TY - JOUR A1 - Grinsven, Bart van A1 - Bon, Natalie vanden A1 - Strauven, Hannelore A1 - Grieten, Lars A1 - Murib, Mohammed A1 - Jiménez Monroy, Kathia L. A1 - Janssens, Stoffel D. A1 - Haenen, Ken A1 - Schöning, Michael Josef A1 - Vermeeren, Veronique A1 - Ameloot, Marcel A1 - Michiels, Luc A1 - Thoelen, Ronald A1 - Ceuninck, Ward de A1 - Wagner, Patrick T1 - Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA. JF - ACS Nano N2 - In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA. Y1 - 2012 U6 - https://doi.org/10.1021/nn300147e SN - 1936-086X VL - 6 IS - 3 SP - 2712 EP - 2721 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Arida, Hassan A. A1 - Al-haddad, Ameera A1 - Schöning, Michael Josef T1 - New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode JF - International Journal of Electrochemical Science. 6 (2011), H. 9 Y1 - 2011 SN - 1452-3981 SP - 3858 EP - 3867 ER - TY - CHAP A1 - Fredebeul-Krein, Markus A1 - Steingröver, Markus T1 - Wholesale Broadband Access to IPTV in an NGA environment : how to deal with it from a regulatory perspective? Y1 - 2012 N1 - Regional ITS Conference of the international Telecommunications Society , February 22-24, 2012 New Delhi, India SP - 1 EP - 16 ER - TY - CHAP A1 - Bohrn, U. A1 - Stütz, E. A1 - Fleischer, M. A1 - Schöning, Michael Josef A1 - Wagner, P. ED - Abdelghani, Adnane ED - Schöning, Michael Josef T1 - Towards a paradigm change – mammalian cells as sensitive biosensor layers for the detection of unexpected toxic substances in air T2 - Nanoscale Science and Technology (NS&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012 Y1 - 2012 SP - 44 EP - 44 ER - TY - BOOK A1 - Havermann, Marc T1 - PIV measurements in shock tunnels : PivNet 2, Final Workshop, Göttingen, 07. - 08.09.2006 Y1 - 2006 N1 - Publication / Institut Franco-Allemand de Recherches de Saint Louis ; 644 PB - ISL CY - Saint-Louis ER - TY - BOOK A1 - Havermann, Marc T1 - PIV measurements of compressible vortex rings generated by a shock tube : 13th International Symposium on Applications of Laser Techniques to Fluid Mechanics, Lisbon, PT, 26-29.06.2006; axe de recherches 2.14 / Haertig, J.; Rey, C.; Havermann, M. Institut Franco-Allemand de Recherches de Saint-Louis Y1 - 2006 N1 - Publication / Institut Franco-Allemand de Recherches de Saint Louis ; 645 PB - ISL CY - Saint-Louis ER - TY - BOOK A1 - Havermann, Marc A1 - Seiler, Friedrich T1 - Boundary layer influence on supersonic jet cross flow interaction in hypersonic flow : DGLR/STAB-Fachsymposium Strömungsmechanik 2004, Bremer Innovations- und Technologiezentrum (BITZ), Bremen, FRG, 16. - 18. November 2004 / Havermann, M.; Seiler, F. Institut Franco-Allemand de Recherches de Saint-Louis Y1 - 2004 N1 - Publication / Institut Franco-Allemand de Recherches de Saint-Louis ; 658 PB - ISL CY - Saint-Louis ER - TY - BOOK A1 - Havermann, Marc T1 - Shock tunnel measurement of the interaction amplification factor for a hot gas side jet in a supersonic cross-flow : 24th International Symposium on Shock Waves, Beijing, China, July 11 - 16, 2004 / Institut Franco-Allemand de Recherches de Saint-Louis. Havermann, M. ... Y1 - 2004 N1 - Publication / Institut Franco-Allemand de Recherches de Saint-Louis ; 642 PB - ISL CY - Saint-Louis ER - TY - BOOK A1 - Havermann, Marc A1 - Ende, Herrybert A1 - Schwenzer, Michael T1 - Shock tunnel study on the interaction of a lateral jet with a supersonic cross flow : West East High-Speed Flow Field Conference, Marseille, France, April 22 - 26, 2002; axe de recherches 2.14 / Havermann, M.; Ende, H.; Schwenzer, M. Institut Franco-Allemand de Recherches de Saint-Louis Y1 - 2002 N1 - Publication / Institut Franco-Allemand de Recherches de Saint-Louis ; 620 PB - ISL CY - Saint-Louis ER - TY - BOOK A1 - Havermann, Marc A1 - Haertig, J. A1 - Rey, C. A1 - George, A. T1 - Application of particle image velocimetry to high-speed supersonic flows in a shock tunnel : 11th International Symposium on Applications of Laser Techniques to Fluid Mechanics, Lisbon, Portugal, July 8 - 11, 2002; Schwerpunkt 0 / Institut Franco-Allemand de Recherches de Saint-Louis. Havermann, M. ... Y1 - 2002 N1 - Publication / Institut Franco-Allemand de Recherches de Saint-Louis ; 640 PB - ISL CY - Saint-Louis ER -