TY - JOUR A1 - Topçu, Murat A1 - Madabhushi, Gopal S.P. A1 - Staat, Manfred T1 - A generalized shear-lag theory for elastic stress transfer between matrix and fibres having a variable radius JF - International Journal of Solids and Structures N2 - A generalized shear-lag theory for fibres with variable radius is developed to analyse elastic fibre/matrix stress transfer. The theory accounts for the reinforcement of biological composites, such as soft tissue and bone tissue, as well as for the reinforcement of technical composite materials, such as fibre-reinforced polymers (FRP). The original shear-lag theory proposed by Cox in 1952 is generalized for fibres with variable radius and with symmetric and asymmetric ends. Analytical solutions are derived for the distribution of axial and interfacial shear stress in cylindrical and elliptical fibres, as well as conical and paraboloidal fibres with asymmetric ends. Additionally, the distribution of axial and interfacial shear stress for conical and paraboloidal fibres with symmetric ends are numerically predicted. The results are compared with solutions from axisymmetric finite element models. A parameter study is performed, to investigate the suitability of alternative fibre geometries for use in FRP. KW - Natural fibres KW - Polymer-matrix composites KW - Biocomposites KW - Stress concentrations KW - Finite element analysis Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.ijsolstr.2022.111464 SN - 0020-7683 VL - 239–240 IS - Art. No. 111464 PB - Elsevier CY - New York, NY ER - TY - JOUR A1 - Thiebes, Anja Lena A1 - Klein, Sarah A1 - Zingsheim, Jonas A1 - Möller, Georg H. A1 - Gürzing, Stefanie A1 - Reddemann, Manuel A. A1 - Behbahani, Mehdi A1 - Cornelissen, Christian G. T1 - Effervescent atomizer as novel cell spray technology to decrease the gas-to-liquid ratio JF - pharmaceutics N2 - Cell spraying has become a feasible application method for cell therapy and tissue engineering approaches. Different devices have been used with varying success. Often, twin-fluid atomizers are used, which require a high gas velocity for optimal aerosolization characteristics. To decrease the amount and velocity of required air, a custom-made atomizer was designed based on the effervescent principle. Different designs were evaluated regarding spray characteristics and their influence on human adipose-derived mesenchymal stromal cells. The arithmetic mean diameters of the droplets were 15.4–33.5 µm with decreasing diameters for increasing gas-to-liquid ratios. The survival rate was >90% of the control for the lowest gas-to-liquid ratio. For higher ratios, cell survival decreased to approximately 50%. Further experiments were performed with the design, which had shown the highest survival rates. After seven days, no significant differences in metabolic activity were observed. The apoptosis rates were not influenced by aerosolization, while high gas-to-liquid ratios caused increased necrosis levels. Tri-lineage differentiation potential into adipocytes, chondrocytes, and osteoblasts was not negatively influenced by aerosolization. Thus, the effervescent aerosolization principle was proven suitable for cell applications requiring reduced amounts of supplied air. This is the first time an effervescent atomizer was used for cell processing. KW - tri-lineage differentiation KW - survival KW - twin-fluid atomizer KW - adipose-derived stromal cells (ASCs) KW - cell atomization KW - cell aerosolization Y1 - 2022 U6 - http://dx.doi.org/10.3390/pharmaceutics14112421 N1 - This article belongs to the Special Issue "Stromal, Stem, Signaling Cells: The Multiple Roles and Applications of Mesenchymal Cells" VL - 14 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Yalcin, Ozlem A1 - Resmi, Halil A1 - Baskurt, Oguz K. T1 - Can white blood cell activation be one of the major factors that affect hemorheological parameters during and after exercise? JF - Clinical Hemorheology and Microcirculation. 26 (2002), H. 3 Y1 - 2002 SN - 1386-0291 N1 - = The 11th European Symposium on Clinical Hemorheology, Rouen, France, 19-22 September 2000 SP - 189 EP - 193 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Saklamaz, Ali A1 - Comlekci, Abdurrahman A1 - Caliskan, Sezer T1 - The beneficial effects of lipid-lowering drugs beyond lipid-lowering effects: A comparative study with pravastatin, atorvastatin, and fenofibrate in patients with type IIa and type IIb hyperlipidemia / Saklamaz, Ali ; Comlekci, Abdurrahman ; Temiz, Aysegu JF - Metabolism. 54 (2005), H. 5 Y1 - 2005 SN - 0026-0495 SP - 677 EP - 681 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Resmi, Halil A1 - Akhunlar, Hülya A1 - Güner, Gül T1 - In vitro effects of high glucose concentrations on membrane protein sulfhydryl oxidation, G-actin and deformability of human erythrocytes. Resmi, Halil ; Akhunlar, Hülya ; Temiz Artmann, Aysegül ; Güner, Gül JF - Cell biochemistry and function. 23 (2005), H. 3 Y1 - 2005 SN - 0263-6484 SP - 163 EP - 168 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Linder, Peter A1 - Kayser, Peter A1 - Digel, Ilya T1 - NMR in vitro effects on proliferation, apoptosis, and viability of human chondrocytes and osteoblasts JF - Methods and findings in Experimental and Clinical Pharmacology. 27 (2005), H. 6 Y1 - 2005 SN - 0379-0355 SP - 391 EP - 394 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Kurulgan demirci, Eylem A1 - Fırat, Ipek Seda A1 - Oflaz, Hakan A1 - Artmann, Gerhard T1 - Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers JF - SHOCK KW - Septic cardiomyopathy KW - LPS KW - cardiomyocyte biomechanics KW - CellDrum KW - actin cytoskeleton Y1 - 2021 U6 - http://dx.doi.org/10.1097/SHK.0000000000001845 SN - 1540-0514 PB - Wolters Kluwer CY - Köln ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Kayser, Peter T1 - Why is Sepsis an Ongoing Clinical Challenge? Lipopolysaccharide Effects on Red Blood Cell Volume / Temiz, Aysegül ; Kayser, Peter JF - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Y1 - 2008 SN - 978-3-540-75408-4 SP - 497 EP - 508 PB - Springer CY - Berlin ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Kayatekin, Muammer B. A1 - Uysal, N. A1 - Resmi, H. T1 - Does antioxidant supplementation alter the effects of acute exercise on erythrocyte aggregation, deformability and endothelium adhesion in untrained rats? Kayatekin, Muammer B.; Uysal N.; Resmi, H.; Bediz, Seref C.; Temiz Artmann, A.; Genç, S.; Tugyan, K. JF - International Journal for Vitamin and Nutrition Research. 75 (2005), H. 4 Y1 - 2005 SN - 0300-9831 SP - 243 EP - 250 ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Cavdar, C. A1 - Yenicerioglu, Y. A1 - Caliskan, S. T1 - The effects of intravenous iron treatment on oxidant stress and erythrocyte deformability in haemodialysis patients. Cavdar, C.; Temiz, A.; Yenicerioglu, Y.; Caliskan, S.; Celik, A.; Sifil, A.; Onvural, B.; Camsari, T. JF - Scandinavian Journal of Urology and Nephrology. 37 (2003), H. 1 Y1 - 2003 SN - 0036-5599 SP - 77 EP - 82 ER -