TY - JOUR A1 - Poghossian, Arshak A1 - Jablonski, Melanie A1 - Molinnus, Denise A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2 and Plant Viral Enhancers JF - Frontiers in Plant Science N2 - Coronavirus disease 2019 (COVID-19) is a novel human infectious disease provoked by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, no specific vaccines or drugs against COVID-19 are available. Therefore, early diagnosis and treatment are essential in order to slow the virus spread and to contain the disease outbreak. Hence, new diagnostic tests and devices for virus detection in clinical samples that are faster, more accurate and reliable, easier and cost-efficient than existing ones are needed. Due to the small sizes, fast response time, label-free operation without the need for expensive and time-consuming labeling steps, the possibility of real-time and multiplexed measurements, robustness and portability (point-of-care and on-site testing), biosensors based on semiconductor field-effect devices (FEDs) are one of the most attractive platforms for an electrical detection of charged biomolecules and bioparticles by their intrinsic charge. In this review, recent advances and key developments in the field of label-free detection of viruses (including plant viruses) with various types of FEDs are presented. In recent years, however, certain plant viruses have also attracted additional interest for biosensor layouts: Their repetitive protein subunits arranged at nanometric spacing can be employed for coupling functional molecules. If used as adapters on sensor chip surfaces, they allow an efficient immobilization of analyte-specific recognition and detector elements such as antibodies and enzymes at highest surface densities. The display on plant viral bionanoparticles may also lead to long-time stabilization of sensor molecules upon repeated uses and has the potential to increase sensor performance substantially, compared to conventional layouts. This has been demonstrated in different proof-of-concept biosensor devices. Therefore, richly available plant viral particles, non-pathogenic for animals or humans, might gain novel importance if applied in receptor layers of FEDs. These perspectives are explained and discussed with regard to future detection strategies for COVID-19 and related viral diseases. Y1 - 2020 U6 - https://doi.org/10.3389/fpls.2020.598103 VL - 11 IS - Article 598103 SP - 1 EP - 14 PB - Frontiers CY - Lausanne ER - TY - JOUR A1 - El-Deib, Khaled A1 - Butenweg, Christoph A1 - Klinkel, Sven T1 - Erdbebennachweis von Mauerwerksbauten mit realistischen Modellen und erhöhten Verhaltensbeiwerten JF - Bautechnik N2 - Die Anwendung des linearen Nachweiskonzepts auf Mauerwerksbauten führt dazu, dass bereits heute Standsicherheitsnachweise für Gebäude mit üblichen Grundrissen in Gebieten mit moderaten Erdbebeneinwirkungen nicht mehr geführt werden können. Diese Problematik wird sich in Deutschland mit der Einführung kontinuierlicher probabilistischer Erdbebenkarten weiter verschärfen. Aufgrund der Erhöhung der seismischen Einwirkungen, die sich vielerorts ergibt, ist es erforderlich, die vorhandenen, bislang nicht berücksichtigten Tragfähigkeitsreserven in nachvollziehbaren Nachweiskonzepten in der Baupraxis verfügbar zu machen. Der vorliegende Beitrag stellt ein Konzept für die gebäudespezifische Ermittlung von erhöhten Verhaltensbeiwerten vor. Die Verhaltensbeiwerte setzen sich aus drei Anteilen zusammen, mit denen die Lastumverteilung im Grundriss, die Verformungsfähigkeit und Energiedissipation sowie die Überfestigkeiten berücksichtigt werden. Für die rechnerische Ermittlung dieser drei Anteile wird ein nichtlineares Nachweiskonzept auf Grundlage von Pushover-Analysen vorgeschlagen, in denen die Interaktionen von Wänden und Geschossdecken durch einen Einspanngrad beschrieben werden. Für die Bestimmung der Einspanngrade wird ein nichtlinearer Modellierungsansatz eingeführt, mit dem die Interaktion von Wänden und Decken abgebildet werden kann. Die Anwendung des Konzepts mit erhöhten gebäudespezifischen Verhaltensbeiwerten wird am Beispiel eines Mehrfamilienhauses aus Kalksandsteinen demonstriert. Die Ergebnisse der linearen Nachweise mit erhöhten Verhaltensbeiwerten