TY - CHAP A1 - Wilke, Thomas ED - Merlotti, Andrea T1 - Planning Process of the Di Castellamonte’s Chapel of the Holy Shroud T2 - Carlo e Amedeo di Castellamonte : 1571-1683, ingegneri e architetti per i duchi di Savoia Y1 - 2016 SN - 978-88-98229-57-4 N1 - Architettura e potere ; 4 SP - 141 EP - 152 PB - Campisano editore CY - Rom ER - TY - CHAP A1 - Wilke, Thomas ED - Heussler, Carla T1 - Piemont – Grenzregion zwischen Frankreich und Italien T2 - Sehnsucht Italien – Die schönsten Kunstlandschaften von Piemont bis Sizilien Y1 - 2010 SN - 978-3-534-22986-4 SP - 13 EP - 24 PB - WBG CY - Darmstadt ER - TY - CHAP A1 - Wilke, Thomas ED - Castor, Markus A. T1 - Vorlagegraphik versus Künstlergraphik: Überlegungen zu Jean Lepautres Kupferstichfolgen für die Innenraumgestaltung T2 - Druckgraphik : zwischen Reproduktion und Invention Y1 - 2010 SN - 978-3-422-06940-4 N1 - Passagen ; 31 SP - 419 EP - 432 PB - Dt. Kunstverl. CY - Berlin ER - TY - CHAP A1 - Wilke, Thomas ED - Karge, Henrik T1 - Architektonische Innovation in Deutschland und Italien vor 1848: Gottfried Semper und Alessandro Antonelli T2 - Gottfried Semper - Dresden und Europa : die moderne Renaissance der Künste ; Akten des Internationalen Kolloquiums der Technischen Universität Dresden aus Anlass des 200. Geburtstags von Gottfried Semper Y1 - 2007 SN - 3-422-06606-3 N1 - Internationales Kolloquium aus Anlass des 200. Geburtstags von Gottfried Semper <2003, Dresden> ; Technische Universität Dresden SP - 277 EP - 288 PB - Dt. Kunstverl. CY - Berlin ER - TY - CHAP A1 - Wilke, Thomas T1 - Peyre, Marie-Josephe T2 - Allgemeines Künstler-Lexikon. Bd. 95 Y1 - 2017 SN - 978-3-11-023261-5 N1 - namentlich gekennzeichneter Lexikon-Eintrag SP - 301 EP - 302 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Wilke, Thomas T1 - Peyre, Antoine-Francois T2 - Allgemeines Künstler-Lexikon. Bd. 95 Y1 - 2017 SN - 978-3-11-023261-5 N1 - namentlich gekennzeichneter Lexikon-Eintrag SP - 300 EP - 301 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Wilke, Thomas T1 - Patte, Pierre T2 - Allgemeines Künstler-Lexikon. Bd. 94 Y1 - 2017 SN - 978-3-11-023260-8 N1 - namentlich gekennzeichneter Lexikon-Eintrag SP - 429 EP - 430 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Staat, Manfred A1 - Heitzer, Michael ED - Staat, Manfred ED - Heitzer, Michael T1 - Probabilistic limit and shakedown problems T2 - Numerical methods for limit and shakedown analysis. Deterministic and probabilistic problems Y1 - 2003 SN - 3-00-010001-6 N1 - NIC Series VL - 15 SP - 217 EP - 268 PB - John von Neumann Institute for Computing (NIC) CY - Jülich ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Mechanics of soft tissue reactions to textile mesh implants T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - For pelvic floor disorders that cannot be treated with non-surgical procedures, minimally invasive surgery has become a more frequent and safer repair procedure. More than 20 million prosthetic meshes are implanted each year worldwide. The simple selection of a single synthetic mesh construction for any level and type of pelvic floor dysfunctions without adopting the design to specific requirements increase the risks for mesh related complications. Adverse events are closely related to chronic foreign body reaction, with enhanced formation of scar tissue around the surgical meshes, manifested as pain, mesh erosion in adjacent structures (with organ tissue cut), mesh shrinkage, mesh rejection and eventually recurrence. Such events, especially scar formation depend on effective porosity of the mesh, which decreases discontinuously at a critical stretch when pore areas decrease making the surgical reconstruction ineffective that further augments the re-operation costs. The extent of fibrotic reaction is increased with higher amount of foreign body material, larger surface, small pore size or with inadequate textile elasticity. Standardized studies of different meshes are essential to evaluate influencing factors for the failure and success of the reconstruction. Measurements of elasticity and tensile strength have to consider the mesh anisotropy as result of the textile structure. An appropriate mesh then should show some integration with limited scar reaction and preserved pores that are filled with local fat tissue. This chapter reviews various tissue reactions to different monofilament mesh implants that are used for incontinence and hernia repairs and study their mechanical behavior. This helps to predict the functional and biological outcomes after tissue reinforcement with meshes and permits further optimization of the meshes for the specific indications to improve the success of the surgical treatment. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_11 SP - 251 EP - 275 PB - Springer CY - Singapore ER - TY - CHAP A1 - Artmann, Gerhard A1 - Meruvu, Haritha A1 - Kizildag, Sefa A1 - Temiz Artmann, Aysegül ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative “CellDrum technology” was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_7 SP - 157 EP - 192 PB - Springer CY - Singapore ER -