TY  - CHAP
A1  - Azat, Seitkhan
A1  - Kerimkulova, Almagul R.
A1  - Mansurov, Zulkhair A.
A1  - Adekenov, Sergazy
A1  - Artmann, Gerhard
T1  - The Use of Fusicoccin as Anticancer Compound
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.
Y1  - 2020
SN  - 978-0-429-42864-7
U6  - http://dx.doi.org/10.1201/9780429428647-8
SP  - 149
EP  - 172
PB  - Jenny Stanford Publishing
CY  - New York
ER  - 
TY  - RPRT
A1  - Artmann, Gerhard
T1  - HPBioforce: Integrierte und automatisierte Screening Plattform eines 96-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an einige um dicken Zell- und Gewebeschichten für die Arzneimittelforschung : gemeinsamer Abschlussbericht der FH Aachen, Hitec Zang GmbH, IKFE Mainz, IKFE Berlin und der Dr. Gerhard Schmidt GmbH zum InnoNet-Projekt ... ; Programm "Förderung von innovativen Netzwerken" (InnoNet) des Bundesministerium für Wirtschaft und Technologie (BMWi) ; Laufzeit: 01.05.2007 bis 31.12.2010
Y1  - 2011
U6  - http://dx.doi.org/10.2314/GBV:68757076X
N1  - Förderkennzeichen BMWi 16IN0536. - Verbund-Nr. 01056220
PB  - Technische Informationsbibliothek u. Universitätsbibliothek
CY  - Aachen [u.a.]
ER  - 
TY  - RPRT
A1  - Artmann, Gerhard
T1  - FhprofUnd EasyBioforce Abschlussbericht : Miniaturisierte, integrierte und automatisierte Screening Plattform eines 36-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an Zell- und Gewebeschichten für die Arzneimittelforschung : Laufzeit des Vorhabens: 01.03.2007 - 31.12.2010
Y1  - 2011
U6  - http://dx.doi.org/10.2314/GBV:782964621
N1  - Förderkennzeichen BMBF 1760X07
PB  - Technische Informationsbibliothek u. Universitätsbibliothek
CY  - Aachen
ER  - 
TY  - RPRT
A1  - Artmann, Gerhard
T1  - Escherichia Coli Infektion und Zellschädigung - Wie perfekt wirken Antibiotika? : Abschlussbericht zum Projekt 1703701
Y1  - 2004
U6  - http://dx.doi.org/10.2314/GBV:482527137
PB  - Technische Informationsbibliothek u. Universitätsbibliothek
CY  - Jülich
ER  - 
TY  - RPRT
A1  - Artmann, Gerhard
T1  - Plant mutant scanner : Hochdurchsatzscanner zur Charakterisierung von Pflanzenmutanten.  Abschlussbericht ; FHprofUnd ; PhytoScan ; Laufzeit des Vorhabens: 01.07.2008 - 30.06.2011
Y1  - 2011
U6  - http://dx.doi.org/10.2314/GBV:747569150
N1  - Förderkennzeichen BMBF 1736X08
PB  - Technische Informationsbibliothek u. Universitätsbibliothek
CY  - Aachen
ER  - 
TY  - RPRT
A1  - Artmann, Gerhard
A1  - Bäumler, H.
T1  - Pharmamikrocontainer mit designgesteuerter Permeabilität als Transporter für ausgewählte Pharmaka.  Ein Gemeinschaftsprojekt im Forschungsschwerpunkt "Celluar Engineering"  [Laufzeit: 01.09.2000 - 28.02.2002]
Y1  - 2002
PB  - FH Aachen
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Uysal, Karya
A1  - Firat, Ipek Serat
A1  - Creutz, Till
A1  - Aydin, Inci Cansu
A1  - Artmann, Gerhard
A1  - Teusch, Nicole
A1  - Temiz Artmann, Aysegül
T1  - A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes
JF  - membranes
N2  - Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.
Y1  - 2022
U6  - http://dx.doi.org/10.3390/membranes13010022
N1  - This article belongs to the Special Issue "Latest Scientific Discoveries in Polymer Membranes"
VL  - 2023
IS  - 13(1)
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Akimbekov, N. Sh.
A1  - Zhubanova, A. A.
A1  - Mansurov, Z. A.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Use of Carbonized Rise Shell for the local treatment of wounds
JF  - Eurasian ChemTech Journal
N2  - On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.
Y1  - 2010
U6  - http://dx.doi.org/10.18321/ectj35
SN  - 2522-4867
VL  - 12
IS  - 2
SP  - 133
EP  - 138
PB  - Institute of Combustion Problems
CY  - Almaty
ER  - 
TY  - JOUR
A1  - Kozhalakova, A. A.
A1  - Zhubanova, Azhar A.
A1  - Mansurov, Z. A.
A1  - Digel, Ilya
A1  - Tazhibayeva, S. M.
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Adsorption of bacterial lipopolysaccharides on carbonized rice shell
JF  - Science of Central Asia (2010)
Y1  - 2010
SP  - 50
EP  - 54
ER  - 
TY  - JOUR
A1  - Kurz, R.
A1  - Linder, Peter
A1  - Trzewik, Jürgen
A1  - Rüffer, M.
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Rothermel, A.
A1  - Robitzki, A.
A1  - Temiz Artmann, Aysegül
T1  - Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes
JF  - Medical and Biological Engineering and Computing
N2  - The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching.
Y1  - 2010
U6  - http://dx.doi.org/10.1007/s11517-009-0552-y
SN  - 1741-0444
VL  - 48
IS  - 1
SP  - 59
EP  - 65
PB  - Springer Nature
CY  - Cham
ER  -