für dieses Gebäude liegen deutlich näher an den Ergebnissen nichtlinearer Nachweise und somit bleiben übliche Grundrisse in Erdbebengebieten mit den traditionellen linearen Rechenansätzen nachweisbar. Y1 - 2020 U6 - https://doi.org/10.1002/bate.202000016 VL - 97 IS - 11 SP - 756 EP - 765 PB - Ernst & Sohn CY - Berlin ER - TY - JOUR A1 - Fiedler, Thomas M. A1 - Ladd, Mark E. A1 - Clemens, Markus A1 - Bitz, Andreas T1 - Safety of subjects during radiofrequency exposure in ultra-high-field magnetic resonance imaging JF - IEEE Letters on Electromagnetic Compatibility Practice and Applications N2 - Magnetic resonance imaging (MRI) is one of the most important medical imaging techniques. Since the introduction of MRI in the mid-1980s, there has been a continuous trend toward higher static magnetic fields to obtain i.a. a higher signal-to-noise ratio. The step toward ultra-high-field (UHF) MRI at 7 Tesla and higher, however, creates several challenges regarding the homogeneity of the spin excitation RF transmit field and the RF exposure of the subject. In UHF MRI systems, the wavelength of the RF field is in the range of the diameter of the human body, which can result in inhomogeneous spin excitation and local SAR hotspots. To optimize the homogeneity in a region of interest, UHF MRI systems use parallel transmit systems with multiple transmit antennas and time-dependent modulation of the RF signal in the individual transmit channels. Furthermore, SAR increases with increasing field strength, while the SAR limits remain unchanged. Two different approaches to generate the RF transmit field in UHF systems using antenna arrays close and remote to the body are investigated in this letter. Achievable imaging performance is evaluated compared to typical clinical RF transmit systems at lower field strength. The evaluation has been performed under consideration of RF exposure based on local SAR and tissue temperature. Furthermore, results for thermal dose as an alternative RF exposure metric are presented. Y1 - 2020 SN - 2637-6423 U6 - https://doi.org/10.1109/LEMCPA.2020.3029747 VL - 2 IS - 3 SP - 1 EP - 8 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Molinnus, Denise A1 - Beging, Stefan A1 - Lowis, Carsten A1 - Schöning, Michael Josef T1 - Towards a multi-enzyme capacitive field-effect biosensor by comparative study of drop-coating and nano-spotting technique JF - Sensors N2 - Multi-enzyme immobilization onto a capacitive field-effect biosensor by nano-spotting technique is presented. The nano-spotting technique allows to immobilize different enzymes simultaneously on the sensor surface with high spatial resolution without additional photolithographical patterning. The amount of applied enzymatic cocktail on the sensor surface can be tailored. Capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors with Ta2O5 as pH-sensitive transducer layer have been chosen to immobilize the three different (pL droplets) enzymes penicillinase, urease, and glucose oxidase. Nano-spotting immobilization is compared to conventional drop-coating method by defining different geometrical layouts on the sensor surface (fully, half-, and quarter-spotted). The drop diameter is varying between 84 µm and 102 µm, depending on the number of applied drops (1 to 4) per spot. For multi-analyte detection, penicillinase and urease are simultaneously nano-spotted on the EIS sensor. Sensor characterization was performed by C/V (capacitance/voltage) and ConCap (constant capacitance) measurements. Average penicillin, glucose, and urea sensitivities for the spotted enzymes were 81.7 mV/dec, 40.5 mV/dec, and 68.9 mV/dec, respectively. Y1 - 2020 SN - 1424-8220 U6 - https://doi.org/10.3390/s20174924 N1 - Special issue: Multisensor Systems and Signal Processing in Analytical Chemistry VL - 20 IS - 17 PB - MDPI CY - Basel ER - TY - JOUR A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - Comparative assessment of parallel-hybrid-electric propulsion systems for four different aircraft JF - Journal of Aircraft N2 - Until electric energy storage systems are ready to allow fully electric aircraft, the combination of combustion engine and electric motor as a hybrid-electric propulsion system seems to be a promising