TY  - CHAP
A1  - Jung, Alexander
A1  - Frotscher, Ralf
A1  - Staat, Manfred
T1  - Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts
T2  - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK
N2  - The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample.
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Nix, Yvonne
A1  - Frotscher, Ralf
A1  - Staat, Manfred
ED  - Eberhardsteiner, J.
T1  - Implementation of the edge-based smoothed extended finite element method
T2  - Proceedings 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Vienna, Austria, September 10-14, 2012
Y1  - 2012
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Trenz, Eva
A1  - Lohmann, Philipp
A1  - Frotscher, Ralf
A1  - Klinge, Uwe
A1  - Tabaza, Ruth
A1  - Kirschner-Hermanns, Ruth
T1  - New measurements to compare soft tissue anchoring systems in pelvic floor surgery
JF  - Journal of Biomedical Materials Research Part B: Applied Biomaterials
N2  - Suburethral slings as well as different meshes are widely used treating stress urinary incontinence and prolaps in women. With the development of MiniSlings and special meshes using less alloplastic material anchorage systems become more important to keep devices in place and to put some tension especially on the MiniSlings. To date, there are many different systems of MiniSlings of different companies on the market which differ in the structure of the used meshes and anchors. A new objective measurement method to compare different properties of MiniSling systems (mesh and anchor) is presented in this article. Ballistic gelatine acts as soft tissue surrogate. Significant differences in parameters like pull-out strength of anchors or shrinkage of meshes under loading conditions have been determined. The form and size of the anchors as well as the structural stability of the meshes are decisive for a proper integration. The tested anchorings sytems showed markedly different mechanical function at their respective load bearing capacity. As the stable fixation of the device in tissue is a prerequisite for a permanet reinforcement, the proposed test system permits further optimisation of anchor and mesh devices to improve the success of the surgical treatment
Y1  - 2012
U6  - http://dx.doi.org/10.1002/jbm.b.32654
SN  - 1552-4981
VL  - 100B
IS  - 4
SP  - 924
EP  - 933
PB  - Wiley
CY  - Hoboken, NJ
ER  -