TY  - CHAP
A1  - Samuelsson, K.
A1  - Scheer, Nico
A1  - Wilson, I.
A1  - Wolf, C.R.
A1  - Henderson, C.J.
ED  - Chackalamannil, Samuel
T1  - Genetically Humanized Animal Models
T2  - Comprehensive Medicinal Chemistry III. 3rd Edition
N2  - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
KW  - Chimeric liver-humanized mice
KW  - Drug distribution
KW  - Drug metabolism
KW  - Toxicology
KW  - Knockout mice
Y1  - 2017
SN  - 978-0-12-803201-5
U6  - http://dx.doi.org/10.1016/B978-0-12-409547-2.12376-5
SP  - 130
EP  - 149
PB  - Elsevier
CY  - Saint Louis
ER  - 
TY  - CHAP
A1  - Sauerborn, Markus
A1  - Liebenstund, Lena
A1  - Raue, Markus
A1  - Mang, Thomas
A1  - Herrmann, Ulf
A1  - Dueing, Andreas
T1  - Analytic method for material aging and quality analyzing to forecast long time stability of plastic micro heliostat components
T2  - AIP Conference Proceedings
Y1  - 2017
U6  - http://dx.doi.org/10.1063/1.4984388
VL  - 1850
IS  - 1
SP  - 030045-1
EP  - 030045-8
ER  - 
TY  - JOUR
A1  - Savitskaya, I. S.
A1  - Kistaubayeva, A. S.
A1  - Digel, Ilya
A1  - Shokatayeva, D. H.
T1  - Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials
JF  - Eurasian Chemico-Technological Journal
Y1  - 2017
U6  - http://dx.doi.org/10.18321/ectj670
SN  - 2522-4867
VL  - 19
IS  - 3
SP  - 255
EP  - 264
ER  - 
TY  - CHAP
A1  - Schiffer, Stefan
A1  - Ferrein, Alexander
T1  - A System Layout for Cognitive Service Robots
T2  - Cognitive Robot Architectures. Proceedings of EUCognition 2016
Y1  - 2017
SN  - 1613-0073
N1  - CEUR-WS Vol-1855
SP  - 44
EP  - 45
ER  - 
TY  - CHAP
A1  - Schildt, P.
A1  - Braun, Carsten
A1  - Marcocca, P.
T1  - Flight testing the extra 330LE flying testbed
T2  - 48th Annual International Symposium of the Society of Flight Test Engineers 2017
Y1  - 2017
SN  - 978-151085387-4
N1  - 48th Annual International Symposium of the Society of Flight Test Engineers 2017, SFTE 2017; Destin; United States; 30 October 2017 through 2 November 2017
SP  - 349
EP  - 362
ER  - 
TY  - CHAP
A1  - Schlemmer, Katharina
A1  - Porst, Dariusz
A1  - Bassam, Rasha
A1  - Artmann, Gerhard
A1  - Digel, Ilya
ED  - Erni, Daniel
ED  - Fischerauer, Alice
ED  - Himmel, Jörg
ED  - Seeger, Thomas
ED  - Thelen, Klaus
T1  - Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability
T2  - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West
Y1  - 2017
SN  - 978-3-9814801-9-1
U6  - http://dx.doi.org/10.17185/duepublico/43984
N1  - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017
SP  - 100
EP  - 101
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - CHAP
A1  - Schleupen, Josef
A1  - Engemann, Heiko
A1  - Bagheri, Mohsen
A1  - Kallweit, Stephan
A1  - Dahmann, Peter
T1  - Developing a climbing maintenance robot for tower and rotor blade service of wind turbines
T2  - Advances in Robot Design and Intelligent Control : Proceedings of the 25th Conference on Robotics in Alpe-Adria-Danube Region (RAAD16)
Y1  - 2017
SN  - 978-3-319-49058-8
U6  - http://dx.doi.org/10.1007/978-3-319-49058-8_34
N1  - Advances in Robot Design and Intelligent Control ; Vol. 540
SP  - 310
EP  - 319
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Schmidts, Oliver
A1  - Boltes, Maik
A1  - Kraft, Bodo
A1  - Schreiber, Marc
T1  - Multi-pedestrian tracking by moving Bluetooth-LE beacons and stationary receivers
T2  - 2017 International Conference on Indoor Positioning and Indoor Navigation (IPIN), 18-21 September 2017, Sapporo, Japan
Y1  - 2017
N1  - International Conference on Indoor Positioning and Indoor Navigation <8, 2017, Sapporo, Japan>
SP  - 1
EP  - 4
ER  - 
TY  - CHAP
A1  - Schneider, Oliver
A1  - Al Hakim, Taher
A1  - Kayser, Peter
A1  - Digel, Ilya
ED  - Erni, Daniel
ED  - Fischerauer, Alice
ED  - Himmel, Jörg
ED  - Seeger, Thomas
ED  - Thelen, Klaus
T1  - Development and trials of a test chamber for ultrasound-assisted sampling of living cells from solid surfaces
T2  - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West
Y1  - 2017
SN  - 978-3-9814801-9-1
U6  - http://dx.doi.org/10.17185/duepublico/43984
N1  - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017
SP  - 96
EP  - 97
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Scholl, Fabio
A1  - Morais, Paulo
A1  - Gabriel, Rayla
A1  - Schöning, Michael Josef
A1  - Siqueira, Jose Roberto, Jr.
A1  - Caseli, Luciano
T1  - Carbon nanotubes arranged as smart interfaces in lipid Langmuir-Blodgett films enhancing the enzymatic properties of penicillinase for biosensing applications
JF  - Applied Materials & Interfaces
N2  - In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir–Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air–water interface was investigated by surface pressure–area isotherms, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy. Enzyme activity was studied with UV–vis spectroscopy and the feasibility of the supramolecular device nanostructured as ultrathin films were essayed in a capacitive electrolyte–insulator–semiconductor (EIS) sensor device. The presence of CNTs in the enzyme–lipid LB film not only tuned the catalytic activity of penicillinase but also helped conserve its enzyme activity after weeks, showing increased values of activity. Viability as penicillin sensor was demonstrated with capacitance/voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results may be related not only to the nanostructured system provided by the film, but also to the synergism between the compounds on the active layer, leading to a surface morphology that allowed a fast analyte diffusion because of an adequate molecular accommodation, which also preserved the penicillinase activity. This work therefore demonstrates the feasibility of employing LB films composed of lipids, CNTs, and enzymes as EIS devices for biosensing applications.
Y1  - 2017
U6  - http://dx.doi.org/10.1021/acsami.7b08095
SN  - 1944-8252
VL  - 9
IS  - 36
SP  - 31054
EP  - 31066
PB  - ACS
CY  - Washington
ER  -