TY - JOUR A1 - Behbahani, Mehdi A1 - Nam, J. A1 - Waluga, C. A1 - Behr, M. A1 - Pasquali, M. A1 - Mottaghy, K. T1 - Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs Y1 - 2010 U6 - http://dx.doi.org/10.1097/01.mat.0000369377.65122.a3 N1 - Posterpresentation American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Mai, A. A1 - Bergmann, B. A1 - Waluga, C. A1 - Behr, M. A1 - Tran, L. A1 - Vonderstein, K. A1 - Mottaghy, K. T1 - Modeling and Numerical Simulation of Blood Damage Y1 - 2010 N1 - Posterpresentation ; Umbrella Symposium "Modelling and Simulation in Medicine, Engineering and Sciences", Forschungszentrum Jülich, January 18-20, 2010 ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Nguyen, N. H. A1 - Staat, Manfred T1 - Modeling and simulation of a growing mass by the Smoothed Finite Element Method (SFEM) T2 - Conference proceedings of the YIC GACM 2015 : 3rd ECCOMAS Young Investigators Conference and 6th GACM Colloquium on Computational Mechanics , Aachen, Germany, 20.07.2015 - 23.07.2015 / ed.: Stefanie Elgeti ; Jaan-Willem Simon Y1 - 2015 SP - 1 EP - 4 PB - RWTH Aachen University CY - Aachen ER - TY - JOUR A1 - Jung, Alexander A1 - Staat, Manfred T1 - Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue JF - GAMM - Mitteilungen der Gesellschaft für Angewandte Mathematik und Mechanik Y1 - 2019 U6 - http://dx.doi.org/10.1002/gamm.201900002 SN - 1522-2608 VL - 42 IS - 4 PB - Wiley CY - Weinheim ER - TY - THES A1 - Behbahani, Mehdi T1 - Modeling and Simulation of Shear-Dependent Platelet Reactions in Blood Vessels and Blood-Contacting Medical Devices Y1 - 2011 SN - 978-3-8439-0134-5 PB - Verlag Dr. Hut CY - München ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Waluga, C. A1 - Stock, S. A1 - Mai, A. A1 - Bergmann, B. A1 - Behr, M. A1 - Tran, L. A1 - Vonderstein, K. A1 - Scheidt, H. A1 - Oedekoven, B. A1 - Mottaghy, K. T1 - Modelling and Numerical Analysis of Platelet Reactions and Surface Thrombus Growth Y1 - 2009 N1 - Posterpresentation ; European Society of Biomaterials (ESB), Lausanne, Switzerland, September 7-10, 2009 ER - TY - JOUR A1 - Horbach, Andreas A1 - Duong, Minh Tuan A1 - Staat, Manfred T1 - Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement JF - Journal of the mechanical behavior of biomedical materials Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.jmbbm.2017.06.012 SN - 1751-6161 VL - 74 SP - 400 EP - 410 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Staat, Manfred T1 - Modelling of Soft Connective Tissues to Investigate Female Pelvic Floor Dysfunctions JF - Computational and Mathematical Methods in Medicine N2 - After menopause, decreased levels of estrogen and progesterone remodel the collagen of the soft tissues thereby reducing their stiffness. Stress urinary incontinence is associated with involuntary urine leakage due to pathological movement of the pelvic organs resulting from lax suspension system, fasciae, and ligaments. This study compares the changes in the orientation and position of the female pelvic organs due to weakened fasciae, ligaments, and their combined laxity. A mixture theory weighted by respective volume fraction of elastin-collagen fibre compound (5%), adipose tissue (85%), and smooth muscle (5%) is adopted to characterize the mechanical behaviour of the fascia. The load carrying response (other than the functional response to the pelvic organs) of each fascia component, pelvic organs, muscles, and ligaments are assumed to be isotropic, hyperelastic, and incompressible. Finite element simulations are conducted during Valsalva manoeuvre with weakened tissues modelled by reduced tissue stiffness. A significant dislocation of the urethrovesical junction is observed due to weakness of the fascia (13.89 mm) compared to the ligaments (5.47 mm). The dynamics of the pelvic floor observed in this study during Valsalva manoeuvre is associated with urethral-bladder hypermobility, greater levator plate angulation, and positive Q-tip test which are observed in incontinent females. Y1 - 2018 U6 - http://dx.doi.org/10.1155/2018/9518076 SN - 1748-6718 VL - 2018 IS - Article ID 9518076 SP - 1 EP - 16 PB - Hindawi CY - New York, NY ER - TY - CHAP A1 - Raman, Aravind Hariharan A1 - Jung, Alexander A1 - Horváth, András A1 - Becker, Nadine A1 - Staat, Manfred ED - Staat, Manfred ED - Erni, Daniel T1 - Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich). Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 10 EP - 11 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Albanna, Walid A1 - Lüke, Jan Niklas A1 - Schubert, Gerrit Alexander A1 - Dibué-Adjei, Maxine A1 - Kotliar, Konstantin A1 - Hescheler, Jürgen A1 - Clusmann, Hans A1 - Steiger, Hans-Jakob A1 - Hänggi, Daniel A1 - Kamp, Marcel A. A1 - Schneider, Toni A1 - Neumaier, Felix T1 - Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity JF - Molecular and Cellular Neuroscience Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.mcn.2019.03.003 SN - 1044-7431 VL - 96 IS - 4 SP - 35 EP - 46 PB - Elsevier CY - Amsterdam ER -