intermediate solution. Consequently, the design space for future aircraft is expanded considerably, as serial hybrid-electric, parallel hybrid-electric, fully electric, and conventional propulsion systems must all be considered. While the best propulsion system depends on a multitude of requirements and considerations, trends can be observed for certain types of aircraft and certain types of missions. This Paper provides insight into some factors that drive a new design toward either conventional or hybrid propulsion systems. General aviation aircraft, regional transport aircraft vertical takeoff and landing air taxis, and unmanned aerial vehicles are chosen as case studies. Typical missions for each class are considered, and the aircraft are analyzed regarding their takeoff mass and primary energy consumption. For these case studies, a high-level approach is chosen, using an initial sizing methodology. Only parallel-hybrid-electric powertrains are taken into account. Aeropropulsive interaction effects are neglected. Results indicate that hybrid-electric propulsion systems should be considered if the propulsion system is sized by short-duration power constraints. However, if the propulsion system is sized by a continuous power requirement, hybrid-electric systems offer hardly any benefit. Y1 - 2020 U6 - https://doi.org/10.2514/1.C035897 SN - 1533-3868 VL - 57 IS - 5 PB - AIAA CY - Reston, Va. ER - TY - CHAP A1 - Geiben, Benedikt A1 - Götten, Falk A1 - Havermann, Marc T1 - Aerodynamic analysis of a winged sub-orbital spaceplane N2 - This paper primarily presents an aerodynamic CFD analysis of a winged spaceplane geometry based on the Japanese Space Walker proposal. StarCCM was used to calculate aerodynamic coefficients for a typical space flight trajectory including super-, trans- and subsonic Mach numbers and two angles of attack. Since the solution of the RANS equations in such supersonic flight regimes is still computationally expensive, inviscid Euler simulations can principally lead to a significant reduction in computational effort. The impact on accuracy of aerodynamic properties is further analysed by comparing both methods for different flight regimes up to a Mach number of 4. Y1 - 2020 U6 - https://doi.org/10.25967/530170 N1 - 69. Deutscher Luft- und Raumfahrtkongress 2020, 1. September 2020 - 3. September 2020, online PB - DGLR CY - Bonn ER - TY - CHAP A1 - Hippe, Jonas A1 - Finger, Felix A1 - Götten, Falk A1 - Braun, Carsten T1 - Propulsion System Qualification of a 25 kg VTOL-UAV: Hover Performance of Single and Coaxial Rotors and Wind-Tunnel Experiments on Cruise Propellers T2 - Deutscher Luft- und Raumfahrtkongress - DLRK 2020 N2 - This paper presents an approach for UAV propulsion system qualification and validation on the example of FH Aachen's 25 kg cargo UAV "PhoenAIX". Thrust and power consumption are the most important aspects of a propulsion system's layout. In the initial design phase, manufacturers' data has to be trusted, but the validation of components is an essential step in the design process. This process is presented in this paper. The vertical takeoff system is designed for efficient hover; therefore, performance under static conditions is paramount. Because an octo-copter layout with coaxial rotors is considered, the impact of this design choice is analyzed. Data on thrust, voltage stability, power consumption, rotational speed, and temperature development of motors and controllers are presented for different rotors. The fixed-wing propulsion system is designed for efficient cruise flight. At the same time, a certain static thrust has to be provided, as the aircraft needs to accelerate to cruise speed. As for the hover-system, data on different propellers is compared. The measurements were taken for static conditions, as well as for different inflow velocities, using the FH-Aachen's wind-tunnel. Y1 - 2020 N1 - 69. Deutscher Luft- und Raumfahrtkongress 2020, 1. September 2020 - 3. September 2020, online ER - TY - CHAP A1 - Götten, Falk A1 - Finger, Felix A1 - Havermann, Marc A1 - Braun, Carsten A1 - Marino, Matthew A1 - Bil, Cees T1 - Full Configuration Drag Estimation of Small-to-Medium Range UAVs and its Impact on Initial Sizing