TY  - JOUR
A1  - Wu, Chunsheng
A1  - Poghossian, Arshak
A1  - Bronder, Thomas
A1  - Schöning, Michael Josef
T1  - Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor
JF  - Sensors and Actuators B: Chemical
N2  - A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules.
KW  - Layer-by-layer adsorption
KW  - Poly(allylamine hydrochloride)
KW  - Label-free detection
KW  - DNA biosensor
KW  - LAPS
KW  - Field effect
Y1  - 2016
U6  - https://doi.org/10.1016/j.snb.2016.02.004
SN  - 0925-4005
IS  - 229
SP  - 506
EP  - 512
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Laack, Walter van
T1  - Schnittstelle Tod: Wo stehen wir nach 40 Jahren NTE-Forschung?
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:101:1-201603132912
SN  - 978-3-936624-30-4 (Print-Ausgabe)
SN  - 978-3-936624-32-8 (Online-Ausgabe)
N1  - Tagungsbeiträge des 4. Europäischen Seminars am 07. November 2015 in Aachen zum Thema Nahtoderfahrungen mit dem Serientitel: "Schnittstelle Tod"
PB  - van Laack GmbH
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Mykoniou, Konstantin
A1  - Butenweg, Christoph
A1  - Holtschoppen, Britta
A1  - Klinkel, Sven
T1  - Seismic response analysis of adjacent liquid-storage tanks
JF  - Earthquake engineering and structural dynamics
N2  - A refined substructure technique in the frequency domain is developed, which permits consideration of the interaction effects among adjacent containers through the supporting deformable soil medium. The tank-liquid systems are represented by means of mechanical models, whereas discrete springs and dashpots stand for the soil beneath the foundations. The proposed model is employed to assess the responses of adjacent circular, cylindrical tanks for harmonic and seismic excitations over wide range of tank proportions and soil conditions. The influence of the number, spatial arrangement of the containers and their distance on the overall system's behavior is addressed. The results indicate that the cross-interaction effects can substantially alter the impulsive components of response of each individual element in a tank farm. The degree of this impact is primarily controlled by the tank proportions and the proximity of the predominant natural frequencies of the shell-liquid-soil systems and the input seismic motion. The group effects should be not a priori disregarded, unless the tanks are founded on shallow soil deposit overlying very stiff material or bedrock.
KW  - liquid-structure interaction
KW  - seismic response
KW  - impulsive effects
KW  - liquid-storage tank
KW  - structure-soil-structure interaction
Y1  - 2016
U6  - https://doi.org/10.1002/eqe.2726
SN  - 1096-9845 (E-Journal); 0098-8847 (Print)
VL  - 45
IS  - 11
SP  - 1779
EP  - 1796
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Fissabre, Anke
A1  - Wilson, Ariane
ED  - Feiglstorfer, Hubert
T1  - "Lehmbaupropaganda" : On the tradition of earth building literature
T2  - Earth Construction and Tradition. Vol. I
Y1  - 2016
SN  - 978-3-900265-34-2
SP  - 47
EP  - 69
PB  - IVA Institut für vergleichende Architekturforschung
CY  - Wien
ER  - 
TY  - CHAP
A1  - Niemueller, Tim
A1  - Reuter, Sebastian
A1  - Ewert, Daniel
A1  - Ferrein, Alexander
A1  - Jeschke, Sabina
A1  - Lakemeyer, Gerhard
ED  - Almeida, Luis
T1  - The Carologistics Approach to Cope with the Increased Complexity and New Challenges of the RoboCup Logistics League 2015
T2  - RoboCup 2015: Robot World Cup XIX
Y1  - 2016
SN  - 978-3-319-29339-4
U6  - https://doi.org/10.1007/978-3-319-29339-4_4
N1  - Lecture Notes in Computer Science ; 9513
SP  - 47
EP  - 59
PB  - Springer International Publishing
CY  - Cham
ER  - 
TY  - CHAP
A1  - Niemueller, Tim
A1  - Reuter, Sebastian
A1  - Ferrein, Alexander
A1  - Jeschke, Sabina
A1  - Lakemeyer, Gerhard
ED  - Almeida, Luis
T1  - Evaluation of the RoboCup Logistics League and Derived Criteria for Future Competitions
T2  - RoboCup 2015: Robot World Cup XIX
Y1  - 2016
SN  - 978-3-319-29339-4
U6  - https://doi.org/10.1007/978-3-319-29339-4_3
N1  - Lecture Notes in Computer Science ; 9513
SP  - 31
EP  - 43
PB  - Springer International Publishing
CY  - Cham
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Eurlings, Y.
