TY - JOUR A1 - Atlas, Glen A1 - Brealey, David A1 - Dhar, Sunil A1 - Dikta, Gerhard A1 - Singer, Meryvn T1 - Additional hemodynamic measurements with an esophageal Doppler monitor: a preliminary report of compliance, force, kinetic energy, and afterload in the clinical setting JF - Journal of clinical monitoring and computing N2 - The esophageal Doppler monitor (EDM) is a minimally-invasive hemodynamic device which evaluates both cardiac output (CO), and fluid status, by estimating stroke volume (SV) and calculating heart rate (HR). The measurement of these parameters is based upon a continuous and accurate approximation of distal thoracic aortic blood flow. Furthermore, the peak velocity (PV) and mean acceleration (MA), of aortic blood flow at this anatomic location, are also determined by the EDM. The purpose of this preliminary report is to examine additional clinical hemodynamic calculations of: compliance (C), kinetic energy (KE), force (F), and afterload (TSVRi). These data were derived using both velocity-based measurements, provided by the EDM, as well as other contemporaneous physiologic parameters. Data were obtained from anesthetized patients undergoing surgery or who were in a critical care unit. A graphical inspection of these measurements is presented and discussed with respect to each patient’s clinical situation. When normalized to each of their initial values, F and KE both consistently demonstrated more discriminative power than either PV or MA. The EDM offers additional applications for hemodynamic monitoring. Further research regarding the accuracy, utility, and limitations of these parameters is therefore indicated. KW - Acceleration KW - Velocity KW - Kinetic energy KW - Force KW - Compliance KW - Afterload KW - Contractility KW - Volume status KW - Esophageal Doppler monitor Y1 - 2012 SN - 1573-2614 U6 - https://doi.org/10.1007/s10877-012-9386-5 IS - 26 SP - 473 EP - 482 PB - Springer Nature CY - London ER - TY - BOOK A1 - Artmann, Gerhard T1 - Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds. Y1 - 2011 SN - 978-3-642-11864-7 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Iken, Heiko A1 - Kirsanov, D. A1 - Legin, A. A1 - Schöning, Michael Josef T1 - Novel Thin-Film Polymeric Materials for the Detection of Heavy Metals JF - Procedia Engineering N2 - A variety of transition metals, e.g., copper, zinc, cadmium, lead, etc. are widely used in industry as components for wires, coatings, alloys, batteries, paints and so on. The inevitable presence of transition metals in industrial processes implies the ambition of developing a proper analytical technique for their adequate monitoring. Most of these elements, especially lead and cadmium, are acutely toxic for biological organisms. Quantitative determination of these metals at low activity levels in different environmental and industrial samples is therefore a vital task. A promising approach to achieve an at-side or on-line monitoring on a miniaturized and cost efficient way is the combination of a common potentiometric sensor array with heavy metal-sensitive thin-film materials, like chalcogenide glasses and polymeric materials, respectively. Y1 - 2012 U6 - https://doi.org/10.1016/j.proeng.2012.09.148 SN - 1877-7058 N1 - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012" IS - 47 SP - 322 EP - 325 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, K. A1 - Ichimura, H. A1 - Wagner, Torsten A1 - Yoshinobu, T. A1 - Schöning, Michael Josef T1 - Chemical Imaging of ion Diffusion in a Microfluidic Channel JF - Procedia Engineering N2 - The chemical imaging sensor is a chemical sensor which is capable of visualizing the spatial distribution of chemical species in sample solution. In this study, a novel measurement system based on the chemical imaging sensor was developed to observe the inside of a Y-shaped microfluidic channel while injecting two sample solutions from two branches. From the collected chemical images, it was clearly observed that the injected solutions formed laminar flows in the microfluidic channel. In addition, ion diffusion across the laminar flows was observed. This label-free method can acquire quantitative data of ion distribution and diffusion in microfluidic devices, which can be used to determine the diffusion coefficients, and therefore, the molecular weights of chemical species in the sample solution. Y1 - 2012 U6 - https://doi.org/10.1016/j.proeng.2012.09.289 SN - 1877-7058 N1 - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012" IS - 47 SP - 886 EP - 889 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wagner, Torsten A1 - Shigiahara, N. A1 - Miyamoto, K. A1 - Suzurikawa, J. A1 - Finger, F. A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Light-addressable Potentiometric Sensors and Light–addressable Electrodes as