TY - JOUR A1 - Albanna, Walid A1 - Conzen, Catharina A1 - Weiss, Miriam A1 - Seyfried, Katharina A1 - Kotliar, Konstantin A1 - Schmidt, Tobias Philip A1 - Kuerten, David A1 - Hescheler, Jürgen A1 - Bruecken, Anne A1 - Schmidt-Trucksäss, Arno A1 - Neumaier, Felix A1 - Wiesmann, Martin A1 - Clusmann, Hans A1 - Schubert, Gerrit Alexander T1 - Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis JF - Frontiers in Neurology N2 - Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus. Y1 - 2021 U6 - https://doi.org/10.3389/fneur.2021.690183 SN - 1664-2295 VL - 12 IS - 12 SP - 1 EP - 15 ER - TY - CHAP A1 - Kotliar, Konstantin ED - Pallikaris, I. ED - Tsilimbaris, M. K. ED - Dastiridou, A. I. T1 - Ocular rigidity: clinical approach T2 - Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye N2 - The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications. KW - Coefficient of ocular rigidity KW - Eyeball KW - Corneo-scleral shell KW - Pressure-volume relationship KW - Differential tonometry Y1 - 2021 SN - 978-3-030-64422-2 U6 - https://doi.org/10.1007/978-3-030-64422-2_2 SP - 15 EP - 43 PB - Springer CY - Cham ER - TY - JOUR A1 - Neumaier, Felix A1 - Kotliar, Konstantin A1 - Haeren, Roel Hubert Louis A1 - Temel, Yasin A1 - Lüke, Jan Niklas A1 - Seyam, Osama A1 - Lindauer, Ute A1 - Clusmann, Hans A1 - Hescheler, Jürgen A1 - Schubert, Gerrit Alexander A1 - Schneider, Toni A1 - Albanna, Walid T1 - Retinal Vessel Responses to Flicker Stimulation Are Impaired in Ca v 2.3-Deficient Mice—An in- vivo Evaluation Using Retinal Vessel Analysis (RVA) JF - Frontiers in Neurology Y1 - 2021 U6 - https://doi.org/10.3389/fneur.2021.659890 VL - 12 SP - 1 EP - 11 PB - Frontiers ER - TY - JOUR A1 - Fiedler, Thomas M. A1 - Orzada, Stephan A1 - Flöser, Martina A1 - Rietsch, Stefan H. G. A1 - Quick, Harald H. A1 - Ladd, Mark E. A1 - Bitz, Andreas T1 - Performance analysis of integrated RF microstrip transmit antenna arrays with high channel count for body imaging at 7 T JF - NMR in Biomedicine N2 - The aim of the current study was to investigate the performance of integrated RF transmit arrays with high channel count consisting of meander microstrip antennas for body imaging at 7 T and to optimize the position and number of transmit ele- ments. RF simulations using multiring antenna arrays placed behind the bore liner were performed for realistic exposure conditions for body imaging. Simulations were performed for arrays with as few as eight elements and for arrays with high channel counts of up to 48 elements. The B1+ field was evaluated regarding the degrees of freedom for RF shimming in the abdomen. Worst-case specific absorption rate (SARwc ), SAR overestimation in the matrix compression, the number of virtual obser- vation points (VOPs) and SAR efficiency were evaluated. Constrained RF shimming was performed in differently oriented regions of interest in the body, and the devia- tion from a target B1+ field was evaluated. Results show that integrated multiring arrays are able to generate homogeneous B1+ field distributions for large FOVs, espe- cially for coronal/sagittal slices, and thus enable body imaging at 7 T with a clinical workflow; however, a low duty cycle or a high SAR is required to achieve homoge- neous B1+ distributions and to exploit the full potential. In conclusion, integrated arrays allow for high element counts that have high degrees of freedom for the pulse optimization but also produce high SARwc , which reduces the SAR accuracy in the VOP compression for low-SAR protocols, leading to a potential reduction in array performance. Smaller SAR overestimations can increase SAR accuracy, but lead to a high number of VOPs, which increases the computational cost for VOP evaluation and makes