TY  - CHAP
A1  - Henderson, Colin J.
A1  - Wolf, C. Roland
A1  - Scheer, Nico
ED  - Woolf, Thomas F.
T1  - The use of transgenic animals to study drug metabolism
T2  - Handbook of Drug Metabolism. 2nd Edition
Y1  - 2009
SN  - 978-1-4200-7647-9
SP  - 637
EP  - 658
PB  - Informa Healthcare
CY  - New York
ER  - 
TY  - JOUR
A1  - Engel, Mareike
A1  - Bayer, Hendrik
A1  - Holtmann, Dirk
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - Flavin secretion of Clostridium acetobutylicum in a bioelectrochemical system - Is an iron limitation involved?
JF  - Bioelectrochemistry
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bioelechem.2019.05.014
SN  - 1567-5394
IS  - In Press, Accepted Manuscript
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Ross, Jillian
A1  - Rode, Anja
A1  - Zevnik, Branko
A1  - Niehaves, Sandra
A1  - Faust, Nicole
A1  - Wolf, C. Roland
T1  - A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response
JF  - Journal of Clinical Investigation
Y1  - 2008
U6  - http://dx.doi.org/https://doi.org/10.1172/JCI35483
SN  - 1558-8238
VL  - 118
IS  - 9
SP  - 3228
EP  - 3239
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - McEwan, Jillian
A1  - Beuger, Vincent
A1  - Stanley, Lesley A.
A1  - Rode, Anja
A1  - Wolf, C. Roland
T1  - Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines
JF  - Molecular Pharmacology
N2  - The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.
Y1  - 2012
U6  - http://dx.doi.org/10.1124/mol.111.075192
SN  - 1521-0111
VL  - 81
IS  - 1
SP  - 63
EP  - 72
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Reugels, Alexander M.
A1  - Boggetti, Barbara
A1  - Scheer, Nico
A1  - Campos-Ortega, José A.
T1  - Asymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio
JF  - Developmental Dynamics
Y1  - 2006
U6  - http://dx.doi.org/10.1002/dvdy.20699
SN  - 1097-0177
VL  - 235
IS  - 4
SP  - 934
EP  - 948
ER  - 
TY  - JOUR
A1  - Hans, Stefan
A1  - Scheer, Nico
A1  - Riedl, Iris
A1  - Weizäcker, Elisabeth von
A1  - Blader, Patrick
A1  - Campos-Ortega, José A.
T1  - her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling
JF  - Development
Y1  - 2004
U6  - http://dx.doi.org/10.1242/dev.01167
SN  - 1477-9129
VL  - 131
IS  - 12
SP  - 2957
EP  - 2969
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Riedl, Iris
A1  - Warren, J.T.
A1  - Kuwada, John Y.
A1  - Campos-Ortega, José A.
T1  - A quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish
JF  - Mechanism of Development
Y1  - 2002
U6  - http://dx.doi.org/10.1016/S0925-4773(01)00621-9
SN  - 0925-4773
VL  - 112
IS  - 1-2
SP  - 9
EP  - 14
ER  - 
TY  - JOUR
A1  - Lawson, Nathan D.
A1  - Scheer, Nico
A1  - Pham, Van N.
A1  - Kim, Ceol-Hee
A1  - Chitnis, Ajay B.
A1  - Campos-Ortega, José A.
A1  - Weinstein, Brant M.
T1  - Notch signaling is required for arterial-venous differentiation during embryonic vascular development
JF  - Development
Y1  - 2001
SN  - 1477-9129
VL  - 128
IS  - 19
SP  - 3675
EP  - 3683
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Groth, Anne
A1  - Hans, Stefan
A1  - Campos-Ortega, José A.
T1  - An instructive function for Notch in promoting gliogenesis in the zebrafish retina
JF  - Development
Y1  - 2001
SN  - 0950-1991
VL  - 128
IS  - 7
SP  - 1099
EP  - 1107
ER  - 
TY  - JOUR
A1  - Halbach, Thorsten
A1  - Scheer, Nico
T1  - Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins
JF  - Nucleic Acids Research
Y1  - 2000
U6  - http://dx.doi.org/10.1093/nar/28.18.3542
SN  - 1362-4962
VL  - 28
IS  - 18
SP  - 3542
EP  - 3550
ER  -