TY  - JOUR
A1  - Honarvarfard, Elham
A1  - Gamella, Maria
A1  - Channaveerappa, Devika
A1  - Darie, Costel C.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - Electrochemically Stimulated Insulin Release from a Modified Graphene–functionalized Carbon Fiber Electrode
JF  - Electroanalysis
N2  - A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9–10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of −1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species.
Y1  - 2017
U6  - https://doi.org/10.1002/elan.201700095
SN  - 1521-4109
VL  - 29
IS  - 6
SP  - 1543
EP  - 1553
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Enning, Manfred
A1  - Pfaff, Raphael
T1  - Güterwagen 4.0 - Der Güterwagen für das Internet der Dinge. Teil 1: Gesamtsystembetrachtung und grundlegendes Konzept
JF  - ETR - Eisenbahntechnische Rundschau
Y1  - 2017
SN  - 0013-2845
VL  - 66
IS  - 1/2
SP  - 12
EP  - 16
PB  - DVV Media Group
CY  - Hamburg
ER  - 
TY  - JOUR
A1  - Enning, Manfred
T1  - Vom "König der Landstraße" zur "Ameise 4.0"
JF  - ETR - Eisenbahntechnische Rundschau
N2  - Auf Eisenbahn- und Logistikkonferenzen werden gelegentlich Videos von Blattschneiderameisen gezeigt, die effizient und selbstorganisiert große Mengen Material durch den Dschungel transportieren. Daran sollen wir uns ein Beispiel nehmen.
Y1  - 2017
SN  - 0013-2845
VL  - 66
IS  - 1/2
SP  - 3
PB  - DVV Media Group
CY  - Hamburg
ER  - 
TY  - CHAP
A1  - Pieper, Martin
A1  - Wählisch, Georg
T1  - Mehrwert von E-Learning durch fächerübergreifenden Einsatz
T2  - Teaching is Touching the Future & ePS 2016 - Kompetenzorientiertes Lehren, Lernen und Prüfen
Y1  - 2017
SN  - 978-3-946017-05-9
SP  - 193
EP  - 196
PB  - UVW Universitätsverlag Webler
CY  - Bielefeld
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Wegmann, Kilian
A1  - Kahmann, Stephanie Lucina
A1  - Heinze, Nicolai
A1  - Staat, Manfred
A1  - Neiss, Wolfram F.
A1  - Scaal, Martin
A1  - Müller, Lars P.
T1  - Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow
JF  - Knee Surgery, Sports Traumatology, Arthroscopy
Y1  - 2017
U6  - https://doi.org/10.1007/s00167-017-4468-z
SN  - 1433-7347
VL  - 25
IS  - 7
SP  - 2280
EP  - 2288
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Czupalla, Markus
T1  - Pflanzen oder Maschinen - was läßt uns auf dem Mars überleben?
T2  - Überleben im Weltraum. Auf dem Weg zu neuen Grenzen. 21. Berliner Kolloquium der Daimler und Benz Stiftung 24. Mai 2017
Y1  - 2017
SP  - 12
EP  - 12
ER  - 
TY  - CHAP
A1  - Blome, Hans-Joachim
A1  - Gerzer, Rupert
A1  - Baumstark-Khan, Christa
A1  - Ewald, Reinhold
A1  - Heinicke, Christiane
A1  - Czupalla, Markus
A1  - Carter, Layne
A1  - Anderson, Molly
T1  - Überleben im Weltraum. Auf dem Weg zu neuen Grenzen. 21. Berliner Kolloquium der Daimler und Benz Stiftung 24. Mai 2017
Y1  - 2017
ER  - 
TY  - JOUR
A1  - Karnatak, Rajat
A1  - Kantz, Holger
A1  - Bialonski, Stephan
T1  - Early warning signal for interior crises in excitable systems
JF  - Physical Review E
Y1  - 2017
U6  - https://doi.org/10.1103/PhysRevE.96.042211
SN  - 2470-0053
VL  - 96
IS  - 4
SP  - 042211
ER  - 
TY  - JOUR
A1  - Olbertz, Klaus
A1  - Groth, Alexandra
T1  - Änderungen durch das Flexirentengesetz - Neue Anreize zur Beschäftigung von Rentnern
JF  - NWB - Steuer- und Wirtschaftsrecht
Y1  - 2018
SN  - 1860-9449
IS  - 10
SP  - 738
EP  - 748
PB  - NWB Verlag
CY  - Herne
ER  - 
TY  - JOUR
A1  - Olbertz, Klaus
T1  - Aufhebungsverträge und Sperrzeit beim Bezug von Arbeitslosengeld - Neue Gestaltungsmöglichkeiten aufgrund geänderter Geschäftsanweisung der Bundesagentur für Arbeit
JF  - NWB - Steuer- und Wirtschaftsrecht
Y1  - 2018
SN  - 1860-9449
IS  - 21
SP  - 1588
EP  - 1593
ER  -