TY  - CHAP
A1  - Wolf, C. Roland
A1  - Kapelyukh, Yury
A1  - Scheer, Nico
A1  - Henderson, Colin J.
ED  - Wilson, Alan G. E.
T1  - Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs
N2  - The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.
Y1  - 2015
SN  - 978-1-78262-778-4
U6  - http://dx.doi.org/10.1039/9781782622376-00152
SP  - 152
EP  - 176
PB  - RSC Publ.
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Ulamec, S.
A1  - Feuerbacher, B.
A1  - Rosenbauer, H. (u.a.)
T1  - Rosetta Lander - In Situ Investigation of a Cometary Nucleus
JF  - Lunar and Planetary Science. 28 (1997)
Y1  - 1997
SN  - 0270-9511
N1  - Proceedings of the 28th Annual Lunar and Planetary Science Conference, March 17-21, 1997, Houston, Texas
SP  - 1461
EP  - 1462
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Ulamec, S.
A1  - Feuerbacher, B.
A1  - Rosenbauer, H.
T1  - Technical Challenge, Scientific Thrill: A Long Term Lander on an Active Comet
JF  - Lunar and Planetary Science. 26 (1995)
Y1  - 1995
SN  - 0270-9511
N1  - Proceedings of the 26th Lunar and Planetary Science Conference / org. by Lunar and Planetary Institute, Houston Texas
SP  - 1431
EP  - 1432
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Ulamec, S
A1  - Richter, L
T1  - Lander Systems for Planetary Missions
JF  - Laboratory astrophysics and space research / ed. by P. Ehrenfreund
Y1  - 1999
SN  - 0-7923-5338-2
N1  - Serie Astrophysics and space science library 236
SP  - 597
EP  - 621
PB  - Kluwer
CY  - Dordrecht [u.a.]
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Schmidt, H. P.
A1  - Padeken, D.
A1  - Hildmann, B.
T1  - The Microgravity User Support Centre (MUSC)
JF  - ESA SP. 277 (1988)
Y1  - 1988
SN  - 0379-6566
N1  - Proceedings of the International Symposium on Europe in Space--the Manned Space System : 25-29 April 1988, Strasbourg, France  David, Valerie ; Longdon, Norman [ed]
SP  - 525
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Schmidt, H. P.
A1  - Feuerbacher, B.
T1  - Microgravity research and user support in the Space Station era: The Microgravity User Support Centre
JF  - Acta Astronautica. 17 (1988), H. 11-12
Y1  - 1988
SN  - 0094-5765
SP  - 1161
EP  - 1168
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Padeken, D.
T1  - The User Center for Microgravity MUSC - Support for space experiments
JF  - DLR-Nachrichten. 70 (1993)
Y1  - 1993
SN  - 0937-0420
SP  - 19
EP  - 24
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Kell, G.
A1  - Winkler, F.
A1  - Günther, M. (u.a.)
T1  - High resolution temperature measurement technique for materials sciences experiments in space
JF  - Acta Astronautica. 43 (1998), H. 7-8
Y1  - 1998
SN  - 0094-5765
SP  - 385
EP  - 395
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Kehr, J.
A1  - Willnecker, R.
T1  - Decentralized Payload Operations Concept for Columbus
Y1  - 2000
N1  - 51st IAF Congress, Rio de Janeiro, Brazil, Oct. 2000
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Gillessen, F.
A1  - Otto, G.
A1  - Röstel, R.
T1  - Undercooling and solidification of metallic melts suspended in a non-nucleating matrix: Experiment NUCAL of the German Spacelab Mission D-2
JF  - Acta Astronautica. 38 (1996), H. 1
Y1  - 1996
SN  - 0094-5765
SP  - 63
EP  - 68
ER  -