online SAR monitoring or pulse optimization challenging. Arrays with interleaved rings showed the best results in the study. KW - body imaging at UHF MRI KW - integrated transmit coil arrays KW - VOP compression Y1 - 2021 U6 - https://doi.org/10.1002/nbm.4515 SN - 0952-3480 (ISSN) SN - 1099-1492 (eISSN) VL - 34 IS - 7 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Kurulgan demirci, Eylem A1 - Fırat, Ipek Seda A1 - Oflaz, Hakan A1 - Artmann, Gerhard T1 - Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers JF - SHOCK KW - Septic cardiomyopathy KW - LPS KW - cardiomyocyte biomechanics KW - CellDrum KW - actin cytoskeleton Y1 - 2021 U6 - https://doi.org/10.1097/SHK.0000000000001845 SN - 1540-0514 PB - Wolters Kluwer CY - Köln ER - TY - CHAP A1 - El Moussaoui, Noureddine A1 - Kassmi, Khalil A1 - Alexopoulos, Spiros A1 - Schwarzer, Klemens A1 - Chayeb, Hamid A1 - Bachiri, Najib T1 - Simulation studies on a new innovative design of a hybrid solar distiller MSDH alimented with a thermal and photovoltaic energy T2 - Materialstoday: Proceedings N2 - In this paper, we present the structure, the simulation the operation of a multi-stage, hybrid solar desalination system (MSDH), powered by thermal and photovoltaic (PV) (MSDH) energy. The MSDH system consists of a lower basin, eight horizontal stages, a field of four flat thermal collectors with a total area of 8.4 m2, 3 Kw PV panels and solar batteries. During the day the system is heated by thermal energy, and at night by heating resistors, powered by solar batteries. These batteries are charged by the photovoltaic panels during the day. More specifically, during the day and at night, we analyse the temperature of the stages and the production of distilled water according to the solar irradiation intensity and the electric heating power, supplied by the solar batteries. The simulations were carried out in the meteorological conditions of the winter month (February 2020), presenting intensities of irradiance and ambient temperature reaching 824 W/m2 and 23 °C respectively. The results obtained show that during the day the system is heated by the thermal collectors, the temperature of the stages and the quantity of water produced reach 80 °C and 30 Kg respectively. At night, from 6p.m. the system is heated by the electric energy stored in the batteries, the temperature of the stages and the quantity of water produced reach respectively 90 °C and 104 Kg for an electric heating power of 2 Kw. Moreover, when the electric power varies from 1 Kw to 3 Kw the quantity of water produced varies from 92 Kg to 134 Kg. The analysis of these results and their comparison with conventional solar thermal desalination systems shows a clear improvement both in the heating of the stages, by 10%, and in the quantity of water produced by a factor of 3. Y1 - 2021 U6 - https://doi.org/10.1016/j.matpr.2021.03.115 SN - 2214-7853 N1 - The Fourth edition of the International Conference on Materials & Environmental Science (ICMES 2020), virtual conference, November 18-28, 2020, Morocco VL - 45 IS - 8 SP - 7653 EP - 7660 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dickhoff, Jens A1 - Horikawa, Atsushi A1 - Funke, Harald T1 - Hydrogen Combustion - new DLE Combustor Addresses NOx Emissions and Flashback JF - Turbomachinery international : the global journal of energy equipment Y1 - 2021 SN - 2767-2328 SN - 0149-4147 VL - 62 IS - 4 SP - 26 EP - 27 PB - MJH Life Sciences CY - Cranbury ER - TY - CHAP A1 - Butenweg, Christoph A1 - Gellert, Christoph A1 - Meyer, Udo T1 - Erdbebenbemessung bei Mauerwerksbauten T2 - Mauerwerk Kalender 2021: Kunststoffverankerungen Digitalisierung im Mauerwerksbau N2 - Der vorliegende Beitrag stellt den seismischen Nachweis von