TY  - JOUR
A1  - Becht, Alexander
A1  - Schollmayer, Curd
A1  - Monakhova, Yulia
A1  - Holzgrabe, Ulrike
T1  - Tracing the origin of paracetamol tablets by near-infrared, mid-infrared, and nuclear magnetic resonance spectroscopy using principal component analysis and linear discriminant analysis
JF  - Analytical and Bioanalytical Chemistry
N2  - Most drugs are no longer produced in their own countries by the pharmaceutical companies, but by contract manufacturers or at manufacturing sites in countries that can produce more cheaply. This not only makes it difficult to trace them back but also leaves room for criminal organizations to fake them unnoticed. For these reasons, it is becoming increasingly difficult to determine the exact origin of drugs. The goal of this work was to investigate how exactly this is possible by using different spectroscopic methods like nuclear magnetic resonance and near- and mid-infrared spectroscopy in combination with multivariate data analysis. As an example, 56 out of 64 different paracetamol preparations, collected from 19 countries around the world, were chosen to investigate whether it is possible to determine the pharmaceutical company, manufacturing site, or country of origin. By means of suitable pre-processing of the spectra and the different information contained in each method, principal component analysis was able to evaluate manufacturing relationships between individual companies and to differentiate between production sites or formulations. Linear discriminant analysis showed different results depending on the spectral method and purpose. For all spectroscopic methods, it was found that the classification of the preparations to their manufacturer achieves better results than the classification to their pharmaceutical company. The best results were obtained with nuclear magnetic resonance and near-infrared data, with 94.6%/99.6% and 98.7/100% of the spectra of the preparations correctly assigned to their pharmaceutical company or manufacturer.
KW  - IR
KW  - Manufacturer
KW  - Linear discriminant analysis
KW  - Principal component analysis
Y1  - 2021
U6  - https://doi.org/10.1007/s00216-021-03249-z
SN  - 1618-2650
VL  - 413
SP  - 3107
EP  - 3118
PB  - Springer Nature
ER  - 
TY  - JOUR
A1  - Bode, J.
A1  - Bartsch, J.
A1  - Boulikas, T.
A1  - Iber, M.
A1  - Mielke, C.
A1  - Schübeler, D.
A1  - Seibler, Jost
A1  - Benham, C.
T1  - Transcription-promoting genomic sites in mammalia: their elucidation and architectural principles
JF  - Gene therapy & molecular biology
Y1  - 1998
SN  - 1529-9120
VL  - 1
IS  - 1
SP  - 1
EP  - 29
ER  - 
TY  - JOUR
A1  - Halbach, Thorsten
A1  - Scheer, Nico
T1  - Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins
JF  - Nucleic Acids Research
Y1  - 2000
U6  - https://doi.org/10.1093/nar/28.18.3542
SN  - 1362-4962
VL  - 28
IS  - 18
SP  - 3542
EP  - 3550
ER  - 
TY  - JOUR
A1  - Bongaerts, Johannes
A1  - Zoschke, Sascha
A1  - Weidner, Uwe
A1  - Linden, Gottfried
T1  - Transcriptional regulation of the proton translocating NADH
JF  - Molecular microbiology
Y1  - 1995
SN  - 1365-2958 (E-Journal); 0950-382x (Print)
VL  - Vol. 16
IS  - Iss. 3
SP  - 521
EP  - 534
ER  - 
TY  - CHAP
A1  - Seibler, Jost
A1  - Schwenk, Frieder
T1  - Transgenic RNAi Applications in the Mouse
T2  - Methods in Enzymology : Guide to Techniques in Mouse Development, Part B: Mouse Molecular Genetics. 2nd Edition
Y1  - 2010
SN  - 978-0-12-384880-2
N1  - Methods in Enzymology : Vol. 477
SP  - 367
EP  - 386
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Barbazán, Paula
A1  - Hagenbach, Adelheid
A1  - Paulßen, Elisabeth
A1  - Abram, Ulrich
A1  - Carballo, Rosa
A1  - Rodriguez-Hermida, Sabina
A1  - Vázquez-López, Ezequiel M.
