TY  - CHAP
A1  - Duong, Minh Tuan
A1  - Seifarth, Volker
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Staat, Manfred
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries.
KW  - Mechanical simulation
KW  - Growth modelling
KW  - Ureter
KW  - Bladder
KW  - Reconstruction
Y1  - 2018
SN  - 978-981-10-7904-7
U6  - https://doi.org/10.1007/978-981-10-7904-7_9
SP  - 209
EP  - 232
PB  - Springer
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Staat, Manfred
T1  - Physical response of hyperelastic models for composite materials and soft tissues
T2  - Advances in Composite Material
Y1  - 2017
SN  - 978-1-61896-300-0 (Hardcover), 978-1-61896-299-7 (Paperback)
N1  - Chapter 5
PB  - Scientific Research Publishing
CY  - Wuhan
ER  - 
TY  - CHAP
A1  - Dachwald, Bernd
A1  - Ulamec, Stephan
A1  - Biele, Jens
T1  - Clean in situ subsurface exploration of icy environments in the solar system
T2  - Habitability of other planets and satellites. - (Cellular origin, life in extreme habitats and astrobiology ; 28)
N2  - "To assess the habitability of the icy environments in the solar system, for example, on Mars, Europa, and Enceladus, the scientific analysis of material embedded in or underneath their ice layers is very important. We consider self-steering robotic ice melting probes to be the best method to cleanly access these environments, that is, in compliance with planetary protection standards. The required technologies are currently developed and tested."
Y1  - 2013
SN  - 978-94-007-6545-0 (Druckausgabe)
SN  - 978-94-007-6546-7 (E-Book)
SP  - 367
EP  - 397
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - CHAP
A1  - Goh, Kheng Lim
A1  - Topçu, Murat
A1  - Madabhushi, Gopal S. P.
A1  - Staat, Manfred
ED  - Maia, Fatima Raquel Azevedo
ED  - Miguel Oliveira, J.
ED  - Reis, Rui L.
T1  - Collagen fibril reinforcement in connective tissue extracellular matrices
T2  - Handbook of the extracellular matrix
N2  - The connective tissues such as tendons contain an extracellular matrix (ECM) comprising collagen fibrils scattered within the ground substance. These fibrils are instrumental in lending mechanical stability to tissues. Unfortunately, our understanding of how collagen fibrils reinforce the ECM remains limited, with no direct experimental evidence substantiating current theories. Earlier theoretical studies on collagen fibril reinforcement in the ECM have relied predominantly on the assumption of uniform cylindrical fibers, which is inadequate for modelling collagen fibrils, which possessed tapered ends. Recently, Topçu and colleagues published a paper in the International Journal of Solids and Structures, presenting a generalized shear-lag theory for the transfer of elastic stress between the matrix and fibers with tapered ends. This paper is a positive step towards comprehending the mechanics of the ECM and makes a valuable contribution to formulating a complete theory of collagen fibril reinforcement in the ECM.
KW  - Connective tissues
KW  - Extracellular matrix (ECM)
KW  - Collagen fibrils
KW  - Mechanical stability
KW  - Tapered ends
Y1  - 2024
SN  - 978-3-031-56362-1 (Print)
SN  - 978-3-031-56363-8 (Online)
U6  - https://doi.org/10.1007/978-3-031-56363-8_6
SP  - 89
EP  - 108
PB  - Springer Nature
CY  - Cham
ER  -