TY  - CHAP
A1  - Frotscher, Ralf
A1  - Staat, Manfred
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.
Y1  - 2018
SN  - 978-981-10-7904-7
U6  - https://doi.org/10.1007/978-981-10-7904-7_10
SP  - 233
EP  - 250
PB  - Springer
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Kramer, Matthias
A1  - Valero, Daniel
A1  - Chanson, Hubert
A1  - Bung, Daniel Bernhard
T1  - Towards reliable turbulence estimations with phase-detection probes: an adaptive window cross-correlation technique
JF  - Experiments in Fluids
Y1  - 2019
U6  - https://doi.org/10.1007/s00348-018-2650-9
SN  - 1432-1114
VL  - 60
EP  - Article number 2
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Platen, J.
A1  - Schöning, Michael Josef
T1  - Towards self-aligned nanostructures by means of layerexpansion technique
JF  - Electrochimica Acta. 51 (2005), H. 5
Y1  - 2005
SN  - 0013-4686
SP  - 838
EP  - 843
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Behr, Marek
A1  - Nicolai, Mike
A1  - Probst, Markus
T1  - Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM
JF  - NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum Jülich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot Münster; Dietrich Wolf; Manfred Kremer (ed.)
Y1  - 2008
SN  - 978-3-9810843-5-1
N1  - NIC series ; 39
SP  - 325
EP  - 332
PB  - Forschungszentrum
CY  - Jülich
ER  - 
TY  - CHAP
A1  - Lüpfert, E.
A1  - Herrmann, Ulf
A1  - Price, Henry
A1  - Zarza, E.
A1  - Kistener, R.
ED  - Ramos, C.
T1  - Towards Standard Performance Analysis for Parabolic Trough Collector Fields
T2  - 12th International Symposium Solar Power and Chemical Energy Systems, October 6-8, 2004, Oaxaca Mexico ; SolarPACES International Symposium, 12
Y1  - 2004
SN  - 968-6114-18-1
PB  - Instituto de Investigaciones Electricas
CY  - [s.l.]
ER  - 
TY  - GEN
A1  - Waiczies, Helmar
A1  - Kühne, André
A1  - Winter, Lukas
A1  - Frauenrath, Tobias
A1  - Hoffmann, Werner
A1  - Ittermann, Bernd
A1  - Waiczies, Sonia
A1  - Niendorf, Thoralf
T1  - Towards theranostics of rheumatoid arthritis: 1H/19F imaging of non-steroidal anti-inflammatory drugs in hand and wrist at 7 Tesla
T2  - 2013 ISMRM Annual Meeting Proceedings
N2  - We have developed a double-tuned ¹H/¹⁹F birdcage resonator dedicated for hand and wrist imaging at 7 T to locally image non-steroidal anti-inflammatory drugs (NSAID) such as 2-{[3-(Trifluoromethyl) phenyl]amino}benzoic acid. The preliminary in vivo images acquired by the double-tuned ¹H/¹⁹F birdcage resonator demonstrate the feasibility for ¹H/¹⁹F hand- and wrist-imaging at 7 T. While the diagnostic quality of the coil needs to be assessed in patients with inflammatory rheumatoid disease, first ¹⁹F images of the NSAID are encouraging, and point towards the prospect of applying ¹⁹F-MRI to visualize and quantify the concentration of therapeutically-active compound at the sites of inflammation.
Y1  - 2013
SN  - 1545-4428
N1  - ISMRM 21st Annual Meeting & Exhibition, 20-26 April 2013, Salt Lake City, Utah, USA
ER  - 
TY  - CHAP
A1  - Burgeth, Bernhard
A1  - Kleefeld, Andreas
A1  - Zhang, Eugene
A1  - Zhang, Yue
ED  - Baudrier, Étienne
ED  - Naegel, Benoît
ED  - Krähenbühl, Adrien
ED  - Tajine, Mohamed
T1  - Towards Topological Analysis of Non-symmetric Tensor Fields via Complexification
T2  - Discrete Geometry and Mathematical Morphology
N2  - Fields of asymmetric tensors play an important role in many applications such as medical imaging (diffusion tensor magnetic resonance imaging), physics, and civil engineering (for example Cauchy-Green-deformation tensor, strain tensor with local rotations, etc.). However, such asymmetric tensors are usually symmetrized and then further processed. Using this procedure results in a loss of information. A new method for the processing of asymmetric tensor fields is proposed restricting our attention to tensors of second-order given by a 2x2 array or matrix with real entries. This is achieved by a transformation resulting in Hermitian matrices that have an eigendecomposition similar to symmetric matrices. With this new idea numerical results for real-world data arising from a deformation of an object by external forces are given. It is shown that the asymmetric part indeed contains valuable information.
Y1  - 2022
SN  - 978-3-031-19897-7
U6  - https://doi.org/10.1007/978-3-031-19897-7_5
N1  - Second International Joint Conference, DGMM 2022, Strasbourg, France, October 24–27, 2022
N1  - Corresponding author: Andreas Kleefeld
SP  - 48
EP  - 59
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Raab, Monika
A1  - Kappel, Sven
A1  - Krämer, Andrea
A1  - Sanhaji, Mourad
A1  - Matthess, Yves
A1  - Kurunci-Csacsko, Elisabeth
A1  - Calzada-Wack, Julia
A1  - Rathkolb, Birgit
A1  - Rosman, Jan
A1  - Adler, Thure
A1  - Busch, Dirk H.
A1  - Esposito, Irene
A1  - Fuchs, Helmut
A1  - Gailus-Durner, Valérie
A1  - Klingenspor, Martin
A1  - Wolf, Eckhard
A1  - Sänger, Nicole
A1  - Prinz, Florian
A1  - Hrabe de Angelis, Martin
A1  - Seibler, Jost
A1  - Yuan, Juping
A1  - Bergmann, Martin
A1  - Knecht, Rainald
A1  - Kreft, Bertolt
A1  - Strebhardt, Klaus
T1  - Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
JF  - Nature Communications
Y1  - 2011
U6  - https://doi.org/10.1038/ncomms1395
SN  - 2041-1723
VL  - 2
IS  - 395
SP  - 1
EP  - 11
PB  - Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Glück, O.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
A1  - Otto, A.
A1  - Emons, H.
T1  - Trace metal determination by dc resistance changes of microstructured thin gold film electrodes
JF  - Electrochimica Acta. 44 (1999), H. 21-22
Y1  - 1999
SN  - 0013-4686
SP  - 3761
EP  - 3768
ER  - 
TY  - JOUR
A1  - Glück, O.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
A1  - Emons, H.
A1  - Hanewinkel, C.
A1  - Schumacher, D.
A1  - Otto, A.
T1  - Trace metal determination with gold microelectrodes fabricated by silicon technology
JF  - Proceedings of the 11th European Conference on Solid-State Transducers / Eurosensors XI, September 21 - 24, 1997, Warsaw, Poland. [Organised by] Warsaw University of Technology. Vol 2.
Y1  - 1997
SN  - 83-908335-0-6
N1  - Eurosensors ; (11, 1997, Warszawa) ; Eurosensors - European Conference on Solid-State Transducers ; (11 : ; 1997.09.21-24 : ; Warsaw)
SP  - 615
EP  - 618
PB  - Sensor Lab Sp.
CY  - Warsaw
ER  -