TY - CHAP A1 - Schildt, P. A1 - Braun, Carsten A1 - Marcocca, P. T1 - Flight testing the extra 330LE flying testbed T2 - 48th Annual International Symposium of the Society of Flight Test Engineers 2017 Y1 - 2017 SN - 978-151085387-4 N1 - 48th Annual International Symposium of the Society of Flight Test Engineers 2017, SFTE 2017; Destin; United States; 30 October 2017 through 2 November 2017 SP - 349 EP - 362 ER - TY - CHAP A1 - Schiffer, Stefan A1 - Ferrein, Alexander T1 - A System Layout for Cognitive Service Robots T2 - Cognitive Robot Architectures. Proceedings of EUCognition 2016 Y1 - 2017 SN - 1613-0073 N1 - CEUR-WS Vol-1855 SP - 44 EP - 45 ER - TY - JOUR A1 - Savitskaya, I. S. A1 - Kistaubayeva, A. S. A1 - Digel, Ilya A1 - Shokatayeva, D. H. T1 - Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials JF - Eurasian Chemico-Technological Journal Y1 - 2017 U6 - https://doi.org/10.18321/ectj670 SN - 2522-4867 VL - 19 IS - 3 SP - 255 EP - 264 ER - TY - CHAP A1 - Sauerborn, Markus A1 - Liebenstund, Lena A1 - Raue, Markus A1 - Mang, Thomas A1 - Herrmann, Ulf A1 - Dueing, Andreas T1 - Analytic method for material aging and quality analyzing to forecast long time stability of plastic micro heliostat components T2 - AIP Conference Proceedings Y1 - 2017 U6 - https://doi.org/10.1063/1.4984388 VL - 1850 IS - 1 SP - 030045-1 EP - 030045-8 ER - TY - CHAP A1 - Samuelsson, K. A1 - Scheer, Nico A1 - Wilson, I. A1 - Wolf, C.R. A1 - Henderson, C.J. ED - Chackalamannil, Samuel T1 - Genetically Humanized Animal Models T2 - Comprehensive Medicinal Chemistry III. 3rd Edition N2 - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development. KW - Chimeric liver-humanized mice KW - Drug distribution KW - Drug metabolism KW - Toxicology KW - Knockout mice Y1 - 2017 SN - 978-0-12-803201-5 U6 - https://doi.org/10.1016/B978-0-12-409547-2.12376-5 SP - 130 EP - 149 PB - Elsevier CY - Saint Louis ER - TY - JOUR A1 - Röhlen, Desiree A1 - Pilas, Johanna A1 - Schöning, Michael Josef A1 - Selmer, Thorsten T1 - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid JF - Applied Biochemistry and Biotechnology N2 - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates. Y1 - 2017 U6 - https://doi.org/10.1007/s12010-017-2578-1 SN - 1559-0291 VL - 183 SP - 566 EP - 581 PB - Springer CY - Berlin ER - TY - CHAP A1 - Rosin, J. A1 - Mykoniou, K. A1 - Butenweg, Christoph T1 - Analysis Of Base Isolated Liquid Storage Tanks With 3D Fsi-Analysis As Well As Simplified Approaches T2 - 16th World Conference on Earthquake Engineering, 16WCEE 2017 Santiago Chile, January 9th to 13th 2017 N2 - Tanks are preferably designed, for cost-saving reasons, as circular, cylindrical, thin-walled shells. In case of seismic excitation, these constructions are highly vulnerable to stability failures. An earthquake-resistant design of rigidly supported tanks for high seismic loading demands, however, uneconomic wall thicknesses. A cost-effective alternative can be provided by base isolation systems. In this paper, a simplified seismic design procedure for base isolated tanks is introduced, by appropriately modifying the standard mechanical model for flexible, rigidly supported tanks. The non-linear behavior of conventional base isolation systems becomes an integral part of a proposed simplified process, which enables the assessment of the reduced hydrodynamic forces acting on the tank walls and the corresponding stress distribution. The impulsive and convective actions of the liquid are taken into account. The validity of this approach is evaluated by employing a non-linear fluid-structure interaction algorithm of finite element method. Special focus is placed on the boundary conditions imposed from the base isolation and the resulting hydrodynamic pressures. Both horizontal and vertical component of ground motion are considered in order to study the principal effects of the base isolation on the pressure distribution of the tank walls. The induced rocking effects associated with elastomeric bearings are discussed. The results manifest that base isolated tanks can be designed for seismic loads by means of the proposed procedure with sufficient accuracy, allowing to dispense with numerically expensive techniques. KW - liquid storage tank KW - seismic isolation KW - elastomeric bearing KW - friction pendulum bearing KW - simplified approach Y1 - 2017 N1 - Paper No 2246 SP - 1 EP - 14 PB - Chilean Association on Seismology and Earthquake Engineering (ACHISINA) ER - TY - JOUR A1 - Rietsch, Stefan H. G. A1 - Pfaffenrot, Viktor A1 - Bitz, Andreas A1 - Orzada, Stephan A1 - Brunheim, Sascha A1 - Lazik-Palm, Andrea A1 - Theysohn, Jens M. A1 - Ladd, Mark E. A1 - Quick, Harald H. A1 - Kraff, Oliver T1 - An 8-channel transceiver 7-channel receive RF coil setup for high SNR ultrahigh-field MRI of the shoulder at 7T JF - Medical Physics Y1 - 2017 U6 - https://doi.org/10.1002/mp.12612 SN - 0094-2405 IS - Article in press PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Richter, Charlotte A1 - Braunstein, Bjoern A1 - Winnard, Andrew A1 - Nasser, Mona A1 - Weber, T. T1 - Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review JF - Frontiers in physiology Y1 - 2017 U6 - https://doi.org/10.3389/fphys.2017.00583 IS - 8, article 583 ER - TY - CHAP A1 - Rajan, Sreelakshmy A1 - Kubalski, Thomas A1 - Altay, Okyay A1 - Dalguer, Luis A A1 - Butenweg, Christoph T1 - Multi-dimensional fragility analysis of a RC building with components using response surface method T2 - 24th International Conference on Structural Mechanics in Reactor Technology, Busan, Korea, 20-25 August, 2017 N2 - Conventional fragility curves describe the vulnerability of the main structure under external hazards. However, in complex structures such as nuclear power plants, the safety or the risk depends also on the components associated with a system. The classical fault tree analysis gives an overall view of the failure and contains several subsystems to the main event, however, the interactions in the subsystems are not well represented. In order to represent the interaction of the components, a method suggested by Cimellaro et al. (2006) using multidimensional performance limit state functions to obtain the system fragility curves is adopted. This approach gives the possibility of deriving the cumulative fragility taking into account the interaction of the response of different components. In this paper, this approach is used to evaluate seismic risk of a representative electrical building infrastructure, including the component, of a nuclear power plant. A simplified model of the structure, with nonlinear material behavior is employed for the analysis in Abaqus©. The input variables considered are the material parameters, boundary conditions and the seismic input. The variability of the seismic input is obtained from selected ground motion time histories of spectrum compatible synthetic ccelerograms. Unlike the usual Monte Carlo methods used for the probabilistic analysis of the structure, a computationally effective response surface method is used. This method reduces the computational effort of the calculations by reducing the required number of samples. Y1 - 2017 SN - 9781510856776 SP - 3126 EP - 3135 PB - International Assn for Structural Mechanics in Reactor Technology (IASMiRT) CY - Raleigh, USA ER -