A1  - Grinsven, B. van
A1  - Boyen, H.-G.
A1  - Conings, B.
A1  - Michiels, L.
A1  - Ameloot, M.
A1  - Carleer, R.
A1  - Warmer, J.
A1  - Kaul, P.
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Ceuninck, W. de
A1  - Wagner, P.
T1  - Heat-transfer based characterization of DNA on synthetic sapphire chips
JF  - Sensors and Actuators B: Chemical
N2  - In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material.
Y1  - 2016
U6  - https://doi.org/10.1016/j.snb.2016.02.027
SN  - 0925-4005
VL  - 230
IS  - 230
SP  - 260
EP  - 271
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Niemueller, Tim
A1  - Reuter, Sebastian
A1  - Ferrein, Alexander
ED  - Almeida, Luis
T1  - Fawkes for the RoboCup Logistics League
T2  - RoboCup 2015: Robot World Cup XIX
Y1  - 2016
SN  - 978-3-319-29339-4
U6  - https://doi.org/10.1007/978-3-319-29339-4_31
N1  - Lecture Notes in Computer Science ; 9513
SP  - 365
EP  - 373
PB  - Springer International Publishing
CY  - Cham
ER  - 
TY  - JOUR
A1  - Kowalski, Julia
A1  - Linder, Peter
A1  - Zierke, S.
A1  - Wulfen, B. van
A1  - Clemens, J.
A1  - Konstantinidis, K.
A1  - Ameres, G.
A1  - Hoffmann, R.
A1  - Mikucki, J.
A1  - Tulaczyk, S.
A1  - Funke, O.
A1  - Blandfort, D.
A1  - Espe, Clemens
A1  - Feldmann, Marco
A1  - Francke, Gero
A1  - Hiecker, S.
A1  - Plescher, Engelbert
A1  - Schöngarth, Sarah
A1  - Dachwald, Bernd
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Eliseev, D.
A1  - Heinen, D.
A1  - Scholz, F.
A1  - Wiebusch, C.
A1  - Macht, S.
A1  - Bestmann, U.
A1  - Reineking, T.
A1  - Zetzsche, C.
A1  - Schill, K.
A1  - Förstner, R.
A1  - Niedermeier, H.
A1  - Szumski, A.
A1  - Eissfeller, B.
A1  - Naumann, U.
A1  - Helbing, K.
T1  - Navigation technology for exploration of glacier ice with maneuverable melting probes
JF  - Cold Regions Science and Technology
N2  - The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.
Y1  - 2016
U6  - https://doi.org/10.1016/j.coldregions.2015.11.006
SN  - 0165-232X
IS  - 123
SP  - 53
EP  - 70
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hamad, E. M.
A1  - Bilatto, S. E. R.
A1  - Adly, N. Y.
A1  - Correa, D. S.
A1  - Wolfrum, B.
A1  - Schöning, Michael Josef
A1  - Offenhäusser, A.
A1  - Yakushenko, A.
T1  - Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices
JF  - Lab on a Chip
N2  - Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing.
Y1  - 2016
U6  - https://doi.org/10.1039/C5LC01195G
SN  - 1473-0189
VL  - 16
IS  - 1
SP  - 70
EP  - 74
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -