TY  - CHAP
A1  - Schwarte, Rudolf
A1  - Heinol, Horst-Guenther
A1  - Buxbaum, Bernd
A1  - Ringbeck, Thorsten
A1  - Xu, Z.
A1  - Hartmann, K.
ED  - Jähne, Bernd
T1  - Principles of three-dimensional imaging techniques
T2  - Sensors and imaging. - (Handbook of computer vision and applications ; Vol. 1)
Y1  - 1999
SN  - 0-12-379771-3 (Einzelbd.)
SN  - 0-12-379770-5 (Gesamtwerk)
SP  - 463
EP  - 485
PB  - Academic Press
CY  - San Diego
ER  - 
TY  - CHAP
A1  - Brandt, D.
A1  - Güsken, J.
A1  - Büchen, W.
A1  - Wahle, Michael
A1  - Huppatz, W.
A1  - Koewius, A.
A1  - Linn, W.
A1  - Sedlaceck, G.
T1  - Konstruieren mit Aluminium [Kapitel 4]
T2  - Aluminium-Taschenbuch / Hrsg.: Aluminium-Zentrale Düsseldorf. - Bd. 3: Weiterverarbeitung und Anwendung
Y1  - 1997
SN  - 3-87017-243-6
SP  - 359
EP  - 544
PB  - Aluminium-Verlag
CY  - Düsseldorf
ET  - 15. Auflage
ER  - 
TY  - JOUR
A1  - Porschen, W.
A1  - Gartzen, J.
A1  - Gewehr, K.
A1  - Mühlensiepen, H.
A1  - Weber, Hans-Joachim
A1  - Feinedegen, L E.
T1  - In vivo assay of the radiation sensitivity of hypoxic tumour cells : influence of γ-rays, cyclotron neutrons, misonidazole, hyperthermia and mixed modalities
JF  - The British journal of cancer / Supplement
N2  - Tumour cell death can be evaluated in the living mouse by externally measuring the rate of loss of tumour-bound DNA tracer. By sequentially labelling the tumour-bearing animals with ¹²⁵IUdR and ¹³¹IUdR 50 h apart, the average tumour cells at the time of the second injection are labelled by ¹²⁵IUdR and the euoxic tumour cells are specifically labelled with ¹³¹IUdR. Tumour treatment at this stage of labelling permits the observation of the reaction of euoxic cells and average tumour cells and finally yields data on hypoxic cells and thus on the oxygen enhancement ratio. This information adds to results from tumour control and growth delay.

With this technique effects were analysed of 60-Co γ-rays, cyclotron neutrons (E = 6 MeV), misonidazole (500 mg/kg body wt) and hyperthermia (42°C water-bath), or combinations of these.

Misonidazole (15 min before irradiation) altered the oxygen enhancement ratio by a factor of 1·5 for γ-rays and of 1·1 for neutrons; when evaluated from tumour-growth delay and TCD-50 misonidazole gave a dose modifying factor of 1·47 for γ-rays and of 1·2-1·3 for neutrons.

Based on percentage tumour regression 100 days after treatment, the enhancement ratio from hyperthermia (after irradiation) was 2·75 for γ-rays (at 10 Gray) and 2·2 for neutrons (at 3·2 Gray). For neutrons combined with misonidazole and hyperthermia the ratio was 2·4.

