TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, Gamal A1 - Falk, R. A1 - Crookshank, M. T1 - Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration. G. Baroud, R. Falk, M. Crookshank, S. Sponagel, T. Steffen JF - Journal of Biomechanics. 37 (2004), H. 2 Y1 - 2004 SN - 0021-9290 SP - 189 EP - 196 ER - TY - JOUR A1 - Digel, Ilya A1 - Wehlitz, V. A1 - Kayser, Peter A1 - Figiel-Lange, A. A1 - Bassam, Rasha A1 - Rundstedt, F. von T1 - Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids JF - Plant Pathology N2 - Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel ‘suspension depletion’ approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10–12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach. Y1 - 2018 U6 - https://doi.org/10.1111/ppa.12750 SN - 1365-3059 VL - 67 IS - 2 SP - 358 EP - 365 PB - Wiley CY - Oxford ER - TY - JOUR A1 - Staat, Manfred A1 - Baroud, Gamal A1 - Topcu, M. A1 - Sponagel, Stefan T1 - Soft Materials in Technology and Biology – Characteristics, Properties, and Parameter Identification JF - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Y1 - 2008 SN - 978-3-540-75408-4 SP - 253 EP - 315 PB - Springer CY - Berlin ER - TY - JOUR A1 - Temiz Artmann, Aysegül A1 - Yalcin, Ozlem A1 - Resmi, Halil A1 - Başkurt, Oǧuz Kerim T1 - Can white blood cell activation be one of the major factors that affect hemorheological parameters during and after exercise? JF - Clinical Hemorheology and Microcirculation. 26 (2002), H. 3 Y1 - 2002 SN - 1386-0291 N1 - = The 11th European Symposium on Clinical Hemorheology, Rouen, France, 19-22 September 2000 SP - 189 EP - 193 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, Gamal A1 - Falk, R. A1 - Crookshank, M. T1 - Corrigendum to “Experimental and theoretical investigation of directional permeability of human vertebral cancellous bone for cement infiltration”. Baroud, G.; Falk, R.; Crookshank, M.; Sponagel, S.; Steffen, T. JF - Journal of Biomechanics. 37 (2004), H. 2 Y1 - 2004 SN - 0021-9290 SP - 1802 ER - TY - JOUR A1 - Sponagel, Stefan A1 - Baroud, Gamal A1 - Steffen, T. A1 - Wu, J. T1 - Parameter identification for cement infiltration of osteoporotic bone JF - Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ... Y1 - 2002 SN - 90-5809-394-8 SP - 55 EP - 58 PB - Balkema CY - Lisse [u.a.] ER - TY - JOUR A1 - Scholz, A. A1 - Ley, Wilfried A1 - Dachwald, Bernd A1 - Miau, J. J. A1 - Juang, J. C. T1 - Flight results of the COMPASS-1 picosatellite mission JF - Acta Astronautica N2 - The mission of the COMPASS-1 picosatellite is to take pictures of the earth, to validate a space-borne GPS receiver developed by the German Aerospace Center, and to verify the proper operation of the magnetic attitude control system in orbit. The spacecraft was launched on April 28, 2008 from the Indian space port Sriharikota, as part of the PSLV-C9 world record launch that simultaneously brought ten satellites into orbit. The mission operations were carried out from the ground stations in Aachen and Tainan. Arising difficulties in the communication link were overcome with the support of individuals from the amateur radio community. After several months of mission operation, abundant housekeeping and mission data has been commanded, received and analyzed and is presented in this paper. Y1 - 2010 U6 - https://doi.org/10.1016/j.actaastro.2010.06.040 SN - 0094-5765 VL - 76 IS - 9-10 SP - 1289 EP - 1298 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ortner, Marion A1 - Hauser, Christine A1 - Schmaderer, Christoph A1 - Muggenthaler, Claudia A1 - Hapfelmeier, Alexander A1 - Sorg, Christian A1 - Diehl-Schmid, Janine A1 - Kurz, Alexander A1 - Förstl, Hans A1 - Ikenberg, Benno A1 - Kotliar, Konstantin A1 - Holger, Poppert A1 - Grimmer, Timo T1 - Decreased vascular pulsatility in Alzheimer’s disease dementia measured by transcranial color-coded duplex sonography JF - Neuropsychiatric disease and treatment N2 - Purpose: Impaired paravascular drainage of β-Amyloid (Aβ) has been proposed as a contributing cause for sporadic Alzheimer’s disease (AD), as decreased cerebral blood vessel pulsatility and subsequently reduced propulsion in this pathway could lead to the accumulation and deposition of Aβ in the brain. Therefore, we hypothesized that there is an increased impairment in pulsatility across AD spectrum. Patients and Methods: Using transcranial color-coded duplex sonography (TCCS) the resistance and pulsatility index (RI; PI) of the middle cerebral artery (MCA) in healthy controls (HC, n=14) and patients with AD dementia (ADD, n=12) were measured. In a second step, we extended the sample by adding patients with mild cognitive impairment (MCI) stratified by the presence (MCI-AD, n=8) or absence of biomarkers (MCI-nonAD, n=8) indicative for underlying AD pathology, and