TY - JOUR A1 - Achtsnicht, Stefan A1 - Pourshahidi, Ali Mohammad A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim T1 - Multiplex detection of different magnetic beads using frequency scanning in magnetic frequency mixing technique JF - Sensors N2 - In modern bioanalytical methods, it is often desired to detect several targets in one sample within one measurement. Immunological methods including those that use superparamagnetic beads are an important group of techniques for these applications. The goal of this work is to investigate the feasibility of simultaneously detecting different superparamagnetic beads acting as markers using the magnetic frequency mixing technique. The frequency of the magnetic excitation field is scanned while the lower driving frequency is kept constant. Due to the particles’ nonlinear magnetization, mixing frequencies are generated. To record their amplitude and phase information, a direct digitization of the pickup-coil’s signal with subsequent Fast Fourier Transformation is performed. By synchronizing both magnetic beads using frequency scanning in magnetic frequency mixing technique magnetic fields, a stable phase information is gained. In this research, it is shown that the amplitude of the dominant mixing component is proportional to the amount of superparamagnetic beads inside a sample. Additionally, it is shown that the phase does not show this behaviour. Excitation frequency scans of different bead types were performed, showing different phases, without correlation to their diverse amplitudes. Two commercially available beads were selected and a determination of their amount in a mixture is performed as a demonstration for multiplex measurements. KW - frequency mixing magnetic detection KW - magnetic sandwich immunoassay KW - multiparametric immunoassays Y1 - 2019 U6 - https://doi.org/10.3390/s19112599 SN - 1424-8220 VL - 19 IS - 11 PB - MDPI CY - Basel ER - TY - BOOK A1 - Uibel, Thomas A1 - Peterson, Leif Arne ED - Uibel, Thomas ED - Peterson, Leif Arne T1 - Tagungsband Aachener Holzbautagung 2019 Y1 - 2019 SN - 2197-4489 PB - FH Aachen CY - Aachen ER - TY - JOUR A1 - Schieren, Mark A1 - Kleinschmidt, Joris A1 - Schmutz, Axel A1 - Loop, Torsten A1 - Gatzweiler, Karl-Heinz A1 - Staat, Manfred A1 - Wappler, Frank A1 - Defosse, Jerome T1 - Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study JF - Anaesthesia Y1 - 2019 SN - 1365-2044 U6 - https://doi.org/10.1111/anae.14815 N1 - Die Anhänge "Table S1 (Impact of sex and level of training on dental force. Results presented as median (IQR [range]) and n (%))" und "Appendix S1 (Measurement technique.)" stehen unter "Supporting Information" zum Download bereit. VL - 74 IS - 12 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Scheer, Nico A1 - Henderson, Colin James A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Mclaren, Aileen W. A1 - MacLeod, Alastair Kenneth A1 - Lin, De A1 - Wright, Jayne A1 - Stanley, Lesley A1 - Wolf, C. Roland T1 - An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials JF - Drug Metabolism and Disposition Y1 - 2019 U6 - https://doi.org/10.1124/dmd.119.086397 IS - Early view ER - TY - CHAP A1 - Steinbauer, Gerald A1 - Ferrein, Alexander T1 - CogRob 2018 : Cognitive Robotics Workshop. Proceedings of the 11th Cognitive Robotics Workshop 2018 co-located with 16th International Conference on Principles of Knowledge Representation and Reasoning (KR 2018). Tempe, AZ, USA, October 27th, 2018. T2 - CEUR workshop proceedings Y1 - 2019 SN - 1613-0073 N1 - edited by Gerald Steinbauer, Alexander Ferrein IS - Vol-2325 ER - TY - CHAP A1 - Donner, Ralf A1 - Rabel, Matthias A1 - Scholl, Ingrid A1 - Ferrein, Alexander A1 - Donner, Marc A1 - Geier, Andreas A1 - John, André A1 - Köhler, Christian A1 - Varga, Sebastian T1 - Die Extraktion bergbaulich relevanter Merkmale aus 3D-Punktwolken eines untertagetauglichen mobilen Multisensorsystems T2 - Tagungsband Geomonitoring Y1 - 2019 U6 - https://doi.org/10.15488/4515 SP - 91 EP - 110 ER - TY - JOUR A1 - Baringhaus, Ludwig A1 - Gaigall, Daniel T1 - On an asymptotic relative efficiency concept based on expected volumes of confidence regions JF - Statistics - A Journal of Theoretical and Applied Statistic N2 - The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting. KW - Volume of confidence regions KW - asymptotic relative efficiency KW - likelihood ratio test KW - multivariate normal distribution KW - multinomial distribution Y1 - 2019 U6 - https://doi.org/10.1080/02331888.2019.1683560 SN - 1029-4910 VL - 53 IS - 6 SP - 1396 EP - 1436 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Zingsheim, Jonas A1 - Grimmer, Timo A1 - Ortner, Marion A1 - Schmaderer, Christoph A1 - Hauser, Christine A1 - Kotliar, Konstantin ED - Staat, Manfred ED - Erni, Daniel T1 - Recognition of subjects with mild cognitive impairment (MCI) by the use of retinal arterial vessels. T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen Y1 - 2019 SN - 978-3-940402-22-6 U6 - https://doi.org/10.17185/duepublico/48750 SP - 36 EP - 37 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Ferrein, Alexander A1 - Bharatheesha, Mukunda A1 - Schiffer, Stefan A1 - Corbato, Carlos Hernandez T1 - TRROS 2018 : Teaching Robotics with ROS Workshop at ERF 2018; Proceedings of the Workshop on Teaching Robotics with ROS (held at ERF 2018), co-located with European Robotics Forum 2018 (ERF 2018), Tampere, Finland, March 15th, 2018 T2 - CEUR Workshop Proceedings Y1 - 2019 SN - 1613-0073 IS - Vol-2329 ER - TY - CHAP A1 - Ferrein, Alexander A1 - Scholl, Ingrid A1 - Neumann, Tobias A1 - Krückel, Kai A1 - Schiffer, Stefan T1 - A system for continuous underground site mapping and exploration Y1 - 2019 U6 - https://doi.org/10.5772/intechopen.85859 ER -