TY  - CHAP
A1  - Frotscher, Ralf
A1  - Staat, Manfred
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.
Y1  - 2018
SN  - 978-981-10-7904-7
U6  - http://dx.doi.org/10.1007/978-981-10-7904-7_10
SP  - 233
EP  - 250
PB  - Springer
CY  - Singapore
ER  - 
TY  - THES
A1  - Frotscher, Ralf
T1  - Electromechanical modeling and simulation of thin cardiac tissue constructs - smoothed FEM applied to a biomechanical plate problem
Y1  - 2016
N1  - Duisburg, Essen, Universität Duisburg-Essen, Diss., 2016
ER  - 
TY  - JOUR
A1  - Colombo, Daniele
A1  - Drira, Slah
A1  - Frotscher, Ralf
A1  - Staat, Manfred
T1  - An element-based formulation for ES-FEM and FS-FEM models for implementation in standard solid mechanics finite element codes for 2D and 3D static analysis
JF  - International Journal for Numerical Methods in Engineering
N2  - Edge-based and face-based smoothed finite element methods (ES-FEM and FS-FEM, respectively) are modified versions of the finite element method allowing to achieve more accurate results and to reduce sensitivity to mesh distortion, at least for linear elements. These properties make the two methods very attractive. However, their implementation in a standard finite element code is nontrivial because it requires heavy and extensive modifications to the code architecture. In this article, we present an element-based formulation of ES-FEM and FS-FEM methods allowing to implement the two methods in a standard finite element code with no modifications to its architecture. Moreover, the element-based formulation permits to easily manage any type of element, especially in 3D models where, to the best of the authors' knowledge, only tetrahedral elements are used in FS-FEM applications found in the literature. Shape functions for non-simplex 3D elements are proposed in order to apply FS-FEM to any standard finite element.
KW  - distorted element
KW  - ES-FEM
KW  - FS-FEM
KW  - non-simplex S-FEM elements
KW  - S-FEM
Y1  - 2022
U6  - http://dx.doi.org/10.1002/nme.7126
SN  - 1097-0207
VL  - 124
IS  - 2
SP  - 402
EP  - 433
PB  - Wiley
CY  - Chichester
ER  -