These results demonstrate that effects of neutron irradiation may be modified by electron-affinic substances and/or hyperthermia.
Y1  - 1978
SN  - 0306-9443
N1  - Section 6: Sensitization and Hypoxic Cytotoxicity: Effects of Hyperthermia and High Let
IS  - 3
SP  - 194
EP  - 197
PB  - Lewis
CY  - London
ER  - 
TY  - JOUR
A1  - Danho, Waleed
A1  - Naithani, Vinod K.
A1  - Sasaki, André N.
A1  - Föhles, Joseph
A1  - Berndt, Heinz
A1  - Büllesbach, Erika E.
A1  - Zahn, H.
T1  - Human proinsulin, VII : synthesis of two protected peptides corresponding to the sequences 1—45 and 46—86 of the prohormone
JF  - Hoppe-Seyler's Zeitschrift für physiologische Chemie
Y1  - 1980
U6  - https://doi.org/10.1515/bchm2.1980.361.1.857
SN  - 1437-4315
SN  - 0018-4888
VL  - 361
IS  - 1
SP  - 857
EP  - 863
ER  - 
TY  - JOUR
A1  - Kalbe, Jochen
A1  - Kuropka, Rolf
A1  - Meyer-Stork, L. Sebastian
A1  - Berndt, Heinz
A1  - Sauter, Sybille L.
A1  - Loss, Peter
A1  - Hendo, Karsten
A1  - Riesner, Detlev
A1  - Höcker, Hartwig
T1  - Isolation and characterization of high-molecular mass DNA from hair shafts
JF  - Biological chemistry
Y1  - 1988
SN  - 0177-3593
U6  - https://doi.org/10.1515/bchm3.1988.369.1.413
VL  - 369
IS  - 1
SP  - 413
EP  - 416
ER  - 
TY  - CHAP
A1  - Weber, Hans-Joachim
A1  - Porschen, W.
A1  - Dietzel, F.
ED  - Streffer, Christian
T1  - In vivo analysis of the influence of combined hyperthermia and gamma irradiation on euoxic and hypoxic tumor cells
T2  - Cancer therapy by hyperthermia and radiation : [proceedings of the 2. International Symposium on Cancer Therapy by Hyperthermia and Radiation, Essen, 2.-4.6.1977]
Y1  - 1978
SN  - 0-8067-1701-7
SN  - 3-541-71701-7
SP  - 276
EP  - 277
PB  - Urban and Schwarzenberg
CY  - Baltimore ; Munich [u.a.]
ER  - 
TY  - CHAP
A1  - Gitter, R.
A1  - Hornhardt, Ch.
A1  - Koewius, A.
A1  - Wahle, Michael
A1  - Landwein, Th. M.
A1  - Linn, W.
A1  - Meiners, F.
A1  - Wenk, L.
T1  - Konstruieren mit Aluminium [Kapitel 4]
T2  - Aluminium-Taschenbuch / Hrsg.: Aluminium-Zentrale Düsseldorf. - Bd. 3: Weiterverarbeitung und Anwendung
Y1  - 2003
SN  - 3-87017-275-4
SP  - 355
EP  - 599
PB  - Aluminium-Verlag
CY  - Düsseldorf
ET  - 16. Auflage
ER  - 
TY  - JOUR
A1  - Kuperjans, Isabel
A1  - Starke, M.
A1  - Esser, J.
A1  - Meyer, J.
A1  - Donner, O.
T1  - Analyse und Konzeption von Energieanlagen unter ökologischen, wirtschaftlichen und technischen Gesichtspunkten
JF  - WLB : Umwelttechnik für Industrie und Kommune
Y1  - 2000
SN  - 0341-2679
VL  - 44
IS  - 11/12
SP  - 26
EP  - 29
ER  - 
TY  - CHAP
A1  - Fabo, Sabine
A1  - Lemke, Inga
ED  - Hartmann, Doreen
ED  - Nitsche, Jessica
T1  - Gefährliche Liebschaften : Kunst zwischen Wderstand und Umarmung
T2  - Interventionen : Grenzüberschreitungen in Ästhetik, Politik und Ökonomie
Y1  - 2012
SN  - 978-3-7705-5283-2
SP  - 173
EP  - 189
PB  - Fink
CY  - München [u.a.]
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Conzen, Catharina
A1  - Weiss, Miriam
A1  - Clusmann, Hans
A1  - Fuest, Matthias
A1  - Mueller, Marguerite
A1  - Brockmann, Marc Alexander
A1  - Vilser, Walthard
A1  - Schmidt-Trucksäss, Arno
A1  - Hoellig, Anke
A1  - Seiz, Marcel
A1  - Thomé, Claudius
A1  - Kotliar, Konstantin
A1  - Schubert, Gerrit Alexander
T1  - Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study
JF  - PLoS ONE
N2  - Background
Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH.

Methods
In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2–14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling.

Results
Image quality was satisfactory in the majority of cases (93.3%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion.

Conclusion
RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort.
Y1  - 2016
U6  - https://doi.org/10.1371/journal.pone.0158781
SN  - 1932-6203
VL  - 11
IS  - 7
PB  - PLOS
CY  - San Francisco
ER  -