Mauerwerksbauten in Deutschland auf Grundlage der DIN EN 1998‐1/NA vor, wobei auch die wesentlichen Änderungen zu der Norm DIN 4149 vergleichend erläutert werden. Vorgestellt werden die Definition der Erdbebeneinwirkung, das seismische Verhalten von Mauerwerksbauten und die Erläuterung der Rechenverfahren. Darauf aufbauend wird die Anwendung an drei Praxisbeispielen demonstriert. Y1 - 2021 SN - 9783433032930 SN - 9783433610732 U6 - https://doi.org/10.1002/9783433610732.ch12 SP - 329 EP - 355 PB - Ernst & Sohn CY - Berlin ER - TY - CHAP A1 - Diekmann, Julian A1 - Eggert, Mathias T1 - Is a Progressive Web App an Alternative for Native App Development? T2 - 3. Wissenschaftsforum: Digitale Transformation (WiFo21) (Lecture Notes in Informatics ; P-319) N2 - The existence of several mobile operating systems, such as Android and iOS, is a challenge for developers because the individual platforms are not compatible with each other and require separate app developments. For this reason, cross-platform approaches have become popular but lack in cloning the native behavior of the different operating systems. Out of the plenty cross-platform approaches, the progressive web app (PWA) approach is perceived as promising but needs further investigation. Therefore, the paper at hand aims at investigating whether PWAs are a suitable alternative for native apps by developing a PWA clone of an existing app. Two surveys are conducted in which potential users test and evaluate the PWA prototype with regard to its usability. The survey results indicate that PWAs have great potential, but cannot be treated as a general alternative to native apps. For guiding developers when and how to use PWAs, four design guidelines for the development of PWA-based apps are derived based on the results. KW - Progressive Web App KW - PWA KW - Cross-platform KW - Evaluation KW - Mobile web Y1 - 2021 SN - 978-3-88579-713-5 SP - 35 EP - 48 PB - Gesellschaft für Informatik CY - Darmstadt ER - TY - JOUR A1 - Butenweg, Christoph A1 - Kubalski, Thomas A1 - El-Deib, Khaled A1 - Gellert, Christoph ED - Jesse, Dirk T1 - Erdbebennachweis von Mauerwerksbauten nach DIN EN 1998-1/NA-2021 JF - Bautechnik : Zeitschrift für den gesamten Ingenieurbau N2 - Mauerwerksbauten in Deutschland sind mit Einführung des nationalen Anwendungsdokuments DIN EN 1998-1/NA auf Grundlage einer neuen probabilistischen Erdbebenkarte nachzuweisen. Für erfolgreiche Erdbebennachweise üblicher Grundrissformen von Mauerwerksbauten stehen in dem zukünftigen Anwendungsdokument neue rechnerische Nachweismöglichkeiten zur Verfügung, mit denen die Tragfähigkeitsreserven von Mauerwerksbauten in der Baupraxis mit einem überschaubaren Aufwand besser in Ansatz gebracht werden können. Das Standardrechenverfahren ist weiterhin der kraftbasierte Nachweis, der nun mit höheren Verhaltensbeiwerten im Vergleich zur DIN 4149 durchgeführt werden kann. Die höheren Verhaltensbeiwerte basieren auf der besseren Ausnutzung der gebäudespezifischen Verformungsfähigkeit und Energiedissipation sowie der Lastumverteilung der Schubkräfte im Grundriss mit Ansatz von Rahmentragwirkung durch Wand-Deckeninteraktionen. Alternativ dazu kann ein nichtlinearer Nachweis auf Grundlage von Pushover-Analysen zur Anwendung kommen. Vervollständigt werden die Regelungen für Mauerwerksbauten durch neue Regelungen für nichttragende Innenwände und Außenmauerschalen. Der vorliegende Beitrag stellt die Grundlagen und Hintergründe der neuen rechnerischen Nachweise in DIN EN 1998-1/NA vor und demonstriert deren Anwendung an einem Beispiel aus der Praxis. Y1 - 2021 U6 - https://doi.org/10.1002/bate.202100064 SN - 1437-0999 SN - 0005-6820, 0932-8351 VL - 98 IS - 11 SP - 852 EP - 863 PB - Ernst & Sohn CY - Berlin ER -