TY - JOUR A1 - Weckesser, Martin A1 - Grießmeier, Martin A1 - Schmidt, Daniela A1 - Sonnenberg, Frank A1 - Ziemons, Karl A1 - Kemna, Lars A1 - Holschbach, Marcus A1 - Langen, Karl-J. A1 - Müller-Gärtner, Hans-W. T1 - Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent JF - European Journal of Nuclear Medicine N2 - Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7%±6.1% (range 2.7%–25.0%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment. Y1 - 1998 SN - 1619-7089 VL - 25 IS - 2 SP - 150 EP - 156 ER - TY - JOUR A1 - Feuerriegel, Uwe A1 - Klose, W. T1 - Investigations into the Mechanism of the Deactivation of a Palladium-Supported Catalyst by Hydrogen Sulfide Poisoning. Klose, W. ; Feuerriegel, U. JF - Chemical engineering & technology. 21 (1998), H. 7 Y1 - 1998 SN - 0930-7516 N1 - gleicher Artikel in Deutsch In: Chem.Ing.Tech 70(1998) No S. 449-452 u.d.T.: Untersuchungen zum Mechanismus der Desaktivierung eines Palladium-Trägerkatalysators durch Vergiftung mit Schwefelwasserstoff SP - 562 EP - 564 ER - TY - JOUR A1 - Lindemann, Markus T1 - Internet, Intranet, Extranet JF - Anzeiger St. Gallen. Das Ostschweizer Magazin. Ausg. Juni 1998 Y1 - 1998 ER - TY - BOOK A1 - Ley, Wilfried T1 - Internationale Raumstation : Konfiguration, Betrieb und Nutzung ; Gemeinschaftsveranstaltung der FH Aachen, der DGLR und des DLR / 11. Raumfahrt-Kolloquium an der Fachhochschule Aachen, 26. November 1998. / Ley, Wilfried [Hrsg.] Y1 - 1998 SN - 3-932182-04-9 PB - DGLR CY - Bonn ER - TY - BOOK A1 - Janz, Norbert A1 - Beise, Marian A1 - Ebling, Günther A1 - Licht, Georg T1 - Innovationsverhalten im Verarbeitenden Gewerbe. Erhebung 1997 / Janz, N., M. Beise, G. Ebling, G. Licht und H. Niggemann Y1 - 1998 PB - ZEW Zentrum für Europäische Wirtschaftsförderung CY - Mannheim ER - TY - BOOK A1 - Janz, Norbert A1 - Ebling, Günther A1 - Hipp, C. A1 - Licht, Georg T1 - Innovationsaktivitäten im Dienstleistungssektor. Erhebung 1997 / Janz, N., G. Ebling, C. Hipp, G. Licht und H. Niggemann Y1 - 1998 PB - ZEW Zentrum für Europäische Wirtschaftsförderung CY - Mannheim ER - TY - BOOK A1 - Thielemann, Frank A1 - Staudt, Erich T1 - Innovation durch strategische Allianzen : ein Wegweiser für die Druck- und Medienbranche . Staudt, Erich; Thielemann, Frank Y1 - 1998 SN - 3-928854-14-3 N1 - Innovation ; 14 PB - IAI, Inst. für Angewandte Innovationsforschung CY - Bochum ER - TY - JOUR A1 - Kern, Alexander A1 - Heidler, F. A1 - Zischank, W. T1 - Induced overvoltages in cable ducts taking into account the current flow into earth / F. Heidler ; W. Zischank ... A. Kern ... JF - Conference proceedings : 14th - 18th September 1998, [Burlington Hotel, Birmingham, United Kingdom] / organised by: School of Engineering and Advanced Technology, Staffordshire University, United Kingdom Y1 - 1998 N1 - International Conference on Lightning Protection <24, 1998, Birmingham> ; School of Engineering and Advanced Technology ; ICLP <4, 1998, Birmingham> CY - Birmingham ER - TY - JOUR A1 - Thust, M. A1 - Schroth, P. A1 - Töpler, A. A1 - Schöning, Michael Josef A1 - Müller-Veggian, Mattea A1 - Kordos, P. A1 - Lüth, H. T1 - Improving the detection limit of a capacitive sensor by means of a diffusion barrier JF - Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1 Y1 - 1998 SN - 0-7503-0595-9 N1 - Eurosensors ; (12, 1998, Southampton) ; UK Conference on Sensors and Their Applications ; (9, 1998, Southampton) SP - 507 EP - 510 PB - Inst. of Physics Publ. CY - Bristol [u.a.] ER - TY - JOUR A1 - Wollert, Jörg T1 - Im Sog des Standards : Windows CE als Betriebssystem für Embedded Controller JF - Elektronik : Fachmedium für industrielle Anwender und Entwickler Y1 - 1998 SN - 0013-5658 N1 - Printausg. in der Bibliothek vorhanden: 63 ZS 030 VL - Bd. 47 IS - H. 9 SP - 40 EP - 51 ER -