T1  - Tricarbonyl Rhenium(I) and Technetium(I) Complexes with Hydrazones Derived from 4,5-Diazafluoren-9-one and 1,10-Phenanthroline-5,6-dione
JF  - European Journal of Inorganic Chemistry
N2  - Tricarbonylrhenium(I) and -technetium(I) halide (halide = Cl and Br) complexes of ligands derived from 4,5-diazafluoren-9-one (df) and 1,10-phenanthroline-5,6-dione (phen) derivatives of benzoic and 2-hydroxybenzoic acid hydrazides have been prepared. The complexes have been characterized by elemental analysis, MS, IR, 1H NMR and absorption and emission UV/Vis spectroscopic methods. The metal centres (ReI and TcI) are coordinated through the nitrogen imine atoms and establish five-membered chelate rings, whereas the hydrazone groups stand uncoordinated. The 1H NMR spectra suggest the same behaviour in solution on the basis of only marginal variations in the chemical shifts of the hydrazine protons.
Y1  - 2010
U6  - https://doi.org/10.1002/ejic.201000522
SN  - 1099-0682
IS  - 29
SP  - 4622
EP  - 4630
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Ngyugen, Hung Huy
A1  - Kahlcke, Nils
A1  - Deflon, Victor M.
A1  - Abram, Ulrich
T1  - Tricarbonyltechnetium(I) and -rhenium(I) complexes with N′-thiocarbamoylpicolylbenzamidines
JF  - Polyhedron
N2  - N,N-Dialkylamino(thiocarbonyl)-N′-picolylbenzamidines react with (NEt4)2[M(CO)3X3] (M = Re, X = Br; M = Tc, X = Cl) under formation of neutral [M(CO)3L] complexes in high yields. The monoanionic NNS ligands bind in a facial coordination mode and can readily be modified at the (CS)NR1R2 moiety. The complexes [99Tc(CO)3(LPyMor)] and [Re(CO)3(L)] (L = LPyMor, LPyEt) were characterized by X-ray diffraction. Reactions of [99mTc(CO)3(H2O)3]+ with the N′-thiocarbamoylpicolylbenzamidines give the corresponding 99mTc complexes. The ester group in HLPyCOOEt allows linkage between biomolecules and the metal core.
Y1  - 2012
U6  - https://doi.org/10.1016/j.poly.2012.04.008
SN  - 0277-5387
VL  - 40
IS  - 1
SP  - 153
EP  - 158
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Hermann, Gloria
A1  - Jessen, Holly
A1  - Gokarn, Ravi R.
T1  - Two beta-alanyl-CoA:ammonia lyases in Clostridium propionicum / Herrmann , G. ;  Selmer,  T. ; Jessen,  HJ. ; Gokarn,  RR. ; Selifonova,  O. ;  Gort , SJ. ; , Buckel, W.
JF  - The FEBS Journal. 272 (2005), H. 3
Y1  - 2005
SN  - 1742-464X
SP  - 813
EP  - 821
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Jacobi, M.
A1  - Castillo, J.
A1  - Foerstel, D. H.
T1  - Ultra-low-level measurements of 3H and 14C in wines and champagne / Scherer, U. W. ; Jacobi, M. ; Castillo, J. ; Foerstel, D. H.
JF  - Radiation effects and defects in solids. 164 (2009), H. 5-6
Y1  - 2009
SN  - 1042-0150
SP  - 382
EP  - 385
ER  - 
TY  - CHAP
A1  - Srivastava, Alok
A1  - Knolle, Friedhart
A1  - Hoyler, Friedrich
A1  - Scherer, Ulrich W.
A1  - Schnug, Ewald
T1  - Uranium Toxicity in the State of Punjab in North-Western India
T2  - Management of Natural Resources in a Changing Environment
N2  - Lately there has been an increasing concern about uranium toxicity in some districts of Punjab State located in the North Western part of India after the publication of a report (Blaurock-Busch et al. 2010) which showed that the concentration of uranium in hair and urine of children suffering from physical deformities, neurological and mental disorder from Malwa region (Fig. 1) of Punjab State was manifold higher than the reference ranges. A train which connects the affected region with the nearby city of Bikaner which has a Cancer Hospital has been nicknamed as Cancer Express due to the frenzy generated on account of uranium related toxicity.
Y1  - 2015
SN  - 978-3-319-12559-6
U6  - https://doi.org/10.1007/978-3-319-12559-6_21
SP  - 271
EP  - 275
PB  - Springer
CY  - Cham
ER  -