TY  - JOUR
A1  - Capri, Miriam
A1  - Morsiani, Cristina
A1  - Santoro, Aurelia
A1  - Moriggi, Manuela
A1  - Conte, Maria
A1  - Martucci, Morena
A1  - Bellavista, Elena
A1  - Fabbri, Cristina
A1  - Giampieri, Enrico
A1  - Albracht, Kirsten
A1  - Flück, Martin
A1  - Ruoss, Severin
A1  - Brocca, Lorenza
A1  - Canepari, Monica
A1  - Longa, Emanuela
A1  - Giulio, Irene Di
A1  - Bottinelli, Roberto
A1  - Cerretelli, Paolo
A1  - Salvioli, Stefano
A1  - Gelfi, Cecilia
A1  - Franceschi, Claudio
A1  - Narici, Marco
A1  - Rittweger, Jörn
T1  - Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting
JF  - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Y1  - 2019
U6  - http://dx.doi.org/10.1096/fj.201801625R
VL  - 33
IS  - 4
SP  - 5168
EP  - 5180
ER  - 
TY  - JOUR
A1  - Rittweger, Jörn
A1  - Albracht, Kirsten
A1  - Flück, Martin
A1  - Ruoss, Severin
A1  - Brocca, Lorenza
A1  - Longa, Emanuela
A1  - Moriggi, Manuela
A1  - Seynnes, Olivier
A1  - Di Giulio, Irene
A1  - Tenori, Leonardo
A1  - Vignoli, Alessia
A1  - Capri, Miriam
A1  - Gelfi, Cecilia
A1  - Luchinat, Claudio
A1  - Franceschi, Claudio
A1  - Bottinelli, Roberto
A1  - Cerretelli, Paolo
A1  - Narici, Marco
T1  - Sarcolab pilot study into skeletal muscle’s adaptation to longterm spaceflight
JF  - npj Microgravity
Y1  - 2018
U6  - http://dx.doi.org/10.1038/s41526-018-0052-1
SN  - 2373-8065
VL  - 4
IS  - 1
SP  - 1
EP  - 9
PB  - Nature Portfolio
ER  - 
TY  - JOUR
A1  - Waldvogel, Janice
A1  - Ritzmann, Ramona
A1  - Freyler, Kathrin
A1  - Helm, Michael
A1  - Monti, Elena
A1  - Albracht, Kirsten
A1  - Stäudle, Benjamin
A1  - Gollhofer, Albert
A1  - Narici, Marco
T1  - The Anticipation of Gravity in Human Ballistic Movement
JF  - Frontiers in Physiology
N2  - Stretch-shortening type actions are characterized by lengthening of the pre-activated muscle-tendon unit (MTU) in the eccentric phase immediately followed by muscle shortening. Under 1 g, pre-activity before and muscle activity after ground contact, scale muscle stiffness, which is crucial for the recoil properties of the MTU in the subsequent push-off. This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g. During parabolic flights, 17 subjects performed drop jumps while electromyography (EMG) of the lower limb muscles was combined with ultrasound images of the gastrocnemius medialis, 2D kinematics and kinetics to depict changes in energy management and performance. Neuro-mechanical coupling in 1 g was characterized by high magnitudes of pre-activity and eccentric muscle activity allowing an isometric muscle behavior during ground contact. EMG during pre-activity and the concentric phase systematically increased from 0.1 to 1 g. Below 1 g the EMG in the eccentric phase was diminished, leading to muscle lengthening and reduced MTU stretches. Kinetic energy at take-off and performance were decreased compared to 1 g. Above 1 g, reduced EMG in the eccentric phase was accompanied by large MTU and muscle stretch, increased joint flexion amplitudes, energy loss and reduced performance. The energy outcome function established by linear mixed model reveals that the central nervous system regulates the extensor muscles phase- and load-specifically. In conclusion, neuro-mechanical coupling appears to be optimized in 1 g. Below 1 g, the energy outcome is compromised by reduced muscle stiffness. Above 1 g, loading progressively induces muscle lengthening, thus facilitating energy dissipation.
Y1  - 2021
U6  - http://dx.doi.org/10.3389/fphys.2021.614060
SN  - 1664-042X
PB  - Frontiers
CY  - Lausanne
ER  -