-to-fluid mass transfer in liquid-sol fluidized beds / Schmidt, S. ; Büchs, J. ; Born, C. ; Biselli, M.
JF  - Chemical Engineering Science. 54 (1999), H. 6
Y1  - 1999
SN  - 0009-2509
SP  - 829
EP  - 839
ER  - 
TY  - JOUR
A1  - Winckler, Silvia
A1  - Krueger, Rolf
A1  - Schnitzler, Thomas
A1  - Zang, Werner
A1  - Fischer, Rainer
A1  - Biselli, Manfred
T1  - A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach
JF  - Bioprocess and biosystems engineering
N2  - Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.
Y1  - 2014
U6  - http://dx.doi.org/10.1007/s00449-013-1062-8
SN  - 1615-7591 (Print) 1615-7605 (Online)
VL  - 37
IS  - 5
SP  - 901
EP  - 912
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Born, C.
A1  - Thömmes, J.
A1  - Wandrey, C.
T1  - An approach to integrated antibody production: Coupling of fluidized bed cultivation and  fluidized bed adsorption / Born, C. ; Thömmes, J. ; Biselli, M. ; Wandrey, C. ; Kula, M.-R.
JF  - Bioprocess Engineering. 15 (1996), H. 1
Y1  - 1996
SN  - 1615-7591
SP  - 21
EP  - 29
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Klyushnichenko, Vadim
A1  - Rodenbrock, Anja
A1  - Thömmes, Jörg
T1  - Analysis of Hybridoma Cell Culture Processes by SDS-Gel Capillary Electrophoresis and matrix-assisted laser desorption ionization–time-of-flight MS / Vadim Klyushnichenko, Anja Rodenbrock, Jörg Thömmes, Maria-Regina Kula, Holger Heine, Manfred Biselli
JF  - Biotechnology and Applied Biochemistry. 27 (1998), H. 3
Y1  - 1998
SN  - 0885-4513
SP  - 181
EP  - 188
ER  - 
TY  - JOUR
A1  - Canzoneri, M.
A1  - Krüger, R.
A1  - Zang, Werner
A1  - Biselli, Manfred
T1  - Atmungsaktivität von Säugerzellen: Kontinuierliche Onlineermittlung im Schüttelkolben
JF  - BIOforum. 3 (2006)
Y1  - 2006
SN  - 0940-0079
SP  - 45
EP  - 47
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Van der Pol, Jens J.
A1  - De Gooijer, Cornelis D.
A1  - Wandrey, Christian
T1  - Automation of selective assays for on-line bioprocess monitoring by  flow-injection analysis / van der Pol, Jens J. ; de Gooijer, Cornelis D. ; Biselli, Manfred ; Wandrey, Christian ; Tramper, Johannes
JF  - Trends in Biotechnology. 14 (1996), H. 12
Y1  - 1996
SN  - 0167-7799
SP  - 471
EP  - 477
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Thömmes, J.
A1  - Kula, M.-R.
A1  - Wandrey, Christian
T1  - Batch kinetic data of hybridoma growth and productivity as a basis for the simulation of antibody production in various culture systems /  Thömmes, J. ; Biselli, M. ; Kula, M.-R. ; Wandrey, C.
JF  - Animal cell technology : products of today, prospects for tomorrow ; ESACT, European Society for Animal Cell Technology, the 12th meeting / Ed. R. E. Spier
Y1  - 1994
SN  - 0750618450
N1  - Meeting / European Society for Animal Cell Technology ; 12
SP  - 513
EP  - 517
PB  - Butterworth-Heinemann
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Maggakis-Kelemen, C.
A1  - Bork, M.
A1  - Kayser, Peter
A1  - Biselli, Manfred
A1  - Artmann, Gerhard
T1  - Biological and mechanical quality of red blood cells cultured from human umbilical cord blood stem cells
JF  - Medical and biological engineering and computing. 41 (2003), H. 3
Y1  - 2003
SN  - 0140-0118
SP  - 350
EP  - 356
ER  -