a Combined Sensor-and-manipulator Microsystem with High Flexibility JF - Procedia Engineering N2 - This work describes the novel combination of the light-addressable electrode (LAE) and the light-addressable potentiometric sensor (LAPS) into a microsystem set-up. Both the LAE as well as the LAPS shares the principle of addressing the active spot by means of a light beam. This enables both systems to manipulate resp. to detect an analyte with a high spatial resolution. Hence, combining both principles into a single set-up enables the active stimulation e.g., by means of electrolysis and a simultaneous observation e.g., the response of an entrapped biological cell by detection of extracellular pH changes. The work will describe the principles of both technologies and the necessary steps to integrate them into a single set-up. Furthermore, examples of application and operation of such systems will be presented. Y1 - 2012 U6 - https://doi.org/10.1016/j.proeng.2012.09.290 SN - 1877-7058 N1 - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012" IS - 47 SP - 890 EP - 893 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Murib, Mohammed S. A1 - Tran, Anh Quang A1 - Ceuninck, Ward de A1 - Schöning, Michael Josef A1 - Nesladek, Milos A1 - Serpengüzel, Ali A1 - Wagner, Patrick T1 - Analysis of an optical biosensor based on elastic light scattering from diamond-, glass-, and sapphire microspheres JF - Physica Status Solidi A N2 - Deoxyribonucleic acid (DNA) and protein recognition are now standard tools in biology. In addition, the special optical properties of microsphere resonators expressed by the high quality factor (Q-factor) of whispering gallery modes (WGMs) or morphology dependent resonances (MDRs) have attracted the attention of the biophotonic community. Microsphere-based biosensors are considered as powerful candidates to achieve label-free recognition of single molecules due to the high sensitivity of their WGMs. When the microsphere surface is modified with biomolecules, the effective refractive index and the effective size of the microsphere change resulting in a resonant wavelength shift. The transverse electric (TE) and the transverse magnetic (TM) elastic light scattering intensity of electromagnetic waves at 600 and 1400 nm are numerically calculated for DNA and unspecific binding of proteins to the microsphere surface. The effect of changing the optical properties was studied for diamond (refractive index 2.34), glass (refractive index 1.50), and sapphire (refractive index 1.75) microspheres with a 50 µm radius. The mode spacing, the linewidth of WGMs, and the shift of resonant wavelength due to the change in radius and refractive index, were analyzed by numerical simulations. Preliminary results of unspecific binding of biomolecules are presented. The calculated shift in WGMs can be used for biomolecules detection. Y1 - 2012 U6 - https://doi.org/10.1002/pssa.201100795 SN - 1862-6319 N1 - Special Issue: "Fundamentals and Applications of Diamond" VL - 209 IS - 9 SP - 1804 EP - 1810 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Bohrn, Ulrich A1 - Stütz, Evamaria A1 - Fleischer, Maximilian A1 - Schöning, Michael Josef A1 - Wagner, Patrick T1 - Using a cell-based gas biosensor for investigation of adverse effects of acetone vapors in vitro JF - Biosensors and Bioelectronics. 40 (2013), H. 1 Y1 - 2013 SN - 0956-5663 SP - 393 EP - 400 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Kotliar, Konstantin T1 - Functional in-vivo assessment and biofluidmechanical analysis of age-related and pathological microstructural changes in retinal vessels [Elektronische Ressource] Y1 - 2008 N1 - München, Techn. Univ., Diss., 2008 PB - - ER - TY - THES A1 - Kotliar, Konstantin T1 - Razrabotka i analiz matematicheskih modelei nezavisimogo i svyazannogo funkcionirovaniya drenazhnoi i akkomodacionnoi regulyatornyh sistem chelovecheskogo glaza T2 - Mathematische Modelle der interaktiven und unabhängigen Funktion von Drainage- und Akkommodations-Regelungssystemen des menschlichen Auges Y1 - 1998 N1 - St.-Petersburg, Russland, Univ., Diss., 1998 [Lehrstuhl für Theoretische Mechanik der Staatlichen Polytechnischen Universität St.-Petersburg] Originaltitel: Razrabotka i analiz matematicheskih modelei nezavisimogo i svyazannogo funkcionirovaniya drenazhnoi i akkomodacionnoi regulyatornyh sistem chelovecheskogo glaza. 328 S. PB - - ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Hierarchical methods for dynamics in complex molecular systems : IAS Winter School, 5 - 9 March 2012, Forschungszentrum Jülich GmbH ; lecture notes / ed. by Johannes Grotendorst, Godehard Sutmann, Gerhard Gompper, Dominik Marx Y1 - 2012 SN - 978-3-89336-768-9 N1 - (Schriften des Forschungszentrums Jülich IAS Series 10) PB - Forschungszentrum Jülich CY - Jülich ER -