compared RI and PI across the groups. To control for atherosclerosis as a confounder, we measured the arteriolar-venular-ratio of retinal vessels. Results: Left and right RI (p=0.020; p=0.027) and left PI (p=0.034) differed between HC and ADD controlled for atherosclerosis with AUCs of 0.776, 0.763, and 0.718, respectively. The RI and PI of MCI-AD tended towards ADD, of MCI-nonAD towards HC, respectively. RIs and PIs were associated with disease severity (p=0.010, p=0.023). Conclusion: Our results strengthen the hypothesis that impaired pulsatility could cause impaired amyloid clearance from the brain and thereby might contribute to the development of AD. However, further studies considering other factors possibly influencing amyloid clearance as well as larger sample sizes are needed. Y1 - 2019 U6 - https://doi.org/10.2147/NDT.S225754 SN - 1178-2021 IS - 15 SP - 3487 EP - 3499 PB - Dove Medical Press CY - Albany, Auckland ER - TY - JOUR A1 - Bandlitz, Stefan A1 - Nakhoul, Makram A1 - Kotliar, Konstantin T1 - Daily variations of corneal white-to-white diameter measured with different methods JF - Clinical and experimental optometry N2 - Purpose: A precise determination of the corneal diameter is essential for the diagnosis of various ocular diseases, cataract and refractive surgery as well as for the selection and fitting of contact lenses. The aim of this study was to investigate the agreement between two automatic and one manual method for corneal diameter determination and to evaluate possible diurnal variations in corneal diameter. Patients and Methods: Horizontal white-to-white corneal diameter of 20 volunteers was measured at three different fixed times of a day with three methods: Scheimpflug method (Pentacam HR, Oculus), placido based topography (Keratograph 5M, Oculus) and manual method using an image analysis software at a slitlamp (BQ900, Haag-Streit). Results: The two-factorial analysis of variance could not show a significant effect of the different instruments (p = 0.117), the different time points (p = 0.506) and the interaction between instrument and time point (p = 0.182). Very good repeatability (intraclass correlation coefficient ICC, quartile coefficient of dispersion QCD) was found for all three devices. However, manual slitlamp measurements showed a higher QCD than the automatic measurements with the Keratograph 5M and the Pentacam HR at all measurement times. Conclusion: The manual and automated methods used in the study to determine corneal diameter showed good agreement and repeatability. No significant diurnal variations of corneal diameter were observed during the period of time studied. Y1 - 2022 U6 - https://doi.org/10.2147/OPTO.S360651 SN - 0816-4622 IS - 14 SP - 173 EP - 181 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Dachwald, Bernd A1 - Mikucki, Jill A1 - Tulaczyk, Slawek A1 - Digel, Ilya A1 - Espe, Clemens A1 - Feldmann, Marco A1 - Francke, Gero A1 - Kowalski, Julia A1 - Xu, Changsheng T1 - IceMole : A maneuverable probe for clean in situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems JF - Annals of Glaciology N2 - There is significant interest in sampling subglacial environments for geobiological studies, but they are difficult to access. Existing ice-drilling technologies make it cumbersome to maintain microbiologically clean access for sample acquisition and environmental stewardship of potentially fragile subglacial aquatic ecosystems. The IceMole is a maneuverable subsurface ice probe for clean in situ analysis and sampling of glacial ice and subglacial materials. The design is based on the novel concept of combining melting and mechanical propulsion. It can change melting direction by differential heating of the melting head and optional side-wall heaters. The first two prototypes were successfully tested between 2010 and 2012 on glaciers in Switzerland and Iceland. They demonstrated downward, horizontal and upward melting, as well as curve driving and dirt layer penetration. A more advanced probe is currently under development as part of the Enceladus Explorer (EnEx) project. It offers systems for obstacle avoidance, target detection, and navigation in ice. For the EnEx-IceMole, we will pay particular attention to clean protocols for the sampling of subglacial materials for biogeochemical analysis. We plan to use this probe for clean access into a unique subglacial aquatic environment at Blood Falls, Antarctica, with return of a subglacial brine sample. KW - Antarctic Glaciology KW - Extraterrestrial Glaciology KW - Glaciological instruments and methods KW - Subclacial exploration KW - Subglacial lakes Y1 - 2014 U6 - https://doi.org/10.3189/2014AoG65A004 SN - 1727-5644 VL - 55 IS - 65 SP - 14 EP - 22 PB - Cambridge University Press CY - Cambridge ER -