Optimization T2 - CEAS Aeronautical Journal N2 - The paper presents the derivation of a new equivalent skin friction coefficient for estimating the parasitic drag of short-to-medium range fixed-wing unmanned aircraft. The new coefficient is derived from an aerodynamic analysis of ten different unmanned aircraft used on surveillance, reconnaissance, and search and rescue missions. The aircraft are simulated using a validated unsteady Reynolds-averaged Navier Stokes approach. The UAV's parasitic drag is significantly influenced by the presence of miscellaneous components like fixed landing gears or electro-optical sensor turrets. These components are responsible for almost half of an unmanned aircraft's total parasitic drag. The new equivalent skin friction coefficient accounts for these effects and is significantly higher compared to other aircraft categories. It is used to initially size an unmanned aircraft for a typical reconnaissance mission. The improved parasitic drag estimation yields a much heavier unmanned aircraft when compared to the sizing results using available drag data of manned aircraft. Y1 - 2020 U6 - https://doi.org/10.1007/s13272-021-00522-w SN - 1869-5590 N1 - 69. Deutscher Luft- und Raumfahrtkongress 2020, 1. September 2020 - 3. September 2020, online VL - 12 SP - 589 EP - 603 PB - Springer CY - Wien ER - TY - JOUR A1 - Butenweg, Christoph A1 - Rosin, Julia T1 - Seismischer Nachweis von Mauerwerksbauten in deutschen Erdbebengebieten JF - Mauerwerk N2 - Mit finanzieller Unterstützung der Deutschen Gesellschaft für Mauerwerks- und Wohnungsbau e.V. (DGfM) und des Deutschen Instituts für Bautechnik in Berlin (DIBt) wurden zwei aufeinander aufbauende Forschungsvorhaben zur Verbesserung der seismischen Nachweise von Mauerwerksbauten in deutschen Erdbebengebieten durchgeführt. Zunächst wurde das seismische Verhalten von drei modernen unbewehrten Mauerwerksgebäuden in der Region Emilia Romagna in Italien während der Erdbebenserie im Jahr 2012 in Kooperation mit der Universität Pavia eingehend untersucht. Aufbauend auf den Erkenntnissen dieser Untersuchungen wurde ein verbessertes seismisches Bemessungskonzept für unbewehrte Mauerwerksbauten erarbeitet. Der Beitrag stellt die wesentlichen Ergebnisse dieser Forschungsarbeiten und deren Eingang in die Normung vor. Y1 - 2020 U6 - https://doi.org/10.1002/dama.202000006 SN - 1437-1022 VL - 24 IS - 2 SP - 108 EP - 113 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Marinkovic, Marko A1 - Butenweg, Christoph T1 - Ausfachungen aus Ziegelmauerwerk in Stahlbetonrahmentragwerken unter Erdbebenbeanspruchung JF - Mauerwerk N2 - Stahlbetonrahmentragwerke mit Ausfachungen aus Mauerwerk weisen nach Erdbeben häufig schwere Schäden auf. Gründe hierfür sind die Beanspruchungen der Ausfachungswände durch die aufgezwungenen Rahmenverformungen in Wandebene und die gleichzeitig auftretenden Trägheitskräfte senkrecht zur Wandebene in Kombination mit der konstruktiven Ausführung des Ausfachungsmauerwerks. Die Ausfachung wird in der Regel knirsch gegen die Rahmenstützen gemauert, wobei der Verschluss der oberen Fuge mit Mörtel oder Montageschaum erfolgt. Dadurch kommt es im Erdbebenfall zu lokalen Interaktionen zwischen Ausfachung und Rahmen, die in der Folge zu einem Versagen einzelner Ausfachungswände oder zu einem sukzessiven Versagen des Gesamtgebäudes führen können. Die beobachteten Schäden waren die Motivation dafür, in dem europäischen Forschungsprojekt INSYSME für Stahlbetonrahmentragwerke mit Ausfachungen aus hochwärmedämmenden Ziegelmauerwerk innovative Lösungen zur Verbesserung des seismischen Verhaltens zu entwickeln. Der vorliegende Beitrag stellt die im Rahmen des Projekts von den deutschen Projektpartnern (Universität Kassel, SDA-engineering GmbH) entwickelten Lösungen vor und vergleicht deren seismisches Verhalten mit der traditionellen Ausführung der Ausfachungswände. Grundlage für den Vergleich sind statisch-zyklische Wandversuche und Simulationen auf Wandebene. Aus den Ergebnissen werden Empfehlungen für die erdbebensichere Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk abgeleitet. Y1 - 2020 U6 - https://doi.org/10.1002/dama.202000011 SN - 1437-1022 VL - 24 IS - 4 SP - 194 EP - 205 PB - Wiley CY - Weinheim ER -